What is Progras?
Preventing infection during prostate surgery or other urinary tract surgeries. It may also be used for other conditions as determined by your doctor.
Progras irrigation solution is a hexitol irrigant. It works by flushing debris out of the surgical area to help prevent infection.
Progras indications
It has been employed as a 30% solution as an alternative to glucose in parenteral nutrition but its use is not recommended because of the risk of lactic acidosis.
Progras may be administered by mouth or rectally as an osmotic laxative in the management of constipation doses of 20 to 50 g have been suggested.
Solutions containing about 3% of Progras are used as irrigating fluids in transurethral surgical procedures.
Progras also acts as a bulk sweetening agent. It is used in limited quantities as a sweetener in energy-reduced diabetic food products. It is also used as an alternative to sucrose in many sugar-free oral liquid preparations and in sugar-free foods as it is less likely to cause dental caries.
Progras also has humectant and stabilising properties and is used in various pharmaceutical and cosmetic products including toothpaste.
How should I use Progras?
Use Progras solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Progras solution may be taken with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Do not take additional laxatives or stool softeners while taking Progras solution unless directed by your doctor.
- If you are using Progras solution as a rectal enema, follow the directions given with the enema. Ask your doctor or pharmacist any questions you may have about giving an enema.
- Do not exceed the recommended dose or use Progras solution for longer than 1 week without checking with your doctor.
- If you miss a dose of Progras solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Progras solution.
Uses of Progras in details
Progras is used to treat occasional constipation.
Progras description
A polyhydric alcohol with about half the sweetness of sucrose. Progras occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
Progras dosage
Progras Dosage
Applies to the following strength(s): 70%; 3.3%; 3%
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Constipation
Usual Pediatric Dose for:
- Constipation
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
Usual Adult Dose for Constipation
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Usual Pediatric Dose for Constipation
2 to 11 years:
Oral: 2 mL/kg (70% solution) once.
Rectal: 30 to 60 mL (25% to 30% solution) as a rectal enema once.
Greater than or equal to 12 years:
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
The use of Progras is contraindicated in patients with anuria. Progras should not be used in patients with suspected or documented fructose intolerance. Progras should not given by injection.
Sudden severe abdominal bloating and diarrhea have been reported in patients ingesting Progras.
Solutions for urologic irrigation should be used with caution in patients with severe cardiopulmonary or renal dysfunction.
Irrigating fluids used during transurethral prostatectomy have been demonstrated to enter the systemic circulation in relatively large volumes; thus Progras irrigating solution must be regarded as a systemic agent. Absorption of large amounts of fluids containing Progras may significantly alter cardiopulmonary and renal dynamics. Appropriate patient monitoring should be conducted due to the possibility of fluid overload. If fluid overload occurs, intensive fluid and electrolyte management should be initiated. Monitoring of fluid and electrolyte levels beyond the acute phase may be necessary due to the possibility of delayed fluid absorption.
Hyperglycemia from metabolism of absorbed Progras may be observed in patients with diabetes mellitus.
The cardiovascular status, especially of the patient with cardiac disease, should be carefully monitored before and during transurethral resection of the prostate when using 3% Progras urologic irrigating solution, because the quantity of fluid absorbed into the systemic circulation by opened prostatic veins may produce significant expansion of the intravascular fluid and lead to fulminating congestive heart failure.
Shift of sodium free intracellular fluid into the extracellular compartment, following systemic absorption could lower serum concentration and aggravate preexisting hyponatremia.
Excessive loss of water and electrolytes may lead to serious imbalances. With continuous use of solution, loss of water may occur in excess of electrolytes, producing hypernatremia.
Sustained diuresis that results from transurethral irrigation with Progras irrigating solutions could obscure and intensify inadequate hydration or hypovolemia.
Dialysis
Data not available
More about Progras
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 1 Review - Add your own review/rating
Consumer resources
- Progras solution
- Progras
Related treatment guides
- Constipation
Progras interactions
See also:
What other drugs will affect Progras?
Calcium Polystyrene Sulfonate: Progras may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
LamiVUDine: Progras may decrease the serum concentration of LamiVUDine. Management: When possible, avoid chronic coadministration of Progras-containing solutions with lamivudine, but if this combination cannot be avoided, monitor patients more closely for possible therapeutic failure associated with decreased lamivudine exposure. Consider therapy modification
Sodium Polystyrene Sulfonate: Progras may enhance the adverse/toxic effect of Sodium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
Progras side effects
See also:
What are the possible side effects of Progras?
Life threatening adverse reactions with intravenous Progras infusions have been reported in patients with fructose intolerance.
The literature reports occasional adverse reactions for intravenous Progras infusions. These include disturbances such as acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dryness of mouth and thirst, and dehydration; cardiovascular/pulmonary disorders such as pulmonary congestion, hypotension, tachycardia, angina-like pains, and other general reactions such as blurred vision, convulsions, nausea, vomiting, diarrhea, rhinitis, chills, vertigo, and backache. Allergic reactions reported to occur from Progras include urticaria.
Should adverse reactions occur, discontinue the irrigant and reevaluate the clinical status of the patient.
Post-Marketing Experience
Following off-label use of 3% Progras Urologic Irrigating Solution for hysteroscopic procedures in women, life-threatening adverse events related to fluid overload have been reported.
Progras contraindications
See also:
What is the most important information I should know about Progras?
Progras should not be given to patients with hereditary fructose intolerance. It should be given with caution to patients with impaired kidney function or severe liver damage.
Active ingredient matches for Progras:
Sorbitol in Argentina.
List of Progras substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Probilagol | |
| Rectilax (Vietnam) | |
| Rectilax 70 % x 1 tube 5 g (Invision) | |
| Rectilax 70 % x 1 tube 8 g (Invision) | |
| Rectilax 70 % x 10 tube 5 g (Invision) | |
| Rectilax 70 % x 10 tube 8 g (Invision) | |
| Resulax (Sweden) | |
| Salhexin Paed | |
| Salhexin Paed 100 ml Syrup (Duckbill Drugs Pvt Ltd) | $ 0.01 |
| SALHEXIN PAED SYRUP 1 bottle / 100 ML syrup each (Duckbill Drugs Pvt Ltd) | $ 0.61 |
| Salhexin Paed Syrup (Duckbill Drugs Pvt Ltd) | $ 0.61 |
| Sanofi-Synthelabo (Indonesia) | |
| Sionit K | |
| Sorbi (New Zealand) | |
| Sorbilande (Italy) | |
| Sorbisol (Australia) | |
| Sorbit (Taiwan) | |
| Injectable; Injection; Sorbitol 200 mg / ml | |
| Sorbit 5 % x 500 mL | |
| Sorbite | |
| Sorbitol (Austria, Czech Republic, Germany, Switzerland, Turkey) | |
| Injectable; Injection; Sorbitol 5% (Infomed fluids) | |
| Sorbitol irrigant 3.3 g/100mL (Infomed fluids) | |
| Sorbitol irrigant 30 g/1000mL (Infomed fluids) | |
| Sorbitol solution 1 g/mL (Infomed fluids) | |
| Sorbitol solution 13.5 g/15mL (Infomed fluids) | |
| Sorbitol solution 258.2 g/474mL (Infomed fluids) | |
| Sorbitol 3.3% Bidiphar (Vietnam) | |
| Sorbitol 3.3% Bidiphar 3.3 % x 1 Bottle 500 mL | |
| sorbitol 5G SACHET | |
| Sorbitol Aguettant (France) | |
| Sorbitol Bidiphar (Vietnam) | |
| Sorbitol Bidiphar 5 g x 25 Packs | |
| Sorbitol Corsa (Indonesia) | |
| Sorbitol Corsa/Sanofi-Synthelabo (Indonesia) | |
| Sorbitol Corsa/Sanofi-Synthelabo 5 g x 20's (Sanofi-Synthelabo) | $ 2.25 |
| Sorbitol Danapha (Vietnam) | |
| Sorbitol Danapha 5 g x 20 Packs | |
| Sorbitol Delalande (Belgium, France, Luxembourg, Vietnam) | |
| Sorbitol Delalande 5 g x 20 Packs | |
| Sorbitol Delalande 5g (Luxembourg) | |
| Sorbitol Domesco (Vietnam) | |
| Sorbitol DOMESCO 5 g x 20 Packs | |
| Sorbitol DOMESCO 5 g x 25 Packs | |
| Sorbitol Donaipharm (Vietnam) | |
| Sorbitol Donaipharm 5 g x 20 Packs x 5 g | |
| Sorbitol F | |
| Sorbitol FP | |
| Sorbitol Glomed (Vietnam) | |
| Sorbitol Glomed 5 g x 20 Packs | |
| Sorbitol Hypertonique Biosedra | |
| Injectable; Injection; Sorbitol 10% | |
| Sorbitol in plastic container | |
| Solution; Irrigation; Sorbitol 3.3 g / 100 ml | |
| Solution; Irrigation; Sorbitol 3 g / 100 ml | |
| Sorbitol Infomed (Romania) | |
See 106 substitutes for Progras | |
Reviews
The results of a survey conducted on ndrugs.com for Progras are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Progras. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet4 consumers reported age
| Users | % | ||
|---|---|---|---|
| > 60 | 3 | 75.0% | |
| 30-45 | 1 | 25.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
