What is Betacap-TR?
Betacap-TR is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of stroke and heart attacks.
Betacap-TR is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle).
Betacap-TR may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). It may also be used to reduce the risk of death in patients who have heart attacks.
Betacap-TR oral solution is used to treat proliferating infantile hemangioma.
Betacap-TR is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.
Betacap-TR is available only with your doctor's prescription.
Betacap-TR indications
Hypertension
Betacap-TR is indicated in the management of hypertension. It may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Betacap-TR is not indicated in the management of hypertensive emergencies.
Angina Pectoris Due to Coronary Atherosclerosis
Betacap-TR is indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris.
Atrial Fibrillation
Betacap-TR is indicated to control ventricular rate in patients with atrial fibrillation and a rapid ventricular response.
Myocardial Infarction
Betacap-TR is indicated to reduce cardiovascular mortality in patients who have survived the acute phase of myocardial infarction and are clinically stable.
Migraine
Betacap-TR is indicated for the prophylaxis of common migraine headache. The efficacy of Betacap-TR in the treatment of a migraine attack that has started has not been established, and Betacap-TR is not indicated for such use.
Essential Tremor
Betacap-TR is indicated in the management of familial or hereditary essential tremor. Familial or essential tremor consists of involuntary, rhythmic, oscillatory movements, usually limited to the upper limbs. It is absent at rest, but occurs when the limb is held in a fixed posture or position against gravity and during active movement. Betacap-TR causes a reduction in the tremor amplitude, but not in the tremor frequency. Betacap-TR is not indicated for the treatment of tremor associated with Parkinsonism.
Hypertrophic Subaortic Stenosis
Betacap-TR improves NYHA functional class in symptomatic patients with hypertrophic subaortic stenosis.
Pheochromocytoma
Betacap-TR is indicated as an adjunct to alpha-adrenergic blockade to control blood pressure and reduce symptoms of catecholamine-secreting tumors.
How should I use Betacap-TR?
Use Betacap-TR solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Betacap-TR solution comes with extra patient information sheets called a Medication Guide and Instructions for Use. Read them carefully. Read them again each time you get Betacap-TR solution refilled.
- Do NOT shake Betacap-TR solution before use.
- Use the syringe that comes with Betacap-TR solution to measure the dose. Ask the pharmacist for help if you are unsure of how to measure the dose.
- Give Betacap-TR solution right into your child's mouth. If needed, Betacap-TR solution may be mixed in a small amount of milk or fruit juice and given in a baby's bottle.
- Give Betacap-TR solution with or right after a feeding.
- Give doses of Betacap-TR solution at least 9 hours apart.
- The dose of Betacap-TR solution may need to be changed as your child's weight changes. Have your child's weight checked often. Talk with the doctor before changing your child's dose.
- Give Betacap-TR solution on a regular schedule to get the most benefit from it. Giving Betacap-TR solution at the same time each day will help you remember to give it.
- If your child spits up a dose or if you are not sure your child got all of the medicine, do not give another dose. Wait until the next scheduled dose.
- If you miss giving your child a dose of Betacap-TR solution, give it as soon as possible. If it is almost time for the next dose, skip giving the missed dose and go back to your child's regular dosing schedule. Do not give 2 doses at once.
Ask your health care provider any questions you may have about how to use Betacap-TR solution.
Uses of Betacap-TR in details
Use: Labeled Indications
Angina, chronic stable: To decrease angina frequency and increase exercise tolerance in patients with angina pectoris.
Cardiac arrhythmias: Control of supraventricular arrhythmias (eg, atrial fibrillation and flutter, atrioventricular nodal reentrant tachycardia) and ventricular tachycardias (eg, catecholamine-induced arrhythmias, digoxin toxicity).
Essential tremor: Management of familial or hereditary essential tremor.
Hypertension: Management of hypertension. Note: Beta-blockers are not recommended as first-line therapy (ACC/AHA [Whelton 2018]).
Migraine headache prophylaxis: Prophylaxis of common migraine headache.
Myocardial infarction, early treatment and secondary prevention: To reduce cardiovascular mortality in patients who have survived the acute phase of myocardial infarction and are clinically stable.
Obstructive hypertrophic cardiomyopathy: Symptomatic treatment of obstructive hypertrophic cardiomyopathy (formerly known as hypertrophic subaortic stenosis).
Pheochromocytoma: As an adjunct to alpha-adrenergic blockade to control blood pressure and reduce symptoms of catecholamine-secreting tumors.
Proliferating infantile hemangioma (Betacap-TR): Treatment of proliferating infantile hemangioma requiring systemic therapy.
Off Label Uses
Akathisia, antipsychotic-induced
Data from a limited number of patients in 5 randomized, double-blind, controlled studies support the use of Betacap-TR in antipsychotic-induced akathisia.
Based on the American Association for the Study of Liver Diseases guidelines on the management of portal hypertensive bleeding in cirrhosis and the British Society of Gastroenterology guidelines on the management of variceal hemorrhage in cirrhotic patients, use of nonselective beta-blockers, such as Betacap-TR, is effective and recommended for primary and secondary prophylaxis of variceal hemorrhage.
Betacap-TR description
A widely used non-cardioselective beta-adrenergic antagonist. R,S-Betacap-TR Hydrochloride is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety.
Betacap-TR dosage
Betacap-TR Dosage
Generic name: Betacap-TR HYDROCHLORIDE 80mg
Dosage form: capsule, extended release
See also:
- Betacap-TR Tablets
- Betacap-TR capsule, extended release
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Betacap-TR should be administered once daily at bedtime and should be taken consistently either on an empty stomach or with food. Initiate dosing at 80 mg and titrate to 120 mg daily as needed for blood pressure control. Doses above 120 mg have no additional effects on blood pressure. The time needed for full antihypertensive response is variable, but is usually achieved within 2 to 3 weeks.
More about Betacap-TR (Betacap-TR)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 0 Reviews - Add your own review/rating
Consumer resources
- Betacap-TR
- Betacap-TR (Advanced Reading)
- Other brands: Betacap-TR, Betacap-TR, InnoPran XL, Betacap-TR
Professional resources
- Betacap-TR (FDA)
- Betacap-TR Hydrochloride (AHFS Monograph)
Related treatment guides
- Atrial Fibrillation
- Ventricular Tachycardia
Betacap-TR interactions
See also:
What other drugs will affect Betacap-TR?
Patients receiving catecholamine-depleting drugs such as reserpine should be closely observed if Beta-Betacap-TR HCl is administered. The added catecholamine-blocking action may produce an excessive reduction of resting sympathetic nervous activity, which may result in hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.
Caution should be exercised when patients receiving a beta blocker are administered a calcium-channel blocking drug, especially intravenous verapamil, for both agents may depress myocardial contractility or atrioventricular conduction. On rare occasions, the concomitant intravenous use of a beta blocker and verapamil has resulted in serious adverse reactions, especially in patients with severe cardiomyopathy, congestive heart failure, or recent myocardial infarction.
Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported.
Hypotension and cardiac arrest have been reported with the concomitant use of Betacap-TR and haloperidol.
Aluminum hydroxide gel: Greatly reduces intestinal absorption of Betacap-TR.
Ethanol: Slows the rate of absorption of Betacap-TR.
Phenytoin, phenobarbitone: and rifampin accelerate Betacap-TR clearance.
Chlorpromazine: When used concomitantly with Betacap-TR, results in increased plasma levels of both drugs.
Antipyrine: and lidocaine have reduced clearance when used concomitantly with Betacap-TR.
Thyroxine: May result in a lower than expected T3 concentration when used concomitantly with Betacap-TR.
Cimetidine Decreases the hepatic metabolism of Betacap-TR, delaying elimination and incre:asing blood levels.
Theophylline: Clearance is reduced when used concomitantly with Betacap-TR.
Betacap-TR side effects
See also:
What are the possible side effects of Betacap-TR?
The following serious adverse reactions are discussed in greater detail in other sections of the labeling:
- Hypoglycemia and related events, like hypoglycemic seizure.
- Bronchospasm.
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug may not reflect the rates observed in clinical practice.
Clinical Trials Experience with Betacap-TR in Infants with proliferating infantile hemangioma
In clinical trials for proliferating infantile hemangioma, the most frequently reported adverse reactions ( > 10%) in infants treated with Betacap-TR were sleep disorders, aggravated respiratory tract infections such as bronchitis and bronchiolitis associated with cough and fever, diarrhea, and vomiting. Adverse reactions led to treatment discontinuation in fewer than 2% of treated patients.
Overall, 479 patients in the pooled safety population were exposed to study drug in the clinical study program (456 in placebo-controlled trials). A total of 424 patients were treated with Betacap-TR at doses 1.2 mg/kg/day or 3.4 mg/kg/day for 3 or 6 months. Of these, 63% of patients were aged 91-150 days and 37% were aged 35-90 days at randomization.
The following table lists according to the dosage the most common adverse reactions (treatment-emergent adverse events with an incidence at least 3% greater on one of the two doses than on placebo).
Table 2: Treatment-emergent adverse events occurring at least 3% more often on Betacap-TR than on placebo.
Reaction | Placebo N=236 | Betacap-TR 1.2 mg/kg/day N=200 | Betacap-TR 3.4 mg/kg/day N=224 |
Sleep disorder | 5.90% | 17.50% | 16.10% |
Bronchitis | 4.7 | 8 | 13.4 |
Peripheral coldness | 0.4 | 8 | 6.7 |
Agitation | 2.1 | 8.5 | 4.5 |
Diarrhea | 1.3 | 4.5 | 6.3 |
Somnolence | 0.4 | 5 | 0.9 |
Nightmare | 1.7 | 2 | 6.3 |
Irritability | 1.3 | 5.5 | 1.3 |
Decreased appetite | 0.4 | 2.5 | 3.6 |
Abdominal pain | 0.4 | 3.5 | 0.4 |
The following adverse events have been observed during clinical studies, with an incidence of less than 1%:
Cardiac disorders: Second degree atrioventricular heart block, in a patient with underlying conduction disorder, required definitive treatment discontinuation.
Skin and subcutaneous tissue disorders: Urticaria, alopecia
Investigations: Decreased blood glucose, decreased heart rate
Compassionate Use Program
More than 600 infants received Betacap-TR in a compassionate use program (CUP). Mean age at treatment initiation was 3.6 months. Mean dose of Betacap-TR was 2.2 mg/kg/day and mean treatment duration was 7.1 months.
The adverse reactions reported in the CUP were similar to the ADRs observed during clinical trials but some were more severe.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of Betacap-TR. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
These adverse reactions are as follows:
Blood and lymphatic system disorders: Agranulocytosis
Psychiatric disorders: Hallucination
Skin and subcutaneous tissues disorders: Purpura
Betacap-TR contraindications
See also:
What is the most important information I should know about Betacap-TR?
You should not use this medication if you are allergic to Betacap-TR, if you have asthma, a slow heart rate, or a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker).
If you need surgery, tell the surgeon ahead of time that you are using Betacap-TR. You may need to stop using the medicine for a short time.
Do not skip doses or stop using Betacap-TR without first talking to your doctor. You may need to use less and less before you stop the medication completely.
Avoid drinking alcohol. It may increase your blood levels of Betacap-TR.
Betacap-TR is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Active ingredient matches for Betacap-TR:
Propranolol in India.
Unit description / dosage (Manufacturer) | Price, USD |
40 mg x 10's | $ 0.17 |
80 mg x 10's | $ 0.29 |
60 mg x 10's | $ 0.50 |
Betacap-TR 40mg TAB / 10 | $ 0.17 |
Betacap-TR 80mg TAB / 10 | $ 0.29 |
Betacap-TR 40mg ER-CAP / 10 | $ 0.47 |
Betacap-TR 60mg ER-CAP / 10 | $ 0.50 |
Betacap-TR 80mg ER-CAP / 10 | $ 0.62 |
BETACAP-TR tab 40 mg x 10's (Sun) | $ 0.17 |
BETACAP-TR tab 80 mg x 10's (Sun) | $ 0.29 |
BETACAP-TR ER cap 40 mg x 10's (Sun) | $ 0.49 |
BETACAP-TR ER cap 60 mg x 10's (Sun) | $ 0.50 |
BETACAP-TR ER cap 80 mg x 10's (Sun) | $ 0.71 |
Betacap-TR 40mg TAB / 10 | $ 0.17 |
Betacap-TR 80mg TAB / 10 | $ 0.29 |
Betacap-TR 40mg ER-CAP / 10 | $ 0.47 |
Betacap-TR 60mg ER-CAP / 10 | $ 0.50 |
Betacap-TR 80mg ER-CAP / 10 | $ 0.62 |
List of Betacap-TR substitutes (brand and generic names): | |
BETACAP TR (India) | |
Betacap TR 60 mg Capsule (Sun Pharmaceutical Industries Ltd.) | $ 0.05 |
Betachron (United States) | |
Betacurb | |
Betacurb 40mg Capsule (Medishri Healthcare) | $ 0.06 |
Betadur CR (United Kingdom) | |
Betagem | |
Betagem 10mg Tablet (Bondane Pharma) | $ 0.01 |
Betagem 20mg Tablet (Bondane Pharma) | $ 0.02 |
Betagem 40mg Capsule TR (Bondane Pharma) | $ 0.05 |
Betalevedim (Brazil) | |
Betalol (India, Pakistan, Thailand) | |
Betalol 10 mg x 100's (East West Pharma) | |
Betalol 10 mg x 1, 000's (East West Pharma) | |
Betalol 10 mg x 100 x 10's (East West Pharma) | |
Betalol 40 mg x 100's (East West Pharma) | |
Betalol 40 mg x 1, 000's (East West Pharma) | |
Betalol 40 mg x 100 x 10's (East West Pharma) | |
2.5 mg x 10's (East West Pharma) | $ 0.51 |
5 mg x 10's (East West Pharma) | $ 0.82 |
Betalol 2.5mg TAB / 10 (East West Pharma) | $ 0.51 |
Betalol 5mg TAB / 10 (East West Pharma) | $ 0.82 |
Betalol 5 mg Tablet (East West Pharma) | $ 0.08 |
Betalol 2.5 mg Tablet (East West Pharma) | $ 0.05 |
BETALOL 2.5MG TABLET 1 strip / 10 tablets each (East West Pharma) | $ 0.51 |
Betalol tab 10 mg 100 x 10's (East West Pharma) | |
Betalol tab 40 mg 100 x 10's (East West Pharma) | |
BETALOL tab 2.5 mg x 10's (East West Pharma) | $ 0.51 |
BETALOL tab 5 mg x 10's (East West Pharma) | $ 0.82 |
Betalol 2.5mg Tablet (East West Pharma) | $ 0.05 |
Betalong | |
Betanol (Bangladesh, Pakistan) | |
Solution; Ophthalmic; Metipranolol 0.1% (Vencare Formulations Pvt Ltd) | |
Solution; Ophthalmic; Metipranolol 0.3% (Vencare Formulations Pvt Ltd) | |
Solution; Ophthalmic; Metipranolol 0.6% (Vencare Formulations Pvt Ltd) | |
Betanol 25 mg Tablet (Vencare Formulations Pvt Ltd) | $ 0.02 |
BETANOL TR 40MG CAPSULE 1 strip / 10 capsules each (Vencare Formulations Pvt Ltd) | $ 0.48 |
Betanol 40mg Capsule TR (Vencare Formulations Pvt Ltd) | $ 0.05 |
BETAPRO (CONSEM) | |
BETAPRO 40 MG CAPSULE SR 1 strip / 10 capsule srs each (Consern Pharma P Ltd) | $ 0.29 |
BETAPRO 80 MG CAPSULE SR 1 strip / 10 capsule srs each (Consern Pharma P Ltd) | $ 0.52 |
Betapro SR | |
Betapro SR 40 mg Capsule (Consern Pharma Pvt Ltd.) | $ 0.03 |
Betapro SR 80 mg Capsule (Consern Pharma Pvt Ltd.) | $ 0.04 |
Betapro SR 60 mg Capsule (Consern Pharma Pvt Ltd.) | $ 0.03 |
Betaprp | |
Betaprp 20 mg Tablet (Consern Pharma Pvt Ltd.) | $ 0.01 |
Betaprp-20 | |
Betaprp-20 20mg TAB / 10 | $ 0.13 |
Betarp | |
Betarp 20 mg Tablet (Consern Pharma Pvt Ltd.) | $ 0.01 |
Betasav TR | |
Betasav TR 40 mg Capsule (Saviour Drugs) | $ 0.04 |
See 1250 substitutes for Betacap-TR |
References
- PubChem. "propranolol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "propranolol". http://www.drugbank.ca/drugs/DB00571 (accessed September 17, 2018).
- MeSH. "Vasodilator Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Betacap-TR are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Betacap-TR. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Betacap-TR drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users | % | ||
---|---|---|---|
Useful | 1 | 100.0% |
1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Betacap-TR drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users | % | ||
---|---|---|---|
Not expensive | 1 | 100.0% |
2 consumers reported time for results
To what extent do I have to use Betacap-TR before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Betacap-TR. To get the time effectiveness of using Betacap-TR drug by other patients, please click here.
Users | % | ||
---|---|---|---|
1 month | 1 | 50.0% | |
1 week | 1 | 50.0% |
6 consumers reported age
Users | % | ||
---|---|---|---|
> 60 | 3 | 50.0% | |
30-45 | 2 | 33.3% | |
16-29 | 1 | 16.7% |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology