What are the possible side effects of Centicillin?
Get emergency medical help if you have any of these signs of an allergic reaction to Centicillin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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diarrhea that is watery or bloody;
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fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
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swollen glands, rash or itching, joint pain, or general ill feeling;
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pale or yellowed skin, yellowing of the eyes, dark colored urine, fever, confusion or weakness;
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severe tingling, numbness, pain, muscle weakness;
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easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
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severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Centicillin side effects may include:
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stomach pain, nausea, vomiting, diarrhea;
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vaginal itching or discharge;
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headache; or
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swollen, black, or "hairy" tongue.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of Centicillin in details
As with other penicillins, it may be expected that untoward reactions will be essentially limited to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever, or urticaria. The following adverse reactions have been reported as associated with the use of penicillins:
Gastrointestinal: nausea, vomiting, diarrhea, and hemorrhagic/pseudomembranous colitis.
Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.
Hypersensitivity Reactions: Serum sickness like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and urticaria have been reported.
NOTE: These hypersensitivity reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, Centicillin should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to Centicillin therapy.
Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted, but the significance of this finding is unknown. Hepatic dysfunction including cholestatic jaundice, hepatic cholestasis, and acute cytolytic hepatitis have been reported.
Renal: Crystalluria has also been reported.
Hemic and Lymphatic Systems: Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.
Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and/or dizziness have been reported rarely.
Miscellaneous: Tooth discoloration (brown, yellow, or gray staining) has been rarely reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.
Combination therapy with clarithromycin and lansoprazole
In clinical trials using combination therapy with Centicillin plus clarithromycin and lansoprazole, and Centicillin plus lansoprazole, no adverse reactions peculiar to these drug combinations were observed. Adverse reactions that have occurred have been limited to those that had been previously reported with Centicillin, clarithromycin, or lansoprazole.
Triple therapy: Centicillin/clarithromycin/lansoprazole
The most frequently reported adverse events for patients who received triple therapy were diarrhea (7%), headache (6%), and taste perversion (5%). No treatment-emergent adverse events were observed at significantly higher rates with triple therapy than with any dual therapy regimen.
Dual therapy: Centicillin/lansoprazole
The most frequently reported adverse events for patients who received Centicillin t.i.d. plus lansoprazole t.i.d. dual therapy were diarrhea (8%) and headache (7%). No treatment-emergent adverse events were observed at significantly higher rates with Centicillin t.i.d. plus lansoprazole t.i.d. dual therapy than with lansoprazole alone.
For more information on adverse reactions with clarithromycin or lansoprazole, refer to their package inserts, ADVERSE REACTIONS.
What is the most important information I should know about Centicillin?
- Centicillin drops may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Centicillin drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Centicillin drops only works against bacteria; it does not treat viral infections (eg, the common cold).
- Be sure to use Centicillin drops for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Long-term or repeated use of Centicillin drops may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Do not receive a live vaccine (eg, oral typhoid vaccine) while you are taking Centicillin drops. Talk with your doctor before you receive any vaccine.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using Centicillin drops. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Brown, yellow, or gray tooth discoloration has occurred rarely in some patients taking Centicillin drops. It occurred most often in children. The discoloration was reduced or removed by brushing or dental cleaning in most cases. Contact your doctor if you experience this effect.
- Diabetes patients - Centicillin drops may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
- Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed if you use Centicillin drops for a long period of time. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Caution is advised when using Centicillin drops in CHILDREN younger than 3 months old; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Centicillin drops while you are pregnant. Centicillin drops is found in breast milk. If you are or will be breast-feeding while you use Centicillin drops, check with your doctor. Discuss any possible risks to your baby.
Centicillin contraindications
Do not use this medication if you are allergic to Centicillin or to any other penicillin antibiotic, such as ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others.
Before using Centicillin, tell your doctor if you are allergic to cephalosporins such as Omnicef, Cefzil, Ceftin, Keflex, and others. Also tell your doctor if you have asthma, liver or kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called "mono"), or any type of allergy.
Centicillin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy while taking Centicillin.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Centicillin will not treat a viral infection such as the common cold or flu.
Do not share this medication with another person, even if they have the same symptoms you have.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Centicillin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Amoxicillin: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
- HSDB. "AMOXICILLIN". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Centicillin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Centicillin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
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Information checked by Dr. Sachin Kumar, MD Pharmacology
