What is Dulcolactol?
Dulcolactol is a type of sugar. It is broken down in the large intestine into mild acids that draw water into the colon, which helps soften the stools.
Dulcolactol is used to treat chronic constipation.
Dulcolactol is sometimes used to treat or prevent certain conditions of the brain that are caused by liver failure, which can lead to confusion, problems with memory or thinking, behavior changes, tremors, feeling irritable, sleep problems, loss of coordination, and loss of consciousness.
Dulcolactol may also be used for purposes not listed in this medication guide.
Dulcolactol indications
For the prevention and treatment of portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma.
Controlled studies have shown that Dulcolactol therapy reduces the blood ammonia levels by 25–50%; this is generally paralleled by an improvement in the patients' mental state and by an improvement in EEG patterns. The clinical response has been observed in about 75% of patients, which is at least as satisfactory as that resulting from neomycin therapy. An increase in patients' protein tolerance is also frequently observed with Dulcolactol solution therapy. In the treatment of chronic portal-systemic encephalopathy, Dulcolactol solution has been given for over 2 years in controlled studies.
How should I use Dulcolactol?
Use Dulcolactol crystals as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Dulcolactol crystals may be mixed with food, fruit juice, water, or milk. It also may be taken dry from a spoon and washed down with water, juice, or milk.
- Drink one or more 8-ounce glasses of liquid with each dose.
- If you miss a dose of Dulcolactol crystals and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Dulcolactol crystals.
Uses of Dulcolactol in details
This medication is a laxative used to treat constipation. It may help to increase the number of bowel movements per day and the number of days you have a bowel movement. Dulcolactol is a colonic acidifier that works by increasing stool water content and softening the stool. It is a man-made sugar solution.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug, but may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if has been so prescribed by your health care professional.
This drug is also used to treat or prevent complications of liver disease (hepatic encephalopathy).
How to use Dulcolactol
Take this medication by mouth, usually once daily for constipation, or as directed by your doctor. If you are taking the solution, to improve the taste, you may mix it into fruit juice, water, milk, or a soft dessert. If you are using the crystals in packets, dissolve the contents of the packet in half a glass of water (4 ounces or 120 milliliters), or as directed by your doctor.
Use this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. Dosage is based on your medical condition and response to therapy.
It may take up to 48 hours to have a bowel movement. Inform your doctor if your condition persists or worsens.
Dulcolactol description
Dulcolactol syrup, which contains Lactulose with other sugars eg, galactose and lactose, is used in the treatment of constipation and hepatic encephalopathy. Dulcolactol is a disaccharide, a sugar molecule composed of 2 smaller sugar molecules bonded together, in this case, fructose and galactose. Dulcolactol is a solid substance that is very soluble in water and has a sweet taste. It is sweeter than lactose but not as sweet as fructose. Chemically, Dulcolactol is also known as 4-O-β-D-galactopyranosyl-D-fructofuranose. The molecular formula is C12H22O11 with a molecular weight of 342.3 daltons.
Dulcolactol dosage
Dulcolactol Dosage
Generic name: Dulcolactol 10g in 15mL
Dosage form: oral solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Oral
Adult
The usual adult oral dosage is 30 to 45 mL (2 to 3 tablespoonfuls, containing 20 g to 30 g of Dulcolactol Solution) three or four times daily. The dosage may be adjusted every day or two to produce 2 or 3 soft stools daily.
Hourly doses of 30 to 45 mL of Dulcolactol Solution may be used to induce the rapid laxation indicated in the initial phase of the therapy of portal-systemic encephalopathy. When the laxative effect has been achieved, the dose of Dulcolactol Solution may then be reduced to the recommended daily dose. Improvement in the patient's condition may occur within 24 hours but may not begin before 48 hours or even later.
Continuous long-term therapy is indicated to lessen the severity and prevent the recurrence of portal-systemic encephalopathy. The dose of Dulcolactol Solution for this purpose is the same as the recommended daily dose.
Pediatric
Very little information on the use of Dulcolactol in pediatric patients has been recorded. As with adults, the subjective goal in proper treatment is to produce 2 to 3 soft stools daily. On the basis of information available, the recommended initial daily oral dose in infants is 2.5 to 10 mL in divided doses. For older pediatric patients, the total daily dose is 40 to 90 mL. If the initial dose causes diarrhea, the dose should be reduced immediately. If diarrhea persists, Dulcolactol Solution should be discontinued.
Rectal
When the adult patient is in the impending coma or coma stage of portal-systemic encephalopathy and the danger of aspiration exists, or when the necessary endoscopic or intubation procedures physically interfere with the administration of the recommended oral doses, Dulcolactol Solution may be given as a retention enema via a rectal balloon catheter. Cleansing enemas containing soapsuds or other alkaline agents should not be used.
Three hundred mL of Dulcolactol Solution should be mixed with 700 mL of water or physiologic saline and retained for 30 to 60 minutes. Dulcolactol Solution enema may be repeated every 4 to 6 hours. If the enema is inadvertently evacuated too promptly, it may be repeated immediately.
The goal of treatment is reversal of the coma stage in order that the patient may be able to take oral medication. Reversal of coma may take place within 2 hours of the first enema in some patients. Dulcolactol Solution, given orally in the recommended doses, should be started before Dulcolactol Solution by enema is stopped entirely.
More about Dulcolactol (Dulcolactol)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- 3 Reviews - Add your own review/rating
Consumer resources
- Dulcolactol solution
- Other brands: Enulose, Kristalose, Constulose
Professional resources
- Dulcolactol (FDA)
- Dulcolactol (AHFS Monograph)
Related treatment guides
- Constipation, Chronic
- Constipation, Acute
- Hepatic Encephalopathy
Dulcolactol interactions
See also:
What other drugs will affect Dulcolactol?
No laxative should be taken within 2 hrs of another medication because the desired effect of the other medication may be reduced.
Antacids: Antacids given concurrently with Dulcolactol may inhibit the desired Dulcolactol-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with Dulcolactol.
Neomycin: In some situations, neomycin administered together with Dulcolactol is more effective than either one alone.
Although, theoretically, the elimination of certain colonic bacteria by neomycin and possibly other anti-infective agents may interfere with the desired degradation of Dulcolactol and thus prevent the acidification of colonic contents. There have been some reports that Dulcolactol-fermenting bacteria are relatively resistant to neomycin, which may explain why a combination could work in some cases. The status of the Dulcolactol-treated patients should be closely monitored in the event of concomitant oral antibiotic therapy.
Dulcolactol side effects
See also:
What are the possible side effects of Dulcolactol?
Summary of the Safety Profile: Flatulence may occur during the 1st few days of treatment. As a rule, it disappears after a few days. When dosages higher than instructed are used, abdominal pain and diarrhea may occur. In such cases, the dosage should be decreased.
If high doses (normally only associated with, hepatic encephalopathy or portal systemic encephalopathy) are used for an extended period of time, the patient may experience an electrolyte imbalance due to diarrhea.
List of Adverse Reactions: The following undesirable effects have been experienced with the following indicated frequencies in Dulcolactol-treated patients in placebo-controlled clinical trials: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1000 to <1/100); rare (≥1/10,000 to <1/1000); very rare (<1/10,000). Gastrointestinal Disorders: Very Common: Diarrhea. Common: Flatulence, abdominal pain, nausea, vomiting.
Investigations: Uncommon: Electrolyte imbalance due to diarrhea.
Paediatric Population: The safety profile in children is expected to be similar as in adults.
Dulcolactol contraindications
See also:
What is the most important information I should know about Dulcolactol?
Since KRISTALOSE™ (D-Dulcolactol) for
Oral Solution contains galactose (less than 0.3 g/10 g as a total sum with lactose), it is contraindicated in patients who require a low galactose diet.
Active ingredient matches for Dulcolactol:
Lactulose in Indonesia.
| Unit description / dosage (Manufacturer) | Price, USD |
| Dulcolactol 10 g/15 mL x 60 mL x 1's | $ 4.94 |
List of Dulcolactol substitutes (brand and generic names): | |
| Dulax (Ireland) | |
| Dulax NA Syrup (Antigen) | $ 0.92 |
| Dulose (Australia) | |
| Duolax (Spain) | |
| Duphalac (Australia, Austria, Bahrain, Belgium, Bosnia & Herzegowina, Bulgaria, Chile, China, Croatia (Hrvatska), Czech Republic, Estonia, Finland, France, Georgia, Greece, Hong Kong, Hungary, India, Indonesia, Ireland, Italy, Latvia, Lithuania, Malaysia, Malta, Mexico, Myanmar, Netherlands, New Zealand, Norway, Oman, Peru, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Singapore, Slovakia, South Africa, South Korea, Spain, Sweden, Taiwan, Thailand, Tunisia, Turkey, United Kingdom, Vietnam) | |
| Powder; Oral; Lactulose 95 g / 100 g (Solvay Pharma India Pvt Ltd) | |
| Solution; Oral; Lactulose 10 g / 15 ml (Solvay Pharma India Pvt Ltd) | |
| Syrup; Oral; Lactulose 10 g / 15 ml (Solvay Pharma India Pvt Ltd) | |
| Duphalac 15ml - 10 Syrup (Solvay Pharma India Pvt Ltd) | $ 20.80 |
| Duphalac 6.7g/10ml-200ml - 1 Syrup (Solvay Pharma India Pvt Ltd) | $ 22.90 |
| Duphalac 6.7g/10ml-500ml - 1 Syrup (Solvay Pharma India Pvt Ltd) | $ 39.60 |
| DUPHALAC Liquid / 10gm per 15ml / 200ml units (Solvay Pharma India Pvt Ltd) | $ 1.79 |
| DUPHALAC Liquid / 10gm per 15ml / 100ml units (Solvay Pharma India Pvt Ltd) | $ 0.95 |
| DUPHALAC Liquid / 10gm per 15ml / 60ml units (Solvay Pharma India Pvt Ltd) | $ 0.55 |
| DUPHALAC Liquid / 10gm per 15ml / 450ml units (Solvay Pharma India Pvt Ltd) | $ 3.74 |
| Duphalac 3.35g/5ml LIQD / 100ml (Solvay Pharma India Pvt Ltd) | $ 0.99 |
| Duphalac 3.35g/5ml LIQD / 200ml (Solvay Pharma India Pvt Ltd) | $ 1.86 |
| Duphalac 3.35g/5ml LIQD / 450ml (Solvay Pharma India Pvt Ltd) | $ 3.89 |
| Duphalac 15 mL x 20 Packs (Solvay Pharma India Pvt Ltd) | |
| Duphalac 1 Bottle 200 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 1 Bottle 500 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 300 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 1 L (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 1 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 200 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 500 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 1000 mL (Solvay Pharma India Pvt Ltd) | |
| 3.35 g x 5 mL x 100ml (Solvay Pharma India Pvt Ltd) | $ 0.99 |
| 3.35 g x 5 mL x 200ml (Solvay Pharma India Pvt Ltd) | $ 1.86 |
| 3.35 g x 5 mL x 450ml (Solvay Pharma India Pvt Ltd) | $ 3.89 |
| Duphalac 3.3 g/5 mL x 45 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 3.3 g/5 mL x 120 mL (Solvay Pharma India Pvt Ltd) | $ 6.11 |
| Duphalac 67 % x 200 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac 10 g/15 mL x 100 mL (Solvay Pharma India Pvt Ltd) | |
| Duphalac / sachet 10 g/15 mL x 15 mL x 10's (Solvay Pharma India Pvt Ltd) | |
| Duphalac 3.35 g/5 mL x 120 mL (Solvay Pharma India Pvt Ltd) | $ 5.09 |
| Duphalac 67 % x 200 mL x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac 200 ml Suspension (Solvay Pharma India Pvt Ltd) | $ 0.05 |
| Duphalac 100 ml Suspension (Solvay Pharma India Pvt Ltd) | $ 0.05 |
| Duphalac 60 ml Suspension (Solvay Pharma India Pvt Ltd) | $ 0.05 |
| DUPHALAC 3.35GM/5ML ORAL SOLUTION 1 bottle / 450 ML oral solution each (Solvay Pharma India Pvt Ltd) | $ 5.58 |
| DUPHALAC 3.35GM/5ML ORAL SOLUTION 1 bottle / 250 ML oral solution each (Solvay Pharma India Pvt Ltd) | $ 3.10 |
| DUPHALAC 3.35GM/5ML ORAL SOLUTION 1 bottle / 150 ML oral solution each (Solvay Pharma India Pvt Ltd) | $ 1.86 |
| DUPHALAC ENEMA 3.35 GM/5ML SOLUTION 1 bottle / 300 ML solution each (Solvay Pharma India Pvt Ltd) | $ 3.72 |
| DUPHALAC FIBER 2.5 GM / 5ML SYRUP 1 bottle / 200 ML syrup each (Solvay Pharma India Pvt Ltd) | $ 2.48 |
| DUPHALAC FIBER 2.5 GM / 5ML SYRUP 1 bottle / 100 ML syrup each (Solvay Pharma India Pvt Ltd) | $ 1.24 |
| DUPHALAC oral liqd 3.35 g x 5 mL x 100ml (Solvay Pharma India Pvt Ltd) | $ 1.30 |
| DUPHALAC oral liqd 3.35 g x 5 mL x 200ml (Solvay Pharma India Pvt Ltd) | $ 2.23 |
| DUPHALAC oral liqd 3.35 g x 5 mL x 450ml (Solvay Pharma India Pvt Ltd) | $ 3.89 |
| DUPHALAC enema 20 % w/v x 300ml (Solvay Pharma India Pvt Ltd) | $ 4.64 |
| Duphalac syr 67 % 200 mL x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac oral soln 10 g/15 mL 15 mL x 20 x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac syr 10 g/15 mL 1 L x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac syr 10 g/15 mL / sachet 15 mL x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac syr 10 g/15 mL 100 mL x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac syr 10 g/15 mL 200 mL x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac oral soln 67 % 200 mL x 1's (Solvay Pharma India Pvt Ltd) | |
| Duphalac syr 3.3 g/5 mL 45 mL x 1's (Solvay Pharma India Pvt Ltd) | $ 3.24 |
| Duphalac syr 3.3 g/5 mL 120 mL x 1's (Solvay Pharma India Pvt Ltd) | $ 7.94 |
| Duphalac powder 95 g (Solvay Pharma India Pvt Ltd) | |
| Duphalac 3.35gm/5ml Solution (Solvay Pharma India Pvt Ltd) | $ 3.79 |
| Duphalac 2.5gm Oral Solution (Solvay Pharma India Pvt Ltd) | $ 2.53 |
| Duphalac 3.335gm Oral Solution (Solvay Pharma India Pvt Ltd) | $ 1.90 |
| Duphalac 10g/15ml (Luxembourg) | |
| Duphalac 66.5% (France) | |
| Duphalac 66.7g/100ml (Luxembourg) | |
| Duphalac 667 mg/ml (Hungary, Oman) | |
| Duphalac Dry | |
| Powder; Oral; Lactulose 950 mg / g | |
| Duphalac Dry powder 950 mg (Solvay Pharma Inc (Canada)) | |
| Duphalac Fruit | |
| Powder; Oral; Lactulose 95 g / 100 g | |
See 1224 substitutes for Dulcolactol | |
References
- DailyMed. "LACTULOSE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "lactulose". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "lactulose". http://www.drugbank.ca/drugs/DB00581 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Dulcolactol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dulcolactol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet4 consumers reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 1 | 25.0% | |
| 1-5 | 1 | 25.0% | |
| 16-29 | 1 | 25.0% | |
| 46-60 | 1 | 25.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
