Cofal indications
Cofal hydrochloride SYRUP indicated for cough associated with wheeziness (bronchospasm) and tenacious phlegm (sputum).
Uses of Cofal in details
Cofal is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.
Cofal description
Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.
The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.
The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.
Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.
Cofal HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.
Cofal dosage
Unless otherwise prescribed, the following doses are recommended:
Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.
Oral Solution:
Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.
Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.
The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.
Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.
At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.
The syrup is sugar-free and therefore suitable for diabetics and small children.
Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.
Capsule: Adults: 1 cap 3 times daily.
It is recommended for the initial phase of treatment usually lasting not more than a week.
Patients being treated with Cofal should be notified of an expected increase in the flow of secretions.
Cofal interactions
A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.
Cofal hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.
The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.
Cofal side effects
Cofal’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Cofal.
Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.
Cofal contraindications
Cofal hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.
Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Cofal hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.
Safety in pregnancy and lactation has not been established.
Active ingredient matches for Cofal:
Bromhexine in India.
Bromhexine hydrochloride/guaiphenesin/terbutaline sulphate in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Cofal Bromhexine hydrochloride 2 mg, Terbutaline sulphate 1.25 mg, Guaiphenesin 50 mg. SYR / 100ml | $ 0.49 |
| 100ml | $ 0.49 |
| COFAL syr 100ml (Alna Bio) | $ 0.49 |
List of Cofal substitutes (brand and generic names): | |
| Cof D | |
| Cof D 60 ml Syrup (Pfiscar India Limited) | $ 0.02 |
| Cofdex Syr (India) | |
| Cofdex Syr Bromhexine hydrochloride 4 mg, Dextromethorphan Hydrobromide5 mg, ammonium chloride 50 mg, Menthol 2.5 mg. SYR / 100ml (Cipla) | $ 0.42 |
| 100ml (Cipla) | $ 0.42 |
| COFDEX SYR syr 100ml (Cipla) | $ 0.42 |
| Cofex T | |
| Cofex T 100 ml Syrup (Paradigm Healthcare) | $ 0.02 |
| Cofish AX | |
| Cofish AX 100 ml Syrup (Moreish Pharmaceuticals Pvt. Ltd.) | $ 0.02 |
| Coflyt (Bangladesh) | |
| Cofmesin (Japan) | |
| Cofocura (India) | |
| Cofocura Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 4 mg, Guaiphenesin 50 mg, Menthol2.5 mg/5 mL. SYR / 100ml (Daniel Pasteur) | $ 0.51 |
| Cofocura Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 4mg, Guaiphenesin 50 mg, Menthol2.5 mg/5 mL. SYR / 60ml (Daniel Pasteur) | $ 0.35 |
| 100ml (Daniel Pasteur) | $ 0.51 |
| 60ml (Daniel Pasteur) | $ 0.35 |
| Cofocura 60 ml Syrup (Daniel Pasteur) | $ 0.03 |
| Cofocura 100 ml Syrup (Daniel Pasteur) | $ 0.03 |
| COFOCURA syr 100ml (Daniel Pasteur) | $ 0.51 |
| COFOCURA syr 60ml (Daniel Pasteur) | $ 0.35 |
| Cofpet DX | |
| Cofpet DX 120 ml Syrup (Vista Healthcare) | $ 0.02 |
| Cofpet-DX (India) | |
| Cofpet-DX Bromhexine hydrochloride 4 mg, Dextromethorphan hydrobromide5 mg. SYR / 120ml (Vista HC) | $ 0.38 |
| 120ml (Vista HC) | $ 0.38 |
| COFPET-DX syr 120ml (Vista HC) | $ 0.38 |
| Cofq X | |
| Cofq X 100 ml Syrup (Cipla Limited) | $ 0.02 |
| Cofq-X (India) | |
| Cofq-X Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 4 mg, Guaiphenesin 50 mg/5 mL. LIQD / 100ml (Cipla) | $ 0.36 |
| 100ml (Cipla) | $ 0.36 |
| COFQ-X oral liqd 100ml (Cipla) | $ 0.36 |
| Cofrav | |
| Cofrav 100 ml Syrup (Ravian Life Sciences (P) Ltd) | $ 0.03 |
| Cofree Tablet | |
| Cofree Tablet (Stadia Biotech) | $ 0.04 |
| Coftex-BT (India) | |
| Coftex-BT Bromhexine hydrochloride 8 mg, Terbutaline sulphate 2.5 mg, Menthol 5 mg, Guaiphenesin 100mg. SYR / 100ml (Santiago) | |
| 100ml (Santiago) | |
| COFTEX-BT syr 100ml (Santiago) | $ 0.66 |
| Cohexine (Thailand) | |
| Cohexine 8 mg x 50 x 10's (Community Pharm PCL) | |
| Cohexine 4 mg/5 mL x 60 mL (Community Pharm PCL) | |
| Cohexine syr 4 mg/5 mL 60 mL x 1's (Community Pharm PCL) | |
| Cohexine tab 8 mg 50 x 10's (Community Pharm PCL) | |
| Cold-Relieve Syr (India) | |
| Cold-Relieve Syr Phenylephrine hydrochloride2.5 mg, Chlorpheniraminemaleate 1.25 mg, Bromhexinehydrochloride 4 mg. SYR / 60ml (Medico HC) | $ 0.34 |
| 60ml (Medico HC) | $ 0.34 |
| COLD-RELIEVE SYR syr 60ml (Medico HC) | $ 0.34 |
| Copod B | |
| Copod B 100 ml Syrup (Mepfarma (Alna Biotech)) | $ 0.02 |
| Copod-B (India) | |
| Copod-B Bromhexine hydrochloride 2 mg, Terbutaline sulphate 1.25 mg, Guaiphenesin 50 mg. SYR / 100ml (Mepfarma) | $ 0.49 |
| 100ml (Mepfarma) | $ 0.49 |
| COPOD-B syr 100ml (Mepfarma) | $ 0.52 |
| Corivin (India) | |
| Corivin 60 ml Syrup (Olcare Laboratories) | $ 0.02 |
| CORIVIN 0.1% W/V NASAL DROPS 1 packet / 10 ML nasal drops each (Olcare Laboratories) | $ 0.38 |
See 1886 substitutes for Cofal | |
References
- DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "bromhexine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Cofal are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cofal. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yet1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Cofal drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% | |
2 consumers reported time for results
To what extent do I have to use Cofal before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes > 3 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Cofal. To get the time effectiveness of using Cofal drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| > 3 month | 2 | 100.0% | |
10 consumers reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 3 | 30.0% | |
| 16-29 | 2 | 20.0% | |
| 1-5 | 2 | 20.0% | |
| < 1 | 2 | 20.0% | |
| 46-60 | 1 | 10.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
