Consists of Copper, Folic Acid, Iron, Vitamin B, Zinc
Overdose of Copper (Feroglobin Capsules) in details
Copper (Feroglobin Capsules) toxicity can produce prostration, behavior change, diarrhea, progressive marasmus, hypotonia, photophobia and peripheral edema. Such symptoms have been reported with a serum Copper (Feroglobin Capsules) level of 286 mcg/dl. Copper (Feroglobin Capsules) toxicity can also result in hemolysis and liver toxicity, including hepatic necrosis which may be fatal. D-penicillamine has been reported effective as an antidote.
Copper (Feroglobin Capsules) warnings
1. Intrauterine Pregnancy
If intrauterine pregnancy occurs with Copper (Feroglobin Capsules)® in place and the string is visible, Copper (Feroglobin Capsules)® should be removed because of the risk of spontaneous abortion, premature delivery, sepsis, septic shock, and, rarely, death. Removal may be followed by pregnancy loss.
If the string is not visible, and the woman decides to continue her pregnancy, check if the Copper (Feroglobin Capsules)® is in her uterus (for example, by ultrasound). If Copper (Feroglobin Capsules)® is in her uterus, warn her that there is an increased risk of spontaneous abortion and sepsis, septic shock, and rarely, death.1 In addition, the risk of premature labor and delivery is increased.1
Human data about risk of birth defects from Copper (Feroglobin Capsules) exposure are limited. However, studies have not detected a pattern of abnormalities, and published reports do not suggest a risk that is higher than the baseline risk for birth defects.
2. Ectopic Pregnancy
Women who become pregnant while using Copper (Feroglobin Capsules)® should be evaluated for ectopic pregnancy. A pregnancy that occurs with Copper (Feroglobin Capsules)® in place is more likely to be ectopic than a pregnancy in the general population. However, because Copper (Feroglobin Capsules)® prevents most pregnancies, women who use Copper (Feroglobin Capsules)® have a lower risk of an ectopic pregnancy than sexually active women who do not use any contraception.2-3
3. Pelvic Infection
Although pelvic inflammatory disease (PID) in women using IUDs is uncommon, IUDs may be associated with an increased relative risk of PID compared to other forms of contraception and to no contraception. The highest incidence of PID occurs within 20 days following insertion. Therefore, the visit following the first post-insertion menstrual period is an opportunity to assess the patient for infection, as well as to check that the IUD is in place. Since pelvic infection is most frequently associated with sexually transmitted organisms, IUDs are not recommended for women at high risk for sexual infection. Prophylactic antibiotics at the time of insertion do not appear to lower the incidence of PID.4
PID can have serious consequences, such as tubal damage (leading to ectopic pregnancy or infertility), hysterectomy, sepsis, and, rarely, death. It is therefore important to promptly assess and treat any woman who develops signs or symptoms of PID.
Guidelines for treatment of PID are available from the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia at www.cdc.gov or 1-800-311-3435. Antibiotics are the mainstay of therapy. Most healthcare professionals also remove the IUD.
The significance of actinomyces-like organisms on Papanicolaou smear in an asymptomatic IUD user is unknown,5-6 and so this finding alone does not always require IUD removal and treatment. However, because pelvic actinomycosis is a serious infection, a woman who has symptoms of pelvic infection possibly due to actinomyces should be treated and have her IUD removed.
4. Immunocompromise
Women with AIDS should not have IUDs inserted unless they are clinically stable on antiretroviral therapy. Limited data suggest that asymptomatic women infected with human immunodeficiency virus may use intrauterine devices. Little is known about the use of IUDs in women who have illnesses causing serious immunocompromise. Therefore these women should be carefully monitored for infection if they choose to use an IUD. The risk of pregnancy should be weighed against the theoretical risk of infection.
5. Embedment
Partial penetration or embedment of Copper (Feroglobin Capsules)® in the myometrium can make removal difficult. In some cases, surgical removal may be necessary.
6. Perforation
Partial or total perforation of the uterine wall or cervix may occur rarely during placement, although it may not be detected until later. Spontaneous migration has also been reported. If perforation does occur, remove Copper (Feroglobin Capsules)® promptly, since the Copper (Feroglobin Capsules) can lead to intraperitoneal adhesions. Intestinal penetration, intestinal obstruction, and/or damage to adjacent organs may result if an IUD is left in the peritoneal cavity. Pre-operative imaging followed by laparoscopy or laparotomy is often required to remove an IUD from the peritoneal cavity.
7. Expulsion
Expulsion can occur, usually during the menses and usually in the first few months after insertion. There is an increased risk of expulsion in the nulliparous patient. If unnoticed, an unintended pregnancy could occur.
8. Wilson’s Disease
Theoretically, Copper (Feroglobin Capsules)® can exacerbate Wilson’s disease, a rare genetic disease affecting Copper (Feroglobin Capsules) excretion.
What should I discuss with my healthcare provider before taking Copper (Feroglobin Capsules)?
Before having Copper (Feroglobin Capsules) placed, tell your healthcare provider if you have:
- any of the conditions listed above
- slow heart beat (bradycardia)
- dizziness (syncope)
- seizures
- recently had a baby or if you are breastfeeding
- have AIDS, HIV, or any other sexually transmitted infection
Copper (Feroglobin Capsules) precautions
Patients should be counseled that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases.
1. Information for patients
Before inserting Copper (Feroglobin Capsules)® discuss the Patient Package Insert with the patient, and give her time to read the information. Discuss any questions she may have concerning Copper (Feroglobin Capsules)® as well as other methods of contraception. Instruct her to promptly report symptoms of infection, pregnancy, or missing strings.
2. Insertion precautions, continuing care, and removal.
3. Vaginal bleeding
In the 2 largest clinical trials with Copper (Feroglobin Capsules)®, menstrual changes were the most common medical reason for discontinuation of Copper (Feroglobin Capsules)®. Discontinuation rates for pain and bleeding combined are highest in the first year of use and diminish thereafter. The percentage of women who discontinued Copper (Feroglobin Capsules)® because of bleeding problems or pain during these studies ranged from 11.9% in the first year to 2.2 % in year 9. Women complaining of heavy vaginal bleeding should be evaluated and treated, and may need to discontinue Copper (Feroglobin Capsules)®.
4. Vasovagal reactions, including fainting
Some women have vasovagal reactions immediately after insertion. Hence, patients should remain supine until feeling well and should be cautious when getting up.
5. Expulsion following placement after a birth or abortion
Copper (Feroglobin Capsules)® has been placed immediately after delivery, although risk of expulsion may be higher than when Copper (Feroglobin Capsules)® is placed at times unrelated to delivery.7 However, unless done immediately postpartum, insertion should be delayed to the second postpartum month because insertion during the first postpartum month (except for immediately after delivery) has been associated with increased risk of perforation.8
Copper (Feroglobin Capsules)® can be placed immediately after abortion, although immediate placement has a slightly higher risk of expulsion than placement at other times.9 Placement after second trimester abortion is associated with a higher risk of expulsion than placement after the first trimester abortion.9
6. Magnetic resonance imaging (MRI)
Limited data suggest that MRI at the level of 1.5 Tesla is acceptable in women using Copper (Feroglobin Capsules)®. One study examined the effect of MRI on the CU-7® Intrauterine Copper (Feroglobin Capsules) Contraceptive and Lippes Loop™ intrauterine devices. Neither device moved under the influence of the magnetic field or heated during the spin-echo sequences usually employed for pelvic imaging.10 An in vitro study did not detect movement or temperature change when Copper (Feroglobin Capsules)® was subjected to MRI.11
7. Medical diathermy
Theoretically, medical (non-surgical) diathermy (short-wave and microwave heat therapy) in a patient with a metal-containing IUD may cause heat injury to the surrounding tissue. However, a small study of eight women did not detect a significant elevation of intrauterine temperature when diathermy was performed in the presence of a Copper (Feroglobin Capsules) IUD.12
8. Pregnancy
Copper (Feroglobin Capsules)® is contraindicated during pregnancy.
9. Nursing mothers
Nursing mothers may use Copper (Feroglobin Capsules)®. No difference has been detected in concentration of Copper (Feroglobin Capsules) in human milk before and after insertion of Copper (Feroglobin Capsules) IUDs. The literature is conflicting, but limited data suggest that there may be an increased risk of perforation and expulsion if a woman is lactating. 13
10. Pediatric use
Copper (Feroglobin Capsules)® is not indicated before menarche. Safety and efficacy have been established in women over 16 years old.
What happens if I overdose Folic Acid (Feroglobin Capsules)?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately.
Proper storage of Folic Acid (Feroglobin Capsules):
Store Folic Acid (Feroglobin Capsules) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Folic Acid (Feroglobin Capsules) out of the reach of children and away from pets.
Overdose of Folic Acid (Feroglobin Capsules) in details
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: mental/mood changes.
Notes
Do not share this medication with others.
Laboratory and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be performed periodically to monitor your progress. Consult your doctor for more details.
Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic Acid (Feroglobin Capsules) is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/Folic Acid (Feroglobin Capsules).
Missed Dose
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
What should I avoid while taking Folic Acid (Feroglobin Capsules)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Folic Acid (Feroglobin Capsules) warnings
Use Folic Acid (Feroglobin Capsules) IVAX with caution in patients with bronchial asthma, COPD, bronchitis, decompensated heart failure, diabetes, renal and / or liver failure, hyperthyroidism, depression, myasthenia gravis, psoriasis, occlusive peripheral vascular disease, pregnancy, lactation, elderly patients, children (efficacy and safety are not defined).
During the period of treatment it may been exacerbation of psoriasis.
When pheochromocytoma propranolol can be applied only after taking alpha-blockers.
After a lengthy course of treatment Folic Acid (Feroglobin Capsules) IVAX should be lifted gradually, under medical supervision.
During treatment with this drug it should be avoided in the intravenous administration of verapamil, diltiazem.
A few days before the anesthesia it is necessary to stop taking propranolol or find a means of anesthesia with minimal negative inotropic effects.
Patients whose work requires more attention, the application of this medication outpatients should be addressed only after the evaluation of individual patient response.
What should I discuss with my healthcare provider before taking Folic Acid (Feroglobin Capsules)?
Some medical conditions may interact with Folic Acid (Feroglobin Capsules). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a long-term infection, seizure disorder (eg, epilepsy), or liver problems (eg, alcoholic cirrhosis), or if you are on kidney dialysis
- if you drink alcohol regularly
- if you have other types of anemia (eg, anemia due to low vitamin B levels)
Some MEDICINES MAY INTERACT with Folic Acid (Feroglobin Capsules). Tell your health care provider if you are taking any other medicines, especially any of the following:
- Fluorouracil because its actions and side effects may be increased by Folic Acid (Feroglobin Capsules)
- Hydantoins (eg, phenytoin) because their effectiveness may be decreased by Folic Acid (Feroglobin Capsules)
- Barbiturates (eg, phenobarbital), methotrexate, nitrofurantoin, phenytoin, primidone, or pyrimethamine because the effectiveness of Folic Acid (Feroglobin Capsules) may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Folic Acid (Feroglobin Capsules) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Folic Acid (Feroglobin Capsules) precautions
General
Folic Acid (Feroglobin Capsules) in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurologic manifestations remain progressive.
There is a potential danger in administering Folic Acid (Feroglobin Capsules) to patients with undiagnosed anemia, since Folic Acid (Feroglobin Capsules) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress. This may result in severe nervous system damage before the correct diagnosis is made. Adequate doses of vitamin B12 may prevent, halt, or improve the neurologic changes caused by pernicious anemia.
Drug Interactions
There is evidence that the anticonvulsant action of phenytoin is antagonized by Folic Acid (Feroglobin Capsules). A patient whose epilepsy is completely controlled by phenytoin may require increased doses to prevent convulsions if Folic Acid (Feroglobin Capsules) is given.
Folic deficiency may result from increased loss of folate, as in renal dialysis and/or interference with metabolism (e.g., Folic Acid (Feroglobin Capsules) antagonists such as methotrexate); the administration of anticonvulsants, such as diphenylhydantoin, primidone, and barbiturates; alcohol consumption and, especially, alcoholic cirrhosis; and the administration of pyrimethamine and nitrofurantoin.
False low serum and red cell folate levels may occur if the patient has been taking antibiotics, such as tetracycline, which suppress the growth of Lactobacillus casei.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies in animals to evaluate carcinogenic potential and studies to evaluate the mutagenic potential or effect on fertility have not been conducted.
Pregnancy
Teratogenic Effects
Pregnancy Category A
Folic Acid (Feroglobin Capsules) is usually indicated in the treatment of megaloblastic anemias of pregnancy. Folic Acid (Feroglobin Capsules) requirements are markedly increased during pregnancy, and deficiency will result in fetal damage.
Studies in pregnant women have not shown that Folic Acid (Feroglobin Capsules) increases the risk of fetal abnormalities if administered during pregnancy. If the drug is used during pregnancy, the possibility of fetal harm appears remote. Because studies cannot rule out the possibility of harm, however, Folic Acid (Feroglobin Capsules) should be used during pregnancy only if clearly needed.
Nursing Mothers
Folic Acid (Feroglobin Capsules) is excreted in the milk of lactating mothers. During lactation, Folic Acid (Feroglobin Capsules) requirements are markedly increased; however, amounts present in human milk are adequate to fulfill infant requirements, although supplementation may be needed in lowbirth-weight infants, in those who are breast-fed by mothers with folic deficiency (50 mcg daily), or in those with infections or prolonged diarrhea.
What happens if I miss a dose of Folic Acid (Feroglobin Capsules)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose Iron (Feroglobin Capsules)?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry stools; blood or streaks of blood in the stool; bluish skin or nails; changes in the amount of urine produced; chest pain; coma; dizziness; dry mouth or eyes; fainting; fast or difficult breathing; fast or irregular heartbeat; flushing; increased thirst or hunger; seizures; severe nausea, vomiting, diarrhea, or stomach pain; severe or unusual tiredness or drowsiness; shortness of breath; sluggishness; unusually pale skin; vomit that looks like blood or coffee grounds.
Proper storage of Iron (Feroglobin Capsules):
Store Iron (Feroglobin Capsules) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Iron (Feroglobin Capsules) out of the reach of children and away from pets.
Overdose of Iron (Feroglobin Capsules) in details
Overdose with Feridex I.V. (ferumoxides injectable solution) has not been reported. Acute toxicity is apt to be related to iron overload, acute back pain and allergic events. Chronic administration of therapeutic iron dextran in excess of the total amount of iron needed for iron stores may lead to hemosiderosis.
A study of (59Fe) complexed iron-dextran utilizing isotonic saline in a 4-hour in vitro dialysis run indicated that less than 0.5% of the injected radio labeled iron dextran traversed the dialysis membrane. Feridex I.V. contains iron associated with dextran. Whether Feridex I.V. (ferumoxides injectable solution) is dialyzable is not known.
What should I avoid while taking Iron (Feroglobin Capsules)?
Avoid taking carbonyl iron within 2 hours before or 2 hours after you take other medicines. Carbonyl iron can make it harder for your body to absorb other medicines.
Iron (Feroglobin Capsules) warnings
As with all iron preparations, a dark colouration of the stool may occur which is without clinical significance.
PREGNANCY AND LACTATION Reproduction studies in animals did not show any foetal risk. Controlled studies in pregnant women after the first trimester have not shown any undesirable effects on mother and neonates. There is no evidence of a risk during the first trimester and the possibility of a negative influence to the foetus is unlikely to occur. Mother’s milk contains iron bound to lactoferrin. It is not known how much iron from the complex is passed into mother’s milk. The administration of Iron (Feroglobin Capsules)ยจ is unlikely to cause undesirable effects to the nursed child.
What should I discuss with my healthcare provider before taking Iron (Feroglobin Capsules)?
Some medical conditions may interact with Iron (Feroglobin Capsules). Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have stomach or bowel problems (eg, colitis, Crohn disease, diverticulitis, ulcers)
- if you have hemolytic anemia, pernicious anemia, or other types of anemia, or if you have a condition that may cause anemia (eg, sickle cell disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency)
- if you have blood problems (eg, porphyria, thalassemia) or you have had multiple blood transfusions
Some MEDICINES MAY INTERACT with Iron (Feroglobin Capsules). Tell your health care provider if you are taking any other medicines, especially any of the following:
- Doxycycline, mycophenolate, penicillamine, or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Iron (Feroglobin Capsules)
This may not be a complete list of all interactions that may occur. Ask your health care provider if Iron (Feroglobin Capsules) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Iron (Feroglobin Capsules) precautions
The Hemoccult Test (selective for Hb) for the proof of occulted blood is not affected accordingly, the iron therapy does not need to be discontinued when testing for occulted blood.
Chewable Tablet: Iron overload of the organism (haemochromatose, chronic haemolysis), iron utilisation disorders (lead anaemia, sidero-achrestic anaemia), thalassaemia, megaloblastic anaemia resulting from vitamin B12 deficiency.
In cases of infection- and tumour-associated anaemia, the substituted iron is deposited in the RES. Iron mobilisation and utilisation will not take place until the primary cause has been relieved.
Anaemia due to infection or malignancy. Do not impact the daily insulin management of diabetes patient (0.03 bread unit per chewable tablet).
What happens if I miss a dose of Iron (Feroglobin Capsules)?
Take the missed dose as soon as you remember. However, if it is almost time to take next dose, skip the dose you missed and take the next regularly scheduled dose as directed. Do not take a double dose.
Overdose of Vitamin B (Feroglobin Capsules) in details
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: stomach pain, nausea, vomiting, diarrhea.
Notes
Keep all regular medical and laboratory appointments.
This product is not a substitute for a proper diet. Remember that it is best to get your vitamins from healthy foods. B vitamins are naturally found in leafy greens and other vegetables, meat, fish, poultry, and enriched breads/cereals.
Missed Dose
If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Refer to storage information printed on the package. If you have any questions about storage, ask your pharmacist. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Vitamin B (Feroglobin Capsules) warnings
Pregnancy & lactation. Childn <12 yr.
Vitamin B (Feroglobin Capsules) precautions
Before taking this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
If you have any of the following health problems, consult your doctor or pharmacist before using this product: diabetes, liver problems, vitamin B12 deficiency (pernicious anemia).
Chewable tablets or liquid products may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this drug safely.
Liquid forms of this product may contain sugar and/or alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Ask your doctor or pharmacist about using this product safely.
Tell your doctor if you are pregnant before using this medication. This product is safe to take during pregnancy when used as directed. Certain spinal cord birth defects may be prevented by maintaining adequate amounts of Vitamin B (Feroglobin Capsules) during pregnancy. Consult your doctor or pharmacist for details.
This product passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
What happens if I overdose Zinc (Feroglobin Capsules)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include nausea, severe vomiting, dehydration, and restlessness.
Overdose of Zinc (Feroglobin Capsules) in details
Single intravenous doses of 1 to 2 mg Zinc (Feroglobin Capsules)/kg body weight have been given to adult leukemic patients without toxic manifestations. However, acute toxicity was reported in an adult when 10 mg Zinc (Feroglobin Capsules) was infused over a period of one hour on each of four consecutive days. Profuse sweating, decreased level of consciousness, blurred vision, tachycardia (140/min), and marked hypothermia (94.2° F) on the fourth day were accompanied by a serum Zinc (Feroglobin Capsules) concentration of 207 mcg/dl. Symptoms abated within three hours.
Hyperamylasemia may be a sign of impending Zinc (Feroglobin Capsules) overdosage; patients receiving an inadvertent overdose (25 mg Zinc (Feroglobin Capsules)/liter of TPN solution, equivalent to 50 to 70 mg Zinc (Feroglobin Capsules)/day) developed hyperamylasemia (557 to 1850 Klein units; normal: 130 to 310).
Death resulted from an overdosage in which 1683 mg Zinc (Feroglobin Capsules) was delivered intravenously over the course of 60 hours to a 72 year old patient.
Symptoms of Zinc (Feroglobin Capsules) toxicity included hypotension (80/40 mm Hg), pulmonary edema, diarrhea, vomiting, jaundice, and oliguria, with a serum Zinc (Feroglobin Capsules) level of 4184 mcg/dl.
Calcium supplements may confer a protective effect against Zinc (Feroglobin Capsules) toxicity.
What should I avoid while taking Zinc (Feroglobin Capsules)?
Avoid taking this medication with foods that are high in calcium or phosphorus, which can make it harder for your body to absorb Zinc (Feroglobin Capsules) sulfate. Foods high in calcium or phosphorus include milk, cheese, yogurt, ice cream, dried beans or peas, lentils, nuts, peanut butter, beer, cola soft drinks, and hot cocoa.
Zinc (Feroglobin Capsules) warnings
Direct intramuscular or intravenous injection of Zinc (Feroglobin Capsules) 1 mg/mL (Zinc (Feroglobin Capsules) Chloride Injection, USP) is contraindicated as the acidic pH of the solution (2) may cause considerable tissue irritation.
Severe kidney disease may make it necessary to reduce or omit chromium and Zinc (Feroglobin Capsules) doses because these elements are primarily eliminated in the urine.
WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
What should I discuss with my healthcare provider before taking Zinc (Feroglobin Capsules)?
- If you have an allergy to Zinc (Feroglobin Capsules) or any part of Zinc (Feroglobin Capsules).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zinc (Feroglobin Capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Zinc (Feroglobin Capsules) precautions
General
Do not use unless the solution is clear and the seal is intact.
Zinc (Feroglobin Capsules) 1 mg/mL (Zinc (Feroglobin Capsules) Chloride Injection, USP) should only be used in conjunction with a pharmacy directed admixture program using aseptic technique in a laminar flow environment; it should be used promptly and in a single operation without any repeated penetrations. Solution contains no preservatives; discard unused portion immediately after admixture procedure is completed.
Zinc (Feroglobin Capsules) should not be given undiluted by direct injection into a peripheral vein because of the likelihood of infusion phlebitis and the potential for increased excretory loss of Zinc (Feroglobin Capsules) from a bolus injection. Administration of Zinc (Feroglobin Capsules) in the absence of Zinc (Feroglobin Capsules) may cause a decrease in serum Zinc (Feroglobin Capsules) levels.
Laboratory Tests
Periodic determinations of serum Zinc (Feroglobin Capsules) as well as Zinc (Feroglobin Capsules) are suggested as a guideline for subsequent Zinc (Feroglobin Capsules) administration.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
Long-term animal studies to evaluate the carcinogenic potential of Zinc (Feroglobin Capsules) 1 mg/mL (Zinc (Feroglobin Capsules) Chloride Injection, USP) have not been performed, nor have studies been done to assess mutagenesis or impairment of fertility.
Nursing Mothers
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Zinc (Feroglobin Capsules) 1 mg/mL (Zinc (Feroglobin Capsules) Chloride Injection, USP) is administered to a nursing woman. Pediatric Use
Pregnancy Category C. Animal reproduction studies have not been conducted with Zinc (Feroglobin Capsules) chloride. It is also not known whether Zinc (Feroglobin Capsules) chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Zinc (Feroglobin Capsules) chloride should be given to a pregnant woman only if clearly needed.
Geriatric Use
An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
What happens if I miss a dose of Zinc (Feroglobin Capsules)?
Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
References
- DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "COPPER: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Copper". http://www.drugbank.ca/drugs/DB09130 (accessed September 17, 2018).
Reviews
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
