Novofine Uses

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What is Novofine?

Novofine is one of many hormones that helps the body turn the food we eat into energy. Also, Novofine helps us store energy that we can use later. After we eat, Novofine works by causing sugar (glucose) to go from the blood into our body's cells to make fat, sugar, and protein. When we need more energy between meals, Novofine will help us use the fat, sugar, and protein that we have stored. This occurs whether we make our own Novofine in the pancreas gland or take it by injection.

Diabetes mellitus (sugar diabetes) is a condition in which the body does not make enough Novofine to meet its needs or does not properly use the Novofine it makes. Without Novofine, glucose cannot get into the body's cells. Without glucose, the cells will not work properly.

To work properly, the amount of Novofine you use must be balanced against the amount and type of food you eat and the amount of exercise you do. If you change your diet, your exercise, or both without changing your Novofine dose, your blood glucose level can drop too low or rise too high. A prescription is not necessary to purchase most Novofine. However, your doctor must first determine your Novofine needs and provide you with special instructions for control of your diabetes

Novofine can be obtained from beef or pork pancreas glands. Another type of Novofine that you may use is called human Novofine. It is just like the Novofine made by humans but it is made by methods called semi-synthetic or recombinant DNA. All types of Novofine must be injected because, if taken by mouth, Novofine is destroyed in the stomach.

Novofine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, regular Novofine is used in certain patients with the following medical conditions:

Novofine indications

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Intramuscular

Diabetic ketoacidosis

Adult: As soluble Novofine, initial loading dose of 20 units, followed by 6 units/hr until blood glucose drops to 10 mmol/l, when the dose is given 2 hrly.

Intravenous

Diabetic ketoacidosis

Adult: As soluble Novofine, given in concentration of 1 unit/ml using an infusion pump: Initially infuse at a rate of 6 units/hr, double or quadruple the rate if blood glucose concentration do not decrease by about 5 mmol/l/hr. If blood glucose concentrations have decreased to 10 mmol/l, reduce the infusion rate to 3 units/hr and continue with 5% glucose to prevent hypoglycaemia, until the patient can eat orally. Do not stop the Novofine infusion before SC Novofine is started. Ensure adequate fluid replacement and include potassium chloride in the infusion to prevent Novofine-induced hypokalaemia.

Child: As soluble Novofine, given in concentration of 1 unit/ml using an infusion pump: Initially infuse at a rate of 0.1 units/kg/hr, double or quadruple the rate if blood glucose concentration do not decrease by about 5 mmol/l/hr. If blood glucose concentrations have decreased to 10 mmol/l, reduce the infusion rate to 0.05 units/kg/hr and continue with 5% glucose to prevent hypoglycaemia, until the patient can eat orally. Do not stop the Novofine infusion before SC Novofine is started. Ensure adequate fluid replacement and include potassium chloride in the infusion to prevent Novofine-induced hypokalaemia.

Subcutaneous

Diabetes mellitus

Adult: Admin according to requirements; inject into thighs, upper arms, buttocks, or abdomen.

How should I use Novofine?

Use Novofine powder as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Novofine powder.

Novofine description

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Novofine is a hormone that is central to regulating energy and glucose metabolism in the body. Novofine causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle.

Novofine stops the use of fat as an energy source. When Novofine is absent, glucose is not taken up by body cells and the body begins to use fat as an energy source, for example, by transfer of lipids from adipose tissue to the liver for mobilization as an energy source. As its level is a central metabolic control mechanism, its status is also used as a control signal to other body systems (such as amino acid uptake by body cells). In addition, it has several other anabolic effects throughout the body.

When control of Novofine levels fails, diabetes mellitus will result. As a consequence, Novofine is used medically to treat some forms of diabetes mellitus. Patients with Type 1 diabetes mellitus depend on external Novofine (most commonly injected subcutaneously) for their survival because the hormone is no longer produced internally. Patients with Type 2 diabetes mellitus are Novofine resistant, and because of such resistance, may suffer from a relative Novofine deficiency. Some patients with Type 2 diabetes may eventually require Novofine if other medications fail to control blood glucose levels adequately, though this is somewhat uncommon.

Novofine also influences other body functions, such as vascular compliance and cognition. Once Novofine enters the human brain, it enhances learning and memory and in particular benefits verbal memory.

Novofine is a peptide hormone composed of 51 amino acids and has a molecular weight of 5808 Da. It is produced in the islets of Langerhans in the pancreas. The name comes from the Latin insula for "island". Novofine's structure varies slightly between species of animal. Novofine from animal sources differs somewhat in "strength" (in carbohydrate metabolism control effects) in humans because of those variations. Porcine (pig) Novofine is especially close to the human version.

Novofine dosage

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Adult : IV Diabetic ketoacidosis As soluble Novofine at a concentration of 1 u/mL via an infusion pump: Initial: Infuse at a rate of 6 u/hr, double or quadruple the rate if blood glucose concentration do not decrease by about 5 mmol/L/hr. If blood glucose concentrations have decreased to 10 mmol/L, reduce infusion rate to 3 u/hr and continue w/ 5% glucose until the patient can eat orally. IM Diabetic ketoacidosis As soluble Novofine: Loading dose: 20 u, then 6 u/hr until blood glucose drops to 10 mmol/L, when the dose is given 2 hrly. SC DM Dosage should be individualised and adjusted based on patient's glycaemic response.

Novofine interactions

Possible absence of hypoglycaemic warning symptoms with β-blockers. Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotic (e.g. olanzapine and clozapine). Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics. Decreased Novofine resistance with octreotide and lanreotide. Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.

Novofine side effects

See also:
What are the possible side effects of Novofine?

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Hypoglycaemia, Novofine resistance, lipoatrophy, hypokalaemia, blurred vision.

Novofine contraindications

See also:
What is the most important information I should know about Novofine?

Hypoglycaemia.

Active ingredient matches for Novofine:

Insulin

Sterile insulin needles in Myanmar.


Unit description / dosage (Manufacturer)Price, USD
NovoFine insulin needles 1's (Novo Nordisk)

List of Novofine substitutes (brand and generic names):

100 IU x 1 mL x 3ml (Novo Nordisk)$ 3.43
Mixtard-30 Novolet 30% Soluble insulin , 70%Insulin, Isophane 100IU x 1mL INJ / 3ml (Novo Nordisk)$ 3.43
MIXTARD-30 NOVOLET Novolet 100 IU x 1 mL x 3ml (Novo Nordisk)$ 3.43
Mixulin HPI Porcine Insulin premix 100iu INJ / 10ml$ 3.43
MIXULIN HPI 40IU INJECTION 1 vial / 10 ML injection each (Cadila Pharmaceuticals Ltd)$ 1.14
Mixulin Hpi 40IU Injection (Cadila Pharmaceuticals Ltd)$ 0.11
Mixulin HPI 30/70 Porcine Insulin 30%, IsophaneInsulin 70%, 40iu INJ / 10ml$ 1.14
Novomix-30 300iu FLEXPEN / 1 (Novo Nordisk)$ 6.33
Novomix-30 Insulin Aspart 300iu PENFILL / 5x3ml (Novo Nordisk)$ 23.67
100 IU x 1 mL x 3ml (Novo Nordisk)$ 2.50
Novomix-30 Soluble insulin aspart 30 %, insulin aspart protamine 70 %.100 IU x 1mL FLEXPEN / 3ml (Novo Nordisk)$ 6.83
Novomix-30 Soluble insulin aspart 30 %, insulin aspart protamine 70 %.100 IU x 1mL PENFILL / 3ml (Novo Nordisk)$ 2.50
NOVOMIX-30 FlexPen 100 IU x 1 mL x 3ml (Novo Nordisk)$ 6.70
NOVOMIX-30 penfill 100 IU x 1 mL x 3mlx5 (Novo Nordisk)$ 26.65
Rapisulin HPI neutral insulin soluble 40iu INJ / 10ml (Cadila)$ 1.14
40 IU x 10ml (Cadila)$ 1.14
RAPISULIN HPI 400IU INJECTION 1 vial / 10 ML injection each (Cadila)$ 1.33
Rapisulin Hpi 400IU Injection (Cadila)$ 0.13
Rapisulin HPI 400 Porcine Insulin Zn suspension400iu INJ / 10ml (Cadila)$ 1.33
400 IU x 10ml (Cadila)$ 1.33
Recosulin-M 30 40iu/ml VIAL / 10ml (Shreya)$ 1.54
40 IU x 1 mL x 10ml (Shreya)$ 1.54
Recosulin-N 40iu/10ml VIAL / 10ml (Shreya)$ 1.54
40 IU x 10 mL x 10ml (Shreya)$ 1.54
Recosulin-R soluble, neutral rapid acting, recombinant human insulin40iu/10ml VIAL / 10ml (Shreya)$ 1.54
40 IU x 10 mL x 10ml (Shreya)$ 1.54
Recosulin-R 40iu x 10mL VIAL / 10ml (Shreya)$ 1.54
Wosulin 30/70 rDNA human monocomponent 30%premixed biphasic Insulin VIAL / 10ml (Wockhardt Ltd.)$ 1.55
Wosulin 30/70 40 iu Injection (Wockhardt Ltd.)$ 0.61
Wosulin 30/70 rDNA human monocomponent 30%premixed biphasic Insulin 40IU x 1mL VIAL / 10ml (Wockhardt Ltd.)$ 1.69
Wosulin 30/70 100IU Cartridge (Wockhardt Ltd.)$ 2.40
Wosulin 30/70 100IU Disposable Pen (Wockhardt Ltd.)$ 1.20
Wosulin 30/70 100IU Injection (Wockhardt Ltd.)$ 0.53
Wosulin 30/70 40IU Injection (Wockhardt Ltd.)$ 0.17
Wosulin 50/50 rDNA human monocomponent 50%premixed biphasic Insulin40iu/ml VIAL / 10ml (Wockhardt)$ 1.55
Wosulin 50/50 100IU Disposable Pen (Wockhardt)$ 1.10
Wosulin 50/50 40IU Cartridge (Wockhardt)$ 2.39
Wosulin 50/50 40IU Injection (Wockhardt)$ 0.17

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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