• Maki indications
• Uses of Maki in details
• Maki description
• Maki dosage
• Maki interactions
• Maki side effects
• Maki contraindications

What is Maki?

Maki is the potassium salt form of iodide, a naturally occurring substance.

Maki can be used as an expectorant to thin mucus and loosen congestion in your chest and throat.

Maki is used in people with chronic breathing problems that can be complicated by thick mucus in the respiratory tract, such as asthma, chronic bronchitis, or emphysema.

Maki may also be used for purposes not listed in this medication guide.

Maki indications

Maki is oral antithyroid agent. Maki is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution. (radiation poisoning;)

How should I use Maki?

Use Maki solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Maki solution. Talk to your pharmacist if you have questions about this information.
• Take Maki solution by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Use the dropper that comes with Maki solution to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you are instructed to take more than 1 dose of Maki solution, do NOT take it sooner than 24 hours after the last dose of Maki solution. Do NOT take more than 1 dose per day.
• If you miss a dose of Maki solution, take it as soon as possible. If you are instructed to take more than 1 dose of Maki solution and it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT take 2 doses at once.

Ask your health care provider any questions you may have about how to use Maki solution.

Uses of Maki in details

Use: Labeled Indications

Antidote: Block thyroidal uptake of radioactive isotopes of iodine in a nuclear radiation emergency.

Expectorant: Expectorant for the symptomatic treatment of chronic pulmonary diseases complicated by mucous.

Off Label Uses

Graves hyperthyroidism (following radioactive iodine therapy)

Data from a retrospective study suggest that Maki may be beneficial in select patients with Graves hyperthyroidism (eg, those who would be candidates for but are allergic to antithyroid drugs) in order to shorten the duration of hyperthyroidism after receiving radioactive iodine therapy.

Thyroid gland protection during radiopharmaceutical use

Based on the European Association of Nuclear Medicine (EANM) procedure guidelines for 131 I-meta-iodobenzylguanidine (131 I-mIBG) therapy, Maki is effective and recommended when given as thyroid gland protection during radiopharmaceutical use.

Thyrotoxic crisis/thyroid storm

Based on the American Thyroid Association and American Association of Clinical Endocrinologists guidelines for the diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis, Maki given to adults for thyrotoxic crisis/thyroid storm is effective and recommended in the management of this condition.

Maki description

Saturated solution of Maki is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). Maki can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Maki dosage

Maki Dosage

Applies to the following strength(s): 1 g/mL; 325 mg/5 mL; 130 mg; 65 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Cough
• Hyperthyroidism
• Cutaneous Sporotrichosis
• Radiation Emergency

Usual Pediatric Dose for:

• Cough
• Hyperthyroidism
• Cutaneous Sporotrichosis
• Radiation Emergency

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dialysis
• Other Comments

Usual Adult Dose for Cough

300 to 650 mg orally 3 to 4 times a day.

Usual Adult Dose for Hyperthyroidism

Oral solution: 250 mg orally 3 times a day. Give for 10 to 14 days prior to thyroid surgery.

May be given as 0.25 mL of a 1 g/mL potassium iodine solution (Maki) or as 4 mL of 325 mg/5 mL solution. Alternatively, 2 to 6 drops of a 10% Maki/5% iodine solution may be given orally 3 times a day with food.

Usual Adult Dose for Cutaneous Sporotrichosis

250 to 500 mg orally 3 times a day. Increase gradually to a maximum of 2 to 2.5 grams 3 times a day. Continue at maximum tolerated dose until the cutaneous lesions have resolved, usually 6 to 12 weeks.

Usual Adult Dose for Radiation Emergency

Pregnant or lactating women with exposure >= 5 centigrays (cGy): 130 mg orally per day.

>18 and <=40 years with exposure >= 10 centigrays (cGy): 130 mg orally per day.

>40 years with exposure >= 500 centigrays (cGy): 130 mg orally per day.

Usual Pediatric Dose for Cough

60 to 250 mg orally every 4 to 6 times a day. Maximum single dose 500 mg.

Usual Pediatric Dose for Hyperthyroidism

Oral solution: 250 mg orally 3 times a day. Give for 10 to 14 days prior to thyroid surgery.

Usual Pediatric Dose for Cutaneous Sporotrichosis

250 to 500 mg orally 3 times a day. Increase gradually to a maximum of 1.25 to 2 grams 3 times a day. Continue at maximum tolerated dose until the cutaneous lesions have resolved, usually 6 to 12 weeks.

Usual Pediatric Dose for Radiation Emergency

<=1 month with exposure >= 5 centigrays (cGy): 16 mg orally per day.

>1 month <=3 years with exposure >= 5 centigrays (cGy): 32 mg orally per day.

>3 years <= 18 years (less than 70 kg) with exposure >= 5 centigrays (cGy): 65 mg orally per day.

>13 years >= 70 kg with exposure >= 5 centigrays (cGy): 130 mg orally per day.

Renal Dose Adjustments

Maki should be used cautiously in patients with renal dysfunction. Due to impaired renal filtering of electrolytes, an increase in serum potassium can occur in patients with renal impairment.

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Administer after meals with food or milk or dilute with a large quantity of water, fruit juice, or broth.

More about Maki

• Side Effects
• During Pregnancy
• Dosage Information
• Drug Interactions
• Support Group
• 1 Review - Add your own review/rating

Consumer resources

• Maki
• Maki drops
• Maki liquid
• Maki solution
• Maki syrup
• Maki (Advanced Reading)

• Other brands: Maki, ThyroShield, Maki, Maki, More (1) »

Professional resources

• Maki (AHFS Monograph)
• More (2) »

Related treatment guides

• Cough
• Cutaneous Sporotrichosis
• Hyperthyroidism
• Radiation Emergency

Maki interactions

See also:
What other drugs will affect Maki?

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: ACE inhibitors (e.g., captopril, lisinopril), angiotensin receptor blockers (ARBs such as losartan, valsartan), certain "water pills" (potassium-sparing diuretics such as amiloride, spironolactone, triamterene), drospirenone, eplerenone, lithium, potassium-containing drugs (e.g., supplements such as potassium chloride).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Maki side effects

See also:
What are the possible side effects of Maki?

Applies to Maki: oral solution, oral syrup

As well as its needed effects, Maki (the active ingredient contained in Maki) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Maki, check with your doctor or nurse as soon as possible:

Less common:

• Hives
• joint pain
• swelling of arms, face, legs, lips, tongue, and/or throat
• swelling of lymph glands

With long-term use

• Burning of mouth or throat
• confusion
• headache (severe)
• increased watering of mouth
• irregular heartbeat
• metallic taste
• numbness, tingling, pain or weakness in hands or feet
• soreness of teeth and gums
• sores on skin
• symptoms of head cold
• unusual tiredness
• weakness or heaviness of legs

Minor Side Effects

Some Maki side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:

• Diarrhea
• nausea or vomiting
• stomach pain

Maki contraindications

See also:
What is the most important information I should know about Maki?

Hypersensitivity to iodide, iodine, or any component of the formulation; dermatitis herpetiformis; hypocomplementemic vasculitis, nodular thyroid condition with heart disease

Active ingredient matches for Maki:

Potassium IODIDE

List of Maki substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Kelpasan
Tablet; Oral; Potassium Iodide 0.05 mg
Maki Pediatric
Microiodid (Russia)
Tablet; Oral; Potassium Iodide 130.8 mcg (Tatkhimfarmpreparaty)
Microiodide
Tablet; Oral; Potassium Iodide 130.8 mcg
Minostoss (Brazil)
MM Tosse (Brazil)
Mono-Jod (Germany)
Navarroyodol (Spain)
NeuroKare Iodine (New Zealand)
NeuroTabs (New Zealand)
Pima
Pima Syrup
Plexa Dulsin Liquid
Liquid; Oral; Potassium Iodide 0.15 mg / 0.06 ml
Potasio Ioduro Pharma Arte (Paraguay)
Potassium Iodate (United Kingdom)
Tablet; Oral; Potassium Iodate 85 mg
Potassium Iodate Alliance (United Kingdom)
Potassium Iodide (Czech Republic, Germany, Hungary, Philippines, Poland, Romania, Slovenia)
Solution; Oral; Potassium Iodide 1 g / ml
Tablet; Oral; Potassium Iodide 125 mg
Tablet; Oral; Potassium Iodide 40 mg
Liquid; Sublingual; Potassium Iodide 1 x / ml
Tablet; Oral; Potassium Iodide 0.131 mg
Tablet; Oral; Potassium Iodide 0.262 mg
Potassium Iodide solution 65 mg/mL (Mission Pharmacal Company (US))
Potassium Iodide 2% Unimed Pharma (Lithuania)
Potassium Iodide Drops
Potassium Iodide Ebisu Seiyaku (Japan)
Potassium Iodide G.L. Pharma (Bulgaria, Estonia, Lithuania)
Potassium Iodide Kozakai M (Japan)
Potassium Iodide Kozakai Seiyaku (Japan)
Potassium Iodide Liquid
Potassium Iodide Mylan (Japan)
Potassium Iodide Nichi-iko (Japan)
Potassium Iodide Nikko (Japan)
Potassium Iodide Nikko Seiyaku (Japan)
Potassium Iodide Roxane (United States)
Potassium Iodide Shiseido Seiyaku (Japan)
Potassium Iodide Solution
Potassium Iodide Sumio (Japan)
Potassium Iodide Syrup
Potassium Iodide Unimed Pharma (Bulgaria, Latvia, Lithuania)
Potassium Iodide Yamazen Seiyaku (Japan)
Potassium Iodide Yoshida Seiyaku (Japan)
See 179 substitutes for Maki

References

1. DailyMed. "POTASSIUM IODIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "Potassium". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. PubChem. "potassium iodide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Maki are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Maki. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology