What is Augmentin 400 mg/57 mg/5 m?
Penicillins are used to treat infections caused by bacteria. They work by killing the bacteria or preventing their growth.
There are several different kinds of penicillins. Each is used to treat different kinds of infections. One kind of penicillin usually may not be used in place of another. In addition, penicillins are used to treat bacterial infections in many different parts of the body. They are sometimes given with other antibacterial medicines (antibiotics). Some of the penicillins may also be used for other problems as determined by your doctor. However, none of the penicillins will work for colds, flu, or other virus infections.
Penicillins are available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, penicillins are used in certain patients with the following medical conditions:
- Chlamydia infections in pregnant women—Augmentin 400 mg/57 mg/5 m and ampicillin
- Gas gangrene—Penicillin G
- Helicobacter pylori-associated gastritis or peptic ulcer disease—Augmentin 400 mg/57 mg/5 m
- Leptospirosis—Ampicillin and penicillin G
- Lyme disease—Augmentin 400 mg/57 mg/5 m and penicillin V
- Typhoid fever—Augmentin 400 mg/57 mg/5 m and ampicillin
Augmentin 400 mg/57 mg/5 m indications
Infections of the Ear, Nose, and Throat
Augmentin 400 mg/57 mg/5 m Capsules, Augmentin 400 mg/57 mg/5 m for oral suspension, Augmentin 400 mg/57 mg/5 m tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae.
Infections of the Genitourinary Tract
Augmentin 400 mg/57 mg/5 m Capsules, Augmentin 400 mg/57 mg/5 m for oral suspension, Augmentin 400 mg/57 mg/5 m tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.
Infections of the Skin and Skin Structure
Augmentin 400 mg/57 mg/5 m Capsules, Augmentin 400 mg/57 mg/5 m for oral suspension, Augmentin 400 mg/57 mg/5 m tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus spp. (α- and β-hemolytic isolates only), Staphylococcus spp., or E. coli.
Infections of the Lower Respiratory Tract
Augmentin 400 mg/57 mg/5 m Capsules, Augmentin 400 mg/57 mg/5 m for oral suspension, Augmentin 400 mg/57 mg/5 m tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus spp. (α- and β-hemolytic isolates only), S. pneumoniae, Staphylococcus spp., or H. influenzae.
Helicobacter pylori Infection
Triple therapy for Helicobacter pylori with clarithromycin and lansoprazole:
Augmentin 400 mg/57 mg/5 m, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1 year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.
Dual therapy for H. pylori with lansoprazole:
Augmentin 400 mg/57 mg/5 m, in combination with lansoprazole delayed-release capsules as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1 year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.
Usage
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Augmentin 400 mg/57 mg/5 m and other antibacterial drugs, Augmentin 400 mg/57 mg/5 m should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Augmentin 400 mg/57 mg/5 m?
Use Augmentin 400 mg/57 mg/5 m suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Augmentin 400 mg/57 mg/5 m suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Shake well before each use.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Augmentin 400 mg/57 mg/5 m suspension may be mixed with formula, milk, fruit juice, water, ginger ale, or other cold drinks. If you mix Augmentin 400 mg/57 mg/5 m suspension, take it at once after mixing. Be sure that the entire dose is swallowed.
- To clear up your infection completely, take Augmentin 400 mg/57 mg/5 m suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
- If you miss a dose of Augmentin 400 mg/57 mg/5 m suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Augmentin 400 mg/57 mg/5 m suspension.
Uses of Augmentin 400 mg/57 mg/5 m in details
Use: Labeled Indications
Ear, nose, and throat infections (pharyngitis/tonsillitis, otitis media):
Immediate release: Treatment of infections due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae.
Extended release: Treatment of tonsillitis and/or pharyngitis due to Streptococcus pyogenes in adults and pediatric patients ≥12 years of age.
Genitourinary tract infections: Immediate release: Treatment of infections of the genitourinary tract due to beta-lactamase-negative Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.
Helicobacter pylori eradication: Immediate release: Eradication of H. pylori to reduce the risk of duodenal ulcer recurrence as a component of combination therapy in patients with active or 1-year history of duodenal ulcer disease.
Lower respiratory tract infections (including pneumonia): Immediate release: Treatment of infections of the lower respiratory tract due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic strains only), S. pneumoniae, Staphylococcus spp., or H. influenzae.
Rhinosinusitis, acute bacterial: Immediate release: Treatment of infections due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic isolates only), S. pneumoniae, Staphylococcus spp., or H. influenzae.
Skin and skin structure infections: Immediate release: Treatment of infections of the skin and skin structure due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic strains only), Staphylococcus spp., or E. coli.
Off Label Uses
Actinomycosis
Data from a small retrospective study suggest that Augmentin 400 mg/57 mg/5 m may be beneficial for the treatment of actinomycosis.
Prosthetic joint infection
Based on the IDSA guidelines for the management of prosthetic joint infection (PJI), Augmentin 400 mg/57 mg/5 m is an effective and recommended agent for chronic oral antimicrobial suppression of PJI with beta-hemolytic streptococci, Enterococcus spp. (penicillin susceptible), and Cutibacterium spp. after completion of parenteral therapy.
Augmentin 400 mg/57 mg/5 m description
A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Augmentin 400 mg/57 mg/5 m is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. [PubChem]
Augmentin 400 mg/57 mg/5 m dosage
Augmentin 400 mg/57 mg/5 m Dosage
Generic name: Augmentin 400 mg/57 mg/5 m 775mg
Dosage form: tablet, film coated, extended release
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Tonsillitis and/or Pharyngitis
The recommended dose of Augmentin 400 mg/57 mg/5 m is 775 mg once daily taken within 1 hour of finishing a meal for 10 days. The full 10-day course of therapy should be completed for effective treatment of tonsillitis and/or pharyngitis secondary to S. pyogenes.
Do not chew or crush tablet.
More about Augmentin 400 mg/57 mg/5 m (Augmentin 400 mg/57 mg/5 m)
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Consumer resources
- Augmentin 400 mg/57 mg/5 m
- Augmentin 400 mg/57 mg/5 m extended-release tablets
- Augmentin 400 mg/57 mg/5 m (Advanced Reading)
- Other brands: Amoxil, Augmentin 400 mg/57 mg/5 m, Augmentin 400 mg/57 mg/5 m, DisperMox, More (2) »
Professional resources
- Augmentin 400 mg/57 mg/5 m (FDA)
- Augmentin 400 mg/57 mg/5 m (AHFS Monograph)
Related treatment guides
- Bronchiectasis
- Dental Abscess
- Tonsillitis/Pharyngitis
Augmentin 400 mg/57 mg/5 m interactions
See also:
What other drugs will affect Augmentin 400 mg/57 mg/5 m?
Allopurinol: Concurrent administration may increase the incidence of rash and other allergic skin reactions.
Anticoagulants: There are rare reports of prolongation of prothrombin time in patients concomitantly on Augmentin 400 mg/57 mg/5 m. It is recommended that appropriate monitoring is carried out when Augmentin 400 mg/57 mg/5 m is prescribed concurrently with anticoagulants.
Oral Contraceptives:
In common with other antibiotics, Augmentin 400 mg/57 mg/5 m may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.Probenecid: Decreases the renal tubular secretion of Augmentin 400 mg/57 mg/5 m. Concurrent use with Augmentin 400 mg/57 mg/5 m may result in increased and prolonged blood levels of Augmentin 400 mg/57 mg/5 m.
Laboratory Tests: Glucose in Urine: Due to the high urinary concentrations of Augmentin 400 mg/57 mg/5 m, false positive readings are common with chemical methods.
The use of enzymatic glucose oxidase methods is recommended, as there is no interference from Augmentin 400 mg/57 mg/5 m.
Augmentin 400 mg/57 mg/5 m side effects
See also:
What are the possible side effects of Augmentin 400 mg/57 mg/5 m?
. Overdosage
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Augmentin 400 mg/57 mg/5 m are not associated with significant clinical symptoms and do not require gastric emptying.3
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Augmentin 400 mg/57 mg/5 m.
Crystalluria, in some cases leading to renal failure, has also been reported after Augmentin 400 mg/57 mg/5 m overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Augmentin 400 mg/57 mg/5 m crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Augmentin 400 mg/57 mg/5 m. Augmentin 400 mg/57 mg/5 m may be removed from circulation by hemodialysis.
Augmentin 400 mg/57 mg/5 m contraindications
See also:
What is the most important information I should know about Augmentin 400 mg/57 mg/5 m?
Do not use this medication if you are allergic to Augmentin 400 mg/57 mg/5 m or to any other penicillin antibiotic, such as ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others.
Before using Augmentin 400 mg/57 mg/5 m, tell your doctor if you are allergic to cephalosporins such as Omnicef, Cefzil, Ceftin, Keflex, and others. Also tell your doctor if you have asthma, liver or kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called "mono"), or any type of allergy.
Augmentin 400 mg/57 mg/5 m can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy while taking Augmentin 400 mg/57 mg/5 m.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Augmentin 400 mg/57 mg/5 m will not treat a viral infection such as the common cold or flu.
Do not share this medication with another person, even if they have the same symptoms you have.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Augmentin 400 mg/57 mg/5 m and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Active ingredient matches for Augmentin 400 mg/57 mg/5 m:
Amoxicillin in Austria, Bulgaria.
List of Augmentin 400 mg/57 mg/5 m substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Atrival (Argentina) | |
| Augprime Tab (India) | |
| Augprime Tab Amoxicillin 500 mg, clavulanicacid 125 mg, lactobacillus 60million cells. TAB / 6 (Rytus) | $ 2.70 |
| AUGPRIME TAB tab 6's (Rytus) | $ 2.70 |
| Augxil-G (Thailand) | |
| Augxil-G 500 mg x 50 x 10's | |
| Augxil-G 500 mg x 500's | |
| Augxil-G 125 mg/5 mL x 60 mL x 1's | |
| Augxil-G 125 mg/5 mL x 60 mL x 1's x 50's | |
| Augxil-G 250 mg/5 mL x 60 mL x 1's | |
| Augxil-G 250 mg/5 mL x 60 mL x 1's x 50's | |
| Aulicin (Germany) | |
| Aulicin Amoxi LA (Germany) | |
| Auro-Amoxicillin (Canada) | |
| Auro-amoxicillin capsule 250 mg (Auro Pharma Inc (Canada)) | |
| Auro-amoxicillin capsule 500 mg (Auro Pharma Inc (Canada)) | |
| AURTIMOX (India) | |
| 500 mg x 10x10 (Auriga) | $ 9.64 |
| Aurtimox 500mg CAP / 10 (Auriga) | $ 0.96 |
| AURTIMOX cap 500 mg x 10's (Auriga) | $ 0.96 |
| Aurtimox 500mg CAP / 10 (Auriga) | $ 0.96 |
| Austell-Amoxicillin (South Africa) | |
| Avimox (South Africa) | |
| Avlomox (Bangladesh) | |
| Avlomox DS (Bangladesh) | |
| Axcel (India) | |
| Axcel 250mg CAP / 10 (Candor) | |
| Axcel 500mg CAP / 10 (Candor) | |
| 250 mg x 10's (Candor) | |
| 500 mg x 10's (Candor) | |
| AXCEL cap 250 mg x 10's (Candor) | |
| AXCEL cap 500 mg x 10's (Candor) | |
| Axcil (Sri Lanka) | |
| Axibiot (Spain) | |
| Axillin (France) | |
| Axillin 500 mg x 100's | |
| AXIMYCINE | |
| Axl-250 (India) | |
| Axl-250 250mg DT-TAB / 10 | $ 0.62 |
| 250 mg x 10's | $ 0.62 |
| Axl-500 (India) | |
| Axl-500 500mg CAP / 6 | $ 0.66 |
| 500 mg x 6's | $ 0.66 |
| Axmel (Philippines) | |
| Axmel 250 mg x 100's | |
| Axmel 500 mg x 100's | |
| Axmel / Pineapple flavor 125 mg/5 mL x 60 mL | |
| Axmel / Pineapple flavor 250 mg/5 mL x 60 mL | |
| Axmel / Pineapple flavor 100 mg/1 mL x 10 mL | |
| Axomox (Vietnam) | |
| Axomox 500 mg x 200 Tablet | |
| Azillin (Switzerland) | |
| Tablet, Film-Coated; Oral; Amoxicillin Trihydrate 375 mg | |
See 6160 substitutes for Augmentin 400 mg/57 mg/5 m | |
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "amoxicillin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "amoxicillin". http://www.drugbank.ca/drugs/DB01060 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Augmentin 400 mg/57 mg/5 m are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Augmentin 400 mg/57 mg/5 m. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
