Consists of Dexchlorpheniramine maleate, paracetamol, thiocol
Actions of Dexchlorpheniramine maleate (Febrinex) in details
Dexchlorpheniramine maleate (Febrinex) belongs to class of medications called antihistamines. It acts by blocking a natural chemical (histamine) that your body makes during an allergic reaction.
How should I take Dexchlorpheniramine maleate (Febrinex)?
Take Dexchlorpheniramine maleate (Febrinex) exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Dexchlorpheniramine maleate (Febrinex) can be taken with or without food.
Do not crush, chew, or break any timed-release forms of Dexchlorpheniramine maleate (Febrinex). Swallow them whole. They are specially formulated to release slowly into your body.
To ensure that you get a correct dose, measure the syrup form of Dexchlorpheniramine maleate (Febrinex) with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Never take more of this medication than is prescribed for you. The regular-release tablets and the syrup are usually taken every 4 to 6 hours as needed (four to six times a day). The timed-release tablets and capsules are usually taken every 8 to 10 hours as needed (two or three times a day).
Store this medicine at room temperature away from moisture and heat.
Dexchlorpheniramine maleate (Febrinex) administration
May be taken with or without food.
Dexchlorpheniramine maleate (Febrinex) pharmacology
Dexchlorpheniramine maleate (Febrinex) competes with histamine for H-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. Dexchlorpheniramine maleate (Febrinex) is the predominant active isomer of chlorpheniramine and is approximately twice as active as the racemic compound (Moreno 2010).
Metabolism
Hepatic (Simons 2004)
Excretion
Urine
Time to Peak
~3 hours (Moreno 2010)
Half-Life Elimination
20 to 30 hours (Moreno 2010)
Actions of Paracetamol (Febrinex) in details
Pharmacology: Paracetamol (Febrinex) exhibits analgesic and antipyretic activity by inhibiting prostaglandin synthesis. It produces analgesia by elevating the pain threshold and antipyresis through action on the hypothalamic heat-regulating center.
In therapeutic doses, Paracetamol (Febrinex)'s analgesic and antipyretic action is comparable to that of aspirin. Paracetamol (Febrinex) does not adversely affect platelet function and hemostasis.
Pharmacokinetics: Paracetamol (Febrinex) is rapidly and completely absorbed after oral administration. Peak plasma concentrations occur between 15 min to 2 hrs after ingestion. The absolute oral bioavailability of Paracetamol (Febrinex) is about 80% and is independent of dose in the range of 5-20 mg/kg.
Paracetamol (Febrinex) is not bound to plasma proteins to any extent. The concentrations of Paracetamol (Febrinex) in saliva are similar to those in plasma. Concentrations in whole blood are up to 20% higher and in breast milk about 20% lower than the plasma concentration. Paracetamol (Febrinex) crosses the placenta.
Paracetamol (Febrinex) is extensively metabolized in the liver and the total body clearance is about 5 mL/kg/min. The clearance of Paracetamol (Febrinex) is reduced and the half-life increased following a hepatotoxic overdose. Prolongation of half-life beyond 4 hrs usually indicates impending liver damage.
Two to five percent of a therapeutic dose of Paracetamol (Febrinex) is excreted unchanged in the urine. Its renal clearance is about 10 mL/min and is weakly dependent on urine flow rate but not on pH.
Paracetamol (Febrinex) administration
May be taken with or without food.
Paracetamol (Febrinex) pharmacology
The analgesic, antipyretic, and anti-inflammatory effects of aspirin are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Paracetamol (Febrinex) directly and irreversibly inhibits the activity of both types of cyclo-oxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes aspirin different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Paracetamol (Febrinex)'s antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation–inhibiting effect of aspirin specifically involves the compound's ability to act as an acetyl donor to the platelet membrane; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Paracetamol (Febrinex) affects platelet function by inhibiting the enzyme prostaglandin cyclooxygenase in platelets, thereby preventing the formation of the aggregating agent thromboxane A2. This action is irreversible; the effects persist for the life of the platelets exposed. Paracetamol (Febrinex) may also inhibit formation of the platelet aggregation inhibitor prostacyclin (prostaglandin I2) in blood vessels; however, this action is reversible.
References
- DailyMed. "DEXCHLORPHENIRAMINE MALEATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Dexchlorpheniramine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- NCIt. "Dexchlorpheniramine Maleate: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Febrinex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Febrinex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
