Actions of Trolovol in details
Trolovol is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of Trolovol. Trolovol also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between Trolovol and cystine, resulting in formation of Trolovol-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily. Trolovol interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of Trolovol in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, Trolovol markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, Trolovol in vitro depresses T-cell activity but not B-cell activity.
How should I take Trolovol?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take Trolovol on an empty stomach, at least 1 hour before or 2 hours after a meal.
Drink plenty of liquids while you are taking Trolovol.
Do not drink milk within 1 hour before or 1 hour after you take Trolovol.
You will need frequent urine tests.
Your condition may seem to get worse for a short time when you first start taking this medicine. Do not change your doses or medication schedule without your doctor's advice. Every person taking Trolovol should remain under the care of a doctor.
It may take up to 3 months before your rheumatoid arthritis symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
You may need to follow a special diet while using Trolovol. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.
If you do stop taking Trolovol for any reason, do not start taking it again until you talk to your doctor.
Your doctor may want you to take a multivitamin or take extra iron or vitamin B6 while you are taking Trolovol. Take only the amount of supplements that your doctor has prescribed.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Trolovol administration
Take Trolovol exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Trolovol must be taken on an empty stomach, at least 1 hour before or 2 hours after a full meal, and at least 1 hour before or after any other drug, food, or milk. Taking Trolovol with anything else in the stomach greatly decreases its effectiveness.
Do not stop taking Trolovol without first talking to your doctor. Stopping therapy may cause your body to react abnormally when therapy is restarted. If you do stop taking the medication, do not restart without first talking to your doctor. You may need special monitoring.
Your doctor may want you to take a vitamin and mineral supplement during treatment with Trolovol. Trolovol may reduce vitamin B6 and iron in the body. Follow your doctor's instructions.
Store Trolovol at room temperature away from moisture and heat.
Trolovol pharmacology
Trolovol is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of Trolovol, it would appear that one gram of Trolovol should be followed by the excretion of about 200 milligrams of copper; however, the actual amount excreted is about one percent of this.
Trolovol also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between Trolovol and cystine, resulting in formation of Trolovol-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily.
Trolovol interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed.
The mechanism of action of Trolovol in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, Trolovol markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, Trolovol in vitro depresses T-cell activity but not B-cell activity.
In vitro, Trolovol dissociates macroglobulins (rheumatoid factor) although the relationship of the activity to its effect in rheumatoid arthritis is not known.
In rheumatoid arthritis, the onset of therapeutic response to Trolovol may not be seen for two or three months. In those patients who respond, however, the first evidence of suppression of symptoms such as pain, tenderness, and swelling is generally apparent within three months. The optimum duration of therapy has not been determined. If remissions occur, they may last from months to years, but usually require continued treatment.
In all patients receiving Trolovol, it is important that Trolovol be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, milk, antacid, zinc or iron-containing preparation. This permits maximum absorption and reduces the likelihood of inactivation by metal binding in the gastrointestinal tract.
Pharmacokinetics
Trolovol is absorbed rapidly but incompletely (40-70%) from the gastrointestinal tract, with wide inter-individual variations. Food, antacids, and iron reduce absorption of the drug. The peak plasma concentration of Trolovol occurs 1-3 hours after ingestion; it is approximately 1-2 mg/L after an oral dose of 250 mg. The drug appears in the plasma as free Trolovol, Trolovol disulfide, and cysteine-Trolovol disulfide. When prolonged treatment is stopped, there is a slow elimination phase lasting 4-6 days.
More than 80% of plasma Trolovol is bound to proteins, especially albumin and ceruloplasmin. The drug also binds to erythrocytes and macrophages. A small fraction of the dose is metabolized in the liver to S-methyl-D-Trolovol. Excretion is mainly renal, mainly as disulfides.
Reviews
The results of a survey conducted on ndrugs.com for Trolovol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Trolovol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported administration
When best can I take Trolovol, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Trolovol should be taken Empty stomach. In any case, this may not be the right description on how you ought to take this Trolovol. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Trolovol can be taken.
| Users | % | ||
|---|---|---|---|
| Empty stomach | 1 | 100.0% | |
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
