Consists of clavulanate K, clavulanic acid, Co-amoxiclav
Clavulanic acid indications
Upper & lower resp tract, urinary tract, skin & soft tissue infections.
Uses of Clavulanic acid in details
Clavulanic acid is used to increase the effect of certain antibiotics (amoxicillin) to treat bacterial infections of the respiratory tract (bronchitis, pneumonia), urinary tract, ear, nose, sinus and throat, skin and soft tissues, bone and joints, and to prevent infections after surgery.
Clavulanic acid dosage
Tab Adult & childn >12 yr 375-625 mg tid. Severe infections One 1,000-mg tab bid. 156 mg/5 mL syr Childn >6 yr 2 tsp, 1-6 yr 1 tsp. 312 mg/5 mL syr Childn >6 yr 1 tsp, 1-6 yr ½ tsp. To be given tid.
Clavulanic acid interactions
Probenecid decreases clearance of ticarcillin. Increased bleeding risk with warfarin, acenocoumarol. Possible increase in ciclosporin, methotrexate levels with concurrent use. Possible contraceptive failure with combined oral contraceptives.
Clavulanic acid side effects
Hypersensitivity reactions, GI disturbances, pseudomembranous colitis, blood dyscrasias, transient increase in liver enzymes, hepatitis, cholestatic jaundice, giddiness, neuromuscular hyperirritability, seizures, electrolyte disturbances, decreased serum uric acid concentration, increased serum creatinine and/or BUN concentrations. Thrombophlebitis and local reactions at the IV infusion site. Haemorrhagic cystitis especially in cystic fibrosis patients.
Potentially Fatal: Anaphylaxis.
Clavulanic acid contraindications
Hypersensitivity to penicillins.
Co-amoxiclav indications
for the treatment of infections caused by amoxycillin resistant organisms producing beta-lactamases sensitive to Co-amoxiclav:
Upper respiratory tract infections, such as sinusitis, recurrent otitis media, tonsillitis.
Lower respiratory tract infections, such as bronchitis (caused by amoxycillin resistant beta-lactamase producing Escherichia coli, Haemophilus influenzae andHaemophilus para-influenzae), bronchopneumonia.
Genito-urinary tract infections, such as cystitis, urethritis, pyelonephritis.
Skin and soft tissue infections.
-formulations will also be effective in the treatment of infections caused by amoxycillin sensitive organisms at the appropriate amoxycillin dosage since in this situation the Co-amoxiclav component does not contribute to the therapeutic effect.
Co-amoxiclav interactions
Augmentin may react with the antigout medication probenecid, resulting in changes in blood levels. A reaction with another antigout drug, allopurinol, may cause a rash. Notify your doctor if you are taking either of these drugs.
Like many antibiotics, Augmentin may reduce the effectiveness of birth control pills. You may want to take additional measures while taking Augmentin.
Co-amoxiclav side effects
Diarrhea; nausea; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal discharge or irritation; yellowing of the skin or eyes.
Co-amoxiclav contraindications
in patients with a history of allergic reactions to any penicillin. It is also contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with Co-amoxiclav.
Active ingredient matches for Clavulanate K/clavulanic acid/Co-amoxiclav:
Clavulanate K/clavulanic acid/Co-amoxiclav
References
- PubChem. "CLAVULANIC ACID". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "CLAVULANIC ACID". http://www.drugbank.ca/drugs/DB00766 (accessed September 17, 2018).
- MeSH. "beta-Lactamase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
