Ticarcillin/ clavulanate Uses

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• Ticarcillin/ clavulanate side effects

What is Ticarcillin/ clavulanate?

Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)) and Clavulanate (Ticarcillin/ clavulanate) combination is used to treat bacterial infections in many different parts of the body.

Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)) and Clavulanate (Ticarcillin/ clavulanate) combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria or preventing their growth. However, Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)) and Clavulanate (Ticarcillin/ clavulanate) will not work for colds, flu, or other virus infections.

Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)) and Clavulanate (Ticarcillin/ clavulanate) was to be given only by or under the direct supervision of a doctor.

The Ticarcillin/ clavulanate combination was withdrawn from the United States market on February 9, 2015.

How should I use Ticarcillin/ clavulanate?

Use Ticarcillin/ clavulanate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Ticarcillin/ clavulanate is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Ticarcillin/ clavulanate at home, a health care provider will teach you how to use it. Be sure you understand how to use Ticarcillin/ clavulanate. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Ticarcillin/ clavulanate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• To clear up your infection completely, use Ticarcillin/ clavulanate for the full course of treatment. Keep taking it even if you feel better in a few days.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Ticarcillin/ clavulanate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ticarcillin/ clavulanate.

Ticarcillin/ clavulanate side effects

See also:
What are the possible side effects of Ticarcillin/ clavulanate?

Applies to Clavulanate (Ticarcillin/ clavulanate) / Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)): intravenous powder for solution, intravenous solution

In addition to its needed effects, some unwanted effects may be caused by Clavulanate (Ticarcillin/ clavulanate) / Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking Clavulanate (Ticarcillin/ clavulanate) / Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)), check with your doctor or nurse immediately:

Rare

• Blood in the urine
• frequent urination
• lower abdominal or stomach cramping
• painful urination

• Abdominal or stomach cramps, pain, or tenderness
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• changes in skin color
• chest pain or discomfort
• chills
• clay-colored stools
• convulsions
• cough
• dark urine
• diarrhea
• diarrhea, watery and severe, which may also be bloody
• dizziness
• fast heartbeat
• fever
• general tiredness and weakness
• headache
• increased thirst
• irritability
• itching
• joint or muscle pain
• loss of appetite
• lower back or side pain
• muscle twitching
• nausea or vomiting
• pain, tenderness, or swelling of the foot or leg
• pinpoint red spots on the skin
• rash
• red skin lesions, often with a purple center
• red, irritated eyes
• restlessness
• seizures
• shortness of breath
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling or inflammation of the mouth
• swollen glands
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• upper right abdominal or stomach pain
• vomiting of blood
• yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with Clavulanate (Ticarcillin/ clavulanate) / Ticarcillin (Ticarcillin/ Clavulanate (Ticarcillin/ clavulanate)) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• change in taste or bad unusual or unpleasant (after) taste
• difficulty with moving
• excess air or gas in the stomach or intestines
• full feeling
• heartburn
• muscle aching, cramping, or stiffness
• passing gas
• swollen joints

What is the most important information I should know about Ticarcillin/ clavulanate?

• Ticarcillin/ clavulanate only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use Ticarcillin/ clavulanate for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Ticarcillin/ clavulanate may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
• Ticarcillin/ clavulanate may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Tell your doctor or dentist that you take Ticarcillin/ clavulanate before you receive any medical or dental care, emergency care, or surgery.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Ticarcillin/ clavulanate. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Do not receive a live vaccine (eg, oral typhoid vaccine) while you are taking Ticarcillin/ clavulanate. Talk with your doctor before you receive any vaccine.
• Ticarcillin/ clavulanate may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Ticarcillin/ clavulanate.
• Use Ticarcillin/ clavulanate with caution in the ELDERLY; they may be more sensitive to its effects.
• Ticarcillin/ clavulanate should be used with extreme caution in CHILDREN younger than 3 months old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ticarcillin/ clavulanate while you are pregnant. It is not known if Ticarcillin/ clavulanate is found in breast milk. If you are or will be breast-feeding while you use Ticarcillin/ clavulanate, check with your doctor. Discuss any possible risks to your baby.

Active ingredient matches for Ticarcillin/ clavulanate:

Ticarcillin/Clavulanate

Clavulanate/ticarcillin

References

1. PubChem. "TICARCILLIN". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "TICARCILLIN". http://www.drugbank.ca/drugs/DB01607 (accessed September 17, 2018).
3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology