Actions of Diclamin in details
Pharmacology: Diclamin HCl acts as a nonselective smooth muscle relaxant by: 1) A specific anticholinergic effect at the acetylcholine-receptor sites; and 2) Acting directly on the bradykinin- and histamine-induced spasm. Diclamin has little or no effect on gastric secretion.
Pharmacokinetics: Diclamin HCl is absorbed rapidly from the gastrointestinal tract, achieving peak plasma concentrations within 1-1.5 hrs after oral administration. Extensive tissue distribution is evident by its apparent volume of distribution which is 3.65 L/kg.
Plasma concentrations of Diclamin decline in a biphasic manner. The t½ of Diclamin in the initial distribution phase is about 1.8 hrs and the t½ in the terminal elimination phase is about 9-10 hrs. About 80% of a dose of Diclamin is eliminated in urine and about 10% in feces.
Diclamin administration
May be taken with or without food. May be taken before or after meals.
Diclamin pharmacology
Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
