Calcium/L-lysine/methionine/niacinamide/vitamin B1/vitamin B12/vitamin B2/vitamin B6 Side effects

Major: (These usually occur only with an overdose of calcium.)

Calcium contraindications

Calcium chloride is contraindicated for cardiac resuscitation in the presence of ventricular fibrillation or in patients with the risk of existing digitalis toxicity.

Side effects of L-lysine in details

Nausea, Abdominal cramp, Diarrhoea

What are the possible side effects of Methionine?

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness
• nausea and vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Side effects of Methionine in details

Along with its needed effects, a medicine may cause some unwanted effects. Side effects that may occur during racemethionine therapy usually do not need medical attention. They may go away during treatment as your body adjusts to the medicine. Check with your doctor if any of the following side effects continue or are bothersome:

More common

Drowsiness; nausea and vomiting

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

What is the most important information I should know about Methionine?

• Methionine may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to methionine. Using methionine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking methionine, discuss with your doctor the benefits and risks of using methionine during pregnancy. It is unknown if methionine is excreted in breast milk. If you are or will be breast-feeding while you are using methionine, check with your doctor or pharmacist to discuss the risks to your baby.

Methionine contraindications

L-methionine is contraindicated in those with the genetic disorder homocystinuria. It is also contraindicated in those who are hypersensitive to any component of a methionine-containing product.

What are the possible side effects of Niacinamide?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Flushing. Taking aspirin 30 minutes before taking Niacinamide (niacinamide extended-release tablets) may help. If you wake up at night with flushing, get up slowly if you feel like passing out or you are dizzy.
• Itching.
• Loose stools (diarrhea).
• Upset stomach or throwing up.
• Cough.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side effects of Niacinamide in details

Applies to niacinamide: tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; itching; nausea; stomach upset; temporary feeling of warmth or flushing of the skin.

Seek medical attention right away if any of these SEVERE side effects occur while taking niacinamide:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; changes in vision; dark urine; decreased urination; fast or irregular heartbeat; loss of appetite; muscle pain or weakness; numbness or persistent tingling of the skin; persistent nausea, vomiting, or general "unwell" feeling; severe or prolonged flushing of the skin; stomach pain; swelling of the hands, legs, or feet; vomit that looks like coffee grounds; yellowing of the skin or eyes.

What is the most important information I should know about Niacinamide?

• Niacinamide is for external use only. Avoid getting Niacinamide in your eyes. If you get Niacinamide in your eyes, rinse thoroughly with cool tap water.
• Follow up with your doctor after 8 to 12 weeks to monitor your progress.
• Do not use any other medicines or special cleansers on your skin unless your doctor instructs you otherwise. Makeup and other acne medicines may be applied over Niacinamide as directed by your doctor.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Niacinamide while you are pregnant. It is not known if Niacinamide is found in breast milk after topical use. If you are or will be breast-feeding while you use Niacinamide, check with your doctor. Discuss any possible risks to your baby.

What are the possible side effects of Vitamin B1?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• blue colored lips;

• chest pain, feeling short of breath;

• black, bloody, or tarry stools; or

• coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

• nausea, tight feeling in your throat;

• sweating, feeling warm;

• mild rash or itching;

• feeling restless; or

• tenderness or a hard lump where a thiamine injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B1 in details

Applies to thiamine: capsule, solution, tablet, tablet enteric coated

As well as its needed effects, thiamine (the active ingredient contained in Vitamin B1) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking thiamine, check with your doctor immediately:

Rare - Soon after receiving injection only

• Coughing
• difficulty in swallowing
• hives
• itching of skin
• swelling of face, lips, or eyelids
• wheezing or difficulty in breathing

What is the most important information I should know about Vitamin B1?

You should not use thiamine if you have ever had an allergic reaction to it.

Ask a doctor or pharmacist before taking thiamine if you have any medical conditions, if you take other medications or herbal products, or if you are allergic to any drugs or foods.

Before you receive injectable thiamine, tell your doctor if you have kidney disease.

Thiamine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

Vitamin B1 contraindications

Contraindications for vitamin B1

Hypersensitivity to vitamin B1 or any component of a product containing vitamin B1.

What are the possible side effects of Vitamin B12?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• numbness or tingling in your hands or feet;

• signs of fluid build-up around your lungs--anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain; or

• signs of low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

• swelling, rapid weight gain;

• diarrhea; or

• itching or mild rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B12 in details

Applies to cyanocobalamin: intramuscular solution

Other dosage forms:

• nasal gel/jelly, nasal spray

As well as its needed effects, cyanocobalamin (the active ingredient contained in Vitamin B12) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking cyanocobalamin, check with your doctor or nurse immediately:

Incidence not known:

• Abdominal or stomach pain
• bleeding from the gums or nose
• blue lips and fingernails
• chest pain
• cough
• coughing that sometimes produces a pink frothy sputum
• decreased urine output
• difficult, fast, noisy breathing, sometimes with wheezing
• difficulty with swallowing
• dilated neck veins
• dizziness
• extreme fatigue
• eye pain
• fast heartbeat
• headache
• hives, itching, or skin rash
• increased sweating
• irregular breathing
• irregular heartbeat
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• ringing in the ears
• swelling of the face, fingers, feet, or lower legs
• tightness in the chest
• unusual tiredness or weakness
• weight gain

Minor Side Effects

Some cyanocobalamin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

• Diarrhea
• skin rash with a general disease

What is the most important information I should know about Vitamin B12?

You should not use this medication if you have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.

Vitamin B12 contraindications

Hypersensitivity to the components of the formula. History of allergy to the cobalamins (vitamin B12 and similar substances). Malignant tumors. By stimulating the growth of tissues, the Cobamamide could increase the high rate of cell multiplication. Sensitivity to cobalt. History of allergies to cobalamin (vitamin B12 and related substances).

- Malignant tumor: Due to the action of vitamin B12 on the growth of tissue cell multiplication rate high, the risk of exacerbation should be taken into account.

- Children under 6 years because of the dosage form

What are the possible side effects of Vitamin B2?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Riboflavin may cause your urine to become a yellow-orange color. This effect is harmless.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B2 in details

Genitourinary

Yellow-orange discoloration of urine.

What is the most important information I should know about Vitamin B2?

Use riboflavin as directed on the label, or as your healthcare provider has prescribed. Do not use this product in larger amounts or for longer than recommended.

Vitamin B2 contraindications

None well documented.

What are the possible side effects of Vitamin B6?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• decreased sensation to touch, temperature, and vibration;

• loss of balance or coordination;

• numbness in your feet or around your mouth;

• clumsiness in your hands; or

• feeling tired.

Common side effects may include:

• nausea;

• headache;

• drowsiness; or

• mild numbness or tingling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Vitamin B6 in details

Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release

As well as its needed effects, pyridoxine (the active ingredient contained in Vitamin B6) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:

With large doses

• Clumsiness
• numbness of hands or feet

What is the most important information I should know about Vitamin B6?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Vitamin B6 contraindications

Contraindications for vitamin B6

Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.

References

1. DailyMed. "CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. European Chemicals Agency - ECHA. "Calcium: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
3. European Chemicals Agency - ECHA. "L-lysine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology