Actions of Dopress in details
Description: Dopress (also known as dothiepin) is a TCA which inhibits norepinephrine and 5-hydroxytryptamine uptake from the nerve endings, thereby increases availability at central norepinephrine synapses. It has anticholinergic, antihistamine and central sedative properties.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Distribution: Enters breast milk (low concentration). Plasma protein binding: Approx 84% (as unchanged drug).
Metabolism: Extensively demethylated by first-pass hepatic metabolism to its primary active metabolite, desmethyldothiepin (northiaden).
Excretion: Via urine (mainly as metabolites); faeces (small amounts). Elimination half-life: Approx 14-24 hr (Dopress); 23-46 hr (metabolites).
Dopress administration
May be taken with or without food.
References
- NCIt. "Dopamine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Dopamine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Dopress are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dopress. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
2 consumers reported administration
When best can I take Dopress, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Dopress should be taken After food. In any case, this may not be the right description on how you ought to take this Dopress. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Dopress can be taken.
| Users | % | ||
|---|---|---|---|
| After food | 1 | 50.0% | |
| With a meal | 1 | 50.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
