What is D-Sorbitol Kowa Souyaku?
Preventing infection during prostate surgery or other urinary tract surgeries. It may also be used for other conditions as determined by your doctor.
D-Sorbitol Kowa Souyaku irrigation solution is a hexitol irrigant. It works by flushing debris out of the surgical area to help prevent infection.
D-Sorbitol Kowa Souyaku indications
It has been employed as a 30% solution as an alternative to glucose in parenteral nutrition but its use is not recommended because of the risk of lactic acidosis.
D-Sorbitol Kowa Souyaku may be administered by mouth or rectally as an osmotic laxative in the management of constipation doses of 20 to 50 g have been suggested.
Solutions containing about 3% of D-Sorbitol Kowa Souyaku are used as irrigating fluids in transurethral surgical procedures.
D-Sorbitol Kowa Souyaku also acts as a bulk sweetening agent. It is used in limited quantities as a sweetener in energy-reduced diabetic food products. It is also used as an alternative to sucrose in many sugar-free oral liquid preparations and in sugar-free foods as it is less likely to cause dental caries.
D-Sorbitol Kowa Souyaku also has humectant and stabilising properties and is used in various pharmaceutical and cosmetic products including toothpaste.
How should I use D-Sorbitol Kowa Souyaku?
Use D-Sorbitol Kowa Souyaku solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- D-Sorbitol Kowa Souyaku solution may be taken with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Do not take additional laxatives or stool softeners while taking D-Sorbitol Kowa Souyaku solution unless directed by your doctor.
- If you are using D-Sorbitol Kowa Souyaku solution as a rectal enema, follow the directions given with the enema. Ask your doctor or pharmacist any questions you may have about giving an enema.
- Do not exceed the recommended dose or use D-Sorbitol Kowa Souyaku solution for longer than 1 week without checking with your doctor.
- If you miss a dose of D-Sorbitol Kowa Souyaku solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use D-Sorbitol Kowa Souyaku solution.
Uses of D-Sorbitol Kowa Souyaku in details
D-Sorbitol Kowa Souyaku is used to treat occasional constipation.
D-Sorbitol Kowa Souyaku description
A polyhydric alcohol with about half the sweetness of sucrose. D-Sorbitol Kowa Souyaku occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
D-Sorbitol Kowa Souyaku dosage
D-Sorbitol Kowa Souyaku Dosage
Applies to the following strength(s): 70%; 3.3%; 3%
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Constipation
Usual Pediatric Dose for:
- Constipation
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
Usual Adult Dose for Constipation
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Usual Pediatric Dose for Constipation
2 to 11 years:
Oral: 2 mL/kg (70% solution) once.
Rectal: 30 to 60 mL (25% to 30% solution) as a rectal enema once.
Greater than or equal to 12 years:
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
The use of D-Sorbitol Kowa Souyaku is contraindicated in patients with anuria. D-Sorbitol Kowa Souyaku should not be used in patients with suspected or documented fructose intolerance. D-Sorbitol Kowa Souyaku should not given by injection.
Sudden severe abdominal bloating and diarrhea have been reported in patients ingesting D-Sorbitol Kowa Souyaku.
Solutions for urologic irrigation should be used with caution in patients with severe cardiopulmonary or renal dysfunction.
Irrigating fluids used during transurethral prostatectomy have been demonstrated to enter the systemic circulation in relatively large volumes; thus D-Sorbitol Kowa Souyaku irrigating solution must be regarded as a systemic agent. Absorption of large amounts of fluids containing D-Sorbitol Kowa Souyaku may significantly alter cardiopulmonary and renal dynamics. Appropriate patient monitoring should be conducted due to the possibility of fluid overload. If fluid overload occurs, intensive fluid and electrolyte management should be initiated. Monitoring of fluid and electrolyte levels beyond the acute phase may be necessary due to the possibility of delayed fluid absorption.
Hyperglycemia from metabolism of absorbed D-Sorbitol Kowa Souyaku may be observed in patients with diabetes mellitus.
The cardiovascular status, especially of the patient with cardiac disease, should be carefully monitored before and during transurethral resection of the prostate when using 3% D-Sorbitol Kowa Souyaku urologic irrigating solution, because the quantity of fluid absorbed into the systemic circulation by opened prostatic veins may produce significant expansion of the intravascular fluid and lead to fulminating congestive heart failure.
Shift of sodium free intracellular fluid into the extracellular compartment, following systemic absorption could lower serum concentration and aggravate preexisting hyponatremia.
Excessive loss of water and electrolytes may lead to serious imbalances. With continuous use of solution, loss of water may occur in excess of electrolytes, producing hypernatremia.
Sustained diuresis that results from transurethral irrigation with D-Sorbitol Kowa Souyaku irrigating solutions could obscure and intensify inadequate hydration or hypovolemia.
Dialysis
Data not available
More about D-Sorbitol Kowa Souyaku
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 1 Review - Add your own review/rating
Consumer resources
- D-Sorbitol Kowa Souyaku solution
- D-Sorbitol Kowa Souyaku
Related treatment guides
- Constipation
D-Sorbitol Kowa Souyaku interactions
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What other drugs will affect D-Sorbitol Kowa Souyaku?
Calcium Polystyrene Sulfonate: D-Sorbitol Kowa Souyaku may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
LamiVUDine: D-Sorbitol Kowa Souyaku may decrease the serum concentration of LamiVUDine. Management: When possible, avoid chronic coadministration of D-Sorbitol Kowa Souyaku-containing solutions with lamivudine, but if this combination cannot be avoided, monitor patients more closely for possible therapeutic failure associated with decreased lamivudine exposure. Consider therapy modification
Sodium Polystyrene Sulfonate: D-Sorbitol Kowa Souyaku may enhance the adverse/toxic effect of Sodium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
D-Sorbitol Kowa Souyaku side effects
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What are the possible side effects of D-Sorbitol Kowa Souyaku?
Life threatening adverse reactions with intravenous D-Sorbitol Kowa Souyaku infusions have been reported in patients with fructose intolerance.
The literature reports occasional adverse reactions for intravenous D-Sorbitol Kowa Souyaku infusions. These include disturbances such as acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dryness of mouth and thirst, and dehydration; cardiovascular/pulmonary disorders such as pulmonary congestion, hypotension, tachycardia, angina-like pains, and other general reactions such as blurred vision, convulsions, nausea, vomiting, diarrhea, rhinitis, chills, vertigo, and backache. Allergic reactions reported to occur from D-Sorbitol Kowa Souyaku include urticaria.
Should adverse reactions occur, discontinue the irrigant and reevaluate the clinical status of the patient.
Post-Marketing Experience
Following off-label use of 3% D-Sorbitol Kowa Souyaku Urologic Irrigating Solution for hysteroscopic procedures in women, life-threatening adverse events related to fluid overload have been reported.
D-Sorbitol Kowa Souyaku contraindications
See also:
What is the most important information I should know about D-Sorbitol Kowa Souyaku?
D-Sorbitol Kowa Souyaku should not be given to patients with hereditary fructose intolerance. It should be given with caution to patients with impaired kidney function or severe liver damage.
Active ingredient matches for D-Sorbitol Kowa Souyaku:
Sorbitol in Japan.
List of D-Sorbitol Kowa Souyaku substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| D-Sorbitol Maruishi Seiyaku (Japan) | |
| Diget | |
| Diget 170 ml Syrup (Smilax Pharmaceuticals) | $ 0.02 |
| Dokisscool (Vietnam) | |
| Dokisscool 1.8 g x 4 tube x 11 Tablet | |
| Eupasan (Ecuador) | |
| Foodol D 70 | |
| G 1 | |
| G 1 200 ml Syrup (Glyco Labs.) | $ 0.02 |
| Gellax (Vietnam) | |
| Gellax 70 % x 10 tube x 5 g | |
| Gellax 70 % x 6 tube | |
| Glucarine | |
| Karion Carbohydrate | |
| Karion Instant | |
| Klarcid | |
| Klarcid 175 ml Suspension (Klar Sehen Pvt. Limited) | $ 0.01 |
| Klarcid 250+250+50 Tablet (Klar Sehen Pvt. Limited) | $ 0.00 |
| Lactosorbit (Vietnam) | |
| Lactosorbit 5 g x 20 Packs | |
| Multitol | |
| Neosorb 20 / 60DC | |
| Neosorb 70 / 02 | |
| Neosorb 70 / 70 | |
| Neosorb P 20 / 60 | |
| Neosorb P 60 | |
| Noncrystallizing sorbitol solution usnf 26 | |
| Opesorbit (Vietnam) | |
| Opesorbit 5 g x 20 Packs | |
| pms-Sorbitol (Vietnam) | |
| pms-Sorbitol 5 g x 25 Packs | |
| Probilagol | |
| Progras (Argentina) | |
| Rectilax (Vietnam) | |
| Rectilax 70 % x 1 tube 5 g (Invision) | |
| Rectilax 70 % x 1 tube 8 g (Invision) | |
| Rectilax 70 % x 10 tube 5 g (Invision) | |
| Rectilax 70 % x 10 tube 8 g (Invision) | |
| Resulax (Sweden) | |
| Salhexin Paed | |
| Salhexin Paed 100 ml Syrup (Duckbill Drugs Pvt Ltd) | $ 0.01 |
| SALHEXIN PAED SYRUP 1 bottle / 100 ML syrup each (Duckbill Drugs Pvt Ltd) | $ 0.61 |
| Salhexin Paed Syrup (Duckbill Drugs Pvt Ltd) | $ 0.61 |
| Sanofi-Synthelabo (Indonesia) | |
| Sionit K | |
| Sorbi (New Zealand) | |
| Sorbilande (Italy) | |
| Sorbisol (Australia) | |
| Sorbit (Taiwan) | |
| Injectable; Injection; Sorbitol 200 mg / ml | |
| Sorbit 5 % x 500 mL | |
| Sorbite | |
| Sorbitol (Austria, Czech Republic, Germany, Switzerland, Turkey) | |
| Injectable; Injection; Sorbitol 5% (Infomed fluids) | |
See 106 substitutes for D-Sorbitol Kowa Souyaku | |
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
