What is Clamentin?
Amoxicillin (Clamentin) is an antibiotic in a group of drugs called penicillins. Amoxicillin (Clamentin) fights bacteria in the body.
Clavulanate potassium is a form of Clavulanic Acid (Clamentin), which is similar to penicillin. Clavulanate potassium fights bacteria that is often resistant to penicillins and other antibiotics.
The combination of Amoxicillin (Clamentin) and clavulanate potassium is used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.
Amoxicillin (Clamentin) and clavulanate potassium may also be used for purposes not listed in this medication guide.
Clamentin indications
Clamentin-600 is indicated for the treatment of pediatric patients with recurrent or persistent acute otitis media due to S. pneumoniae (penicillin MICs ≤ 2 mcg/mL), H. influenzae (including β-lactamase–producing strains), or M. catarrhalis (including β-lactamase–producing strains) characterized by the following risk factors:
- antibiotic exposure for acute otitis media within the preceding 3 months, and either of the following:
- age ≤ 2 years
- daycare attendance
NOTE: Acute otitis media due to S. pneumoniae alone can be treated with Amoxicillin (Clamentin). Clamentin-600 is not indicated for the treatment of acute otitis media due to S. pneumoniae with penicillin MIC ≥ 4 mcg/mL.
Therapy may be instituted prior to obtaining the results from bacteriological studies when there is reason to believe the infection may involve both S. pneumoniae (penicillin MIC ≤ 2 mcg/mL) and the β-lactamase–producing organisms listed above.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Clamentin-600 and other antibacterial drugs, Clamentin-600 should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Clamentin description
Each film-coated tablet contains Amoxicillin (Clamentin) trihydrate equivalent to Amoxicillin (Clamentin) 500 mg, and potassium clavulanate equivalent to Clavulanic Acid (Clamentin) 125 mg, respectively.
Each vial contains Amoxicillin (Clamentin) sodium equivalent to Amoxicillin (Clamentin) 1000 mg and clavulanate potassium equivalent to Clavulanic Acid (Clamentin) 200 mg, respectively.
Clamentin tablets also contains the following excipients: Microcrystalline cellulose, sodium starch glycolate, anhydrous colloidal silica, povidone (K30), eudragit E 100, isopropyl alcohol, magnesium stearate, white opadryl 03B58965, PEG400, methylene chloride.
Clamentin is an antibacterial combination consisting of the semi-synthetic antibiotic Amoxicillin (Clamentin) and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of Clavulanic Acid (Clamentin)). Amoxicillin (Clamentin) is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. Its molecular formula is C16H19N305S3H20 and the molecular weight is 419.46. Chemically, Amoxicillin (Clamentin) is (2S, 5R, 6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl) acetamido]-3, 3-dimethyl-7-oxo-4-1-azabicyclo[3.2.1] heptane-2-carboxylic acid trihydrate.
Amoxicillin (Clamentin): Clavulanic Acid (Clamentin) is produced by the fermentation of Streptomyces clavuligerus. It is a β-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of β-lactamases by blocking the active sites of these enzymes. Clavulanic Acid (Clamentin) is particularly active against the clinically important plasmid-mediated β-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins. The clavulanate potassium molecular formula is C8H8KN05 and the molecular weight is 237.25. Chemically, clavulanate potassium is potassium (Z)-(2R, 5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate.
Clamentin dosage
Tablet: Tablets should be taken immediately before a meal.
General Information: For infections caused by Amoxicillin (Clamentin)-sensitive organisms, the dosage is that approved for Amoxicillin (Clamentin) as the Clavulanic Acid (Clamentin) component does not contribute to the therapeutic effect.
Adults: 1 or 2 Clamentin 375 mg tab 8 hourly or 1 Clamentin 625 mg tab 8 hourly for more severe infections and infections of the respiratory tract.
For Amoxicillin (Clamentin)-resistant organisms, the dosage of Clamentin tablets are as follows:
Since both Clamentin 375 mg and 625 mg contain the same amount of Clavulanic Acid (Clamentin) (125 mg, as the potassium salt), 2 Clamentin 375 mg are not equivalent to 1 Clamentin 625 mg. Therefore, 2 Clamentin 375 mg should not be substituted for 1 Clamentin 625 mg for treatment of more severe infections.
Renal Failure: Both Amoxicillin (Clamentin) and Clavulanic Acid (Clamentin) are excreted by the kidneys and the serum t½ of each increases in patients with renal failure. Therefore, the dose may need to be reduced or the interval extended. The following schedule in the dosage is proposed:
Haemodialysis decreases serum concentrations of both Amoxicillin (Clamentin) and Clavulanic Acid (Clamentin) and an additional dose should be administered at the end of dialysis.
Oral Suspension:
Suspensions should be taken immediately before a meal.Reconstitution: For reconstitution to 30 mL, add water till the mark, invert the bottle and shake well until all the powder is dispersed.
Children: 25-50 mg/kg/day of the 4 parts Amoxicillin (Clamentin), 1 part Clavulanic Acid (Clamentin) preparations (which corresponds to a daily dosage of the equivalent of Amoxicillin (Clamentin) 20-40 mg/kg and Clavulanic Acid (Clamentin) 5-10 mg/kg) to be taken in divided doses every 8 hrs at the start of a meal.
Dosage Guide:
To correspond to a dosage of 25-50 mg/kg/day.
To correspond to a dosage of 50 mg/kg/day.
IV/IM: Clamentin may be administered by the IV routes.
Clamentin is administered by IM or slow IV injection in doses of 500 mg every 8 hrs.
Severe Infections: 1 g every 6 hrs by slow IV injection over 3-4 min or by infusion over 30-60 min.
Children ≤10 years: 50-100 mg/kg body weight daily by injection in divided doses.
Clamentin interactions
See also:
What other drugs will affect Clamentin?
Probenecid decreases the renal excretion of Amoxicillin (Clamentin). Concurrent use with Clamentin may result in increased and prolonged blood levels of Amoxicillin (Clamentin).
The concurrent administration of allopurinol and ampicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. But it is not known whether this potentiation of ampicillin rash is due to allopurinol or the hyperuricemia present in these patients.
Clamentin should not be co-administrated with disulfiram.
Prolongation of bleeding time and prothrombin time have been reported in some patients receiving Clamentin. Thus, Clamentin should be used with care in patients on anticoagulation therapy.
Clamentin may reduce the effect of oral contraceptives and the caution should be given to patients.
Laboratory Test Interactions: Clamentin results in high urine concentration. High urine concentration of ampicillin may result in false-positive reactions when testing for the presence of glucose in urine using Clinitest, Benedict or Fehling's solution.
Clamentin side effects
See also:
What are the possible side effects of Clamentin?
The most frequently reported adverse effects were diarrhoea, nausea, vomiting, abdominal pain, skin rashes, urticaria and erythema multiforme, vaginitis, abnormal taste, headache, dizziness, tiredness and hot flushes. The incidence and severity of adverse effects, particularly nausea and diarrhoea, increased with the higher recommended dose and can be minimised by administering the agent at the start of a meal. In addition, as these symptoms are especially related to the potassium clavulanate component, where these GI symptoms occur and a higher concentration of Amoxicillin (Clamentin) is required, consideration should be given to administering the additional Amoxicillin (Clamentin) separately.
Hepatitis and cholestatic jaundice have been reported with the combination of Amoxicillin (Clamentin) and Clavulanic Acid (Clamentin); the Clavulanic Acid (Clamentin) component has been implicated. The events associated with Clamentin may be severe and occur predominantly in adult or elderly patients. Signs and symptoms usually occur during or shortly after treatment, but in some cases may not become apparent until several weeks after treatment has ceased. The hepatic events are usually reversible. However, in extremely rare circumstances, death has been reported. These have almost always been cases associated with serious underlying disease or concomitant medication.
A moderate rise in aspartate transaminase and/or alanine transaminase has been noted in patients treated with Clamentin, the significance of these findings is unknown.
The following adverse reactions have been reported for ampicillin class antibiotics and may occur with Clamentin.
Gastrointestinal: Gastritis, stomatitis, glossitis, black hairy tongue, enterocolitis and pseudomembranous colitis. If GI reactions are evident, they may be reduced by taking Clamentin at the start of a meal.
Amoxicillin (Clamentin) causes hypersensitivity reactions similar to those induced by penicillin G and ampicillin, including rashes and fever. The incidence of these reaction is probably no higher than with other penicillins. Sensitivity reactions are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever or uticaria. Hypersensitivity reactions include skin rashes, urticaria, erythema multiforme, rare cases of Stevens-Johnson syndrome and less frequently exfoliative dermatitis and toxic epidermal necrolysis have been reported. Whenever such reactions occur, Clamentin should be discontinued. Serious and occasional fatal hypersensitivity (anaphylactic) reactions and angioneurotic oedema can occur with oral penicillin.
Haematopoietic and Lymphatic: Anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leucopenia and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. A slight thrombocytosis was noted in patients treated with Clamentin. Prolongation of bleeding time and prothrombin time have also been reported less frequently.
Amoxicillin (Clamentin) alone or in combination with Clavulanic Acid (Clamentin) has been associated with acute hepatic dysfunction. The incidence rate (95% confidence intervals) were 1.7 (1.1-2.7) (Amoxicillin (Clamentin)-Clavulanic Acid (Clamentin)) and 0.3 (0.2-0.5)/10,000 prescriptions (Amoxicillin (Clamentin) alone). Risks were increased in patients receiving >1 course and in older recipients.
Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, behavioural changes and/or dizziness have also been reported. Depression, seizures or hallucinations.
Clamentin contraindications
Hypersensitivity to the Amoxicillin (Clamentin)/clavulanate potassium to any of the penicillins or to any of the excipients of Clamentin.
History of a severe immediate hypersensitivity reaction (eg, anaphylaxis) to another β-lactam agent (eg, a cephalosporin, carbapenem or monobactam).
History of cholestatic jaundice/hepatic dysfunction due to Clamentin.
Active ingredient matches for Clamentin:
Amoxicillin/Clavulanic Acid in Malaysia, South Africa.
Amoxicillin trihydrate/clavulanic acid in Malaysia.
Amoxicillin trihydrate/potassium clavulanate in South Africa.
| Unit description / dosage (Manufacturer) | Price, USD |
| Clamentin 10's x 10 | |
| Clamentin 12 g | |
| Clamentin 10's | |
List of Clamentin substitutes (brand and generic names): | |
| CLAMCHEK-BD (India) | |
| 30ml | $ 0.78 |
| Clamicil (Colombia, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama) | |
| Claminat (Vietnam) | |
| Claminat 2 Blister x 7 Tablet | |
| Claminat 12 Packs | |
| Claminat 1 Box 12 Packs | |
| Clamodia (Vietnam) | |
| Clamohexal (Australia) | |
| Clamonex (South Korea) | |
| Clamonex 375 mg x 100's (Yungjin) | |
| Clamonex Duo (South Korea) | |
| Clamonex Neo (South Korea) | |
| Clamosar | |
| Injectable; Subcutaneous; Amoxicillin Sodium 1 g; Clavulanic Acid / Clavulanate Potassium 200 mg | |
| Injectable; Subcutaneous; Amoxicillin Sodium 500 mg; Clavulanic Acid / Clavulanate Potassium 100 mg | |
| Clamoval (Peru) | |
| Clamovet (Finland) | |
| Clamovid (Hong Kong, Malaysia, Philippines, Singapore) | |
| Clamovid 3 x 5's (Hovid) | |
| Clamovid 2 x 5's (Hovid) | |
| Clamovid 100 mL (Hovid) | $ 6.62 |
| Clamovid 70 mL (Hovid) | |
| Clamovid 15's (Hovid) | $ 15.44 |
| Clamovid 100 mL x 1's (Hovid) | |
| Clamovid 1000 mg film-coated tab 2 x 5's (Hovid) | |
| Clamovid 625 mg film-coated tab 3 x 5's (Hovid) | |
| Clamovid FC tab 15's (Hovid) | $ 15.67 |
| Clamovid FC tab 625 mg 3 x 5's (Hovid) | |
| Clamovid FC tab 1000 mg 2 x 5's (Hovid) | |
| Clamox (Bangladesh, India, South Korea) | |
| CLAMOX Capsule/ Tablet / 875mg - 125mg / 5 units (Hamax Pharmaceuticals) | $ 2.95 |
| CLAMOX Capsule/ Tablet / 500mg - 125mg / 6 units (Hamax Pharmaceuticals) | $ 2.53 |
| CLAMOX Capsule/ Tablet / 250mg - 125mg / 6 units (Hamax Pharmaceuticals) | $ 1.81 |
| Clamox Amoxicillin 875mg, ClavulanicAcid 125mg TAB / 5 (Hamax Pharmaceuticals) | $ 2.95 |
| Clamox Amoxicillin 500mg, ClavulanicAcid 125mg TAB / 6 (Hamax Pharmaceuticals) | $ 2.02 |
| Clamox Amoxicillin 250mg, ClavulanicAcid 125mg TAB / 6 (Hamax Pharmaceuticals) | $ 1.45 |
| Clamox Amoxicillin 1000mg, ClavulanicAcid 200mg VIAL / 1 (Hamax Pharmaceuticals) | $ 1.72 |
| 6's (Hamax Pharmaceuticals) | $ 1.33 |
| 1's (Hamax Pharmaceuticals) | $ 1.72 |
| Clamox 500+125 Tablet (Hamax Pharmaceuticals) | $ 0.33 |
| Clamox 250+125 Tablet (Hamax Pharmaceuticals) | $ 0.27 |
| Clamox 875+125 Tablet (Hamax Pharmaceuticals) | $ 0.59 |
| Clamox 250+125 Inga Tablet (Hamax Pharmaceuticals) | $ 0.24 |
| Clamox 30 ml Syrup (Hamax Pharmaceuticals) | $ 0.12 |
| Clamox 1000+200 Injection (Hamax Pharmaceuticals) | $ 0.18 |
| Clamox 30 ml Hamax Suspension (Hamax Pharmaceuticals) | $ 0.14 |
| Clamox Amoxicillin 500 mg, clavulanicacid 125 mg. TAB / 6 (Hamax Pharmaceuticals) | $ 1.63 |
See 7095 substitutes for Clamentin | |
References
- DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "CLAVULANIC ACID". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "amoxicillin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Clamentin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Clamentin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Clamentin drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
2 consumers reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Clamentin drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 1 | 50.0% | |
| Expensive | 1 | 50.0% | |
8 consumers reported time for results
To what extent do I have to use Clamentin before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Clamentin. To get the time effectiveness of using Clamentin drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 5 days | 3 | 37.5% | |
| 3 days | 2 | 25.0% | |
| 1 day | 1 | 12.5% | |
| 2 weeks | 1 | 12.5% | |
| 2 days | 1 | 12.5% | |
31 consumers reported age
| Users | % | ||
|---|---|---|---|
| 46-60 | 8 | 25.8% | |
| 30-45 | 7 | 22.6% | |
| 6-15 | 5 | 16.1% | |
| > 60 | 4 | 12.9% | |
| 1-5 | 4 | 12.9% | |
| < 1 | 2 | 6.5% | |
| 16-29 | 1 | 3.2% | |
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
