• Dermozyme indications
• Uses of Dermozyme in details
• Dermozyme description
• Dermozyme dosage
• Dermozyme interactions
• Dermozyme side effects
• Dermozyme contraindications

What is Dermozyme?

Dermozyme is an antibiotic that fights bacteria in the body.

Dermozyme is used to reduce the risk of infection during surgery of your intestines. Dermozyme is also used to reduce the symptoms of hepatic coma.

Dermozyme may also be used for purposes not listed in this medication guide.

Dermozyme indications

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dermozyme Sulfate tablets and other antibacterial drugs, Dermozyme Sulfate tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Suppression of Intestinal Bacteria

Dermozyme Sulfate tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base.

Hepatic Coma (Portal-Systemic Encephalopathy)

Dermozyme Sulfate has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.

How should I use Dermozyme?

Use Dermozyme solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Dermozyme solution by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Take Dermozyme solution with plenty of water to avoid dehydration.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Take Dermozyme solution on a regular schedule to get the most benefit from it.
• To clear up your infection completely, use Dermozyme solution for the full course of treatment. Keep using it even if you feel better in a few days.
• If you miss a dose of Dermozyme solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.

Ask your health care provider any questions you may have about how to use Dermozyme solution.

Uses of Dermozyme in details

Oral Dermozyme is used before the operation of the gut to kill the bacteria which normally live in the gut that may cause a serious infection and in treatment of patients with coma due to liver disease (hepatic coma).

Dermozyme description

A component of Dermozyme that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Dermozyme is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.

Dermozyme dosage

Dermozyme Dosage

Generic name: Dermozyme SULFATE 87.5mg in 5mL

Dosage form: oral solution

See also:

• Dermozyme

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment for periods longer than two weeks is not recommended.

Hepatic coma

For use as an adjunct in the management of hepatic coma, the recommended dose is 4 to 12 grams per day given in the following regimen:

1. Withdraw protein from diet. Avoid use of diuretic agents.

2. Give supportive therapy including blood products, as indicated.

3. Give Dermozyme

   Oral Solution in doses of four to twelve grams of Dermozyme sulfate per day in divided doses.

   Treatment should be continued over a period of five to six days during which time protein should be returned incrementally to the diet.

4. If less potentially toxic drugs cannot be used for chronic hepatic insufficiency, Dermozyme sulfate in doses of up to four grams daily may be necessary. The risks for the development of Dermozyme induced toxicity progressively increase when the treatment must be extended to preserve the life of a patient with hepatic encephalopathy who has failed to fully respond. Frequent periodic monitoring of these patients to ascertain the presence of drug toxicity is mandatory. Also, Dermozyme serum concentrations should be monitored to avoid potentially toxic levels. The benefits to the patient should be weighed against the risks of nephrotoxicity, permanent ototoxicity and neuromuscular blockade following the accumulation of Dermozyme in the tissues.

More about Dermozyme (Dermozyme)

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Interactions
• Support Group
• En Espanol
• 0 Reviews - Add your own review/rating

Consumer resources

• Dermozyme solution
• Dermozyme
• Dermozyme (Advanced Reading)

• Other brands: Neo-Tab

Professional resources

• Dermozyme (FDA)
• Dermozyme Sulfate (AHFS Monograph)

Related treatment guides

• Bowel Preparation
• Diarrhea
• Hepatic Coma
• Hepatic Encephalopathy

Dermozyme interactions

See also:
What other drugs will affect Dermozyme?

Caution should be taken in concurrent or serial use of other neurotoxic and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of Dermozyme.

Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance Dermozyme's nephrotoxicity and/or ototoxicity and potentiate Dermozyme sulfate's neuromuscular blocking effects.

Oral Dermozyme inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.

Oral Dermozyme sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.

Dermozyme side effects

See also:
What are the possible side effects of Dermozyme?

Applies to Dermozyme: oral solution, oral tablet

In addition to its needed effects, some unwanted effects may be caused by Dermozyme (the active ingredient contained in Dermozyme). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Dermozyme:

Rare

• Any loss of hearing
• clumsiness
• diarrhea
• difficulty in breathing
• dizziness
• drowsiness
• greatly decreased frequency of urination or amount of urine
• increased amount of gas
• increased thirst
• light-colored, frothy, fatty-appearing stools
• ringing or buzzing or a feeling of fullness in the ears
• skin rash
• unsteadiness
• weakness

Minor Side Effects

Some of the side effects that can occur with Dermozyme may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

• Irritation or soreness of the mouth or rectal area
• nausea or vomiting

Dermozyme contraindications

See also:
What is the most important information I should know about Dermozyme?

You should not take this medicine if you are allergic to Dermozyme or similar antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), paromomycin (Humatin, Paromycin), streptomycin, or tobramycin (Nebcin, Tobi).

You should not take Dermozyme if you have ulcerative colitis, Crohn's disease, a blockage in your intestines, or other inflammatory bowel disease.

Do not use Dermozyme if you are pregnant. It could harm the unborn baby.

Before you take Dermozyme, tell your doctor if you have kidney disease, myasthenia gravis, or Parkinson's disease.

Never take Dermozyme in larger amounts than recommended, or for longer than 2 weeks. High doses or long-term use of Dermozyme can cause serious kidney problems, or hearing loss that may not be reversible. The longer you take Dermozyme, the more likely you are to develop these serious side effects.

To be sure this medication is not causing harmful effects, your kidney function, and your nerve and muscle function will need to be tested often. You may also need hearing tests. Dermozyme can have long lasting effects on your body. Do not miss any follow up visits to your doctor for blood or urine tests.

Dermozyme can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using Dermozyme, tell your doctor about all other medicines you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.

If you are being treated for hepatic coma, avoid eating foods that are high in protein. Follow your doctor's instructions about any other restrictions on food, beverages, or activity.

Active ingredient matches for Dermozyme:

Neomycin

Unit description / dosage (Manufacturer)	Price, USD
Dermozyme Skin 10 gm Ointment	$ 0.30
List of Dermozyme substitutes (brand and generic names):
Dermowin NM
Dermowin NM Skin 10 gm Cream (Wings Pharmaceuticals (P) Ltd.)	$ 0.14
Dexa N
Dexa N E/E Drop (Winmac Laboratories Limited)	$ 0.04
Dexalog N
Dexalog N Eye Drop (Prem Pharmaceuticals Ltd.)	$ 0.10
Diarcap (France)
Dibet N
Dibet N Skin 10 gm Cream (Neuron Pharma Pvt. Ltd.)	$ 0.02
Dimicina (Portugal)
Emorex N Berna (Switzerland)
Endomixin (Italy)
Endomycin (Ireland)
Enteromicina (Portugal)
Entocunimycine (France)
Escar-T (Peru)
Flumed N
Flumed N Skin 10 gm Cream (Mediwin Pharmaceuticals)	$ 0.24
Fluted (Taiwan)
Fluted 10 g
Fluted 100 g
Flutop N
Flutop N Skin 15 gm Cream (Novasearch Dermocare (Ultramark Healthcare Pvt Ltd))	$ 0.02
Fradiomycin (Japan)
Fradiomycin Nippon Kayaku (Japan)
Fradyl (Belgium)
Francetin (Japan)
Fraquinol
Gemicina (Mexico)
Izoneocol (Italy)
Klosoft N
Klosoft N Skin 15 gm Ointment (Sandoz Pvt.Ltd)	$ 0.29
KLOSOFT N 0.05%/0.5% CREAM 1 tube / 15 gm cream each (Sandoz Pvt.Ltd)	$ 0.29
Klosoft N 0.05%/5% Cream (Sandoz Pvt.Ltd)	$ 0.29
Kodakon (Mexico)
Lidamycin Creme
Lomicina (Brazil)
Myacine
Myacyne (Germany)
Myacyne Ointment
Ointment; Topical; Neomycin Sulfate
Mycifradin
Solution; Oral; Neomycin Sulfate 87.5 mg / 5 ml (Pharmacia upjohn)
Solution; Oral; Neomycin Sulfate 125 mg / 5 ml (Pharmacia upjohn)
Tablet; Oral; Neomycin Sulfate 350 mg (Pharmacia upjohn)
Mycifradin-N
Myneocin (Myanmar, Thailand)
Myneocin 350 mg x 100's (Greater pharma)
Myrosone (Taiwan)
Myrosone 3.5 mL
Myrosone 5 mL
Myrosone 6 mL
Myrosone 100 mL
N Bet
N Bet 5 ml Drop (Winmac Laboratories Limited)	$ 0.04
See 287 substitutes for Dermozyme

References

1. DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "neomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "neomycin". http://www.drugbank.ca/drugs/DB00452 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Dermozyme are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dermozyme. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology