What is Mefrin?
Mefrin is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Mefrin works by reducing hormones that cause inflammation and pain in the body.
Mefrin is used to treat pain or inflammation caused by arthritis. It is also used to treat menstrual pain.
Mefrin may also be used for other purposes not listed in this medication guide.
Mefrin indications
Carefully consider the potential benefits and risks of Mefrin (Mefrin) and other treatment options before deciding to use Mefrin (Mefrin). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Mefrin (Mefrin) is indicated:
- For relief of mild to moderate pain in patients =14 years of age, when therapy will not exceed one week (7 days).
- For treatment of primary dysmenorrhea.
How should I use Mefrin?
Use Mefrin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Mefrin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Mefrin refilled.
- Take Mefrin by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
- Take Mefrin with a full glass of water (8 oz/240 mL) as directed by your doctor.
- If you miss a dose of Mefrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Mefrin.
Uses of Mefrin in details
Use: Labeled Indications
Pain, mild to moderate: Relief of mild to moderate pain in patients ≥14 years, when therapy will not exceed 1 week.
Primary dysmenorrhea: Treatment of primary dysmenorrhea.
Mefrin description
Mefrin (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Mefrin's structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Mefrin cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Mefrin is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products.
Mefrin dosage
Carefully consider the potential benefits and risks of Mefrin (Mefrin) and other treatment options before deciding to use Mefrin (Mefrin). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
After observing the response to initial therapy with Mefrin (Mefrin), the dose and frequency should be adjusted to suit an individual patient's needs.
For the relief of acute pain in adults and adolescents =14 years of age, the recommended dose is 500 mg as an initial dose followed by 250 mg every 6 hours as needed, usually not to exceed one week.
How supplied
Mefrin (Mefrin) is available as 250 mg blue-banded, ivory capsules, imprinted with "FHPC 400" and "Mefrin® (Mefrin) ".
Bottles of 100...................NDC 59630-400-10
Storage
Store at 20- 25°C (68- 77°F); excursions permitted to 15-30°C (59-86°F).
REFERENCES
4. Glazko AJ: Experimental observations of flufenamic, mefenamic, and meclofenamic acids. Part III. Metabolic disposition, in Fenamates in Medicine. A Symposium, London, 1966. Annals of Physical Medicine, Supplement, pp 23-36, 1967.
5. Data on file, First Horizon (Protocol 356).
Distributed by: Atlanta, GA 30328. Revised March 2007. FDA Rev date: 3/6/2008
Mefrin interactions
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What other drugs will affect Mefrin?
A number of compounds are inhibitors of CYP2C9. Drug interactions studies of Mefrin and these compounds have not been conducted. The possibility of altered safety and efficacy should be considered when Mefrin (Mefrin) is used concomitantly with these drugs.
ACE-inhibitors
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Aspirin
When Mefrin (Mefrin) is administered with aspirin, its protein binding is reduced, although the clearance of free Mefrin (Mefrin) is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Mefrin and aspirin is not generally recommended because of the potential of increased adverse effects.
Diuretics
Clinical studies, as well as post marketing observations, have shown that Mefrin (Mefrin) can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy of NSAIDs, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.
Lithium
NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
Methotrexate
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin
The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
Antacids
In a single dose study (n=6), ingestion of an antacid containing 1.7-gram of magnesium hydroxide with 500-mg of Mefrin increased the Cmax and AUC of Mefrin by 125% and 36%, respectively. Therefore, when the drug is administered to patients receiving oral anticoagulant drugs, frequent monitoring of prothrombin time is necessary.
A false-positive reaction for urinary bile, using the diazo tablet test, may result after Mefrin administration. If biliuria is suspected, other diagnostic procedures, such as the Harrison spot test, should be performed.
REFERENCES
4. Glazko AJ: Experimental observations of flufenamic, mefenamic, and meclofenamic acids. Part III. Metabolic disposition, in Fenamates in Medicine. A Symposium, London, 1966. Annals of Physical Medicine, Supplement, pp 23-36, 1967.
Mefrin side effects
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What are the possible side effects of Mefrin?
Diarrhoea occasionally occurs following the use of Mefrin. Although this may occur soon after starting of treatment, it may also occur after several months of continuous use. The diarrhoea has been investigated in some patients who have continued this drug in spite of its continued presence; these patients were found to have associated proctocolitis.
If diarrhoea does develop; the drug should be discontinued immediately and the patient should not receive Mefrin again.
Skin rashes have been observed following the administration of Mefrin and the occurrence of a rash is a definite indication to stop medication.
As with other prostaglandin inhibitors, allergic glomerulonephritis has occurred occasionally.
Rarely, thrombocytopenia has been reported with Mefrin. In some cases reversible haemolytic anaemia has occurred with continuous administration of Mefrin for 12 months or longer.
Temporary lowering of the white blood cells count has been reported. Blood studies should therefore be carried out during long term administration.
Bronchospasm may be precipitated in patients suffering from, or with a previous history of bronchial asthma or allergic disease.
Patients on prolonged therapy should also be kept under surveillance with particular attention to liver dysfunction; should this appear, it is an indication to discontinue therapy.
Drowsiness and dizziness have rarely been reported.
Mefrin contraindications
See also:
What is the most important information I should know about Mefrin?
Mefrin (Mefrin) is contraindicated in patients with known hypersensitivity to Mefrin.
Mefrin (Mefrin) should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Mefrin (Mefrin) is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Mefrin (Mefrin) is contraindicated in patients with acute active ulceration or chronic inflammation of either the upper or lower gastrointestinal tract.
Mefrin (Mefrin) should not be used in patients with preexisting renal disease.
Active ingredient matches for Mefrin:
Mefenamic acid in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| 250 mg x 10's | $ 0.21 |
| 500 mg x 10's | $ 0.27 |
| Mefrin 250mg TAB / 10 | $ 0.21 |
| Mefrin 500mg TAB / 10 | $ 0.27 |
| MEFRIN tab 250 mg x 10's (Rhine Biogenics) | $ 0.21 |
| MEFRIN tab 500 mg x 10's (Rhine Biogenics) | $ 0.27 |
| Mefrin 250mg TAB / 10 | $ 0.21 |
| Mefrin 500mg TAB / 10 | $ 0.27 |
List of Mefrin substitutes (brand and generic names): | |
| Mefril (Singapore) | |
| Mefril 250 mg x 1's | |
| MEFSINE (India) | |
| 250 mg x 10's (Adley) | |
| Mefsine 250mg TAB / 10 (Adley) | |
| MEFSINE tab 250 mg x 10's (Adley) | |
| Mefsine 250mg TAB / 10 (Adley) | |
| MEFT (India) | |
| MEFT syr 50 mg x 60ml (Systemic) | |
| Meftagesic Susp (India) | |
| Meftagesic Susp Paracetamol 1250mg, MefenamicAcid 50mg/5mL SUSP / 60ml | $ 0.34 |
| 60ml | $ 0.34 |
| Meftagesic TAB (India) | |
| Meftagesic TAB Mefenamic Acid 500mg, Paracetamol 450mg TAB / 10 (Blue Cross (Excel)) | $ 0.31 |
| 10's (Blue Cross (Excel)) | $ 0.31 |
| MEFTAGESIC TAB tab 10's (Blue Cross (Excel)) | $ 0.35 |
| Meftal (India) | |
| Meftal Capsule/ Tablet / 500mg / 10 units (Blue Cross) | $ 0.28 |
| Meftal 250mg TAB / 10 (Blue Cross) | $ 0.22 |
| Meftal 500mg TA22.90B / 10 (Blue Cross) | $ 0.27 |
| 250 mg x 10's (Blue Cross) | $ 0.20 |
| 500 mg x 10's (Blue Cross) | $ 0.27 |
| Meftal 500mg TAB / 10 (Blue Cross) | $ 0.29 |
| MEFTAL 250MG TABLET 1 strip / 10 tablets each (Blue Cross) | $ 0.28 |
| MEFTAL 500MG TABLET 1 strip / 10 tablets each (Blue Cross) | $ 0.35 |
| MEFTAL P SUSPENSION 1 bottle / 60 ML suspension each (Blue Cross) | $ 0.36 |
| MEFTAL P TABLET DT 1 strip / 10 tablet dts each (Blue Cross) | $ 0.28 |
| MEFTAL tab 250 mg x 10's (Blue Cross) | $ 0.25 |
| MEFTAL tab 500 mg x 10's (Blue Cross) | $ 0.31 |
| Meftal 250mg Tablet (Blue Cross) | $ 0.03 |
| Meftal 500mg Tablet (Blue Cross) | $ 0.03 |
| Meftal 100mg/5ml Suspension (Blue Cross) | $ 0.38 |
| Meftal 100mg Tablet DT (Blue Cross) | $ 0.03 |
| Meftal -MR | |
| Meftal -MR Mefenamic Acid 500mg, Tizanidine 2mg TAB / 10 | $ 0.45 |
| MEFTAL-P (India) | |
| 100 mg x 10's (Blue Cross) | $ 0.18 |
| 100 mg x 5 mL x 60ml (Blue Cross) | $ 0.30 |
| Meftal-P 100mg DT-TAB / 10 (Blue Cross) | $ 0.19 |
| Meftal-P 100mg/5mL SUSP / 60ml (Blue Cross) | $ 0.30 |
| Meftal-P 100mgx5mL SUSP / 60ml (Blue Cross) | $ 0.34 |
| MEFTAL-P dispertab 100 mg x 10's (Blue Cross) | $ 0.23 |
| MEFTAL-P oral susp 100 mg x 5 mL x 60ml (Blue Cross) | $ 0.36 |
| Meftal-P 100mg DT-TAB / 10 (Blue Cross) | $ 0.19 |
| Meftal-P 100mgx5mL SUSP / 60ml (Blue Cross) | $ 0.34 |
| Meftan (Oman) | |
| Melur (Switzerland) | |
| Capsule; Oral; Mefenamic Acid 250 mg (Medika) | |
| Tablet, Film-Coated; Oral; Mefenamic Acid 500 mg (Medika) | |
| Memic | |
| Memic 250mg TAB / 10 | |
| Memic 500mg TAB / 10 | |
See 1269 substitutes for Mefrin | |
References
- DailyMed. "MEFENAMIC ACID: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "mefenamic acid". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "mefenamic acid". http://www.drugbank.ca/drugs/DB00784 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Mefrin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Mefrin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
