What is Madopar-F?
Madopar-F (Madopar-F) is an inhaled prescription medicine used to treat symptoms of Parkinson's disease that come back (OFF episodes) while you are taking another medicine called carbidopa and Madopar-F.
Madopar-F is not to be used in place of any medicine you take daily for Parkinson's disease.
It is not known if Madopar-F is safe or effective in children.
Madopar-F indications
Oral
Parkinsonism
Adult: Initially, 125 mg bid; increase gradually every 3-7 days according to response. Max dose: 8 g daily in divided doses.
Oral
Parkinsonism in conjunction with carbidopa
Adult: Patients not previously on Madopar-F therapy: Initially, 25 mg carbidopa with 100 mg Madopar-F tid; gradually increase in increments of 12.5 mg carbidopa with 50 mg Madopar-F or 25 mg carbidopa with 100 mg Madopar-F every day or on alternate days. Maintenance dose: 75-200 mg carbidopa with 750 mg to 2 g Madopar-F daily in divided doses. Max carbidopa dose: 200 mg daily. Patients previously on Madopar-F monotherapy: 20-25% of the dose previously taken 3 or 4 times daily. Patient previously on other Madopar-F/dopa-decarboxylase combination therapy: Initial dose should provide the same daily Madopar-F dose.
Oral
Parkinsonism in conjunction with Madopar-F
Adult: Patients not previously on Madopar-F therapy: Initially, 50 mg 3 or 4 times daily; gradually increase in increments of 100 mg once or twice wkly. Increase initial dose to 100 mg tid for advanced disease stages. Maintenance dose: 400-800 mg daily in divided doses; most require <600 mg daily. Patients previously on Madopar-F monotherapy: 10-15% of the usual dose previously taken. Patient previously on other Madopar-F/dopa-decarboxylase combination therapy: Initially, 50 mg 3 or 4 times daily.
Elderly: Initially, 50 mg once or bid, then increase by 50 mg every 3rd or 4th day.
How should I use Madopar-F?
Use Madopar-F exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Madopar-F is for use only in people who are currently taking carbidopa and Madopar-F. Do not stop taking your daily Parkinson's medications or change your dosing schedule without your doctor's advice.
For best results, use Madopar-F when an "off episode" begins (when your Parkinson's symptoms start to return). Do not use Madopar-F more than 5 times per day.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Madopar-F is a powder that comes with a special inhaler device and blister packs containing capsules of the medicine. You will load 2 capsules (one at a time) into the inhaler device each time you use the medicine. Pushing the handle of the device onto the mouthpiece will pierce the capsule and release the medicine into the inhaler.
Do not swallow a Madopar-F capsule. It is for use only in the Madopar-F inhaler device.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Madopar-F.
Do not stop using Madopar-F suddenly after long-term regular use, or you could have unpleasant withdrawal symptoms (fever, confusion, muscle stiffness, changes in breathing and heart rate). Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat. Keep each capsule in the blister pack until you ready to load the inhaler device. Do not store capsules inside the device.
Throw away the device when your capsules run out. Always use the inhaler device that comes with each new prescription.
Uses of Madopar-F in details
Madopar-F is used to treat symptoms such as stiffness, tremors, spasms, and poor muscle control associated with Parkinson disease and parkinsonism-like symptoms caused by taking certain other drugs such as chlorpromazine, fluphenazine, perphenazine.
Madopar-F description
The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. [PubChem]
Madopar-F dosage
Madopar-F Dosage
Generic name: Madopar-F 42mg
Dosage form: capsule
Medically reviewed on January 3, 2019.
Madopar-F capsules are for oral inhalation only and should be used only with the Madopar-F inhaler.
Important Administration Instructions
Madopar-F capsules are for oral inhalation only and should be used only with the Madopar-F inhaler. Madopar-F capsules must not be swallowed as the intended effect will not be obtained. Madopar-F capsules should be stored in their blister package and only removed immediately before use.
Recommended Dosage
Madopar-F should be taken when symptoms of an OFF period start to return.
The recommended dosage of Madopar-F is oral inhalation of the contents of two 42 mg capsules (84 mg) as needed, up to 5 times a day. The maximum dose per OFF period is 84 mg, and the maximum daily dosage is 420 mg. Madopar-F has been shown to be effective only in combination with carbidopa/Madopar-F.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Madopar-F (Madopar-F)
- Madopar-F Side Effects
- During Pregnancy or Breastfeeding
- Drug Interactions
- Drug class: dopaminergic antiparkinsonism agents
Professional resources
- Madopar-F (FDA)
Related treatment guides
- Parkinson's Disease
Madopar-F interactions
See also:
What other drugs will affect Madopar-F?
Increased postural hypotension and possible reduced absorption with TCAs. Reduced effects with phenothiazines, butyrophenones, thioxanthenes and other antipsychotic agents; reserpine, papaverine, phenytoin, isoniazid. Reversal of effects of Madopar-F monotherapy with pyridoxine. Exacerbation of abnormal involuntary movements and possibly delayed absorption with anticholinergics. Additive hypotensive effects with antihypertensive agents. Increased CNS toxicity with methyldopa. Exacerbation of parkinsonian symptoms with metoclopramide.
Potentially Fatal: Increased risk of hypertensive crises with nonselective MAOIs. Increased risk of cardiac arrhythmias with cyclopropane or halogenated anaesthetics.
Madopar-F side effects
See also:
What are the possible side effects of Madopar-F?
The following serious adverse reactions are discussed below and elsewhere in the labeling:
- Falling Asleep During Activities of Daily Living and Somnolence
- Withdrawal-Emergent Hyperpyrexia and Confusion
- Hallucinations/Psychosis
- Impulse Control/Compulsive Behaviors
- Dyskinesia
- Bronchospasm in Patients with Lung Disease
- Glaucoma
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
Adverse Reactions in Study 1
Table 1 lists the adverse reactions that occurred in at least 2% of patients with Parkinson's disease who were treated with Madopar-F 84 mg and higher than placebo for OFF periods in Study 1. Study 1 was a double-blind, placebo-controlled study, in which 114 patients received Madopar-F 84 mg (two 42 mg capsules) for an average of 2 doses per day, to a maximum of 5 times a day, and 112 patients received placebo. Madopar-F-treated patients were 45-82 years of age (mean 63.5 years of age) and were predominantly male (72%) and white (94%). All patients were also treated with oral carbidopa/Madopar-F. The most common adverse reactions (≥ 5% and higher than placebo) in Study 1 were cough, nausea, upper respiratory tract infection, and sputum discolored.
| Adverse Reactions | Madopar-F 84 mg N=114 % | Placebo N=112 % |
|---|---|---|
| Respiratory, thoracic and mediastinal disorders | ||
| Cough | 15 | 2 |
| Sputum discolored | 5 | 0 |
| Nasal discharge discoloration | 2 | 0 |
| Oropharyngeal pain | 2 | 0 |
| Gastrointestinal disorders | ||
| Nausea | 5 | 3 |
| Vomiting | 3 | 0 |
| Infections and infestations | ||
| Upper respiratory tract infection | 6 | 3 |
| Nasopharyngitis | 3 | 2 |
| Bronchitis/pneumonia | 2 | 0 |
| Nervous system disorders | ||
| Dyskinesia | 4 | 1 |
| Headache | 2 | 0 |
| Injury, poisoning and procedural complications | ||
| Fall | 3 | 2 |
| Laceration | 2 | 0 |
| Skin abrasion | 2 | 0 |
| General disorders and administration site conditions | ||
| Chest discomfort | 2 | 0 |
| Investigations | ||
| Blood bilirubin increased | 2 | 0 |
| Red blood cell count decreased | 2 | 0 |
| Musculoskeletal and connective tissue disorders | ||
| Pain in extremity | 2 | 1 |
| Psychiatric disorders | ||
| Insomnia | 2 | 1 |
| Vascular disorders | ||
| Orthostatic hypotension/blood pressure decreased | 2 | 0 |
Adverse Reactions Leading to Discontinuation in Study 1
In Study 1, 6 of 114 patients (5%) in the Madopar-F 84 mg group and 3 of 112 patients (3%) in the placebo group discontinued because of adverse reactions. The most common of these adverse reactions was cough, which lead to discontinuation in 2% of patients in the Madopar-F 84 mg group and none in the placebo group.
Madopar-F contraindications
See also:
What is the most important information I should know about Madopar-F?
Monoamine oxidase (MAO) inhibitors and Madopar-F should not be given concomitantly and these inhibitors must be discontinued 2 weeks prior to initiating therapy with Madopar-F. Madopar-F is contraindicated in patients with known hypersensitivity to the drug and in narrow angle glaucoma.
Because Madopar-F may activate a malignant melanoma, it should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.
Active ingredient matches for Madopar-F:
Levodopa in India.
Benserazide in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Madopar-F Levodopa 200mg, Benserazide50mg TAB / 10 | $ 1.11 |
| 10's | $ 1.27 |
| MADOPAR-F tab 10's (NPIL (Cognex)) | $ 1.11 |
List of Madopar-F substitutes (brand and generic names): | |
| Dopastral | |
| Doprin | |
| Eldopal (Netherlands) | |
| Eldopar | |
| Eldopatec | |
| Eurodopa | |
| Helfo-Dopa | |
| Inbrija | |
| Insulamina | |
| Laradopa | |
| Larodopa | |
| Capsule; Oral; Levodopa 100 mg (Cambridge) | |
| Capsule; Oral; Levodopa 250 mg (Cambridge) | |
| Capsule; Oral; Levodopa 500 mg (Cambridge) | |
| Tablet; Oral; Levodopa 100 mg (Cambridge) | |
| Tablet; Oral; Levodopa 250 mg (Cambridge) | |
| Tablet; Oral; Levodopa 500 mg (Cambridge) | |
| Ledopa | |
| Levedopa | |
| Levocarbin (Peru) | |
| Levodopa (Albania, Argentina, Aruba, Australia, Austria, Azerbaijan, Belarus, Bolivia, Bosnia & Herzegowina, Bulgaria, Cambodia, China, Croatia (Hrvatska), Cuba, Czech Republic, Denmark, Estonia, Ethiopia, Finland, Georgia, Germany, Greece, Hong Kong, Hungary, Iceland, Indonesia, Ireland, Italy, Jamaica, Japan, Kazakhstan, Laos, Lithuania, Luxembourg, Malta, Mexico, Moldova, Netherlands, New Zealand, Norway, Oman, Paraguay, Peru, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Slovakia, Slovenia, South Africa, South Korea, Spain, Switzerland, Taiwan, Thailand, Trinidad & Tobago, Turkey, Turkmenistan, United Kingdom, Uzbekistan, Venezuela) | |
| L-dopa powder | $ 15.19 |
| Levodopa powder | $ 7.31 |
| Levodopa 250 mg | |
| Lévodopa | |
| L-dopa powder | $ 15.19 |
| Levodopa powder | $ 7.31 |
| Levodopa 250 mg | |
| L-dopa powder | $ 15.19 |
| Levodopa powder | $ 7.31 |
| Levodopa 250 mg | |
| Levodopa - Beida Pharm (China) | |
| Levodopa Fu Seng (Taiwan) | |
| Levodopa-c | |
| Maipedopa | |
| Majormet (Taiwan) | |
| Majormet 1000's | |
| Parda | |
| Rigakin (Netherlands) | |
| Sobiodopa | |
| Symblyopia (China) | |
| Syndpa Plus | |
| Syndpa Plus Carbidopa 25mg, Levodopa 100mg TAB / 10 | $ 0.26 |
| Syndpa Plus Carbidopa 25mg, Levodopa 100mg TAB / 10 | $ 0.26 |
| Veldopa (United Kingdom) | |
| Weldopa | |
See 83 substitutes for Madopar-F | |
References
- DailyMed. "CARBIDOPA; ENTACAPONE; LEVODOPA: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "levodopa". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "benserazide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Madopar-F are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Madopar-F. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
