Lentostamin indications
Infectious-inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, including respiratory diseases, diseases of abdominal and pelvic organs, bones, joints, skin, septicemia; severe infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.
For Lentostamin Citadel Fine Pharmaceuticals local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meybomity. Infectious lesions in the eyes from injury or contact with foreign bodies. Preoperative prophylaxis in ophthalmic surgery.
Lentostamin description
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
Lentostamin dosage
Individual. For oral administration dose of Lentostamin Citadel Fine Pharmaceuticals is 250-750 mg 2 times / day. Treatment duration is from 7-10 days to 4 weeks.
For IV administration a single dose is 200-400 mg, the multiplicity of the introduction is 2 times / day, duration of treatment - 1-2 weeks and more if necessary. May be IV injected as jet but more preferably a drip for 30 minutes.
When Lentostamin Citadel Fine Pharmaceuticals applied topically instilled 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After improving the intervals between instillation can be increased. The maximum oral daily dose for adults is 1.5 g.
Lentostamin interactions
Activity increases when combined with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. Sukralfat, bismuth preparations, antacids containing aluminum ions, magnesium or calcium, cimetidine, ranitidine, vitamin and mineral supplement, iron sulfate, zinc, didanosine (recommended for 2 hours before or 4 hours after these drugs) reduce the suction. Probenecid, azlocillin increase the concentration in the blood. Decreases clearance and increases in plasma caffeine, aminophylline and theophylline (increased likelihood of side effects). Lentostamin Citadel Fine Pharmaceuticals enhances the effect of warfarin and other oral anticoagulants (prolongs bleeding time). Increases nephrotoxicity of cyclosporine, increase the risk of CNS excitability and convulsive reactions against the background of NSAIDs. Medicines alkalinizing the urine (citrates, sodium bicarbonate, carbonic anhydrase inhibitors) reduce the solubility (increases the probability of crystalluria). Infusion solutions of ciprofloxacin ready to use can be combined with infusion solutions: 0.9% sodium chloride solution, Ringer's solution, Ringer lactate, 5 and 10% dextrose, 10% solution of fructose, and a solution containing 5% dextrose with 0,225 or 0.45% sodium chloride. Incompatible with solutions having a pH > 7.
Lentostamin side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Rare
Fever
skin rash or itching
sore throat and fever
unusual tiredness and weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Abdominal or stomach pain or upset
diarrhea
nausea or vomiting
Rare
Dizziness
hair loss
headache
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Lentostamin contraindications
Injection: Lentostamin is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to promethazine.
Under no circumstances should promethazine be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene
Lentostamin HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.
Syrup, Tablets and Suppositories: Phenergan Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.
Phenergan Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
Active ingredient matches for Lentostamin:
Chlorphenamine in Serbia.
Carbinoxamine Maleate/Mepyramine/Phenylpropanolamine
Carbinoxamine/mepyramine/phenylpropanolamine in Mexico.
Chlorphenamine maleate in Italy.
List of Lentostamin substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Kufnil-D (India) | |
| KUFNIL-D syr 60ml (Zodak) | $ 0.47 |
| Lergisina (Paraguay) | |
| Levotus (India) | |
| LEVOTUS syr 60ml (Shasun) | $ 1.19 |
| Linctus Codein (India) | |
| Linctus Codein Codeine phosphate 10 mg, Chlorphenamine maleate 4 mg/5mL. SYR / 100ml (AstraZeneca) | $ 0.75 |
| 100ml (AstraZeneca) | $ 0.75 |
| LINCTUS CODEIN syr 100ml (AstraZeneca) | $ 0.75 |
| Lolrphine (Pakistan) | |
| Lontomin (Taiwan) | |
| Lontomin 2.5 mg | |
| Lontomin Compound | |
| Lorpen (Philippines) | |
| Magotimin (Japan) | |
| Malenate (Taiwan) | |
| Malenate 4 mg | |
| Maleramine (Japan) | |
| Maxtra DPS (India) | |
| Maxtra DPS Pseudoephrine HCI 15mg, Chlorepheniramine maleate1mg/mL DPS / 15ml (Zuventus) | $ 0.33 |
| 15ml (Zuventus) | $ 0.33 |
| MAXTRA DPS oral drops 15ml (Zuventus) | $ 0.33 |
| Mericof (India) | |
| Mericof Dextromethorphan hydrobromide5 mg, Chlorphenamine maleate2.5 mg, Guaiphenesin 50 mg, Ammonium chloride 60 mg. SYR / 100ml (Plus India) | $ 0.48 |
| 100ml (Plus India) | $ 0.48 |
| MERICOF SYRUP 1 bottle / 100 ML syrup each (Plus India) | $ 0.70 |
| MERICOF TABLET 1 strip / 10 tablets each (Plus India) | $ 0.09 |
| MERICOF syr 100ml (Plus India) | $ 0.48 |
| Mericof Syrup (Plus India) | $ 0.70 |
| Mericof Syrup (Plus India) | $ 0.56 |
| Mericof Tablet (Plus India) | $ 0.01 |
| Metromine (Philippines) | |
| Metromine 4 mg x 100's | $ 3.92 |
| Metromine 2 mg/5 mL x 60 mL | $ 1.37 |
| Moredrill-DX (India) | |
| Moredrill-DX Dextromethorphan hydrobromide10 mg, Phenylephrinehydrochloride 5 mg, Chlorphenamine maleate 2 mg/5mL. SYR / 100ml (Avalanche) | $ 0.70 |
| 100ml (Avalanche) | $ 0.70 |
| MOREDRILL-DX syr 100ml (Avalanche) | $ 0.70 |
| Mystacin (Bangladesh) | |
| Naflin DPS (India) | |
| Naflin DPS Naphazoline 0.1 % w/v, Boricacid 25 % w/v, Chlorphenaminemaleate 0.01 % w/v, Hydroxypropyl methylcellulose0.1 % w/v, Zinc sulphate 0.1 %w/v, Phenylmercuric nitrate0.001 % w/v. EYE-DPS / 5ml (Globus) | $ 0.42 |
| 5ml (Globus) | $ 0.42 |
| NAFLIN DPS eye drops 5ml (Globus) | $ 0.42 |
| Nastimed (Peru) | |
| Neo-Antergan (Italy) | |
| Neo-Antihistamine (Taiwan) | |
| Neo-Antihistamine 4 mg | |
| Neo-Benamin (Taiwan) | |
| Neo-Benamin 0.5 mg x 1 mL | |
| Neo-Benamin 0.5 mg x 4 L | |
| Neo-Benamin 5 mg/1 mL x 1 mL | |
| Neomallermin (Japan) | |
| Neomallermin TR (Japan) | |
| Neorestamin (Japan) | |
See 783 substitutes for Lentostamin | |
References
- PubChem. "carbinoxamine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "carbinoxamine". http://www.drugbank.ca/drugs/DB00748 (accessed September 17, 2018).
- MeSH. "Histamine H1 Antagonists". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lentostamin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lentostamin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
