Actions of Extodin in details
Description: Extodin is a selective α2-adrenoceptor agonist w/ anaesth and sedative properties. Its action is thought to be due to activation of G-proteins by α2a-adrenoceptors in the brainstem resulting in inhibition of norepinephrine release.
Onset: 5-10 min.
Duration: 60-120 min.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 15-30 min.
Distribution: Plasma protein binding: Approx 94%.
Metabolism: Almost completely metabolised via direct N-glucuronidation, N-methylation or aliphatic hydroxylation by CYP2A6 isoenzyme.
Excretion: Via urine (95%) and faeces (4%) mainly as metabolites. Terminal elimination half-life: Approx 2 hr.
How should I take Extodin?
Extodin is injected into a vein through an IV. A healthcare provider will give this injection.
Extodin is given using a continuous infusion device that slowly injects the medicine into the body. This type of infusion keeps the patient sedated around the clock.
The patient's breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while Extodin is given.
When Extodin is discontinued after long-term use over several days, the patient may have withdrawal symptoms. The most common withdrawal symptoms are nausea, vomiting, and agitation. The patient may also have rapid heartbeats and increased blood pressure.
Extodin administration
Administer using a controlled infusion device. Advisable to use administration components made with synthetic or coated natural rubber gaskets. If loading dose used, administer over 10 minutes; may extend to 20 minutes to further reduce vasoconstrictive effects. Titration no more frequently than every 30 minutes may reduce the incidence of hypotension when used for ICU sedation (Gerlach 2009).
Extodin pharmacology
Extodin activates 2-adrenoceptors, and causes the decrease of sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anesthesia and surgery; it reduces anesthetic and opioid requirements; and causes sedation and analgesia.
References
- NCIt. "Dexmedetomidine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Extodin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Extodin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
