Overdose of Zotakof C in details
Overdosage of Zotakof C has resulted in a serious degree of metabolic acidosis, disorientation, confusion and coma. Should metabolic acidosis occur following overdosage, the administration of an alkalinizing solution such as sodium bicarbonate or sodium lactate will serve to correct the acidosis.
What should I discuss with my healthcare provider before taking Zotakof C?
- If you have an allergy to Zotakof C or any part of this medicine.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Kidney disease or liver disease.
- If you are losing sodium.
This is not a list of all drugs or health problems that interact with Zotakof C.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Zotakof C precautions
Patients receiving Zotakof C should be constantly observed for symptoms of ammonia toxicity (pallor, sweating, retching, irregular breathing, bradycardia, cardiac arrhythmias, local and general twitching, tonic convulsions and coma).
It should be used with caution in patients with high total CO2 and buffer base secondary to primary respiratory acidosis.
Intravenous administration should be slow to avoid local irritation and toxic effects.
When exposed to low temperatures, concentrated solutions of Zotakof C may crystallize. If crystals are observed, the vial should be warmed to room temperature in a water bath prior to use.
Do not administer unless the solution is clear and seal is intact. Discard unused portion.
Pregnancy Category C: Animal reproduction studies have not been conducted with Zotakof C. It is also not known whether Zotakof C can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Zotakof C should be given to a pregnant woman only if clearly needed.
References
- DailyMed. "AMMONIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Ammonium chloride". http://www.drugbank.ca/drugs/DB06767 (accessed September 17, 2018).
- MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
