What is Centicillin?
Penicillins are used to treat infections caused by bacteria. They work by killing the bacteria or preventing their growth.
There are several different kinds of penicillins. Each is used to treat different kinds of infections. One kind of penicillin usually may not be used in place of another. In addition, penicillins are used to treat bacterial infections in many different parts of the body. They are sometimes given with other antibacterial medicines (antibiotics). Some of the penicillins may also be used for other problems as determined by your doctor. However, none of the penicillins will work for colds, flu, or other virus infections.
Penicillins are available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, penicillins are used in certain patients with the following medical conditions:
- Chlamydia infections in pregnant women—Centicillin and ampicillin
- Gas gangrene—Penicillin G
- Helicobacter pylori-associated gastritis or peptic ulcer disease—Centicillin
- Leptospirosis—Ampicillin and penicillin G
- Lyme disease—Centicillin and penicillin V
- Typhoid fever—Centicillin and ampicillin
Centicillin indications
Infections of the Ear, Nose, and Throat
Centicillin Capsules, Centicillin for oral suspension, Centicillin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae.
Infections of the Genitourinary Tract
Centicillin Capsules, Centicillin for oral suspension, Centicillin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.
Infections of the Skin and Skin Structure
Centicillin Capsules, Centicillin for oral suspension, Centicillin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus spp. (α- and β-hemolytic isolates only), Staphylococcus spp., or E. coli.
Infections of the Lower Respiratory Tract
Centicillin Capsules, Centicillin for oral suspension, Centicillin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus spp. (α- and β-hemolytic isolates only), S. pneumoniae, Staphylococcus spp., or H. influenzae.
Helicobacter pylori Infection
Triple therapy for Helicobacter pylori with clarithromycin and lansoprazole:
Centicillin, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1 year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.
Dual therapy for H. pylori with lansoprazole:
Centicillin, in combination with lansoprazole delayed-release capsules as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1 year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.
Usage
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Centicillin and other antibacterial drugs, Centicillin should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Centicillin?
Use Centicillin suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Centicillin suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Shake well before each use.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Centicillin suspension may be mixed with formula, milk, fruit juice, water, ginger ale, or other cold drinks. If you mix Centicillin suspension, take it at once after mixing. Be sure that the entire dose is swallowed.
- To clear up your infection completely, take Centicillin suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
- If you miss a dose of Centicillin suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Centicillin suspension.
Uses of Centicillin in details
Use: Labeled Indications
Ear, nose, and throat infections (pharyngitis/tonsillitis, otitis media):
Immediate release: Treatment of infections due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae.
Extended release: Treatment of tonsillitis and/or pharyngitis due to Streptococcus pyogenes in adults and pediatric patients ≥12 years of age.
Genitourinary tract infections: Immediate release: Treatment of infections of the genitourinary tract due to beta-lactamase-negative Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.
Helicobacter pylori eradication: Immediate release: Eradication of H. pylori to reduce the risk of duodenal ulcer recurrence as a component of combination therapy in patients with active or 1-year history of duodenal ulcer disease.
Lower respiratory tract infections (including pneumonia): Immediate release: Treatment of infections of the lower respiratory tract due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic strains only), S. pneumoniae, Staphylococcus spp., or H. influenzae.
Rhinosinusitis, acute bacterial: Immediate release: Treatment of infections due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic isolates only), S. pneumoniae, Staphylococcus spp., or H. influenzae.
Skin and skin structure infections: Immediate release: Treatment of infections of the skin and skin structure due to beta-lactamase-negative Streptococcus spp. (alpha- and beta-hemolytic strains only), Staphylococcus spp., or E. coli.
Off Label Uses
Actinomycosis
Data from a small retrospective study suggest that Centicillin may be beneficial for the treatment of actinomycosis.
Prosthetic joint infection
Based on the IDSA guidelines for the management of prosthetic joint infection (PJI), Centicillin is an effective and recommended agent for chronic oral antimicrobial suppression of PJI with beta-hemolytic streptococci, Enterococcus spp. (penicillin susceptible), and Cutibacterium spp. after completion of parenteral therapy.
Centicillin description
A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Centicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. [PubChem]
Centicillin dosage
Centicillin Dosage
Generic name: Centicillin 775mg
Dosage form: tablet, film coated, extended release
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Tonsillitis and/or Pharyngitis
The recommended dose of Centicillin is 775 mg once daily taken within 1 hour of finishing a meal for 10 days. The full 10-day course of therapy should be completed for effective treatment of tonsillitis and/or pharyngitis secondary to S. pyogenes.
Do not chew or crush tablet.
More about Centicillin (Centicillin)
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- 1 Review - Add your own review/rating
Consumer resources
- Centicillin
- Centicillin extended-release tablets
- Centicillin (Advanced Reading)
- Other brands: Amoxil, Centicillin, Centicillin, DisperMox, More (2) »
Professional resources
- Centicillin (FDA)
- Centicillin (AHFS Monograph)
Related treatment guides
- Bronchiectasis
- Dental Abscess
- Tonsillitis/Pharyngitis
Centicillin interactions
See also:
What other drugs will affect Centicillin?
Allopurinol: Concurrent administration may increase the incidence of rash and other allergic skin reactions.
Anticoagulants: There are rare reports of prolongation of prothrombin time in patients concomitantly on Centicillin. It is recommended that appropriate monitoring is carried out when Centicillin is prescribed concurrently with anticoagulants.
Oral Contraceptives:
In common with other antibiotics, Centicillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.Probenecid: Decreases the renal tubular secretion of Centicillin. Concurrent use with Centicillin may result in increased and prolonged blood levels of Centicillin.
Laboratory Tests: Glucose in Urine: Due to the high urinary concentrations of Centicillin, false positive readings are common with chemical methods.
The use of enzymatic glucose oxidase methods is recommended, as there is no interference from Centicillin.
Centicillin side effects
See also:
What are the possible side effects of Centicillin?
. Overdosage
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Centicillin are not associated with significant clinical symptoms and do not require gastric emptying.3
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Centicillin.
Crystalluria, in some cases leading to renal failure, has also been reported after Centicillin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Centicillin crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Centicillin. Centicillin may be removed from circulation by hemodialysis.
Centicillin contraindications
See also:
What is the most important information I should know about Centicillin?
Do not use this medication if you are allergic to Centicillin or to any other penicillin antibiotic, such as ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others.
Before using Centicillin, tell your doctor if you are allergic to cephalosporins such as Omnicef, Cefzil, Ceftin, Keflex, and others. Also tell your doctor if you have asthma, liver or kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called "mono"), or any type of allergy.
Centicillin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy while taking Centicillin.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Centicillin will not treat a viral infection such as the common cold or flu.
Do not share this medication with another person, even if they have the same symptoms you have.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Centicillin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Active ingredient matches for Centicillin:
Amoxicillin in Germany.
List of Centicillin substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Cemoxin (Bangladesh) | |
| Cepmox (Vietnam) | |
| Cepmox 250 mg x 10 Blister x 10 Tablet | |
| Cepmox 250 mg x 1 Bottle 200 Tablet | |
| Cepmox 250 mg x 1 Bottle 500 Tablet | |
| CEPMOX CAPSULE 1 strip / 10 capsules each (Concept Pharmaceuticals Ltd) | $ 0.35 |
| Cepmox NA Capsule (Concept Pharmaceuticals Ltd) | $ 0.03 |
| Checkmox-DX (India) | |
| Checkmox-DX Amoxicillin 250 mg, Dicloxacillin 250 mg. CAP / 100 (Novogen Captab) | $ 9.04 |
| 100's (Novogen Captab) | $ 9.04 |
| CHECKMOX-DX cap 10's (Novogen Captab) | $ 0.90 |
| Chem Mart Amoxycillin | |
| Capsule; Oral; Amoxicillin Trihydrate 250 mg | |
| Capsule; Oral; Amoxicillin Trihydrate 500 mg | |
| Suspension; Oral; Amoxicillin Trihydrate 125 mg / 5 ml | |
| Suspension; Oral; Amoxicillin Trihydrate 250 mg / 5 ml | |
| Capsules; Oral; Amoxicillin Trihydrate 250 mg | |
| Capsules; Oral; Amoxicillin Trihydrate 500 mg | |
| Chemmart Amoxicillin (Australia) | |
| Chemmart Amoxycillin (Australia) | |
| Chenamox (Ecuador) | |
| Cidanamox (Spain) | |
| Cidomex (India) | |
| Cidomex 250mg CAP / 6 (Sanofi Aventis) | $ 0.19 |
| Cidomex 500mg CAP / 6 (Sanofi Aventis) | $ 0.41 |
| Cidomex 125mg/5mL D-SYR / 60ml (Sanofi Aventis) | $ 0.24 |
| 250 mg x 6's (Sanofi Aventis) | $ 0.19 |
| 500 mg x 6's (Sanofi Aventis) | $ 0.41 |
| 125 mg x 5 mL x 60ml (Sanofi Aventis) | $ 0.24 |
| Cidomex 60 ml Syrup (Sanofi Aventis) | $ 0.02 |
| Cidomex 500 mg Capsule (Sanofi Aventis) | $ 0.07 |
| Cidomex 250 mg Capsule (Sanofi Aventis) | $ 0.03 |
| CIDOMEX cap 250 mg x 6's (Sanofi Aventis) | $ 0.19 |
| CIDOMEX cap 500 mg x 6's (Sanofi Aventis) | $ 0.41 |
| CIDOMEX dry syr 125 mg x 5 mL x 60ml (Sanofi Aventis) | $ 0.24 |
| Cilamox (Australia, Philippines) | |
| Capsule; Oral; Amoxicillin Trihydrate 250 mg (Sigma) | |
| Capsule; Oral; Amoxicillin Trihydrate 500 mg (Sigma) | |
| Suspension; Oral; Amoxicillin Trihydrate 125 mg / 5 ml (Sigma) | |
| Suspension; Oral; Amoxicillin Trihydrate 250 mg / 5 ml (Sigma) | |
| Cilamox 250 mg x 20's (Sigma) | |
| Cilamox 500 mg x 20's (Sigma) | |
| Capsules; Oral; Amoxicillin Trihydrate 250 mg (Sigma) | |
| Capsules; Oral; Amoxicillin Trihydrate 500 mg (Sigma) | |
| Cilimox (India) | |
| Cilimox 250mg DT-TAB / 10 (Invision (Infalife)) | $ 0.46 |
| 250 mg x 10's (Invision (Infalife)) | $ 0.46 |
| CILIMOX dispertab 250 mg x 10's (Invision (Infalife)) | $ 0.46 |
See 6160 substitutes for Centicillin | |
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "amoxicillin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "amoxicillin". http://www.drugbank.ca/drugs/DB01060 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Centicillin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Centicillin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
