Consists of Cystine, Methionine, Vitamin B12, Vitamin B5, Vitamin B6, Vitamin H, Zinc Pidolate
How should I take Methionine (Forcapil)?
You should not take more of Methionine (Forcapil), or take it more often, than your doctor ordered. You should also make sure that you get enough protein in your diet. This is especially important in infants. Infants who get too much racemethionine and not enough protein may not gain weight as they should. If you have any questions about this, ask your health care professional.
Take racemethionine with, or just after, meals.
For patients taking racemethionine capsules:
- If you are unable to swallow the capsule, the contents may be added to juice, water, or warm milk or infant formula.
For patients taking racemethionine oral solution:
- Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
Make certain your health care professional knows if you are on any special diet, such as a low-protein diet.
Dosing
The dose of Methionine (Forcapil) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Methionine (Forcapil). If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For making urine more acidic:
- For oral dosage form (capsules):
- Adults and teenagers—The usual dose is 200 milligrams (mg) three or four times a day.
- Children—The usual dose is the contents of 1 capsule (200 mg) added to a warm bottle of milk or formula in the evening, or added to a glass of juice or water.
- For oral dosage form (oral solution):
- Adults and children older than 14 months of age—The usual dose is 2⅔ teaspoonfuls (200 mg) three or four times a day.
- Children 6 to 14 months of age—The usual dose is 1 teaspoonful (75 mg) four times a day for three to five days.
- Children 2 to 6 months of age—The usual dose is 1 teaspoonful (75 mg) three times a day for three to five days.
- Children up to 2 months of age—Dose must be determined by your doctor.
- For oral dosage form (tablets):
- Adults and teenagers—The usual dose is 500 mg three or four times a day.
- Children—The capsule or oral solution is the recommended dosage form for this age group.
- For oral dosage form (capsules):
Missed Dose
If you miss a dose of Methionine (Forcapil), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Methionine (Forcapil) pharmacology
The mechanism of the possible anti-hepatotoxic activity of L-Methionine (Forcapil) is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-Methionine (Forcapil) is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-Methionine (Forcapil) and metabolites of L-Methionine (Forcapil) appear to account for its possible anti-hepatotoxic activity. Recent research suggests that Methionine (Forcapil) itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability.
Actions of Vitamin B12 (Forcapil) in details
Vitamin B12 (Forcapil) refers to a group of water-soluble vitamins. It has high biological activity. Vitamin B12 (Forcapil) Atlantic Laboratories is necessary for normal hematopoiesis (promotes maturation of erythrocytes). Involved in the processes of transmethylation, hydrogen transport, synthesis of Vitamin B12 (Forcapil), nucleic acids, choline, creatine. Contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups. Has a beneficial effect on liver function and the nervous system. Activates the coagulation of blood in high doses causes an increase in the activity of thromboplastin and prothrombin.
How should I take Vitamin B12 (Forcapil)?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Cyanocobalamin injection is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.
Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Your dose needs may change if you become pregnant, if you breast-feed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.
While using cyanocobalamin injection, you may need frequent blood tests.
Use cyanocobalamin injection regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Pernicious anemia is also treated with folic acid to help maintain red blood cells. However, folic acid will not treat Vitamin B12 (Forcapil) deficiency and will not prevent possible damage to the spinal cord. Use all of your medications as directed.
To treat pernicious anemia, you may have to use cyanocobalamin for the rest of your life. Do not stop using the medicine unless your doctor tells you to. Untreated Vitamin B12 (Forcapil) deficiency can lead to a recurrence of anemia and irreversible nerve damage.
Store this medication at room temperature away from moisture, heat, and light.
Vitamin B12 (Forcapil) pharmacology
Vitamin B12 (Forcapil) exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Vitamin B12 (Forcapil) synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into Vitamin B12 (Forcapil). Vitamin B12 (Forcapil) in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Actions of Vitamin B6 (Forcapil) in details
Vitamin B6 (Forcapil), principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Vitamin B6 (Forcapil) pharmacology
Vitamin B6 (Forcapil) is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as Vitamin B6 (Forcapil), the term Vitamin B6 (Forcapil) is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6 (Forcapil), principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Actions of Zinc Pidolate (Forcapil) in details
Vitamins are organic substances required by the body in small amounts for various metabolic processes. Vitamin deficiency may result from an inadequate diet, perhaps due to increased requirements eg, during pregnancy, or may be induced by disease or drugs. This formulation is a combination providing adequate quantities of all B-complex vitamins, vitamin C and zinc.
Thiamine/vitamin B1 is a water-soluble vitamin. It is an essential co-enzyme for carbohydrate metabolism in the form of the diphosphate (thiamine pyrophosphate, cocarboxylase). Thiamine deficiency leads to the development of beri-beri.
Riboflavin/Vitamin B2 is a water-soluble vitamin essential for the utilization of energy from food. It acts as co-enzyme in oxidative/reductive metabolic reactions. Riboflavin is also necessary for the functioning of pyridoxine and nicotinic acid. Deficiency of riboflavin leads to the development of ariboflavinosis.
Pyridoxine/Zinc Pidolate (Forcapil) is a water-soluble vitamin, involved in amino acid, carbohydrate and fat metabolism. It is also required for the formation of haemoglobin and for normal antibody-mediated and cell-mediated immune responses. Its deficiency leads to the development of sideroblastic anaemia, dermatitis, cheilosis and neurological symptoms eg, peripheral neuritis and convulsions.
Cyanocobalamin/Zinc Pidolate (Forcapil) is a water-soluble vitamin, occurs in the body mainly as mecobalamin and as cobamamide and hydroxycobalamin. Mecobalamin and cobamamide act as co-enzymes in nucleic acid synthesis. It is also required for the maturation of RBCs. It is also involved with folic acid in several important metabolic pathways. Deficiency leads to the development of megaloblastic anaemias and demyelination and other neurological damage.
Folic acid is a member of the vitamin B group. It is reduced in the body to tetrahydrofolate, which is a co-enzyme for various metabolic processes including the synthesis of DNA and maturation of RBCs in conjunction with Zinc Pidolate (Forcapil). It is also involved in some amino acid conversions, and in the formation and utilization of formate. It also plays an important role in lymphocyte-mediated immune response. Deficiency of folic acid results in megaloblastic anaemia.
Nicotinamide is a water-soluble vitamin B substance, which is converted to NAD and NADP in the body. These co-enzymes are involved in the electron transfer reactions in the respiratory chain. Deficiency of nicotinamide leads to the development of pellagra.
Calcium pantothenate is a salt of pantothenic acid, a vitamin B substance. It is a component of co-enzyme A, which is essential in the metabolism of carbohydrate, fat and protein. It is also required for normal antibody response in conjunction with pyridoxine.
Ascorbic acid is a water-soluble vitamin, essential for the synthesis of collagen and intercellular material. Deficiency of ascorbic acid leads to the development of scurvy.
Zinc plays an important role in various biological activities particularly in numerous enzymatic pathways including synthesis of nucleic acids and metabolism of proteins, carbohydrates and lipids. It also helps in the development of cell-mediated immunity. Zinc deficiency is associated with growth retardation, defects of the skin, the immune system and the intestinal mucosa.
Thus, an adequate supply of these micronutrients is required for the optimum function of various cells and tissues.
Pharmacokinetics: All the ingredients of Zinc Pidolate (Forcapil) are absorbed rapidly following oral administration and distributed into various tissues. Except for Zinc Pidolate (Forcapil), the water-soluble vitamins are not stored in the body to any significant extent, the excess quantities being excreted in the urine. The body pool of readily available zinc too, appears to be small and to have a rapid turnover rate. Therefore, a regular and adequate intake of these micronutrients is necessary to meet the metabolic requirements.
References
- DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Forcapil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Forcapil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
5 consumers reported administration
When best can I take Forcapil, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Forcapil should be taken After food. In any case, this may not be the right description on how you ought to take this Forcapil. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Forcapil can be taken.
| Users | % | ||
|---|---|---|---|
| After food | 3 | 60.0% | |
| Empty stomach | 1 | 20.0% | |
| With a meal | 1 | 20.0% | |
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
