• Hydrochlorothiazide indications
• Uses of Hydrochlorothiazide in details
• Hydrochlorothiazide description
• Hydrochlorothiazide dosage
• Hydrochlorothiazide interactions
• Hydrochlorothiazide side effects
• Hydrochlorothiazide contraindications

What is Hydrochlorothiazide?

Hydrochlorothiazide is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Hydrochlorothiazide is also used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a steroid or hormone medicine.

Hydrochlorothiazide is a thiazide diuretic (water pill). It is used to help reduce the amount of water in the body by increasing the flow of urine. It may also be used for other conditions as determined by your doctor.

Hydrochlorothiazide is available only with your doctor's prescription.

Hydrochlorothiazide indications

Hydrochlorothiazide Capsules are indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other antihypertensives. Unlike potassium sparing combination diuretic products, Hydrochlorothiazide Capsules may be used in those patients in whom the development of hyperkalemia cannot be risked, including patients taking ACE inhibitors.

Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances this edema may cause extreme discomfort which is not relieved by rest. In these cases a short course of diuretics may provide relief and may be appropriate.

How should I use Hydrochlorothiazide?

Use Hydrochlorothiazide capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Hydrochlorothiazide capsules by mouth with or without food.
• If you take colestipol or cholestyramine for high cholesterol, ask your doctor or pharmacist how to take it with Hydrochlorothiazide capsules.
• Hydrochlorothiazide capsules may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
• If you miss a dose of Hydrochlorothiazide capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrochlorothiazide capsules.

Uses of Hydrochlorothiazide in details

This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra salt and water.

This medication also reduces extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, or kidney disease. This can lessen symptoms such as shortness of breath or swelling in your ankles or feet.

How to use Hydrochlorothiazide

Take this medication by mouth as directed by your doctor, usually once daily in the morning with or without food. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Cholestyramine and colestipol can decrease the absorption of Hydrochlorothiazide. If you are taking either of these drugs, take them at least 4 hours before or after taking Hydrochlorothiazide.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings increase).

Hydrochlorothiazide description

Each film-coated tablet contains losartan potassium 50 mg and Hydrochlorothiazide 12.5 mg.

Losartan potassium is 2-Butyl-4-chloro-1-[p-o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol, potassium. Its empirical formula is C₂₂H₂₂ClKN₆O and molecular weight is 461.

Hydrochlorothiazide is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C₇H₈ClN₃O₄S₂ and molecular weight is 297.7.

Hydrochlorothiazide dosage

Hydrochlorothiazide Dosage

Generic name: Hydrochlorothiazide 12.5mg

Dosage form: capsule, gelatin coated

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

For Control of Hypertension: The adult initial dose of Hydrochlorothiazide is one capsule given once daily whether given alone or in combination with other antihypertensives. Total daily doses greater than 50 mg are not recommended.

More about Hydrochlorothiazide (Hydrochlorothiazide)

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• During Pregnancy or Breastfeeding
• Dosage Information
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• Drug Interactions
• Support Group
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• En Espanol
• 0 Reviews - Add your own review/rating
• Generic Availability

Consumer resources

• Hydrochlorothiazide
• Hydrochlorothiazide (Advanced Reading)

• Other brands: Aquazide H

Professional resources

• Hydrochlorothiazide (AHFS Monograph)
• Hydrochlorothiazide (FDA)

Related treatment guides

• Diabetes Insipidus
• Edema
• High Blood Pressure
• Nephrocalcinosis
• Osteoporosis

Hydrochlorothiazide interactions

See also:
What other drugs will affect Hydrochlorothiazide?

DIAMOX®. modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy.

By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.

Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable.

Hydrochlorothiazide may increase the effects of other folic acid antagonists.

Hydrochlorothiazide may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents.

Hydrochlorothiazide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.

Hydrochlorothiazide reduces urinary excretion of quinidine and may enhance its effect.

Hydrochlorothiazide may prevent the urinary antiseptic effect of methenamine.

Hydrochlorothiazide increases lithium excretion and the lithium may be decreased.

Hydrochlorothiazide and sodium bicarbonate used concurrently increases the risk of renal calculus formation.

Hydrochlorothiazide may elevate cyclosporine levels.

Hydrochlorothiazide side effects

See also:
What are the possible side effects of Hydrochlorothiazide?

The adverse reactions associated with Hydrochlorothiazide have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg Hydrochlorothiazide once daily were comparable to placebo. The following adverse reactions have been reported for doses of Hydrochlorothiazide 25 mg and greater and, within each category, are listed in the order of decreasing severity.

Body as a whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic: Electrolyte imbalance, hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal: Muscle Spasm.

Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis.

Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.

Special Senses: Transient blurred vision, xanthopsia.

Urogenital: Impotence.

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.

Hydrochlorothiazide contraindications

See also:
What is the most important information I should know about Hydrochlorothiazide?

You should not use this medication if you are allergic to Hydrochlorothiazide or if you are unable to urinate.

Before using this medication, tell your doctor if you have liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs or penicillin.

Avoid drinking alcohol, which can increase some of the side effects of Hydrochlorothiazide.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

There are many other drugs that can interact with Hydrochlorothiazide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Active ingredient matches for Hydrochlorothiazide:

Hydrochlorothiazide

Unit description / dosage (Manufacturer)	Price, USD
Tablet; Oral; Hydrochlorothiazide 25 mg
Tablet; Oral; Hydrochlorothiazide 50 mg
Capsule; Oral; Hydrochlorothiazide 12.5 mg
Tablet; Oral; Hydrochlorothiazide 100 mg
Tablet; Oral; Hydrochlorothiazide 12.5 mg
Solution; Oral; Hydrochlorothiazide 50 mg / 5 ml
Capsule; Oral; Hydrochlorothiazide 100 mg
Capsule; Oral; Hydrochlorothiazide 25 mg
Niferex-150 Forte 100 80-70 mg capsule Box	$ 109.86
Niferex 100 mg/5ml Elixir 236ml Bottle	$ 80.55
Niferex 100 40-20 mg capsule Box	$ 77.99
Capozide 50-25 mg tablet	$ 3.63
Ziac 10-6.25 mg tablet	$ 3.60
Ziac 2.5-6.25 mg tablet	$ 3.60
Ziac 5-6.25 mg tablet	$ 3.60
Capozide 50-15 tablet	$ 3.49
Capozide 50-25 tablet	$ 3.49
Capozide 50-15 mg tablet	$ 2.59
Lotensin 20 mg tablet	$ 2.25
Lotensin 10 mg tablet	$ 2.09
Lotensin 40 mg tablet	$ 2.09
Lotensin 5 mg tablet	$ 2.09
Accuretic 20-12.5 mg tablet	$ 2.04
Capozide 25-15 tablet	$ 2.03
Capozide 25-25 tablet	$ 2.03
Accuretic 10-12.5 mg tablet	$ 2.00
Accuretic 20-25 mg tablet	$ 2.00
Lotensin HCT 20-12.5 mg tablet	$ 1.97
Lotensin HCT 10-12.5 mg tablet	$ 1.95
Lotensin HCT 20-25 mg tablet	$ 1.94
Lotensin hct 10-12.5 tablet	$ 1.90
Lotensin hct 20-12.5 tablet	$ 1.90
Lotensin hct 20-25 tablet	$ 1.90
Lotensin hct 5-6.25 tablet	$ 1.90
Niferex-150 150-50-50 mg capsule	$ 1.62
Capozide 25-15 mg tablet	$ 1.51
Lotensin HCT 5-6.25 mg tablet	$ 1.31
Hydrochlorothiazide powder	$ 1.10
Hydrochlorothiazide 12.5 mg tablet	$ 0.82
Moduretic 5-50 mg tablet	$ 0.68
Hydrochlorothiazide 12.5 mg capsule	$ 0.50
Hydrochlorothiazide 50 mg tablet	$ 0.16
Apo-Hydro 100 mg Tablet	$ 0.13
Hydrochlorothiazide 25 mg tablet	$ 0.11
Apo-Hydro 50 mg Tablet	$ 0.06
Novo-Hydrazide 50 mg Tablet	$ 0.06
Apo-Hydro 25 mg Tablet	$ 0.04
Novo-Hydrazide 25 mg Tablet	$ 0.04
Hydrochlorothiazide / N.C.P. 25 mg
Hydrochlorothiazide / Jen Sheng 25 mg
Hydrochlorothiazide / Shinlon 25 mg
Hydrochlorothiazide / VPP 50 mg x 1000's
Hydrochlorothiazide / VPP 50 mg x 100 x 10's
Tablets; Oral; Hydrochlorothiazide 25 mg
Tablets; Oral; Hydrochlorothiazide 50 mg
Capsules; Oral; Hydrochlorothiazide 12.5 mg
Tablets; Oral; Hydrochlorothiazide 100 mg
Tablets; Oral; Hydrochlorothiazide 12.5 mg
Capsules; Oral; Hydrochlorothiazide 100 mg
Capsules; Oral; Hydrochlorothiazide 25 mg
Hydrochlorothiazide capsule, gelatin coated 12.5 mg/1 (REMEDYREPACK INC. (US))
Hydrochlorothiazide tablet 50 mg (Sanis Health Inc (Canada))
Hydrochlorothiazide tablet 25 mg (Sanis Health Inc (Canada))
Hydrochlorothiazide tablet 25 mg/1 (Blenheim Pharmacal, Inc. (US))
Hydrochlorothiazide tablet 12.5 mg/1 (REMEDYREPACK INC. (US))
Hydrochlorothiazide capsule 12.5 mg/1 (REMEDYREPACK INC. (US))
Hydrochlorothiazide tablet 50 mg/1 (Pd Rx Pharmaceuticals, Inc. (US))
Hydrochlorothiazide tablet 50 mg/50mg (Westminster Pharmaceuticals, Llc (US))
Hydrochlorothiazide tablet 25 mg/25mg (Westminster Pharmaceuticals, Llc (US))
List of Hydrochlorothiazide substitutes (brand and generic names):
Hydrochlorothiazid Léčiva (Czech Republic, Slovakia)
Hydrochlorothiazide - Sine (China)
HYDROCHLOROTHIAZIDE 50MG TAB
Hydrochlorothiazide Accord Healthcare (United States)
Hydrochlorothiazide Actavis (United States)
Hydrochlorothiazide Alembic (United States)
Hydrochlorothiazide Apotex (United States)
Hydrochlorothiazide Aurobindo (United States)
Hydrochlorothiazide Capsules
Hydrochlorothiazide Caraco (United States)
Hydrochlorothiazide Dava (United States)
Hydrochlorothiazide DHA (Malaysia)
Hydrochlorothiazide DHA 50 mg x 1000's (DHA)
Hydrochlorothiazide DHA tab 50 mg 1000's (DHA)
Hydrochlorothiazide DHA tab 50 mg 3 x 10's (DHA)
Hydrochlorothiazide Excellium (United States)
Hydrochlorothiazide GPO (Thailand)
Hydrochlorothiazide GPO 25 mg x 50 x 10's
Hydrochlorothiazide GPO 50 mg x 50 x 10's
Hydrochlorothiazide Heritage (United States)
Hydrochlorothiazide Intensol
Solution; Oral; Hydrochlorothiazide 100 mg / ml
Hydrochlorothiazide Ipca (United States)
Hydrochlorothiazide Ivax (United States)
Hydrochlorothiazide JSC Schelkovo (Vietnam)
Hydrochlorothiazide JSC Schelkovo 25 mg x 2 Blister x 10 Tablet
Hydrochlorothiazide JSC Schelkovo 100 mg x 2 Blister x 10 Tablet
Hydrochlorothiazide Jubilant (United States)
Hydrochlorothiazide Kausikh (Myanmar)
Hydrochlorothiazide Lannett (United States)
Hydrochlorothiazide Micro Labs (Georgia)
Hydrochlorothiazide Mylan (United States)
Hydrochlorothiazide OD (Japan)
Hydrochlorothiazide OD Towa (Japan)
Hydrochlorothiazide Orifarm (Norway, Sweden)
Hydrochlorothiazide Orion (Denmark, Norway)
Hydrochlorothiazide Pro Doc (Canada)
Hydrochlorothiazide Remedica (Cyprus)
Hydrochlorothiazide Rup Borisov (Georgia)
Hydrochlorothiazide Sanis Health (Canada)
Hydrochlorothiazide Solution
Hydrochlorothiazide T.O. (Thailand)
Hydrochlorothiazide T.O. 50 mg x 100 x 10's
Hydrochlorothiazide T.O. 50 mg x 1, 000's
Hydrochlorothiazide Towa (Japan)
Hydrochlorothiazide Unichem (United States)
Hydrochlorothiazide Union Drug (Thailand)
Hydrochlorothiazide Union Drug 50 mg x 1, 000's	$ 6.06
See 878 substitutes for Hydrochlorothiazide

References

1. DailyMed. "AMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "hydrochlorothiazide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "hydrochlorothiazide". http://www.drugbank.ca/drugs/DB00999 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Hydrochlorothiazide are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hydrochlorothiazide. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology