What is Histodar?
Histodar is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Histodar is used to treat a cough.
Histodar will not treat a cough that is caused by smoking, asthma, or emphysema.
Histodar may also be used for purposes not listed in this medication guide.
Histodar indications
*Pholcodine is used to help stop coughing.
* It is a member of a group of drugs called anti-tussives, sometimes known as cough suppressants.
* In general this drug is used to relieve dry and tickly coughs that do not produce any mucus (phlegm).
* Benefits of being on this drug can include decreasing or stopping you coughing.
Listed below are the typical uses of Pholcodine:
* Relief of dry, tickly cough (does not produce any mucus (phlegm)) which is linked to an infection in your nose, sinuses or windpipe (upper respiratory tract).
How should I use Histodar?
Use Histodar as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Histodar by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Do not remove the strip from the pouch until you are ready to take Histodar. Be sure that your hands are dry when you touch the strip.
- Remove the strip from the pouch and place it onto the tongue. The strip dissolves quickly and can be swallowed with saliva. It may be taken with or without water.
- Use the strip right away after you open the pouch. Do not store it for future use.
- If you miss a dose of Histodar and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Histodar.
Uses of Histodar in details
This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (e.g., sinusitis, common cold). This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (e.g., chronic bronchitis, emphysema) unless directed by your doctor. This product contains Histodar. It is a cough suppressant that works by decreasing the feeling of needing to cough.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use Histodar
Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication. Do not use a household spoon because you may not get the correct dose. If you are taking a suspension, shake the product well before measuring out your dose.
Dosage is based on the product you are taking and your age, medical condition, and response to treatment. If you are using this medication for self-treatment (without a prescription from your doctor), follow the specific dosing instructions on the packaging to find the correct dose for your age.
If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Improper use of this medication (abuse) may result in serious harm (e.g., brain damage, seizure, death). Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.
Tell your doctor if your symptoms persist or worsen after more than 1 week or if you also have fever, chills, headache, or rash. These may be signs of a more serious condition.
Histodar description
The d-isomer of the codeine analog of levorphanol. Histodar shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Histodar dosage
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral, as hydrobromide:
Robafen Cough: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40]
Robitussin Lingering CoughGels: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, polyethylene glycol, propylene glycol]
Gel,
Oral, as hydrobromide:
ElixSure Cough: 7.5 mg/5 mL (120 mL) [alcohol free; contains carbomer 934p, propylene glycol, propylparaben; cherry bubblegum flavor]
Liquid,
Oral, as hydrobromide:
Buckleys Cough: 12.5 mg/5 mL (118 mL) [alcohol free, sugar free; contains butylparaben, menthol, propylparaben, saccharin sodium]
Little Colds Cough Formula: 7.5 mg/mL (30 mL) [alcohol free, dye free, saccharin free; contains sodium benzoate; grape flavor]
PediaCare Childrens Long-Act: 7.5 mg/5 mL (118 mL) [contains brilliant blue fcf (fd&c blue #1), saccharin sodium, sodium benzoate]
Robitussin Lingering LA Cough: 15 mg/5 mL (118 mL [DSC]) [contains alcohol, usp, fd&c red #40, menthol, saccharin sodium, sodium benzoate]
Histodar: 10 mg/5 mL (480 mL [DSC], 3780 mL [DSC]) [alcohol free, dye free, fructose free, sodium free, sorbitol free, sugar free]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL) [alcohol free, dye free, pseudoephedrine free; contains benzoic acid, propylene glycol]
Lozenge, Mouth/Throat, as hydrobromide:
Hold: 5 mg (10 ea)
Hold: 5 mg (10 ea) [cherry flavor]
Trocal Cough Suppressant: 7.5 mg (1 ea [DSC])
Strip,
Oral, as hydrobromide:
Triaminic Long Acting Cough: 7.5 mg (14 ea, 16 ea) [contains alcohol, usp, fd&c red #40; cherry flavor]
Triaminic Long Acting Cough: 7.5 mg (14 ea) [contains alcohol, usp, fd&c red #40, isopropyl alcohol]
Suspension Extended Release,
Oral:
Cough DM: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite; orange flavor]
Delsym: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), disodium edta, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; grape flavor]
Delsym: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; orange flavor]
Delsym Cough Childrens: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), edetate disodium, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; grape flavor]
Delsym Cough Childrens: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; orange flavor]
GoodSense Cough DM: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
GoodSense Cough DM Childrens: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL, 148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 (quinoline yellow), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough
Child: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Generic: Histodar polistirex [equivalent to Histodar 30 mg/5 mL] (89 mL)
Syrup,
Oral, as hydrobromide:
Creomulsion
Adult: 20 mg/15 mL (118 mL [DSC])
Creomulsion for Children: 5 mg/5 mL (118 mL [DSC]) [cherry flavor]
Robitussin Childrens Cough LA: 7.5 mg/5 mL (118 mL) [alcohol free; contains fd&c red #40, propylene glycol, saccharin sodium, sodium benzoate; fruit punch flavor]
Silphen DM Cough: 10 mg/5 mL (118 mL) [contains alcohol, usp; strawberry flavor]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL [DSC]) [alcohol free, dye free; contains benzoic acid, edetate disodium, propylene glycol]
Dosing: Adult
Cough suppressant:
Oral: 10 to 20 mg every 4 hours
or 20 to 30 mg every 6 to 8 hours; extended release: 60 mg twice daily; maximum: 120 mg/24 hours
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Note: Safety and efficacy for the use of cough and cold products in infants and young children limited; the AAP warns against the use of these products for respiratory illnesses in infants and young children (AAP 2018; FDA 2017).
Cough suppressant:
Oral:
Oral syrup (immediate release):
Children 2 to <6 years: 5 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children 6 to <12 years: 10 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children ≥12 years and Adolescents: 20 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Long-acting liquid: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Oral capsule: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Extended-release suspension (Histodar polistirex):
Children 4 to <6 years: 15 mg every 12 hours as needed; do not exceed 30 mg in 24 hours.
Children 6 to <12 years: 30 mg every 12 hours as needed; do not exceed 60 mg in 24 hours.
Children ≥12 years and Adolescents: 60 mg every 12 hours as needed; do not exceed 120 mg in 24 hours.
Histodar interactions
See also:
What other drugs will affect Histodar?
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.
This drug should not be used with the following medications because very serious, possibly fatal interactions may occur: Monoamine Oxidase Inhibitors (MAOIs).
If you are currently using any such medicine, tell your doctor or pharmacist before starting Pholcodine.
Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of:
* CNS depressants e.g. hypnotics (sleeping tablets including barbiturates)
* Minor tranquillisers (drugs used to relax muscles or decrease anxiety)
* Opioid analgesics (drugs used to relieve pain e.g. codeine, tramadol, morphine)
* Tricyclic antidepressants (drugs to treat mood disorders)
* Phenothiazine (drug used to treat mood disorders)
* Diuretics (water pills used for high blood pressure)
* Antihypertensives (drugs used to treat high blood pressure and other conditions)
* Neuromuscular blocking agents (anaesthetics used during surgery)
* Any other cough or cold medicines
Histodar side effects
See also:
What are the possible side effects of Histodar?
If any of these persist or you consider them severe then inform your doctor or pharmacist.
Tell your doctor immediately if you develop any of the following symptoms: sudden wheeziness; difficulty in breathing.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
Histodar contraindications
See also:
What is the most important information I should know about Histodar?
This medication is not recommended cons in the following situations:
- Hypersensitivity to any component of the syrup,
- Respiratory failure,
- Cough in asthmatic
- Breastfeeding: pholcodine passes into breast milk with codeine, some cases of hypotonia and respiratory pauses were described in infants after ingestion by mothers of supratherapeutic doses of codeine. If breastfeeding, and by extrapolation of codeine, this medication is given cons-
Due to the presence of sucrose, this drug is cons-indicated in cases of fructose intolerance, malabsorption of glucose and galactose or sucrase-isomaltase.
Active ingredient matches for Histodar:
Unit description / dosage (Manufacturer) | Price, USD |
Histodar 100 ml Syrup | $ 0.03 |
List of Histodar substitutes (brand and generic names): | |
Fluditec toux sèche (France) | |
Solution; Oral; Dextromethorphan Hydrobromide 7.5 mg / 5 ml (Innotech) | |
Humex pro deti (Czech Republic) | |
Humex toux sèche dextromethorphane (France) | |
Syrup; Oral; Dextromethorphan Hydrobromide 20 mg / 5 ml (Urgo) | |
Syrup; Oral; Dextromethorphan Hydrobromide 5 mg / 5 ml (Urgo) | |
Inokoff | |
Inokoff 100 ml Syrup (H.L.Healthcare Pvt. Ltd.) | $ 0.03 |
Jack + jill thin strips cough (Canada) | |
Kamex Plus | |
Kamex Plus 100 ml Expectorant (Kamakshi Drugs & Pharmaceuticals) | $ 0.02 |
Koycal | |
Koycal 100 ml Syrup (Eoan Pharma) | $ 0.02 |
Kufcol D | |
Kufcol D 100 ml Syrup (Rockstar Pharma (group of Athens Labs)) | $ 0.03 |
Kufcol D 60 ml Syrup (Rockstar Pharma (group of Athens Labs)) | $ 0.03 |
Kuff D NF | |
Kuff D NF 100 ml Syrup (Intas Laboratories Pvt Ltd) | $ 0.03 |
Kuff D NF 50 ml Syrup (Intas Laboratories Pvt Ltd) | $ 0.04 |
M&B (India) | |
100ml (AHPL) | $ 0.34 |
M&B Dextromethorphan hydrobromide7.5 mg, pseudoephedrinehydrochloride 15 mg, guaifenesin 50 mg. SYR / 100ml (AHPL) | $ 0.34 |
M&B syr 100ml (AHPL) | $ 0.34 |
Neo citran cough (Canada) | |
Notuxal (Belgium) | |
Oktus D | |
Oktus D 100 ml Syrup (Sapient Laboratories Pvt Ltd) | $ 0.02 |
Rami-dextromethorfan (Netherlands) | |
Robitussin dm coughgels (Canada) | |
Robitussin for Dry Coughs (United Kingdom) | |
Sancoff D | |
Sancoff D 100 ml Syrup (Santo Formulations) | $ 0.02 |
Sedorex DX | |
Sedorex DX 50 ml Expectorant (Embiotic Laboratories (P) Ltd.) | $ 0.03 |
Sedorex DX 100 ml Expectorant (Embiotic Laboratories (P) Ltd.) | $ 0.02 |
SEDOREX DX 10MG/4MG SYRUP 1 bottle / 100 ML syrup each (Embiotic Laboratories (P) Ltd.) | $ 0.87 |
Sedorex DX 10 mg/4 mg Syrup (Embiotic Laboratories (P) Ltd.) | $ 0.87 |
Soludril antiussivum (Belgium) | |
St joseph cough suppressant (United States) | |
Sucrets dm (United States) | |
Suprekof dm (Philippines) | |
Throatsil-dex (Thailand) | |
Trussex DMR Tablet | |
Trussex DMR Tablet (Hamax Pharmaceuticals) | $ 0.04 |
Tusq D Cough | |
Tusq D Cough Mouth/Throat Lozenges (Blue Cross Laboratories Ltd.) | $ 0.05 |
Tussalpront (Switzerland) | |
TUSSILAR | |
Vicks children`s cough syrup (Canada) | |
Vicks Cough Syrup with Honey for Dry Coughs (United Kingdom) | |
Vicks toux sèche (France) | |
Vicks vaposyrup toux sèche (France) | |
Syrup; Oral; Dextromethorphan Hydrobromide (Lachartre) | |
XL 90 Cofgels | |
XL 90 Cofgels 10+100+2 Capsule (DWD Pharmaceuticals Ltd.) | $ 0.04 |
Yoyo DX | |
Yoyo DX 100 ml Syrup (Slaney Healthcare Pvt. Ltd.) | $ 0.03 |
See 64 substitutes for Histodar |
References
- DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "dextromethorphan". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "dextromethorphan". http://www.drugbank.ca/drugs/DB00514 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Histodar are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Histodar. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology