Actions of Dex-Forte in details
Pharmacology: Mechanism of Action: The mechanism of action of NSAIDs is related to the reduction of prostaglandin synthesis by the inhibition of cyclooxygenase pathway. Dex-Forte has been demonstrated to be an inhibitor for COX-1 and COX-2 activities in experimental animals and humans. Specifically, there is an inhibition of the transformation of arachidonic acid into cyclic endoperoxides, PGG2 and PGH2, which produce prostaglandins PGE1, PGE2, PGF2α and PGD2 and also prostacyclin PGI2, and thromboxanes (TxA2 and TxB2). Inhibition of the synthesis of prostaglandins may also affect other inflammatory mediators like kinins which is an indirect action. Clinical studies performed on several pain models demonstrated effective analgesic activity of Dex-Forte trometamol. The onset of the analgesic activity was obtained in some studies at 30 min post-administration. The analgesic effect persists for 4-6 hrs.
Pharmacokinetics: After oral administration of Dex-Forte trometamol to humans, the peak plasma concentration-time curve (Cmax) is reached at 30 min (range 15-60 min). When administered concomitantly with food, the AUC does not change, however the Cmax of Dex-Forte trometamol decreases and its absorption rate is delayed (increased Tmax). The distribution half-life (t½) and elimination t½ values of Dex-Forte trometamol are 0.35 and 1.65 hrs, respectively. As with other drugs with a high plasma protein-binding (99%), its volume of distribution has a mean value <0.25 L/kg. The main elimination route for Dex-Forte is glucuronide conjugation followed by renal excretion. There is no conversion of Dex-Forte to the R-(-) enantiomer in humans. Dex-Forte does not accumulate after multiple doses in humans.
Dex-Forte administration
Should be taken on an empty stomach. Take 30 min before meals, esp for quick relief of acute pain.
Reviews
The results of a survey conducted on ndrugs.com for Dex-Forte are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dex-Forte. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
3 consumers reported administration
When best can I take Dex-Forte, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Dex-Forte should be taken After food. In any case, this may not be the right description on how you ought to take this Dex-Forte. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Dex-Forte can be taken.
| Users | % | ||
|---|---|---|---|
| After food | 2 | 66.7% | |
| Empty stomach | 1 | 33.3% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
