What is Cefzid?
Cefzid injection is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Cefzid will not work for colds, flu, or other virus infections.
Cefzid is available only with your doctor's prescription.
Cefzid indications
Cefzid (Cefzid for injection, USP) is indicated for the treatment of patients with infections caused by susceptible strains of the designated organisms in the following diseases:
- 1.
- Lower Respiratory Tract Infections, including pneumonia, caused by Pseudomonas aeruginosa and other Pseudomonas spp.; Haemophilus influenzae, including ampicillin-resistant strains; Klebsiella spp.; Enterobacter spp.; Proteus mirabilis; Escherichia coli; Serratia spp.; Citrobacter spp.; Streptococcus pneumoniae; and Staphylococcus aureus (methicillin-susceptible strains).
- 2.
- Skin and Skin-Structure Infections caused by Pseudomonas aeruginosa; Klebsiella spp.; Escherichia coli; Proteus spp., including Proteus mirabilis and indole-positive Proteus; Enterobacter spp.; Serratia spp.; Staphylococcus aureus (methicillin-susceptible strains); and Streptococcus pyogenes (group A beta-hemolytic streptococci).
- 3.
- Urinary Tract Infections, both complicated and uncomplicated, caused by Pseudomonas aeruginosa; Enterobacter spp.; Proteus spp., including Proteus mirabilis and indole-positive Proteus; Klebsiella spp.; and Escherichia coli.
- 4.
- Bacterial Septicemia caused by Pseudomonas aeruginosa, Klebsiella spp., Haemophilus influenzae, Escherichia coli, Serratia spp., Streptococcus pneumoniae, and Staphylococcus aureus (methicillin-susceptible strains).
- 5.
- Bone and Joint Infections caused by Pseudomonas aeruginosa, Klebsiella spp., Enterobacter spp., and Staphylococcus aureus (methicillin-susceptible strains).
- 6.
- Gynecologic Infections, including endometritis, pelvic cellulitis, and other infections of the female genital tract caused by Escherichia coli.
- 7.
- Intra-abdominal Infections, including peritonitis caused by Escherichia coli, Klebsiella spp., and Staphylococcus aureus (methicillin-susceptible strains) and polymicrobial infections caused by aerobic and anaerobic organisms and Bacteroides spp. (many strains of Bacteroides fragilis are resistant).
- 8.
- Central Nervous System Infections, including meningitis, caused by Haemophilus influenzae and Neisseria meningitidis. Cefzid has also been used successfully in a limited number of cases of meningitis due to Pseudomonas aeruginosa and Streptococcus pneumoniae.
Cefzid (Cefzid for injection, USP) may be used alone in cases of confirmed or suspected sepsis. Cefzid has been used successfully in clinical trials as empiric therapy in cases where various concomitant therapies with other antibiotics have been used.
Cefzid may also be used concomitantly with other antibiotics, such as aminoglycosides, vancomycin and clindamycin; in severe and life-threatening infections, and in the immuno-compromised patient. When such concomitant treatment is appropriate, prescribing information in the labeling for the other antibiotics should be followed. The dose depends on the severity of the infection and the patient’s condition.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefzid (Cefzid) and other antibacterial drugs, Cefzid (Cefzid) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Cefzid?
Use Cefzid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Cefzid is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Cefzid at home, carefully follow the injection procedures taught to you by your health care provider.
- Do not use Cefzid if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- To clear up your infection completely, take Cefzid for the full course of treatment. Keep taking it even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Cefzid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Cefzid.
Uses of Cefzid in details
Cefzid is used to treat life threatening bacterial infection including infections of the respiratory tract, brain, ear, urinary tract, skin and soft tissues, abdomen, bones and joints.
Cefzid description
Each vial contains 1 g Cefzid (as pentahydrate) with sodium carbonate.
Cefzid is a white to cream colored, crystalline powder which is soluble in alkali and in dimethyl sulfoxide, slightly soluble in dimethylformamide, in methanol, and in water, insoluble in acetone, in alcohol, in chloroform, in dioxane, in ether in ethyl acetate and in toluene. The pH of a 10% aqueous solution is approximately 6.3. The colour of Cefzid solutions ranges from light to amber, depending on the length of storage, concentration and diluent used.
Cefzid for injection USP is a physical blend of sterile Cefzid pentahydrate and sterile sodium carbonate. Chemically, Cefzid for injection USP is 1-[[(6R,7R)-7-[2- (2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-en-3-yl]methyl] pyridinium hydroxide, inner salt,72-(Z)-[O-(1-carboxy-1-methylethyl)oxime], pentahydrate. Its empirical formula is C22H22N6O7S2·5H2O + Na2CO3 with molecular weight of 636.67 + 106.00.
Cefzid dosage
Dosage depends upon the severity, sensitivity, site and type of infection and upon the age and renal function of the patient.
Use Cefzid injection by intravenous (i.v.) or deep intramuscular (i.m.) injection. Recommended i.m. injection sites are the upper outer quadrant of the gluteus maximus or lateral part of the thigh.
Cefzid solutions may be given directly into the vein or introduced into the tubing of a giving set if the patient is receiving parenteral fluids.
Adults: 1 to 6 g/day in two or three divided doses by i.v. or i.m. injection.
Urinary Tract and Less Severe Infections: 500 mg or 1 g every 12 hours.
Most Infections: 1 g every 8 hours or 2 g every 12 hours.
Very Severe Infections Particularly in Immunocompromised Patients Including those with Neutropenia: 2 g every eight or 12 hours, or 3 g every 12 hours.
Fibrocystic Adults with Pseudomonal Lung Infections: 100 to 150 mg/kg/day in three divided doses.
In adults with normal renal function 9 g/day has been used without ill effect.
When used as a prophylactic agent in prostatic surgery, 1 g should be given at the induction of anaesthesia. A second dose should be considered at the time of catheter removal.
Infants and Children (Greater Than 2 Months): 30 to 100 mg/kg/day in two or three divided doses.
Doses up to 150 mg/kg/day (maximum 6 g/day) in three divided doses may be given to infected immunocompromised or fibrocystic children or children with meningitis.
Neonates (0 to 2 Months): 25 to 60 mg/kg/day in two divided doses.
In neonates, the serum half-life of Cefzid can be three to four times that in adults.
Elderly: In view of the reduced clearance of Cefzid in acutely ill elderly patients, the daily dosage should not normally exceed 3 g, especially in those over 80 years of age.
Renal Impairment: Cefzid is excreted unchanged by the kidneys. Therefore, in patients with impaired renal function, the dosage should be reduced.
An initial loading dose of 1 g should be given. Maintenance doses should be based on creatinine clearance as shown in Table 2.
In patients with severe infections the unit dose should be increased by 50% or the dosing frequency increased. In such patients the Cefzid serum levels should be monitored and trough levels should not exceed 40 mg/L.
In children the creatinine clearance should be adjusted for body surface area or lean body mass.
Haemodialysis: The serum half-life during haemodialysis ranges from 3 to 5 hours.
Following each haemodialysis period, the maintenance dose of Cefzid recommended in Table 2 should be repeated.
Peritoneal Dialysis: Cefzid may be used in peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD).
In addition to i.v. use, Cefzid can be incorporated into the dialysis fluid (usually 125 to 250 mg for 2 litres of dialysis solution).
For patients in renal failure on continuous arteriovenous haemodialysis or high-flux haemofiltration in intensive therapy units; 1 g daily either as a single dose or in divided doses. For low-flux haemofiltration, follow the dosage recommended under impaired renal function.
For patients on venovenous haemofiltration and venovenous haemodialysis, follow the dosage recommendations in Tables 3 and 4.
Cefzid interactions
See also:
What other drugs will affect Cefzid?
Probenecid: Concomitant administration of 2 g of oral probenecid does not affect the pharmacokinetics of Cefzid, presumably because Cefzid is excreted principally by glomerular filtration.
Aminoglycosides: In vitro studies indicate that the antibacterial activity of Cefzid and aminoglycosides may be additive or synergistic against some organisms including some strains of Ps. aeruginosa and Enterobacteriaceae. However, synergism is unpredictable and antagonism has also occurred in vitro when Cefzid was used in combination with an aminoglycoside especially with the organisms with high-level resistance.
Concurrent use of aminoglycosides and cephalosporins may increase the risk of nephrotoxicity during therapy. Although this effect has not been reported to date with Cefzid, the manufacturer states that the possibility that nephrotoxicity may be potentiated if the drug is used concomitantly with an aminoglycoside should be considered.
Chloramphenicol: Chloramphenicol has been reported to antagonize the bactericidal activity of beta-lactam antibiotics including Cefzid, in vitro, and the possibility of in vivo antagonism should be considered. Therefore, it is recommended that combined therapy with chloramphenicol and Cefzid be avoided, particularly when bactericidal activity is considered important.
Beta-Lactam Antibiotics: Although a synergistic or partially synergistic effect has occurred in vitro against a few strains of Ps. aeruginosa when Cefzid and carbenicillin, cefsulodin, mezlocillin, or piperacillin were used concomitantly, use of Cefzid and another cephalosporin or an extended-spectrum penicillin has generally resulted in an effect that was only slightly additive or indifferent against Ps. aeruginosa. In addition, the combination of Cefzid and cefoxitin has been antagonistic in vitro against Ps. aeruginosa. The clinical importance is unclear, but concomitant use of Cefzid and ampicillin in vitro has resulted in antagonism against group B streptococci and Listeria monocytogenes. Combination of Cefzid and clavulanic acid, a beta-lactamase inhibitor, is synergistic against some strains of B. fragilis resistant to Cefzid alone. The combination was not effective against other Bacteroides, such as B. distasonis, that are not beta-lactamase producers.
Diuretics: Although concomitant use of cephalosporins and potent diuretics (e.g., furosemide) reportedly may adversely affect renal function, this effect apparently did not occur when furosemide was used concomitantly with Cefzid in a few patients.
Alteration in Laboratory Values: Positive direct Coombs' test is known to develop in individuals during treatment with the cephalosporin group of antibiotics, including Cefzid. In laboratory tests a false-positive reaction to glucose may occur with reducing substances but not with the use of specific glucose oxidase methods.
As with other beta-lactam antibiotics, granulocytopenia and more rarely, agranulocytosis may develop during treatment with Cefzid, particularly if given over long periods. For courses of treatment lasting longer than 10 days, blood counts should therefore be monitored.
Cefzid side effects
See also:
What are the possible side effects of Cefzid?
Cefzid is generally well tolerated. The incidence of adverse reactions associated with the administration of Cefzid was low in clinical trials. The most common were local reactions following IV injection and allergic and gastrointestinal reactions. Other adverse reactions were encountered infrequently. No disulfiram-like reactions were reported.
The following adverse effects from clinical trials were considered to be either related to Cefzid therapy or were of uncertain etiology:
Local Effects, reported in fewer than 2% of patients, were phlebitis and inflammation at the site of injection (1 in 69 patients).
Hypersensitivity Reactions, reported in 2% of patients, were pruritus, rash, and fever. Immediate reactions, generally manifested by rash and/or pruritus, occurred in 1 in 285 patients. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme have also been reported with cephalosporin antibiotics, including Cefzid. Angioedema and anaphylaxis (bronchospasm and/or hypotension) have been reported very rarely.
Gastrointestinal Symptoms, reported in fewer than 2% of patients, were diarrhea (1 in 78), nausea (1 in 156), vomiting (1 in 500), and abdominal pain (1 in 416). The onset of pseudomembranous colitis symptoms may occur during or after treatment.
Central Nervous System Reactions (fewer than 1%) included headache, dizziness, and paresthesia.
Seizures have been reported with several cephalosporins, including Cefzid. In addition, encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia have been reported in renally impaired patients treated with unadjusted dosing regimens of Cefzid.
Less Frequent Adverse Events (fewer than 1%) were candidiasis (including oral thrush) and vaginitis.
Hematologic
Rare cases of hemolytic anemia have been reported.
Laboratory Test Changes noted during clinical trials with Cefzid (Cefzid for injection, USP) were transient and included: eosinophilia (1 in 13), positive Coombs test without hemolysis (1 in 23), thrombocytosis (1 in 45), and slight elevations in one or more of the hepatic enzymes, aspartate aminotransferase (AST, SGOT) (1 in 16), alanine aminotransferase (ALT, SGPT) (1 in 15), LDH (1 in 18), GGT (1 in 19) and alkaline phosphatase (1 in 23). As with some other cephalosporins, transient elevations of blood urea, blood urea nitrogen, and/or serum creatinine were observed occasionally. Transient leukopenia, neutropenia, agranulocytosis, thrombocytopenia, and lymphocytosis were seen very rarely.
Postmarketing Experience with Cefzid (Cefzid for injection, USP) Products
In addition to the adverse events reported during clinical trials, the following events have been observed during clinical practice in patients treated with Cefzid and were reported spontaneously. For some of these events, data are insufficient to allow an estimate of incidence or to establish causation.
General
Anaphylaxis; allergic reactions, which, in rare instances, were severe (e.g., cardiopulmonary arrest); urticaria; pain at injection site.
Hepatobiliary Tract
Hyperbilirubinemia, jaundice.
Renal and Genitourinary
Renal impairment.
Cephalosporin-Class Adverse Reactions
In addition to the adverse reactions listed above that have been observed in patients treated with Cefzid, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:
Adverse Reactions
Colitis, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemorrhage.
Altered Laboratory Tests
Prolonged prothrombin time, false-positive test for urinary glucose, pancytopenia.
Cefzid contraindications
See also:
What is the most important information I should know about Cefzid?
Hypersensitivity Reactions to Cefzid or the Cephalosporin Class of Antibiotics, Penicillins, or Other Beta-lactam Antibiotics
Cefzid for Injection USP and Dextrose Injection USP is contraindicated in patients who have a history of immediate hypersensitivity reactions (e.g., anaphylaxis, serious skin reactions) to Cefzid or the cephalosporin class of antibiotics, penicillins, or other beta-lactam antibiotics.
Active ingredient matches for Cefzid:
Ceftazidime in Vietnam.
| Unit description / dosage (Manufacturer) | Price, USD |
| Injectable; Injection; Ceftazidime Pentahydrate 1 g | |
| CEFZID Injection / 250mg / 1 units (Ind - Swift) | $ 1.14 |
| CEFZID Injection / 1gm / 1 units (Ind - Swift) | $ 3.55 |
| Cefzid 1 g x 1 Bottle | |
| Cefzid 1g VIAL / 1 | $ 3.55 |
| Cefzid 250mg VIAL / 1 | $ 1.14 |
| 1 g x 1's | $ 3.55 |
| 250 mg x 1's | $ 1.14 |
| Cefzid 1000 mg Injection | $ 3.43 |
| Cefzid 250 mg Injection | $ 1.14 |
| Cefzid 250 mg Plus India Injection | $ 1.02 |
| Cefzid 1000 mg Ind-Swift Injection | $ 3.55 |
| Cefzid 1000 mg Plus India Injection | $ 3.13 |
| CEFZID 1000MG INJECTION 1 vial / 20 ML injection each (Ind Swift Laboratories Ltd) | $ 3.33 |
| Cefzid 1000mg Injection (Ind Swift Laboratories Ltd) | $ 0.17 |
List of Cefzid substitutes (brand and generic names): | |
| CEFWIDE 1000MG INJECTION | |
| CEFWIDE 1000MG INJECTION 1 vial / 1000 MG injection each (Neon Laboratories Ltd) | $ 2.58 |
| Cefzid 1000 (India) | |
| Cefzid 1000 1g VIAL / 1 (Elfin) | $ 3.43 |
| 1 g x 1's (Elfin) | $ 3.43 |
| Cefzidime (India) | |
| Cefzidime 1g VIAL / 1 (Chandra Bhagat Pharma Pvt. Ltd.) | $ 3.75 |
| Cefzidime 250mg VIAL / 1 (Chandra Bhagat Pharma Pvt. Ltd.) | $ 1.08 |
| Cefzidime 500mg VIAL / 1 (Chandra Bhagat Pharma Pvt. Ltd.) | |
| 1 g x 1's (Chandra Bhagat Pharma Pvt. Ltd.) | $ 3.75 |
| 250 mg x 1's (Chandra Bhagat Pharma Pvt. Ltd.) | $ 1.08 |
| 500 mg x 1's (Chandra Bhagat Pharma Pvt. Ltd.) | |
| Cefzidime 250 mg Injection (Chandra Bhagat Pharma Pvt. Ltd.) | $ 1.08 |
| Cefzidime 1000 mg Injection (Chandra Bhagat Pharma Pvt. Ltd.) | $ 3.75 |
| CEFZIDIME 1GM INJECTION 1 vial / 1 injection each (Chandra Bhagat Pharma Pvt. Ltd.) | $ 1.20 |
| Cefzidime 1gm Injection (Chandra Bhagat Pharma Pvt. Ltd.) | $ 1.20 |
| CEFZIDOME | |
| CEFZIDOME 1GM INJECTION 1 vial / 1 injection each (Chandra Bhagat Pharma Pvt Ltd) | $ 3.77 |
| CEFZIM (Egypt) | |
| 15 g x 30 mL x 30ml (Zee Laboratories Ltd) | $ 1.07 |
| 250 mg x 100's (Zee Laboratories Ltd) | $ 30.12 |
| 500 mg x 30's (Zee Laboratories Ltd) | $ 17.35 |
| Cefzim 15g x 30mL DRY-SYR / 30ml (Zee Laboratories Ltd) | $ 1.07 |
| Cefzim 250mg TAB / 100 (Zee Laboratories Ltd) | $ 30.12 |
| Cefzim 500mg TAB / 30 (Zee Laboratories Ltd) | $ 17.35 |
| Cefzim 1500 mg Injection (Zee Laboratories Ltd) | $ 2.35 |
| Cefzim 500 mg Tablet (Zee Laboratories Ltd) | $ 0.58 |
| Cefzim 750 mg Injection (Zee Laboratories Ltd) | $ 1.31 |
| Cefzim 100 mg Tablet (Zee Laboratories Ltd) | $ 0.07 |
| Cefzim 200 mg Tablet (Zee Laboratories Ltd) | $ 0.12 |
| Cefzim 250 mg Tablet (Zee Laboratories Ltd) | $ 0.30 |
| CEFZIM 1.5GM INJECTION 1 vial / 1 injection each (Zee Laboratories Ltd) | $ 2.35 |
| CEFZIM 250MG TABLET 1 strip / 10 tablets each (Zee Laboratories Ltd) | $ 2.09 |
| CEFZIM 500MG TABLET 1 strip / 10 tablets each (Zee Laboratories Ltd) | $ 5.30 |
| CEFZIM 750MG INJECTION 1 vial / 1 injection each (Zee Laboratories Ltd) | $ 1.73 |
| CEFZIM dry syr 15 g x 30 mL x 30ml (Zee Laboratories Ltd) | $ 1.07 |
| CEFZIM tab 250 mg x 10's (Zee Laboratories Ltd) | $ 2.64 |
| CEFZIM tab 500 mg x 3's (Zee Laboratories Ltd) | $ 1.59 |
| Cefzim 15g x 30mL DRY-SYR / 30ml (Zee Laboratories Ltd) | $ 1.07 |
| Cefzim 250mg TAB / 100 (Zee Laboratories Ltd) | $ 30.12 |
| Cefzim 500mg TAB / 30 (Zee Laboratories Ltd) | $ 17.35 |
| Cefzim 1.5gm Injection (Zee Laboratories Ltd) | $ 2.35 |
| Cefzim 250mg Tablet (Zee Laboratories Ltd) | $ 0.21 |
| Cefzim 500mg Tablet (Zee Laboratories Ltd) | $ 0.53 |
| Cefzim 750mg Injection (Zee Laboratories Ltd) | $ 1.73 |
| Cefziota (Vietnam) | |
| Cefziota 1 g x 1 Bottle | |
| Cefzis-Max (Vietnam) | |
| Cefzis-Max 1 g x 1 Bottle boät in 1 tube nöôùc caát 5 mL | |
| Cefzita (Vietnam) | |
| Cefzita 1 g x 10 Bottle | |
| Cefzy (Georgia) | |
| Cefzy 1g VIAL / 1 (Zee Laboratories Ltd) | $ 3.13 |
| Cefzy 250mg VIAL / 1 (Zee Laboratories Ltd) | $ 1.14 |
| 1 g x 1's (Zee Laboratories Ltd) | $ 3.13 |
| 250 mg x 1's (Zee Laboratories Ltd) | $ 1.14 |
| Cefzy 250 mg Injection (Zee Laboratories Ltd) | $ 0.90 |
| Cefzy 1000 mg Injection (Zee Laboratories Ltd) | $ 2.65 |
| CEFZY 1GM INJECTION 1 vial / 1 injection each (Zee Laboratories Ltd) | $ 2.65 |
| Cefzy 1gm Injection (Zee Laboratories Ltd) | $ 2.65 |
| Cejoho (Vietnam) | |
| Cejoho 1 g/1 vial x 10 Bottle | |
See 1744 substitutes for Cefzid | |
References
- DailyMed. "CEFTAZIDIME: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "ceftazidime". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "ceftazidime". http://www.drugbank.ca/drugs/DB00438 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Cefzid are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cefzid. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
