Irifone Gel indications
Irifone Gel is a drug used for joint and muscular pain.
Irifone Gel description
Irifone Gel is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
Irifone Gel dosage
When Irifone Gel administered orally for replacement therapy in adults the initial dose is 20-30 mg, maintenance dose is 10.5 mg / day. If necessary, the initial dose is may be 15-100 mg / day, the maintenance one is 5-15 mg / day. The daily dose should be reduced gradually. For children the starting dose is 1-2 mg / kg in 4-6 receptions, the maintenance one is 300-600 mg / kg / day.
For IM or IV dose administration the multiplicity and duration of application are determined individually.
When intra-articular administration in large joints it used a dose of 25-50 mg, for medium-sized joints - 10-25 mg for small joints - 5-10 mg. For the introduction of infiltration into the tissues depending on disease severity and magnitude of the defeat use doses from 5 mg to 50 mg.
Irifone Gel used topically in ophthalmology 3 times / day, course of treatment is no more than 14 days; in dermatology - 1-3 times / day.
Irifone Gel interactions
When this drug applied simultaneously with:
- digoxin slightly increased concentration of digoxin in plasma.
- itraconazole greatly increases the concentration of atorvastatin in plasma, apparently due to inhibition of itraconazole its metabolism in the liver that occurs with the participation of isoenzyme CYP3A4; increased risk of myopathy.
- colestipol may decrease the concentration of atorvastatin in plasma, with lipid-lowering effect is enhanced.
- antacids containing magnesium hydroxide and aluminum hydroxide, reduce the concentration of atorvastatin by approximately 35%.
- cyclosporine, fibrates (including gemfibrozil), azole antifungals derivatives, nicotinic acid increases the risk of myopathy.
- erythromycin, clarithromycin moderately increased concentrations of atorvastatin in plasma, increases the risk of myopathy.
- ethinyl estradiol, norethisterone (norethindrone) slightly increases the concentration of ethinyl estradiol, norethisterone and (norethindrone) in blood plasma.
- protease inhibitors increases the concentration of Eto in plasma, as protease inhibitors are inhibitors of the CYP3A4 isoenzyme.
Diltiazem, verapamil, isradipine inhibit isoenzyme CYP3A4, which participates in the metabolism of Eto, so that while the use of these calcium channel blockers may increase the concentration of atorvastatin in plasma and increased risk of myopathy.
Irifone Gel side effects
Endocrine system: menstrual irregularities, suppression of adrenal function, Itsenko-Cushing's syndrome, suppression of pituitary-adrenal system, reduced tolerance to carbohydrates, steroid diabetes, or a manifestation of latent diabetes, growth retardation in children, delayed sexual development in children.
Digestive system: nausea, vomiting, steroid ulcer and duodenal ulcer, pancreatitis, esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, flatulence, hiccups. In rare cases - elevated liver transaminases and alkaline phosphatase.
Metabolism: the negative nitrogen balance due to protein catabolism, increased excretion of calcium from the body, hypocalcemia, weight gain, increased sweating.
Cardiovascular system: the loss of potassium, hypokalemic alkalosis, arrhythmia, bradycardia (up to cardiac arrest); steroid myopathy, heart failure (the development or worsening of symptoms), ECG changes typical of hypokalemia, increased blood pressure, hypercoagulability, thrombosis. In patients with acute myocardial infarction - the spread of necrosis, slowing the formation of scar tissue that can lead to rupture of the heart muscle.
Musculoskeletal system: slowing growth and ossification processes in children (premature closure of epiphyseal growth zones) and osteoporosis (very rarely - pathological fractures, aseptic necrosis of the humeral head and femoral), rupture of tendons of muscles, muscle weakness, steroid myopathy, loss of muscle mass (atrophy).
CNS: headache, increased intracranial pressure, delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor cerebellum, and seizures.
Vision: the rear subcapsular cataracts, increased intraocular pressure (with the possible damage to the optic nerve), trophic changes of the cornea, exophthalmos, the propensity to develop secondary infections (bacterial, fungal, viral).
Dermatological reactions: petechiae, ecchymosis, thinning and fragility of the skin, hyper- or hypopigmentation, acne, stretch marks, susceptibility to the development of pyoderma and candidiasis.
Reactions due to immunosuppressive effect: slow process of regeneration, reduced resistance to infections.
For parenteral administration: in rare cases of anaphylactic and allergic reactions, hyper- or hypopigmentation, atrophy of skin and subcutaneous tissue, exacerbation after intrasinovialnogo applications such as Charcot arthropathy, sterile abscesses, when injected into pockets on the head - blindness.
Irifone Gel contraindications
Active ingredient matches for Irifone Gel:
Etofenamate in Vietnam.
| Unit description / dosage (Manufacturer) | Price, USD |
| Irifone Gel 1 tube 100 g | |
| Irifone Gel 1 tube 50 g | |
| Irifone Gel 50 mg/1 g x 1 tube 100 g | |
| Irifone Gel 50 mg/1 g x 1 tube 50 g | |
List of Irifone Gel substitutes (brand and generic names): | |
| Irifone 5% (Greece) | |
| Juve (Bosnia & Herzegowina) | |
| Kovotherm (Greece) | |
| Master-Gel (Chile) | |
| Gel; Topical; Etofenamate (Master) | |
| Melferut (Greece) | |
| Melferut 10% (Greece) | |
| Metotrop (Mexico) | |
| Nisolon (Taiwan) | |
| Nisolon 50 mg/1 g x 10 g (CCM Duopharma BioTech) | |
| Nisolon 50 mg/1 g x 15 g (CCM Duopharma BioTech) | |
| Nisolon 100 mg/1 g (CCM Duopharma BioTech) | |
| Nisolon 100 mg/1 g x 10 g (CCM Duopharma BioTech) | |
| Nisolon 100 mg/1 g x 15 g (CCM Duopharma BioTech) | |
| Nisolon 5 mg x 1000's (CCM Duopharma BioTech) | |
| Nisolon tab 5 mg 1000's (CCM Duopharma BioTech) | |
| Painex (Bangladesh, Portugal, Turkey) | |
| Tablet; Oral; Aspirin 375 mg; Caffeine Citrate 30 mg; Codeine Phosphate 15 mg (Mint) | |
| Tablet; Oral; Aspirin 375 mg; Caffeine Citrate 30 mg; Codeine Phosphate 30 mg (Mint) | |
| 100 mg x 2mlx10 (Mint) | |
| Painex 100mg INJ / 2mlx10 (Mint) | |
| PAINEX inj 100 mg x 2ml (Mint) | |
| Painex NA Gel (Mint) | $ 0.66 |
| PAİNEX | |
| Tablet; Oral; Aspirin 375 mg; Caffeine Citrate 30 mg; Codeine Phosphate 15 mg | |
| Tablet; Oral; Aspirin 375 mg; Caffeine Citrate 30 mg; Codeine Phosphate 30 mg | |
| 100 mg x 2mlx10 | |
| Painex 100mg INJ / 2mlx10 | |
| PAINEX inj 100 mg x 2ml (Mint) | |
| Painex NA Gel (Arehk Healthcare) | $ 0.66 |
| Tablet; Oral; Aspirin 375 mg; Caffeine Citrate 30 mg; Codeine Phosphate 15 mg | |
| Tablet; Oral; Aspirin 375 mg; Caffeine Citrate 30 mg; Codeine Phosphate 30 mg | |
| 100 mg x 2mlx10 | |
| Painex 100mg INJ / 2mlx10 | |
| PAINEX inj 100 mg x 2ml (Mint) | |
| Painex NA Gel (Arehk Healthcare) | $ 0.66 |
| Pazergicel (Greece) | |
| Radermin (Greece) | |
| Relex (Taiwan) | |
| Relex 50 mg/1 g x 10 g x 50's | |
| Relex 50 mg/1 g x 20 g x 50's | |
| Relex 50 mg/1 g x 40 g x 50's | |
| Relex 100 mg/1 g x 50 g | |
| Restafen (Turkey) | |
| Reumadol (Georgia) | |
| Reumagel (Mexico) | |
| Reumina (Greece) | |
See 168 substitutes for Irifone Gel | |
References
- PubChem. "ETOFENAMATE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Etofenamate". http://www.drugbank.ca/drugs/DB08984 (accessed September 17, 2018).
- MeSH. "Anti-Inflammatory Agents, Non-Steroidal". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Irifone Gel are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Irifone Gel. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
4 consumers reported useful
Was the Irifone Gel drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 4 | 100.0% | |
8 consumers reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Irifone Gel drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 5 | 62.5% | |
| Expensive | 3 | 37.5% | |
1 consumer reported time for results
To what extent do I have to use Irifone Gel before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Irifone Gel. To get the time effectiveness of using Irifone Gel drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 1 | 100.0% | |
25 consumers reported age
| Users | % | ||
|---|---|---|---|
| 16-29 | 10 | 40.0% | |
| > 60 | 5 | 20.0% | |
| 30-45 | 5 | 20.0% | |
| 46-60 | 3 | 12.0% | |
| 1-5 | 1 | 4.0% | |
| 6-15 | 1 | 4.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
