Corivin indications
Corivin hydrochloride SYRUP indicated for cough associated with wheeziness (bronchospasm) and tenacious phlegm (sputum).
Uses of Corivin in details
Corivin is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.
Corivin description
Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.
The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.
The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.
Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.
Corivin HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.
Corivin dosage
Unless otherwise prescribed, the following doses are recommended:
Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.
Oral Solution:
Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.
Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.
The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.
Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.
At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.
The syrup is sugar-free and therefore suitable for diabetics and small children.
Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.
Capsule: Adults: 1 cap 3 times daily.
It is recommended for the initial phase of treatment usually lasting not more than a week.
Patients being treated with Corivin should be notified of an expected increase in the flow of secretions.
Corivin interactions
A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.
Corivin hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.
The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.
Corivin side effects
Corivin’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Corivin.
Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.
Corivin contraindications
Corivin hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.
Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Corivin hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.
Safety in pregnancy and lactation has not been established.
Active ingredient matches for Corivin:
Bromhexine in India.
Chlorpheniramine/Paracetamol/Phenylephrine
Xylometazoline in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Corivin 60 ml Syrup | $ 0.02 |
| CORIVIN 0.1% W/V NASAL DROPS 1 packet / 10 ML nasal drops each (Olcare Laboratories) | $ 0.38 |
| CORIVIN PEAD DROPS 1 packet / 10 ML drop each (Olcare Laboratories) | $ 0.34 |
| CORIVIN TABLET 1 strip / 10 tablets each (Olcare Laboratories) | $ 0.26 |
| CORIVIN nasal drops 0.1 % w/v x 10ml (Olcare (Fusion)) | $ 0.42 |
| Corivin 0.1% w/v Nasal Drops (Olcare Laboratories) | $ 0.38 |
| Corivin NA Nasal Drops (Olcare Laboratories) | $ 0.34 |
List of Corivin substitutes (brand and generic names): | |
| CORIVEX PAED (India) | |
| CORIVEX PAED nasal drops 0.05 % w/v x 10ml (Olcare (Excare)) | $ 0.35 |
| CORIVIN-PAED (India) | |
| CORIVIN-PAED nasal drops 0.05 % w/v x 10ml (Olcare (Fusion)) | $ 0.35 |
| Corized E | |
| Corized E 100 ml Expectorant (Wander Ltd) | $ 0.01 |
| CORYL | |
| CORYL 500MG/5MG/2.5MG SUSPENSION 1 bottle / 60 ML suspension each (Omega Pharmaceuticals Pvt Ltd) | $ 0.42 |
| Coryl Suspension (Omega Pharmaceuticals Pvt Ltd) | $ 0.42 |
| Cos P | |
| Cos P 100 ml Syrup (Biosync Pharmaceuticals Pvt Ltd) | $ 0.03 |
| Cos-P (India) | |
| Cos-P Terbutaline sulphate 2.5 mg, Bromhexine hydrochloride 8 mg, Guaiphenesin 100 mg, Menthol 2mg. SYR / 100ml (Biosync Pharma) | $ 0.54 |
| 100ml (Biosync Pharma) | $ 0.54 |
| COS-P syr 100ml (Biosync Pharma) | $ 0.54 |
| Cosme | |
| Cosme 100 ml Syrup (Merck (India) Ltd (Merck Ltd)) | $ 0.02 |
| Cosryl (India) | |
| Cosryl Terbutaline 2.5 mg, Guaiphenesin 100 mg, Bromhexine 8 mg, Menthol 5 mg. SYR / 100ml (Cosmas Pharmacls) | |
| Cosryl Terbutaline 2.5 mg, Guaiphenesin 100 mg, Bromhexine 8 mg, Menthol 5 mg. SYR / 60ml (Cosmas Pharmacls) | |
| 100ml (Cosmas Pharmacls) | |
| 60ml (Cosmas Pharmacls) | |
| Cosryl 50 ml Syrup (Cosmas Pharmacls) | $ 0.02 |
| COSRYL syr 100ml (Cosmas Pharmacls) | |
| COSRYL syr 60ml (Cosmas Pharmacls) | |
| Coughtimi (Japan) | |
| Coughxin (Taiwan) | |
| Coughxin 8 mg x 500's | |
| Coughxin 8 mg x 1000's | |
| Covent | |
| Covent 100 ml Syrup (Zaneka Pharmaceuticals (P) Ltd.) | $ 0.02 |
| COVENT 100MG/2.5MG/8MG EXPECTORANT 1 bottle / 100 ML expectorant each (Zaneka Pharmaceuticals (P) Ltd.) | $ 0.46 |
| Covent Expectorant (Zaneka Pharmaceuticals (P) Ltd.) | $ 0.00 |
| Covent Kid | |
| Covent Kid 60 ml Suspension (Zaneka Pharmaceuticals (P) Ltd.) | $ 0.02 |
| COVENT KID 1MG/4MG EXPECTORANT 1 bottle / 60 ML expectorant each (Zaneka Pharmaceuticals (P) Ltd.) | $ 0.16 |
| Covent Kid Expectorant (Zaneka Pharmaceuticals (P) Ltd.) | $ 0.00 |
| COZYMIN FORTE | |
| COZYMIN FORTE SUSPENSION 1 bottle / 60 ML suspension each (Unimarck Healthcare Ltd) | $ 0.48 |
| COZYTAB PLUS | |
| COZYTAB PLUS 1MG/125MG/2.5MG SYRUP 1 bottle / 60 ML syrup each (Swiss Pharma Pvt Ltd) | $ 0.30 |
| Cozytab Plus Syrup (Swiss Pharma Pvt Ltd) | $ 0.30 |
| Cozytab Plus Tablet (Swiss Pharma Pvt Ltd) | $ 0.02 |
| Cuf Gtb | |
| Cuf Gtb 100 ml Syrup (Bindlysh Biotech Ltd) | $ 0.02 |
| Cuf Gtb 60 ml Syrup (Bindlysh Biotech Ltd) | $ 0.03 |
| Cuf Out Tablet | |
| Cuf Out Tablet (Cosmas Pharmacls) | $ 0.01 |
| Cufed | |
| Cufed 60 ml Expectorant (Adcco Limited.) | $ 0.02 |
| Cufex D Tablet | |
| Cufex D Tablet (Rax Health Care Pvt. Ltd.) | $ 0.03 |
| Cufokin (India) | |
| Cufokin Terbutaline 2.5 mg, Guaifenesin 100 mg, Bromhexine8 mg, Menthol 0.5 mg/10 mL. SYR / 100ml (Misha Biotech) | |
| 100ml (Misha Biotech) | |
| CUFOKIN syr 100ml (Misha Biotech) | |
| Cufrid | |
| Cufrid 100 ml Syrup (Agron Remedies Pvt Ltd) | $ 0.02 |
| Cufrid 60 ml Syrup (Agron Remedies Pvt Ltd) | $ 0.01 |
| Cufrid Syrup (Agron Remedies Pvt Ltd) | $ 0.23 |
| Cuftoss | |
| Cuftoss 50 ml Syrup (Brussels Laboratories Pvt. Ltd.) | $ 0.02 |
See 3138 substitutes for Corivin | |
References
- DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "phenylephrine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "xylometazoline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
