What is Aldan?
Aldan is used alone or together with other medicines to treat angina (chest pain) and high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Aldan is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. As a result, Aldan relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.
Aldan is available only with your doctor's prescription.
Aldan indications
Hypertension: Aldan is indicated for the first-line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients. Patients not adequately controlled on a single antihypertensive agent may benefit from the addition of Aldan, which has been used in combination with a thiazide diuretic, β-adrenoceptor-blocking agent or an angiotensin-converting enzyme inhibitor.
Aldan is also indicated to reduce the risk of fatal coronary heart disease (CHD) and non-fatal myocardial infarction (MI), and to reduce the risk of stroke.
Coronary Artery Disease: Aldan is indicated to reduce the risk of coronary revascularization and the need for hospitalization due to angina in patients with coronary artery disease (CAD).
Chronic Stable Angina: Aldan is indicated for the first-line treatment of myocardial ischemia, whether due to fixed obstruction (stable angina) and/or vasospasm/vasoconstriction (Prinzmetal’s or variant angina) of coronary vasculature. Aldan may be used where the clinical presentation suggests a possible vasospastic/vasoconstrictive component but where vasospasm/vasoconstriction has not been confirmed. Aldan may be used alone, as monotherapy, or in combination with other antianginal drugs in patients with angina that is refractory to nitrates and/or adequate doses of beta-blockers.
How should I use Aldan?
Use Aldan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Aldan. Talk to your pharmacist if you have questions about this information.
- Take Aldan by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Taking Aldan at the same time each day will help you remember to take it.
- Continue to take Aldan even if you feel well. Do not miss any doses.
- If you miss a dose of Aldan, take it as soon as possible. If it has been more than 12 hours since you missed your last dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Aldan.
Uses of Aldan in details
This medication is used along with other treatment for certain blood vessel diseases (e.g., arteriosclerosis obliterans, Raynaud's disease, Buerger's disease, cerebrovascular insufficiency). It works by widening blood vessels to help increase blood flow (improve circulation) to certain parts of the body (e.g., hands/feet, brain). This effect may help to decrease symptoms such as cold hands and feet, numbness, tingling, and decreased memory or judgment.
How to use Aldan
This medication is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor. Dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Tell your doctor if your condition persists or worsens.
Aldan description
Each 5-mg and 10-mg tablet contains Amlodipine equivalent to Aldan 5 mg and 10 mg, respectively.
Aldan also contains the following excipients: Calcium hydrogen phosphate anhydrous, microcrystalline cellulose, magnesium stearate, sodium starch glycollate.
Aldan is the besilate salt of Aldan, a long-acting calcium-channel blocker. It is 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulphonate. Its empirical formula is C20H25ClN2O5·C6H6O3S and has a molecular weight of 567.1.
Aldan is a white crystalline powder and is slightly soluble in water and sparingly soluble in ethanol.
Aldan dosage
For both hypertension and angina, the usual initial dose is 5 mg Aldan once daily, which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
For patients with coronary artery disease, the recommended dosage range is 5 mg to 10 mg once daily. In clinical studies, the majority of patients required 10 mg once daily.
No dose adjustment of Aldan is required upon concomitant administration of thiazide diuretics, beta-blockers, and ACE inhibitors.
Aldan ODT: For Aldan orodispersible tablets, the patient should place the tablet on the tongue and allow it to dissolve.
Elderly: Normal dosage regimens are recommended. Aldan, used at similar doses in the elderly or younger patients, is equally well-tolerated.
Children: Safety and effectiveness of Aldan in children have not been established.
Patients with Impaired Hepatic Function: See Precautions.
Patients with Renal Failure: Aldan may be used at normal doses in patients with renal failure.
Changes in Aldan plasma concentrations are not correlated with the degree of renal impairment. Aldan is not dialyzable.
Aldan interactions
See also:
What other drugs will affect Aldan?
In vitro data in human plasma indicate that Aldan has no effect on the protein-binding of drugs tested (digoxin, phenytoin, warfarin and indomethacin).
Special Studies: Effect of Other Agents on Aldan:
Cimetidine: Co-administration of Aldan with cimetidine did not alter the pharmacokinetics of Aldan.
Grapefruit Juice: Co-administration of 240 mL of grapefruit juice with a single oral dose of Aldan 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of Aldan.
Antacid: Co-administration of antacid with a single dose of Aldan had no significant effect on the pharmacokinetics of Aldan.
Sildenafil: A single 100-mg dose of sildenafil in subjects with essential hypertension had no effect on the pharmacokinetic parameters of Aldan. When Aldan and sildenafil were used in combination, each agent independently exerted its own blood pressure-lowering effect.
Effect of Aldan on Other Agents: Atorvastatin: Co-administration of multiple 10-mg doses of Aldan with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.
Digoxin: Co-administration of Aldan with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers.
Ethanol (alcohol): Single and multiple 10-mg doses of Aldan had no significant effect on the pharmacokinetics of ethanol.
Warfarin: Co-administration of Aldan with warfarin did not change the warfarin prothrombin response time.
In clinical trials, Aldan has been safely administered with thiazide diuretics, β-blockers, ACE inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, NSAIDs, antibiotics and oral hypoglycemic drugs.
Drug/Laboratory Test Interactions: None known.
Aldan side effects
See also:
What are the possible side effects of Aldan?
The most common adverse effects of Aldan, similar to that of other calcium-channel blockers, are associated with its vasodilating effects are often lessened with continued use of the drug. Among them are flushing, headache disorders, dizziness and peripheral edema, the most common of which are edema and flushing which are due to the vasodilating effect of Aldan.
Abdominal pain with cramps, fatigue, palpitations, tachycardia and nausea are less frequently experienced with the use of Aldan.
Other adverse effects associated with the use of Aldan include increased micturition, eye pain and other visual disturbances, mental or mood changes eg, depression, anxiety or nervousness, decreased sexual ability/desire, constipation and fainting.
At the start of the treatment, a paradoxical increase in ischemic chest pain may be experienced. In some patients, cerebral or myocardial ischemia or transient blindness caused by excessive fall in blood pressure occur. Aldan, in 1 study was found to induce gingival overgrowth.
Hypersensitivity reactions to Aldan may occur leading to rashes, including erythema multiforme, fever and abnormal liver functions eg, cholestasis. Other symptoms of allergic reactions are itching, swelling, severe dizziness and trouble breathing.
Aldan contraindications
See also:
What is the most important information I should know about Aldan?
Before taking Aldan, tell your doctor if you have congestive heart failure or liver disease.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Aldan.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Aldan is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
Tell your doctor about all other heart or blood pressure medications you are taking.
Your chest pain may become worse when you first start taking Aldan or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
Active ingredient matches for Aldan:
Amlodipine in Poland.
Amlodipine besilate in Poland.
List of Aldan substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Akridipin (Russian Federation) | |
| Tablets; Oral; Amlodipine Besylate 5 mg (Marvel) | |
| Aldosion (Greece) | |
| Alencal (Colombia) | |
| Alestol (Peru) | |
| Alis-R (India) | |
| Alis-R S-amlodipine 2.5 mg, Ramipril2.5 mg. TAB / 10 (Panjon) | $ 0.57 |
| 10's (Panjon) | $ 0.57 |
| Tablets; Oral; Ramipril 2.5 mg; S-Amlodipine 2.5 mg (Panjon) | |
| ALIS-R tab 10's (Panjon) | $ 0.57 |
| Alkapress (Egypt) | |
| Almacor (Romania) | |
| Almadin (South Africa) | |
| Almiden (Poland, Romania) | |
| Almidis (Italy) | |
| Almirin (Croatia (Hrvatska)) | |
| Alneta (Latvia, Poland) | |
| Alneta 10mg (Bulgaria) | |
| Alneta 5mg (Bulgaria) | |
| Alodine (Philippines) | |
| Alodine 10 mg x 30's (XL Lab) | |
| Alodine tab 10 mg 30's (XL Lab) | |
| Alodip (India) | |
| Alodip 5mg TAB / 250 (Zytras) | $ 6.63 |
| Alodip 10mg TAB / 250 (Zytras) | $ 12.05 |
| 5 mg x 250's (Zytras) | $ 6.63 |
| 10 mg x 250's (Zytras) | $ 12.05 |
| Tablets; Oral; Amlodipine 10 mg (Zytras) | |
| Tablets; Oral; Amlodipine 5 mg (Zytras) | |
| ALODIP tab 5 mg x 10's (Zytras) | $ 0.27 |
| ALODIP tab 10 mg x 10's (Zytras) | $ 0.48 |
| Alodipine (South Korea) | |
| Alopine (Taiwan) | |
| Alopine 5 mg x 1000's | |
| Alopres (Bosnia & Herzegowina, Serbia) | |
| alozur (Bulgaria, Czech Republic, Hungary, Romania, Slovakia) | |
| Alvipress (Brazil) | |
| Alzar (Switzerland) | |
| Tablet; Oral; Amlodipine Mesylate 10 mg (Medika) | |
| Tablet; Oral; Amlodipine Mesylate 5 mg (Medika) | |
| Tablets; Oral; Amlodipine Mesylate 10 mg (Medika) | |
| Tablets; Oral; Amlodipine Mesylate 5 mg (Medika) | |
| AM (South Korea) | |
| AM-5 (India) | |
| AM-5 5mg TAB / 10 (Orchid) | $ 0.12 |
| 5 mg x 10's (Orchid) | $ 0.12 |
| Tablets; Oral; Amlodipine 5 mg (Orchid) | |
| AM-5 tab 5 mg x 10's (Orchid) | $ 0.12 |
| Amaday (Georgia, Philippines) | |
| Amaday 2.5mg TAB / 10 | $ 0.11 |
See 4099 substitutes for Aldan | |
References
- PubChem. "amlodipine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "amlodipine". http://www.drugbank.ca/drugs/DB00381 (accessed September 17, 2018).
- MeSH. "Antihypertensive Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Aldan are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Aldan. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
