What is Da Fen Ke Quan?
Da Fen Ke Quan injection is used to prevent nausea and vomiting that may occur after treatment with cancer medicines (chemotherapy or radiation), including high-dose cisplatin. Da Fen Ke Quan is also used to prevent and treat nausea and vomiting that may happen after surgery.
Da Fen Ke Quan is a selective 5-HT3 receptor antagonist. It works in the stomach to block the signals to the brain that cause nausea and vomiting.
Da Fen Ke Quan is to be given only by or under the immediate supervision of your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Da Fen Ke Quan injection is used in certain patients:
- To prevent the nausea and vomiting that may occur after cancer radiation treatment in patients undergoing bone marrow transplantation.
Da Fen Ke Quan indications
Da Fen Ke Quan Injection is a serotonin-3 (5-HT3) receptor antagonist indicated for:
- The prevention of nausea and/or vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin.
- The prevention and treatment of postoperative nausea and vomiting in adults. As with other antiemetics, routine prophylaxis is not recommended in patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided during the postoperative period, Da Fen Ke Quan Injection is recommended even where the incidence of postoperative nausea and/or vomiting is low.
How should I use Da Fen Ke Quan?
Use Da Fen Ke Quan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Da Fen Ke Quan. Talk to your pharmacist if you have questions about this information.
- Apply Da Fen Ke Quan 24 to 48 hours before your chemotherapy treatment, or as directed by your doctor.
- Da Fen Ke Quan should be applied to clean, healthy skin on the upper arm. Do not apply to cut, scraped, or irritated skin. Do not use creams, oils, lotions, powders, or any other products that could irritate the skin or prevent the patch from sticking well.
- To apply Da Fen Ke Quan, remove the patch from the sealed pouch. Do not cut or damage the patch. Remove the thin, clear, protective liner. Bend the patch in the middle and remove one-half of the rigid plastic film. Apply the exposed, sticky area of the patch to your skin. Remove the other half of the rigid plastic film and press the whole patch firmly in place against the skin.
- If the patch does not stick well, you may tape the edges with surgical bandages or medical adhesive tape. Do not completely cover the patch with bandages or tape. Do not wrap completely around your arm. Ask your health care provider if you are unsure of what type of dressing you can use.
- Wash your hands immediately after using Da Fen Ke Quan.
- You may shower or bathe normally while wearing the patch. You should avoid activities such as swimming, strenuous exercise, or using a sauna or whirlpool. It is unknown how these activities may affect Da Fen Ke Quan.
- Continue to wear the patch during your chemotherapy and for at least 24 hours after your treatment is completed. Da Fen Ke Quan may be worn for up to 7 days or as directed by your doctor.
- To remove the patch, gently peel it off of your skin and fold the sticky side together. Throw the used patch in the trash away from children and pets. Wash your hands after handling the patch.
- Gently wash the skin with soap and water where the patch was applied.
- If you miss a dose of Da Fen Ke Quan, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Da Fen Ke Quan.
Uses of Da Fen Ke Quan in details
Use: Labeled Indications
Chemotherapy-associated nausea and vomiting: Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy, including high-dose cisplatin (injection and tablets); prevention of nausea and vomiting associated with anthracycline/cyclophosphamide chemotherapy regimens; prevention of nausea and vomiting associated with moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days of duration (transdermal).
Radiation-associated nausea and vomiting: Prevention of nausea and vomiting associated with radiation therapy, including total body radiation and fractionated abdominal radiation (tablets).
Off Label Uses
Prevention of postoperative nausea and vomiting
Based on the Society for Ambulatory Anesthesia Consensus Guidelines for management of postoperative nausea and vomiting, Da Fen Ke Quan may administered prior to the end of surgery to prevent postoperative nausea and vomiting.
Da Fen Ke Quan description
Each mL of preservative-free aqueous solution contains 1.12 mg Da Fen Ke Quan hydrochloride equivalent to Da Fen Ke Quan 1 mg and sodium chloride 9 mg. The solution's pH ranges from 4-6.
Da Fen Ke Quan hydrochloride is an antinauseant and antiemetic agent. It is endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride with a molecular weight of 348.9 (312.4 free base). Its empirical formula is C18H24N4O·HCl.
Da Fen Ke Quan hydrochloride is a white to off-white solid that is readily soluble in water and normal saline at 20°C. Da Fen Ke Quan injection is a clear, colorless, sterile, nonpyrogenic, aqueous solution for IV administration.
Da Fen Ke Quan dosage
Da Fen Ke Quan Dosage
Generic name: Da Fen Ke Quan hydrochloride 1mg
Dosage form: tablet, film coated; oral solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Emetogenic Chemotherapy
The recommended adult dosage of oral Da Fen Ke Quan (Da Fen Ke Quan hydrochloride) is 2 mg once daily or 1 mg twice daily. In the 2 mg once-daily regimen, two 1 mg tablets or 10 mL of Da Fen Ke Quan
Oral Solution (2 teaspoonfuls, equivalent to 2 mg of Da Fen Ke Quan) are given up to 1 hour before chemotherapy. In the 1 mg twice-daily regimen, the first 1 mg tablet or one teaspoonful (5 mL) of Da Fen Ke Quan
Oral Solution is given up to 1 hour before chemotherapy, and the second tablet or second teaspoonful (5 mL) of Da Fen Ke Quan
Oral Solution, 12 hours after the first. Either regimen is administered only on the day(s) chemotherapy is given. Continued treatment, while not on chemotherapy, has not been found to be useful.
Use in the Elderly, Renal Failure Patients or Hepatically Impaired Patients
No dosage adjustment is recommended.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Radiation (Either Total Body Irradiation or Fractionated Abdominal Radiation)
The recommended adult dosage of oral Da Fen Ke Quan is 2 mg once daily. Two 1 mg tablets or 10 mL of Da Fen Ke Quan
Oral Solution (2 teaspoonfuls, equivalent to 2 mg of Da Fen Ke Quan) are taken within 1 hour of radiation.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Use in the Elderly
No dosage adjustment is recommended.
More about Da Fen Ke Quan (Da Fen Ke Quan)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- 2 Reviews - Add your own review/rating
Consumer resources
- Da Fen Ke Quan
- Da Fen Ke Quan solution
- Da Fen Ke Quan tablets
- Da Fen Ke Quan (Advanced Reading)
- Other brands: Sancuso
Professional resources
- Da Fen Ke Quan (AHFS Monograph)
- Da Fen Ke Quan (FDA)
Related treatment guides
- Nausea/Vomiting, Chemotherapy Induced
- Nausea/Vomiting, Postoperative
- Nausea/Vomiting, Radiation Induced
Da Fen Ke Quan interactions
See also:
What other drugs will affect Da Fen Ke Quan?
Da Fen Ke Quan does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system in vitro. There have been no definitive drug-drug interaction studies to examine pharmacokinetic or pharmacodynamic interaction with other drugs; however, in humans, Da Fen Ke Quan (Da Fen Ke Quan) Injection has been safely administered with drugs representing benzodiazepines, neuroleptics, and anti-ulcer medications commonly prescribed with antiemetic treatments. Da Fen Ke Quan (Da Fen Ke Quan) Injection also does not appear to interact with emetogenic cancer chemotherapies. Because Da Fen Ke Quan is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of Da Fen Ke Quan. No specific interaction studies have been conducted in anesthetized patients. In addition, the activity of the cytochrome P-450 subfamily 3A4 (involved in the metabolism of some of the main narcotic analgesic agents) is not modified by Da Fen Ke Quan (Da Fen Ke Quan) in vitro.
In in vitro human microsomal studies, ketoconazole inhibited ring oxidation of Da Fen Ke Quan (Da Fen Ke Quan). However, the clinical significance of in vivo pharmacokinetic interactions with ketoconazole is not known. In a human pharmacokinetic study, hepatic enzyme induction with phenobarbital resulted in a 25% increase in total plasma clearance of intravenous Da Fen Ke Quan (Da Fen Ke Quan). The clinical significance of this change is not known.
QT prolongation has been reported with Da Fen Ke Quan (Da Fen Ke Quan). Use of Da Fen Ke Quan (Da Fen Ke Quan) in patients concurrently treated with drugs known to prolong the QT interval and/or are arrhythmogenic, this may result in clinical consequences.
Da Fen Ke Quan side effects
See also:
What are the possible side effects of Da Fen Ke Quan?
QT prolongation has been reported with Da Fen Ke Quan.
Chemotherapy-Induced Nausea and Vomiting
Over 3700 patients have received Da Fen Ke Quan (Da Fen Ke Quan) Tablets in clinical trials with emetogenic cancer therapies consisting primarily of cyclophosphamide or cisplatin regimens.
In patients receiving Da Fen Ke Quan (Da Fen Ke Quan) Tablets 1 mg bid for 1, 7 or 14 days, or 2 mg daily for 1 day, adverse experiences reported in more than 5% of the patients with comparator and placebo incidences are listed in Table 4.
Table 4 Principal Adverse Events in Clinical Trials Metoclopramide/dexamethasone and phenothiazines/dexamethasone
In the absence of a placebo group, there is uncertainty as to how many of these events should be attributed to Da Fen Ke Quan (Da Fen Ke Quan), except for headache, which was clearly more frequent than in comparison groups.
Radiation-Induced Nausea and Vomiting
In controlled clinical trials, the adverse events reported by patients receiving Da Fen Ke Quan (Da Fen Ke Quan) Tablets and concurrent radiation were similar to those reported by patients receiving Da Fen Ke Quan (Da Fen Ke Quan) Tablets prior to chemotherapy. The most frequently reported adverse events were diarrhea, asthenia, and constipation. Headache, however, was less prevalent in this patient population.
Postmarketing Experience
QT prolongation has been reported with Da Fen Ke Quan.
Da Fen Ke Quan contraindications
See also:
What is the most important information I should know about Da Fen Ke Quan?
You should not use this medication if you are allergic to Da Fen Ke Quan or to similar medicines such as dolasetron (Anzemet), ondansetron (Zofran), or palonosetron (Aloxi).
Before taking Da Fen Ke Quan, tell your doctor if you have liver disease, a heart rhythm disorder, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a personal or family history of Long QT syndrome.
Da Fen Ke Quan is usually started up to 1 hour before chemotherapy. Tell your doctor if you forget to take the medication within the specified amount of time before your procedure.
Active ingredient matches for Da Fen Ke Quan:
Granisetron in China.
List of Da Fen Ke Quan substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Da Sheng Xin Er (China) | |
| Degrani (Indonesia) | |
| Dialgyl (Greece) | |
| Em Ex (Egypt) | |
| Emegar (Czech Republic, Slovakia) | |
| EMEGRAN (India) | |
| 1 mg x 1 mL x 3ml (Biochem) | $ 0.76 |
| Emegran 1mg x 1mL INJ / 3ml (Biochem) | $ 0.76 |
| EMEGRAN inj 1 mg x 1 mL x 3ml (Biochem) | $ 0.76 |
| Emegran 1mg x 1mL INJ / 3ml (Biochem) | $ 0.76 |
| EMEGRAN 3 | |
| EMEGRAN 3 1MG INJECTION 1 vial / 3 ML injection each (Biochem Pharmaceutical Industries) | $ 0.74 |
| Emetril (Turkey) | |
| Eumetic (Argentina) | |
| Frezitron (Philippines) | |
| G Setron (Egypt) | |
| Ge Nai Ya (China) | |
| Ge Ou Shu (China) | |
| Ge Rui Tong (China) | |
| Gestranol (Georgia) | |
| Gomsetron (Vietnam) | |
| Gomsetron 1 mg/1 mL x 5 tube x 1 mL | |
| Gomsetron 3 mg/3 mL x 5 tube x 3 mL | |
| Graftor (Croatia (Hrvatska)) | |
| GRAITIC (India) | |
| 1 mg x 15ml (Alpha Aromatic) | $ 0.28 |
| Graitic 1mg SYR / 15ml (Alpha Aromatic) | $ 0.28 |
| GRAITIC syr 1 mg x 15ml (Alpha Aromatic) | $ 0.28 |
| Graitic 1mg SYR / 15ml (Alpha Aromatic) | $ 0.28 |
| Gramet (Indonesia) | |
| Grandem | |
| Grandem 1mg SYR / 10ml (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.23 |
| 1 mg x 10ml (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.23 |
| 1 mg x 1 mL x 1's (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.23 |
| 1 mg x 6's (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.34 |
| Grandem 2 mg Tablet (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.12 |
| Grandem 3 mg Injection (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.18 |
| Grandem 10 ml Syrup (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.12 |
| Grandem 1 mg Tablet (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.06 |
| Grandem 5 mg Injection (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.22 |
| Grandem 1mg x 1mL AMP / 1 (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.23 |
| Grandem 1mg FC-TAB / 6 (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.34 |
| GRANDEM 1 MG/ML INJECTION 1 vial / 3 ML injection each (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.81 |
| GRANDEM 1 MG SYRUP 1 bottle / 10 ML syrup each (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.35 |
| GRANDEM 1 MG TABLET 1 strip / 6 tablets each (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.41 |
| GRANDEM 1 MG TABLET MD 1 strip / 6 tablet mds each (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.45 |
| GRANDEM syr 1 mg x 10ml (Aristo Pharmaceuticals Pvt Ltd.) | $ 0.23 |
See 531 substitutes for Da Fen Ke Quan | |
References
- DailyMed. "GRANISETRON: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "granisetron". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "granisetron". http://www.drugbank.ca/drugs/DB00889 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Da Fen Ke Quan are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Da Fen Ke Quan. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
