Sangobion Pregnancy

• Pregnancy of Copper (Sangobion) in details
• Pregnancy of Ferrous Gluconate (Sangobion) in details
• Ferrous Gluconate (Sangobion) breastfeeding
• Pregnancy of Folic Acid (Sangobion) in details
• Folic Acid (Sangobion) breastfeeding
• Pregnancy of Vitamin B12 (Sangobion) in details
• Sangobion reviews

Consists of Copper, Ferrous Gluconate, Folic Acid, Manganese Sulfate, Vitamin B12

Pregnancy of Copper (Sangobion) in details

Animal reproduction studies have not been conducted.

Pregnancy of Ferrous Gluconate (Sangobion) in details

Generally, iron is considered safe for use during pregnancy and is regularly prescribed as a component of prenatal vitamin/mineral supplements (usually as the sulfate salt). However, controversy exists as to whether or not routine iron supplementation is needed in the non-anemic pregnant patient. Anemia may be a risk factor for preterm delivery and low birth weight and should be diagnosed and treated as soon as possible, either before pregnancy or in the first trimester. Because supplementation with iron may reduce the dietary absorption of zinc, it may be important to assess zinc status as well. Most prenatal vitamins also contain adequate amounts of zinc. Absorption of iron and zinc may be reduced if calcium is also a component of the prenatal multivitamin.

Ferrous Gluconate (Sangobion) has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancy. Human case reports have not revealed evidence of teratogenicity. Ferrous Gluconate (Sangobion) should be given during pregnancy only when the potential benefits outweigh the potential risks.

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Ferrous Gluconate (Sangobion) breastfeeding

Several reports suggest that iron supplementation during lactation does not significantly affect the total concentration of iron in human milk. Ferrous Gluconate (Sangobion) administration during lactation is generally considered safe for the infant by most clinicians.

One study demonstrated that a moderate iron supplementation of non-anemic nursing mothers (40 mg elemental iron daily over 3 months starting 2 days after delivery) resulted in increased maternal iron reserves, no significant alterations in milk iron concentration or lactoferrin, and no harmful effect on the infant. Another study evaluated oral iron supplementation in 19 anemic women receiving 100 mg elemental iron per day starting 2 days after delivery and continuing for 30 days. Ten non-anemic women had received iron supplementation during pregnancy. Iron and lactoferrin concentrations in milk obtained at 2 and 30 days after delivery did not differ between groups at either stage of lactation.

See references

References for pregnancy information

1. Harju E "Clinical pharmacokinetics of iron preparations." Clin Pharmacokinet 17 (1989): 69-89
2. Peters PW, Garbis-Berkvens HM, Bannigan JG "Drugs of choice in pregnancy: primary prevention of birth defects." Reprod Toxicol 7 (1993): 399-404
3. Scholl TO, Hediger ML "Anemia and iron-deficiency anemia: compilation of data on pregnancy outcome." Am J Clin Nutr 59 (1994): s492-500dicuion500-5
4. Guldholt IS, Trolle BG, Hvidman LE "Iron supplementation during pregnancy." Acta Obstet Gynecol Scand 70 (1991): 9-12
5. "Routine iron supplementation during pregnancy. Policy statement: US Preventive Services Task Force." JAMA 270 (1993): 2846-8
6. "Routine iron supplementation during pregnancy. Review article: US Preventive Services Task Force." JAMA 270 (1993): 2848-54

References for breastfeeding information

1. Zapata CV, Donangelo CM, Trugo NMF "Effect of iron supplementation during lactation on human milk composition." J Nutr Biochem 5 (1994): 331-7
2. Zavaleta N, Nombera J, Rojas R, Hambraeus L, Gislason J, Lonnerdal B "Iron and lactoferrin in milk of anemic mothers given iron supplements." Nutr Res 15 (1995): 681-90
3. Harju E "Clinical pharmacokinetics of iron preparations." Clin Pharmacokinet 17 (1989): 69-89

Pregnancy of Folic Acid (Sangobion) in details

Folic Acid (Sangobion) has been assigned to pregnancy category A by the FDA. During pregnancy, Folic Acid (Sangobion) is usually used for the treatment of megaloblastic anemia. Folic Acid (Sangobion) requirements are increased during pregnancy, and deficiency may result in fetal harm. Studies involving pregnant women have failed to reveal evidence that Folic Acid (Sangobion) increases the risk of fetal abnormalities if administered during pregnancy. Folic Acid (Sangobion) should only be used during pregnancy if clearly needed.

The recommended daily allowance of Folic Acid (Sangobion) during pregnancy is 400 to 800 mcg/day. Some experts recommend daily doses of 1 mg for twin pregnancies. The Centers of Disease Control (CDC) in the US have recommended 4 mg/day of Folic Acid (Sangobion) at least 4 weeks BEFORE conception through the first 3 months of pregnancy for women who have had an infant or fetus with a neural tube defect and 400 mcg/day for all women of childbearing age. Interestingly, neonates with normal serum folate concentrations have been born to folate-deficient mothers. It appears that the fetus can extract folate from maternal plasma, convert folate to a form that is not available for reverse transfer, and use it for its own advantage. Dietary Folic Acid (Sangobion) is available from green leaves, such as asparagus, broccoli, spinach, and lettuce--each of which contains greater than 1 mg Folic Acid (Sangobion) per 100 grams dry weight. Excessive cooking can remove or destroy the food content of folate.

See references

Folic Acid (Sangobion) breastfeeding

In one study, lactating mothers were given 1 mg of Folic Acid (Sangobion) per day. There were significant correlations between the maternal and infant plasma and RBC folate concentrations. The average maternal plasma Folic Acid (Sangobion) concentration was 5.9 ng/mL, which correlated with an average milk Folic Acid (Sangobion) level of 141.4 ng/mL and an average infant plasma Folic Acid (Sangobion) concentration of 29 ng/mL. The calculated total intake of Folic Acid (Sangobion) by nursing infants was 14 to 25 mcg/kg/day. Colostrum is relatively low in folate, but milk folate increases as lactation proceeds. Folate levels in breast-fed infants are significantly higher than in the mothers.

Folic Acid (Sangobion) is actively excreted into human milk. No adverse effects in nursing infants have been associated with the use of Folic Acid (Sangobion) during lactation. Folic Acid (Sangobion) is considered compatible with breast-feeding by the American Academy of Pediatrics. The recommended maternal daily allowance of Folic Acid (Sangobion) during lactation is 500 mcg. Supplementation is not typically needed in mothers with good nutritional habits.

See references

References for pregnancy information

1. Pritchard JA, Scott DE, Whalley PJ "Maternal folate deficiency and pregnancy wastage. IV. Effects of Folic Acid (Sangobion) supplements, anticonvulsants, and oral contraceptives." Am J Obstet Gynecol 109 (1971): 341-6
2. Dawson DW "Microdoses of Folic Acid (Sangobion) in pregnancy." J Obstet Gynaecol Br Commonw 73 (1966): 44-8
3. Swinhoe DJ, Maclean AB, Gibson BE "Iron and folate supplements during pregnancy." BMJ 298 (1989): 118-9
4. Willett WC "Folic Acid (Sangobion) and neural tube defect: can't we come to closure?" Am J Public Health 82 (1992): 666-8
5. Hibbard BM, Hibbard ED, Jeffcoate TN "Folic Acid (Sangobion) and reproduction." Acta Obstet Gynecol Scand 44 (1965): 375-400
6. Rolschau J, Date J, Kristoffersen K "Folic Acid (Sangobion) supplement and intrauterine growth." Acta Obstet Gynecol Scand 58 (1979): 343-6
7. Hibbard BM, Hibbard ED "The prophylaxis of folate deficiency in pregnancy." Acta Obstet Gynecol Scand 48 (1969): 339-48
8. Kitay DZ "Folic Acid (Sangobion) and reproduction." Clin Obstet Gynecol 22 (1979): 809-17
9. Horn E "Iron and folate supplements during pregnancy: supplementing everyone treats those at risk and is cost effective." BMJ 297 (1988): 1325,1327
10. Chan A, Pickering J, Haan EA, Netting M, Burford A, Johnson A, Keane RJ "''Folate before pregnancy'': the impact on women and health professionals of a population-based health promotion campaign in South Australia." Med J Australia 174 (2001): 631-6
11. Tamura T, Goldenberg RL, Freeberg LE, Cliver SP, Cutter GR, Hoffman HJ "Maternal serum folate and zinc concentrations and their relationships to pregnancy outcome." Am J Clin Nutr 56 (1992): 365-70
12. Cooper BA, Cantlie GS, Brunton L "The case for Folic Acid (Sangobion) supplements during pregnancy." Am J Clin Nutr 23 (1970): 848-54
13. Dansky LV, Rosenblatt DS, Andermann E "Mechanisms of teratogenesis: Folic Acid (Sangobion) and antiepileptic therapy." Neurology 42(4 Suppl) (1992): 32-42
14. Lind T "Nutrient requirements during pregnancy--I." Am J Clin Nutr 34 Suppl 4 (1981): 669-78
15. Department of Health and Human Services, Food and Drug Administration "Food labeling: health claims and label statements; folate and neural tube defects." Fed Regist 61 (1996): 8752-80
16. Alperin JB, Haggard ME, McGanity WJ "Folic Acid (Sangobion), pregnancy, and abruptio placentae." Am J Clin Nutr 22 (1969): 1354-61
17. Girling JC, Shennan AH "Epilepsy and pregnancy. Emphasise the importance of extra folate." BMJ 307 (1993): 937
18. Department of Health and Human Services, Food and Drug Administration "Food standards: amendment of standards of identity for enriched grain products to require addition of Folic Acid (Sangobion)." Fed Regist 61 (1996): 8781-97
19. Pippard MJ, Chanarin I "Iron and folate supplements during pregnancy." BMJ 297 (1988): 1611
20. Rush D "Periconceptional folate and neural tube defect." Am J Clin Nutr 59(2 Suppl) (1994): s511-515dic. 515-516
21. Kitay DZ "Folic Acid (Sangobion) in pregnancy." JAMA 204 (1968): 79
22. Rothman D "Folic Acid (Sangobion) in pregnancy." Am J Obstet Gynecol 108 (1970): 149-75
23. Wise J "Neural tube defects decline in US after Folic Acid (Sangobion) is added to flour." Br Med J 322 (2001): 1510
24. Hibbard BM, Hibbard ED "The treatment of folate deficiency in pregnancy." Acta Obstet Gynecol Scand 48 (1969): 349-56
25. Berkowitz R, Coustan D, Mochizuki T. "Handbook for Prescribing Medications During Pregnancy. 2nd ed." Boston, MA: Little, Brown, and Company (1986): 242

References for breastfeeding information

1. Tamura T, Yoshimura Y, Arakawa T "Human milk folate and folate status in lactating mothers and their infants." Am J Clin Nutr 33 (1980): 193-7
2. O'Connor DL, Tamura T, Picciano MF "Pteroylpolyglutamates in human milk." Am J Clin Nutr 53 (1991): 930-4
3. Jathar VS, Kamath SA, Parikh MN, Rege DV, Satoskar RS "Maternal milk and serum vitamin B12, Folic Acid (Sangobion), and protein levels in Indian subjects." Arch Dis Child 45 (1970): 236-41
4. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
5. Cooperman JM, Lopez R "Pteroylglutamates in human milk." Am J Clin Nutr 54 (1991): 760-2
6. Cooperman JM, Dweck HS, Newman LJ, Garbarino C, Lopez R "The folate in human milk." Am J Clin Nutr 36 (1982): 576-80
7. Cooperman JM "Folates in human milk." Am J Clin Nutr 46 (1987): 863

Pregnancy of Vitamin B12 (Sangobion) in details

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1^st trimester (and there is no evidence of a risk in later trimesters).

References

1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "CUPRIC SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. DailyMed. "COPPER: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).

Reviews

Consumer reviews

Mae ann barrera	01 Dec 2019 04:00
	Is it ok to take sangobion if your also taking cholecalciferol.i have 98/68 bp,is ok to take sangobion? Will it help improve my bp?thankyou

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Information checked by Dr. Sachin Kumar, MD Pharmacology