What is Lincopi?
Lincopi is an antibiotic that fights bacteria.
Lincopi is used to treat severe bacterial infections in people who cannot use penicillin antibiotics.
Lincopi is used only for a severe infection. This medicine will not treat a viral infection such as the common cold or flu.
Lincopi may also be used for purposes not listed in this medication guide.
Lincopi indications
Lincopi Sterile Solution is indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of antibiotic-associated pseudomembranous colitis, as described in Warnings, before selecting Lincopi the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).
Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Lincopi.
Indicated surgical procedures should be performed in conjunction with antibiotic therapy.
Lincopi has been demonstrated to be effective in the treatment of staphylococcal infections resistant to other antibiotics and susceptible to Lincopi. Staphylococcal strains resistant to Lincopi have been recovered; culture and susceptibility studies should be done in conjunction with therapy with Lincopi. In the case of macrolides, partial but not complete cross-resistance may occur. The drug may be administered concomitantly with other antimicrobial agents when indicated.
Lincopi is not indicated in the treatment of minor bacterial infections or viral infections.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Lincopi and other antibacterial drugs, Lincopi should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Lincopi?
Use Lincopi as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Lincopi is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- If you miss a dose of Lincopi, call your doctor to find out what to do.
Ask your health care provider any questions you may have about how to use Lincopi.
Uses of Lincopi in details
Lincopi is used in treatment of bacterial infections.
Lincopi description
Each mL of Lincopi Sterile Solution contains Lincomycin hydrochloride equivalent to Lincopi 300 mg.
Lincopi sterile solution contains Lincomycin hydrochloride which is the monohydrated salt of Lincopi, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis (Fam. Streptomycetaceae).
The chemical name for Lincopi hydrochloride is Methyl 6, 8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrolidinecarboxamido)-1-thio-D-erythro-α-D-galacto-octopyranoside monohydrochloride monohydrate. Its molecular formula is C18H34N2O6S.HCl. H2O and the molecular weight is 461.01.
Lincopi hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. Its solutions are acid and are dextrorotatory. Lincopi hydrochloride is freely soluble in water; soluble in dimethylformamide and very slightly soluble in acetone.
Excipients/Inactive Ingredients: Benzyl alcohol 9.45 mg added as preservative.
Lincopi dosage
Lincopi Dosage
Generic name: Lincopi HYDROCHLORIDE 300mg in 1mL
Dosage form: injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
If significant diarrhea occurs during therapy, this antibacterial should be discontinued.
INTRAMUSCULAR
Adults
Serious infections—600 mg (2 mL) intramuscularly every 24 hours. More severe infections—600 mg (2 mL) intramuscularly every 12 hours or more often.
Pediatric patients over 1 month of age
Serious infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 24 hours. More severe infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 12 hours or more often.
INTRAVENOUS
Adults
The intravenous dose will be determined by the severity of the infection. For serious infections doses of 600 mg of Lincopi (2 mL of Lincopi) to 1 gram are given every 8 to 12 hours. For more severe infections these doses may have to be increased. In life-threatening situations daily intravenous doses of as much as 8 grams have been given.
Intravenous doses are given on the basis of 1 gram of Lincopi diluted in not less than 100 mL of appropriate solution and infused over a period of not less than one hour.
| Dose | Vol. Diluent | Time |
|---|---|---|
| 600 mg | 100 mL | 1 hr |
| 1 gram | 100 mL | 1 hr |
| 2 grams | 200 mL | 2 hr |
| 3 grams | 300 mL | 3 hr |
| 4 grams | 400 mL | 4 hr |
These doses may be repeated as often as required to the limit of the maximum recommended daily dose of 8 grams of Lincopi.
Pediatric patients over 1 month of age
10 to 20 mg/kg/day (5 to 10 mg/lb/day) depending on the severity of the infection may be infused in divided doses as described above for adults.
NOTE: Severe cardiopulmonary reactions have occurred when this drug has been given at greater than the recommended concentration and rate.
SUBCONJUNCTIVAL INJECTION
0.25 mL (75 mg) injected subconjunctivally will result in ocular fluid levels of antibacterial (lasting for at least 5 hours) with MICs sufficient for most susceptible pathogens.
Patients with diminished renal function
When therapy with Lincopi is required in individuals with severe impairment of renal function, an appropriate dose is 25 to 30% of that recommended for patients with normally functioning kidneys.
More about Lincopi (Lincopi)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 1 Review - Add your own review/rating
- Generic Availability
Consumer resources
- Lincopi
- Lincopi (Advanced Reading)
Professional resources
- Lincopi (AHFS Monograph)
- Lincopi (FDA)
Related treatment guides
- Bacterial Infection
- Conjunctivitis, Bacterial
Lincopi interactions
See also:
What other drugs will affect Lincopi?
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination
Doxofylline: Lincopi may increase the serum concentration of Doxofylline. Monitor therapy
Erythromycin (Systemic): May diminish the therapeutic effect of Lincopi. Avoid combination
Kaolin: May decrease the absorption of Lincosamide Antibiotics. Monitor therapy
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy
Mecamylamine: Lincosamide Antibiotics may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination
Neuromuscular-Blocking Agents: Lincosamide Antibiotics may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification
Lincopi side effects
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What are the possible side effects of Lincopi?
Applies to Lincopi: capsule, solution
In addition to its needed effects, some unwanted effects may be caused by Lincopi (the active ingredient contained in Lincopi). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Lincopi:
More common:
- Abdominal or stomach cramps and pain (severe)
- abdominal tenderness
- diarrhea (watery and severe), which may also be bloody
- fever
- Skin rash, redness, and itching
- sore throat and fever
- unusual bleeding and bruising
Note: Some of the above side effects may also occur up to several weeks after you Stop taking Lincopi.
Minor Side Effects
Some of the side effects that can occur with Lincopi may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Diarrhea (mild)
- nausea and vomiting
- stomach pain
- Itching of rectal or genital (sex organ) areas
Lincopi contraindications
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What is the most important information I should know about Lincopi?
Before receiving Lincopi, tell your doctor if you have asthma or allergies, a stomach or intestinal disorder such as colitis, liver or kidney disease, or epilepsy or other seizure disorder.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Serious side effects of Lincopi include fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips, severe blistering or peeling skin rash, feeling like you might pass out, easy bruising or bleeding, unusual weakness, or urinating less than usual or not at all.
Active ingredient matches for Lincopi:
Lincomycin in Vietnam.
| Unit description / dosage (Manufacturer) | Price, USD |
| Lincopi 600 mg/2 mL x 10 tube 2 mL | |
List of Lincopi substitutes (brand and generic names): | |
| Lincopharm 800 (Australia) | |
| Lincoplax (Brazil) | |
| Lincople (Vietnam) | |
| Lincople 600 mg/2 mL x 10 Bottle | |
| Lincoplus (Peru) | |
| Lincorex | |
| Lincosa (Malaysia) | |
| Lincosa 300 mg/1 mL x 10 mL x 1's (ZHPL (Sayona)) | |
| 300 mg x 1ml (ZHPL (Sayona)) | $ 0.11 |
| Lincosa 300mg AMP / 1ml (ZHPL (Sayona)) | $ 0.11 |
| LINCOSA inj 300 mg x 1ml (ZHPL (Sayona)) | $ 0.11 |
| Lincosa 300 mg inj 2 mL x 50 x 1's (ZHPL (Sayona)) | |
| Lincosa 300 mg inj 10 mL x 10 x 1's (ZHPL (Sayona)) | |
| Lincosan (Yemen) | |
| LINCOSCAN 400mg/g dla swin i kurczat For pigs and chickens (Poland) | |
| Lincosol (United States) | |
| Lincostad (Vietnam) | |
| Lincostad 500 mg x 10 Blister x 10 Tablet | |
| Lincotax (Brazil) | |
| Lincotec (Italy) | |
| Lincotic (Pakistan) | |
| Lincotin (Pakistan) | |
| Lincovax (Brazil) | |
| Lincover (Mexico) | |
| LINCOWOCK | |
| LINCOWOCK 1MG INJECTION 1 vial / 1 ML injection each (Wockhardt Ltd) | $ 0.09 |
| LINCOWOCK 2MG INJECTION 1 vial / 2 ML injection each (Wockhardt Ltd) | $ 0.16 |
| Lincowock 2mg Injection (Wockhardt Ltd) | $ 0.08 |
| Lincozaf (Pakistan) | |
| Lincozin (India) | |
| Lincozin 250mg CAP / 10 (Taj Pharma) | $ 0.70 |
| Lincozin 500mg CAP / 10 (Taj Pharma) | $ 1.12 |
| Lincozin 125mg/mL SYR / 60ml (Taj Pharma) | $ 0.55 |
| Lincozin 300mg/mL INJ / 1ml (Taj Pharma) | $ 0.13 |
| Lincozin 300mg/mL INJ / 2ml (Taj Pharma) | $ 0.22 |
| 250 mg x 10's (Taj Pharma) | $ 0.70 |
| 500 mg x 10's (Taj Pharma) | $ 1.12 |
| 125 mg x 1 mL x 60ml (Taj Pharma) | $ 0.55 |
| 300 mg x 1 mL x 1ml (Taj Pharma) | $ 0.13 |
| 300 mg x 1 mL x 2ml (Taj Pharma) | $ 0.22 |
| LINCOZIN cap 250 mg x 10's (Taj Pharma) | $ 0.70 |
| LINCOZIN cap 500 mg x 10's (Taj Pharma) | $ 1.12 |
| LINCOZIN syr 125 mg x 1 mL x 60ml (Taj Pharma) | $ 0.55 |
| LINCOZIN inj 300 mg x 1 mL x 1ml (Taj Pharma) | $ 0.13 |
| LINCOZIN inj 300 mg x 1 mL x 2ml (Taj Pharma) | $ 0.22 |
| LINCY (India) | |
| 300 mg x 2ml (Beulah) | $ 0.22 |
| Lincy 300mg AMP / 2ml (Beulah) | $ 0.22 |
See 520 substitutes for Lincopi | |
References
- PubChem. "lincomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "lincomycin". http://www.drugbank.ca/drugs/DB01627 (accessed September 17, 2018).
- MeSH. "Protein Synthesis Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lincopi are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lincopi. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
