What is Lentisulin HPI?
Lentisulin HPI is one of many hormones that helps the body turn the food we eat into energy. Also, Lentisulin HPI helps us store energy that we can use later. After we eat, Lentisulin HPI works by causing sugar (glucose) to go from the blood into our body's cells to make fat, sugar, and protein. When we need more energy between meals, Lentisulin HPI will help us use the fat, sugar, and protein that we have stored. This occurs whether we make our own Lentisulin HPI in the pancreas gland or take it by injection.
Diabetes mellitus (sugar diabetes) is a condition in which the body does not make enough Lentisulin HPI to meet its needs or does not properly use the Lentisulin HPI it makes. Without Lentisulin HPI, glucose cannot get into the body's cells. Without glucose, the cells will not work properly.
To work properly, the amount of Lentisulin HPI you use must be balanced against the amount and type of food you eat and the amount of exercise you do. If you change your diet, your exercise, or both without changing your Lentisulin HPI dose, your blood glucose level can drop too low or rise too high. A prescription is not necessary to purchase most Lentisulin HPI. However, your doctor must first determine your Lentisulin HPI needs and provide you with special instructions for control of your diabetes
Lentisulin HPI can be obtained from beef or pork pancreas glands. Another type of Lentisulin HPI that you may use is called human Lentisulin HPI. It is just like the Lentisulin HPI made by humans but it is made by methods called semi-synthetic or recombinant DNA. All types of Lentisulin HPI must be injected because, if taken by mouth, Lentisulin HPI is destroyed in the stomach.
Lentisulin HPI is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, regular Lentisulin HPI is used in certain patients with the following medical conditions:
- Growth hormone deficiency testing
- Prevent complications of diabetes, including eye problems (retinopathy), kidney disease (nephropathy), and nerve damage (neuropathy)
- Treat high blood sugar (hyperglycemia) in low birth weight infants
Lentisulin HPI indications
Intramuscular
Diabetic ketoacidosis
Adult: As soluble Lentisulin HPI, initial loading dose of 20 units, followed by 6 units/hr until blood glucose drops to 10 mmol/l, when the dose is given 2 hrly.
Intravenous
Diabetic ketoacidosis
Adult: As soluble Lentisulin HPI, given in concentration of 1 unit/ml using an infusion pump: Initially infuse at a rate of 6 units/hr, double or quadruple the rate if blood glucose concentration do not decrease by about 5 mmol/l/hr. If blood glucose concentrations have decreased to 10 mmol/l, reduce the infusion rate to 3 units/hr and continue with 5% glucose to prevent hypoglycaemia, until the patient can eat orally. Do not stop the Lentisulin HPI infusion before SC Lentisulin HPI is started. Ensure adequate fluid replacement and include potassium chloride in the infusion to prevent Lentisulin HPI-induced hypokalaemia.
Child: As soluble Lentisulin HPI, given in concentration of 1 unit/ml using an infusion pump: Initially infuse at a rate of 0.1 units/kg/hr, double or quadruple the rate if blood glucose concentration do not decrease by about 5 mmol/l/hr. If blood glucose concentrations have decreased to 10 mmol/l, reduce the infusion rate to 0.05 units/kg/hr and continue with 5% glucose to prevent hypoglycaemia, until the patient can eat orally. Do not stop the Lentisulin HPI infusion before SC Lentisulin HPI is started. Ensure adequate fluid replacement and include potassium chloride in the infusion to prevent Lentisulin HPI-induced hypokalaemia.
Subcutaneous
Diabetes mellitus
Adult: Admin according to requirements; inject into thighs, upper arms, buttocks, or abdomen.
How should I use Lentisulin HPI?
Use Lentisulin HPI powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Lentisulin HPI powder comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Lentisulin HPI powder refilled.
- If you are using Lentisulin HPI powder with meals, use your dose within 10 minutes before the meal begins unless your doctor tells you otherwise.
- A health care provider will teach you how to use Lentisulin HPI powder. Be sure you understand how to use Lentisulin HPI powder. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Be sure that you have blisters that contain the correct amount of medicine that you need. Do NOT use three 1 mg blisters in place of one 3 mg blister. If you need a 3 mg blister and do not have one, use two 1 mg blisters unless your doctor tells you otherwise.
- Do NOT open the medicine blister or swallow Lentisulin HPI powder. Lentisulin HPI powder is a powder for inhalation into the lungs. Use it only with the inhaler device provided. Do not use it with any other type of inhaler device.
- To prepare the inhaler device - Hold it so that the words " Exubera Inhaler" face you. Pull the black ring at the bottom of the base to pull the base out of the chamber. You should hear a click when the inhaler device is fully extended. The bottom of the chamber must be above the gray button.
- To load the inhaler device - Hold a medicine blister with the printed side up and the notch pointed toward the inhaler. Insert it into the slot on the inhaler device. Push it in as far as it will go. Make sure the mouthpiece is closed. Pull the blue handle out from the bottom as far as it will go, and then squeeze the blue handle until it snaps shut.
- To use Lentisulin HPI powder - Stand or sit up straight. Hold the inhaler upright, with the blue button facing toward you. Push the blue button until it clicks and watch for the Lentisulin HPI cloud to fill the chamber.
- After the cloud appears, breathe out normally and turn the mouthpiece so that it is facing toward you. Place the mouthpiece fully in your mouth and form a seal around the mouthpiece with your lips. Do NOT blow into the mouthpiece. Do not block the opening with your tongue or teeth. Breathe in slowly and deeply through your mouth to inhale the Lentisulin HPI cloud and then take the inhaler device out of your mouth. Close your mouth and hold your breath for 5 seconds, and then breathe out normally.
- Turn the mouthpiece to the closed position. Press the gray button, pull out the used medicine blister, and throw it away. Do not reuse a medicine blister. If you need to inhale another blister to complete your dose, repeat the steps above. Inhale only one blister at a time.
- To store the inhaler device - Squeeze the 2 chamber release buttons on the side of the base at the same time. Push the base back into the chamber.
- Carefully follow the instructions for cleaning and caring for the inhaler device. Replace the Exubera release unit every 2 weeks to ensure that the inhaler device will work properly.
- Lentisulin HPI powder begins to lower blood sugar about 10 to 20 minutes after you use a dose. The peak effect occurs about 2 hours after you use a dose. The effect of Lentisulin HPI powder lasts for up to 6 hours.
- If you also use bronchodilators or other inhaled products, they may increase the risk of high or low blood sugar. It is important to time your doses consistently with regard to Lentisulin HPI powder. Ask your doctor how to use bronchodilators or other inhaled products with Lentisulin HPI powder.
- It is very important to follow your Lentisulin HPI regimen exactly. Do NOT miss any doses. Ask your doctor for specific instructions to follow in case you ever miss a dose of Lentisulin HPI.
Ask your health care provider any questions you may have about how to use Lentisulin HPI powder.
Lentisulin HPI description
Lentisulin HPI is a hormone that is central to regulating energy and glucose metabolism in the body. Lentisulin HPI causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle.
Lentisulin HPI stops the use of fat as an energy source. When Lentisulin HPI is absent, glucose is not taken up by body cells and the body begins to use fat as an energy source, for example, by transfer of lipids from adipose tissue to the liver for mobilization as an energy source. As its level is a central metabolic control mechanism, its status is also used as a control signal to other body systems (such as amino acid uptake by body cells). In addition, it has several other anabolic effects throughout the body.
When control of Lentisulin HPI levels fails, diabetes mellitus will result. As a consequence, Lentisulin HPI is used medically to treat some forms of diabetes mellitus. Patients with Type 1 diabetes mellitus depend on external Lentisulin HPI (most commonly injected subcutaneously) for their survival because the hormone is no longer produced internally. Patients with Type 2 diabetes mellitus are Lentisulin HPI resistant, and because of such resistance, may suffer from a relative Lentisulin HPI deficiency. Some patients with Type 2 diabetes may eventually require Lentisulin HPI if other medications fail to control blood glucose levels adequately, though this is somewhat uncommon.
Lentisulin HPI also influences other body functions, such as vascular compliance and cognition. Once Lentisulin HPI enters the human brain, it enhances learning and memory and in particular benefits verbal memory.
Lentisulin HPI is a peptide hormone composed of 51 amino acids and has a molecular weight of 5808 Da. It is produced in the islets of Langerhans in the pancreas. The name comes from the Latin insula for "island". Lentisulin HPI's structure varies slightly between species of animal. Lentisulin HPI from animal sources differs somewhat in "strength" (in carbohydrate metabolism control effects) in humans because of those variations. Porcine (pig) Lentisulin HPI is especially close to the human version.
Lentisulin HPI dosage
Adult : IV Diabetic ketoacidosis As soluble Lentisulin HPI at a concentration of 1 u/mL via an infusion pump: Initial: Infuse at a rate of 6 u/hr, double or quadruple the rate if blood glucose concentration do not decrease by about 5 mmol/L/hr. If blood glucose concentrations have decreased to 10 mmol/L, reduce infusion rate to 3 u/hr and continue w/ 5% glucose until the patient can eat orally. IM Diabetic ketoacidosis As soluble Lentisulin HPI: Loading dose: 20 u, then 6 u/hr until blood glucose drops to 10 mmol/L, when the dose is given 2 hrly. SC DM Dosage should be individualised and adjusted based on patient's glycaemic response.
Lentisulin HPI interactions
Possible absence of hypoglycaemic warning symptoms with β-blockers. Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotic (e.g. olanzapine and clozapine). Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics. Decreased Lentisulin HPI resistance with octreotide and lanreotide. Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.
Lentisulin HPI side effects
See also:
What are the possible side effects of Lentisulin HPI?
Hypoglycaemia, Lentisulin HPI resistance, lipoatrophy, hypokalaemia, blurred vision.
Lentisulin HPI contraindications
See also:
What is the most important information I should know about Lentisulin HPI?
Hypoglycaemia.
Active ingredient matches for Lentisulin HPI:
| Unit description / dosage (Manufacturer) | Price, USD |
| Lentisulin HPI Insulin Zn suspension 40iu, Zn 0.096mg, Methylparaben1mg/1ml INJ / 10ml | $ 1.14 |
| Lentisulin HPI Insulin Zn suspension 40iu, Zn 0.096mg, Methylparaben1mg/1ml INJ / 10ml | $ 1.14 |
List of Lentisulin HPI substitutes (brand and generic names): | |
| Lentisulin HPI 400 | |
| Lentisulin HPI 400 400IU VIAL / 10ml | $ 1.33 |
| Lupisulin-M 30 (India) | |
| Lupisulin-M 30 40 IU VIAL / 10ml (Lupin) | $ 1.71 |
| Lupisulin-M 30 100 IU CATRIDGE / 3ml (Lupin) | $ 1.83 |
| Lupisulin-M 50 | |
| Lupisulin-M 50 40 IU VIAL / 10ml | |
| Mixtard HM Penfill | |
| Mixtard HM Penfill 40iu/10ml INJ / 5x3ml | $ 12.59 |
| Mixtard-30 (India) | |
| Mixtard-30 30% insulin , 70% insulin, isophane100IU x 1mL PENFILL / 3.5mlx5 (Novo Nordisk) | $ 12.52 |
| Mixtard-30 30% insulin , 70% insulin, isophane 100IU x 1mL PENFILL / 3.5mlx5 (Novo Nordisk) | $ 12.52 |
| MIXTARD-30 FlexPen 100 IU x 1 mL x 3ml (Novo Nordisk) | $ 3.95 |
| Mixtard-30 Novolet (India) | |
| Mixtard-30 Novolet 30% Soluble insulin , 70%Insulin, Isophane100IU x 1mL INJ / 3ml (Novo Nordisk) | $ 3.43 |
| 100 IU x 1 mL x 3ml (Novo Nordisk) | $ 3.43 |
| Mixtard-30 Novolet 30% Soluble insulin , 70%Insulin, Isophane 100IU x 1mL INJ / 3ml (Novo Nordisk) | $ 3.43 |
| MIXTARD-30 NOVOLET Novolet 100 IU x 1 mL x 3ml (Novo Nordisk) | $ 3.43 |
| Mixulin HPI | |
| Mixulin HPI Porcine Insulin premix 100iu INJ / 10ml | $ 3.43 |
| MIXULIN HPI 40IU INJECTION 1 vial / 10 ML injection each (Cadila Pharmaceuticals Ltd) | $ 1.14 |
| Mixulin Hpi 40IU Injection (Cadila Pharmaceuticals Ltd) | $ 0.11 |
| Mixulin HPI 30/70 | |
| Mixulin HPI 30/70 Porcine Insulin 30%, IsophaneInsulin 70%, 40iu INJ / 10ml | $ 1.14 |
| Musulin | |
| Novofine | |
| NovoFine insulin needles 1's (Novo Nordisk) | |
| Novomix-30 (India) | |
| Novomix-30 300iu FLEXPEN / 1 (Novo Nordisk) | $ 6.33 |
| Novomix-30 Insulin Aspart 300iu PENFILL / 5x3ml (Novo Nordisk) | $ 23.67 |
| 100 IU x 1 mL x 3ml (Novo Nordisk) | $ 2.50 |
| Novomix-30 Soluble insulin aspart 30 %, insulin aspart protamine 70 %.100 IU x 1mL FLEXPEN / 3ml (Novo Nordisk) | $ 6.83 |
| Novomix-30 Soluble insulin aspart 30 %, insulin aspart protamine 70 %.100 IU x 1mL PENFILL / 3ml (Novo Nordisk) | $ 2.50 |
| NOVOMIX-30 FlexPen 100 IU x 1 mL x 3ml (Novo Nordisk) | $ 6.70 |
| NOVOMIX-30 penfill 100 IU x 1 mL x 3mlx5 (Novo Nordisk) | $ 26.65 |
| Rapisulin HPI (India) | |
| Rapisulin HPI neutral insulin soluble 40iu INJ / 10ml (Cadila) | $ 1.14 |
| 40 IU x 10ml (Cadila) | $ 1.14 |
| RAPISULIN HPI 400IU INJECTION 1 vial / 10 ML injection each (Cadila) | $ 1.33 |
| Rapisulin Hpi 400IU Injection (Cadila) | $ 0.13 |
| Rapisulin HPI 400 (India) | |
| Rapisulin HPI 400 Porcine Insulin Zn suspension400iu INJ / 10ml (Cadila) | $ 1.33 |
| 400 IU x 10ml (Cadila) | $ 1.33 |
| Recosulin-M 30 (India) | |
| Recosulin-M 30 40iu/ml VIAL / 10ml (Shreya) | $ 1.54 |
| 40 IU x 1 mL x 10ml (Shreya) | $ 1.54 |
| Recosulin-N (India) | |
| Recosulin-N 40iu/10ml VIAL / 10ml (Shreya) | $ 1.54 |
| 40 IU x 10 mL x 10ml (Shreya) | $ 1.54 |
| Recosulin-R (India) | |
| Recosulin-R soluble, neutral rapid acting, recombinant human insulin40iu/10ml VIAL / 10ml (Shreya) | $ 1.54 |
| 40 IU x 10 mL x 10ml (Shreya) | $ 1.54 |
| Recosulin-R 40iu x 10mL VIAL / 10ml (Shreya) | $ 1.54 |
| Terumo | |
| Wosulin 30/70 (India) | |
| Wosulin 30/70 rDNA human monocomponent 30%premixed biphasic Insulin VIAL / 10ml (Wockhardt Ltd.) | $ 1.55 |
| Wosulin 30/70 40 iu Injection (Wockhardt Ltd.) | $ 0.61 |
| Wosulin 30/70 rDNA human monocomponent 30%premixed biphasic Insulin 40IU x 1mL VIAL / 10ml (Wockhardt Ltd.) | $ 1.69 |
See 133 substitutes for Lentisulin HPI | |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
