Cleartuss T indications
Cleartuss T hydrochloride SYRUP indicated for cough associated with wheeziness (bronchospasm) and tenacious phlegm (sputum).
Uses of Cleartuss T in details
Cleartuss T is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.
Cleartuss T description
Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.
The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.
The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.
Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.
Cleartuss T HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.
Cleartuss T dosage
Unless otherwise prescribed, the following doses are recommended:
Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.
Oral Solution:
Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.
Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.
The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.
Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.
At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.
The syrup is sugar-free and therefore suitable for diabetics and small children.
Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.
Capsule: Adults: 1 cap 3 times daily.
It is recommended for the initial phase of treatment usually lasting not more than a week.
Patients being treated with Cleartuss T should be notified of an expected increase in the flow of secretions.
Cleartuss T interactions
A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.
Cleartuss T hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.
The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.
Cleartuss T side effects
Cleartuss T’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Cleartuss T.
Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.
Cleartuss T contraindications
Cleartuss T hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.
Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Cleartuss T hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.
Safety in pregnancy and lactation has not been established.
Active ingredient matches for Cleartuss T:
| Unit description / dosage (Manufacturer) | Price, USD |
| Cleartuss T 50 ml Syrup | $ 0.02 |
| Cleartuss T 100 ml Syrup | $ 0.02 |
| CLEARTUSS T SYRUP 1 bottle / 100 ML syrup each (Cadila Pharmaceuticals Ltd) | $ 0.65 |
| CLEARTUSS T SYRUP 1 bottle / 50 ML syrup each (Cadila Pharmaceuticals Ltd) | $ 0.15 |
List of Cleartuss T substitutes (brand and generic names): | |
| Cleartuss-T (India) | |
| CLEARTUSS-T syr 50ml (Cadila (Genstar)) | $ 0.22 |
| Clod-B (Bangladesh) | |
| Cloridrato de Bromexina (Brazil) | |
| Cloridrato de Bromexina EMS (Brazil) | |
| Cloridrato de Bromexina Gen.Germed (Brazil) | |
| Cloridrato de Bromexina Gen.Legrand (Brazil) | |
| Cloridrato de Bromexina GeoLab (Brazil) | |
| Cloridrato de Bromexina Globo (Brazil) | |
| Cloridrato de Bromexina Medley (Brazil) | |
| Cloridrato de Bromexina Neo Quimica (Brazil) | |
| Cloridrato de Bromexina Nova Quimica (Brazil) | |
| Cof D | |
| Cof D 60 ml Syrup (Pfiscar India Limited) | $ 0.02 |
| Cofal (India) | |
| Cofal Bromhexine hydrochloride 2 mg, Terbutaline sulphate 1.25 mg, Guaiphenesin 50 mg. SYR / 100ml (Alna Bio) | $ 0.49 |
| 100ml (Alna Bio) | $ 0.49 |
| COFAL syr 100ml (Alna Bio) | $ 0.49 |
| Cofbron (Thailand) | |
| Cofbron 60 mL (Macrophar) | |
| Cofbron M (Thailand) | |
| Cofdex Syr (India) | |
| Cofdex Syr Bromhexine hydrochloride 4 mg, Dextromethorphan Hydrobromide5 mg, ammonium chloride 50 mg, Menthol 2.5 mg. SYR / 100ml (Cipla) | $ 0.42 |
| 100ml (Cipla) | $ 0.42 |
| COFDEX SYR syr 100ml (Cipla) | $ 0.42 |
| Cofex T | |
| Cofex T 100 ml Syrup (Paradigm Healthcare) | $ 0.02 |
| Cofish AX | |
| Cofish AX 100 ml Syrup (Moreish Pharmaceuticals Pvt. Ltd.) | $ 0.02 |
| Coflyt (Bangladesh) | |
| Cofmesin (Japan) | |
| Cofocura (India) | |
| Cofocura Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 4 mg, Guaiphenesin 50 mg, Menthol2.5 mg/5 mL. SYR / 100ml (Daniel Pasteur) | $ 0.51 |
| Cofocura Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 4mg, Guaiphenesin 50 mg, Menthol2.5 mg/5 mL. SYR / 60ml (Daniel Pasteur) | $ 0.35 |
| 100ml (Daniel Pasteur) | $ 0.51 |
| 60ml (Daniel Pasteur) | $ 0.35 |
| Cofocura 60 ml Syrup (Daniel Pasteur) | $ 0.03 |
| Cofocura 100 ml Syrup (Daniel Pasteur) | $ 0.03 |
| COFOCURA syr 100ml (Daniel Pasteur) | $ 0.51 |
| COFOCURA syr 60ml (Daniel Pasteur) | $ 0.35 |
| Cofpet DX | |
| Cofpet DX 120 ml Syrup (Vista Healthcare) | $ 0.02 |
| Cofpet-DX (India) | |
| Cofpet-DX Bromhexine hydrochloride 4 mg, Dextromethorphan hydrobromide5 mg. SYR / 120ml (Vista HC) | $ 0.38 |
| 120ml (Vista HC) | $ 0.38 |
| COFPET-DX syr 120ml (Vista HC) | $ 0.38 |
| Cofq X | |
| Cofq X 100 ml Syrup (Cipla Limited) | $ 0.02 |
| Cofq-X (India) | |
| Cofq-X Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 4 mg, Guaiphenesin 50 mg/5 mL. LIQD / 100ml (Cipla) | $ 0.36 |
| 100ml (Cipla) | $ 0.36 |
| COFQ-X oral liqd 100ml (Cipla) | $ 0.36 |
| Cofrav | |
| Cofrav 100 ml Syrup (Ravian Life Sciences (P) Ltd) | $ 0.03 |
| Cofree Tablet | |
| Cofree Tablet (Stadia Biotech) | $ 0.04 |
See 1939 substitutes for Cleartuss T | |
References
- DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
