What is Ap-Loratadine?
Ap-Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Ap-Loratadine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Ap-Loratadine is also used to treat skin hives and itching in people with chronic skin reactions.
Ap-Loratadine may also be used for purposes not listed in this medication guide.
Ap-Loratadine indications
Treatment of seasonal allergic rhinitis, perennial rhinitis, urticaria, allergic dermatologic disorders, angioedema and conjunctivitis. Ap-Loratadine is generally considered to be ineffective in asthma.
Acute anaphylaxis should be treated with adrenaline; Ap-Loratadine and corticosteroids are given to prevent relapse.
Ap-Loratadine is also used to control the pruritus associated with skin disorders eg, atopic eczema.
How should I use Ap-Loratadine?
Use Ap-Loratadine orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Ap-Loratadine orally disintegrating tablets by mouth with or without food.
- Be sure that your hands are completely dry before you handle Ap-Loratadine orally disintegrating tablets. Use the tablet right away after you remove it from the tablet blister.
- To open the tablet blister, peel back the foil, then gently remove the tablet. Place the tablet on the tongue. The tablet will dissolve quickly. You may take Ap-Loratadine orally disintegrating tablets with or without water.
- If you miss a dose of Ap-Loratadine orally disintegrating tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Ap-Loratadine orally disintegrating tablets.
Uses of Ap-Loratadine in details
This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. It is also used to relieve itching from hives.
Ap-Loratadine does not prevent hives or prevent/treat a serious allergic reaction (e.g., anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Ap-Loratadine in place of your epinephrine.
If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.
Do not use this medication in children younger than 6 years unless directed by the doctor. If you are using the chewable tablets, do not use in children younger than 2 years unless directed by your doctor.
How to use Ap-Loratadine
If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth with or without food, usually once a day or as directed by your doctor or the product package. If you are using the chewable tablets, chew each tablet well and swallow. Dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.
Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Seek immediate medical attention if your condition worsens or you think you have a serious medical problem (e.g., very serious allergic reaction/anaphylaxis).
Ap-Loratadine description
Ap-Loratadine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. Ap-Loratadine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease.
Ap-Loratadine dosage
Ap-Loratadine Dosage
Applies to the following strength(s): 10 mg; 5 mg/5 mL; 5 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Allergic Rhinitis
- Urticaria
Usual Pediatric Dose for:
- Allergic Rhinitis
- Urticaria
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dialysis
Usual Adult Dose for Allergic Rhinitis
10 mg orally once a day
Usual Adult Dose for Urticaria
10 mg orally once a day
Usual Pediatric Dose for Allergic Rhinitis
2 to 5 years: 5 mg orally once a day (syrup)
6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)
Usual Pediatric Dose for Urticaria
2 to 5 years: 5 mg orally once a day (syrup)
6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)
Renal Dose Adjustments
CrCl less than 30 mL/min: administer dosage every other day initially
Liver Dose Adjustments
Liver failure: administer dosage every other day initially
Dialysis
Ap-Loratadine is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis.
More about Ap-Loratadine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 43 Reviews - Add your own review/rating
Consumer resources
- Ap-Loratadine
- Ap-Loratadine capsules
- Ap-Loratadine chewable tablets
- Ap-Loratadine orally disintegrating tablets
- Ap-Loratadine syrup
- Other brands: Claritin, Alavert, Wal-itin, Claritin 24 Hour Allergy, More (7) »
Professional resources
- Ap-Loratadine (AHFS Monograph)
- More (4) »
Related treatment guides
- Allergic Rhinitis
- Urticaria
Ap-Loratadine interactions
See also:
What other drugs will affect Ap-Loratadine?
Ap-Loratadine (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of Ap-Loratadine and/or descarboethoxyloratadine were observed following coadministration of Ap-Loratadine with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of Ap-Loratadine, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of Ap-Loratadine relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.
| TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Ap-Loratadine and Descarboethoxyloratadine After 10 Days of Coadministration (Ap-Loratadine 10 mg) in Normal Volunteers | ||
| Ap-Loratadine | Descarboethoxyloratadine | |
|---|---|---|
| Erythromycin (500 mg q8h) | + 40% | +46% |
| Cimetidine (300 mg qid) | +103% | + 6% |
| Ketoconazole (200 mg q12h) | +307% | +73% |
Ap-Loratadine side effects
See also:
What are the possible side effects of Ap-Loratadine?
Applies to Ap-Loratadine: oral fixed-combination tablets, oral orally disintegrating tablets, oral solution, oral tablets
Side effects include:
Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.
Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.
Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.
Fixed combination Ap-Loratadine (the active ingredient contained in Ap-Loratadine Reditab) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.
Ap-Loratadine contraindications
See also:
What is the most important information I should know about Ap-Loratadine?
Do NOT use Ap-Loratadine if:
you are allergic to any ingredient in Ap-Loratadine
Contact your doctor or health care provider right away if any of these apply to you.
Active ingredient matches for Ap-Loratadine:
Loratadine in South Africa.
List of Ap-Loratadine substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Ao Shu (China) | |
| APC-Loratadine (Canada) | |
| Apex-Loratadine (South Africa) | |
| Apo-Loratadine (Canada, Hong Kong, Malaysia, New Zealand) | |
| Tablet; Oral; Loratadine 10 mg | |
| Apo-Loratadine / strip 10 mg x 20's | |
| Apo-Loratadine / strip 10 mg x 600's | |
| Apo-Loratadine / bottle 10 mg x 100's | |
| Apo-Loratadine 10 mg x 10 x 18's | |
| Apo-loratadine tablet 10 mg (Apotex Inc (Canada)) | |
| Apothecare Loratadine (Lebanon) | |
| Arclenxyl (Vietnam) | |
| Arclenxyl 10 mg x 1 Bottle 300 Tablet | |
| Ardin (Singapore) | |
| Ardin 10 mg x 100 Tablet (Korea Pharm) | |
| Ardin 10 mg x 50 x 10's (Korea Pharm) | |
| Ardin tab 10 mg 50 x 10's (Korea Pharm) | |
| ARDIN syr 200ml (Korea Pharm) | $ 0.90 |
| Aridine (Thailand) | |
| Aridine 10 mg x 500's | |
| Aridine 10 mg x 10 x 10's | |
| Aridine 5 mg x 60 mL | |
| Aridine 5 mg x 960 mL | |
| ASOLOR | |
| ASOLOR 10 MG TABLET 1 strip / 10 tablets each (Asolear Pharma Pvt Ltd) | $ 0.80 |
| Asolor 10mg Tablet (Asolear Pharma Pvt Ltd) | $ 0.08 |
| Astena (Philippines) | |
| Astol (Colombia) | |
| Atinac (Brazil) | |
| AURA (India) | |
| 10 mg x 10's (Daffohils) | |
| Aura 10mg TAB / 10 (Daffohils) | |
| AURA tab 10 mg x 10's (Daffohils) | |
| Aura 10mg TAB / 10 (Daffohils) | |
| Avallert (Peru) | |
| Avotyne (Malaysia) | |
| Avotyne tab 10 mg 1 x 10's (Abio) | |
| Awayke (India) | |
| AWAYKE MD 10MG TABLET 1 strip / 10 tablets each (Panacea) | $ 0.58 |
| Awayke 10mg Tablet MD (Panacea) | $ 0.06 |
| Axalor (Pakistan) | |
| Axcel Loratadine (Malaysia) | |
| Axcel Loratadine 60 mg/60 mL x 1 Bottle 60 mL (Kotra) | |
| Axcel Loratadine 10 mg x 10 Blister x 10 Tablet (Kotra) | |
| Axcel Loratadine 10 mg x 5 x 10 x 10's (Kotra) | |
| Axcel Loratadine 5 mg/5 mL x 60 mL (Kotra) | |
| Axcel Loratadine syr 5 mg/5 mL 60 mL x 1's (Kotra) | |
| Axcel Loratadine syr 5 mg/5 mL 100 mL x 1's (Kotra) | |
| Axcel Loratadine tab 10 mg 10 x 10's (Kotra) | |
| Axcel Loratadine tab 10 mg 5 x 10 x 10's (Kotra) | |
| Ayale (Vietnam) | |
| Ayale 10 mg x 10 Blister x 10 Tablet | |
See 1852 substitutes for Ap-Loratadine | |
References
- DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "loratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "loratadine". http://www.drugbank.ca/drugs/DB00455 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Ap-Loratadine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ap-Loratadine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
