What happens if I overdose Zodryl AC?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Symptoms may include blurred vision; chest pain; cold or clammy skin; confusion; difficult or very slow breathing; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.
Proper storage of Zodryl AC suspension:
Store Zodryl AC suspension at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zodryl AC suspension out of the reach of children and away from pets.
Overdose of Zodryl AC in details
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: confusion, cold/clammy skin, fast/slow/irregular heartbeat, slow/shallow breathing, seizures, loss of consciousness.
Notes
Do not share this medication with others. It is against the law.
Do not take this medication for several days before allergy testing because test results can be affected.
Missed Dose
If you are prescribed this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
What should I avoid while taking Zodryl AC?
Chlorpheniramine (Zodryl AC) and Codeine (Zodryl AC) may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Do not drink alcohol while you are taking medicine that contains Codeine (Zodryl AC). Dangerous side effects or death can occur when alcohol is combined with a narcotic medicine.
Ask a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Antihistamines and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or cough suppressant.
Zodryl AC warnings
Respiratory Depression
Zodryl AC is not recommended for use in pediatric patients under 6 years of age. Pediatric patients under 2 years of age may be more susceptible to the respiratory depressant effects of Codeine (Zodryl AC), including respiratory arrest, coma, and death.
As with other opioids, Codeine (Zodryl AC) produces dose-related respiratory depression by directly acting on brain stem respiratory centers. Codeine (Zodryl AC) affects the center that controls respiratory rhythm, and may produce irregular and periodic breathing. Caution should be exercised when Zodryl AC is used postoperatively, in patients with pulmonary disease or shortness of breath, or whenever ventilatory function is depressed. If respiratory depression occurs, it may be antagonized by the use of naloxone hydrochloride and other supportive measures when indicated.
Head Injury and Increased Intracranial Pressure
Respiratory depressant effects of opioids and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, opioids produce adverse reactions which may obscure the clinical course of patients with head injuries.
Acute Abdominal Conditions
Administration of opioids may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
Obstructive Bowel Disease
Chronic use of opioids may result in obstructive bowel disease especially in patients with underlying intestinal motility disorder.
Respiratory Conditions
Zodryl AC should be used with caution in patients with persistent or chronic cough such as occurs with smoking, asthma, or emphysema, or with cough accompanied by excessive phlegm. In patients with asthma or pulmonary emphysema, the indiscriminate use of antitussives may precipitate respiratory insufficiency due to increased viscosity of bronchial secretions and suppression of the cough reflex. In addition, the anticholinergic activity of antihistamines might reduce the volume and cause thickening of bronchial secretions and thus result in obstruction of the respiratory passages. Benefit to risk ratio should be carefully considered especially in pediatric patients with respiratory embarrassment (e.g., croup).
What should I discuss with my healthcare provider before taking Zodryl AC?
Do not take Zodryl AC without first talking to your doctor if you have
-
an allergy to Codeine (Zodryl AC), morphine, or other narcotic medications;
- kidney disease;
- liver disease;
-
diabetes;
-
glaucoma;
-
a head injury;
-
heart disease or high blood pressure;
-
intestinal problems;
-
Addison's disease;
-
thyroid disease;
-
asthma or lung disease; or
-
difficulty urinating or have an enlarged prostate.
You may not be able to take Zodryl AC, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Zodryl AC is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take Zodryl AC without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zodryl AC passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from Zodryl AC. Your doctor may prescribe a lower dose of the medication.
Zodryl AC precautions
General
Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause of cough is identified, that modification of cough does not increase the risk of clinical or physiologic complications, and that appropriate therapy for the primary disease is provided. Because of its sympathomimetic component Zodryl AC Liquid should be used with caution in patients with diabetes, hypertension, heart disease, or thyroid disease.
Information for Patients
Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery. Patients should be cautioned to get up slowly from a lying or sitting position and to lie down if nausea occurs.
Drug Interactions
Patients receiving other narcotic analgesics, anti-psychotics, anti-anxiety agents, or other CNS depressants (including alcohol) concomitantly with this drug may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced. The concurrent use of anticholinergics with Codeine (Zodryl AC) may produce paralytic ileums. MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, anti-anxiety agents.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Animal studies of Zodryl AC Liquid to assess the carcinogenic and mutagenic potential to the effect on fertility have not been performed.
Pregnancy
Pregnancy Category C
Animal reproduction studies have not been conducted with Zodryl AC Liquid. It is also not known whether Zodryl AC Liquid can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Zodryl AC Liquid should be given to a pregnant woman only if clearly needed.
Nursing Mothers
Zodryl AC Liquid is contraindicated in nursing mothers.
Pediatric Use
Not recommended for use in patients under 6 years of age.
Geriatric Use
The elderly (60 years of age or older) are more likely to exhibit adverse reactions. Caution should be taken when prescribing this drug to the elderly.
What happens if I miss a dose of Zodryl AC?
Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CODEINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "chlorpheniramine". http://www.drugbank.ca/drugs/DB01114 (accessed September 17, 2018).
Reviews
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
