Meni indications
Oral
Meniere's disease
Adult: As Meni HCl: Initially, 8-16 mg tid.
Maintenance: 24-48 mg daily. As Meni mesilate: 6-12 mg tid.
Uses of Meni in details
Meni is used to treat Meniere's disease, condition which typically causes vertigo (sensation of spinning or rotation),tinnitus (ringing in ears), hearing loss and nausea (urge to vomit).
Meni description
Each tablet contains Betahistine dihydrochloride 8 mg.
It also contains the following excipients: β-cyclodextrin, maize starch, microcrystalline cellulose, anhydrous colloidal silica, calcium hydrogen phosphate, povidone, sodium lauryl sulphate, magnesium stearate, purified talc, sodium starch glycolate and purified water.
Meni dosage
Recommended Dose and Mode of Action: Adults: 16-mg Tab:24-48 mg divided over the day.
24-mg Tab: 48 mg divided over the day.
The dosage should be individually adapted according to the response. Improvement can sometimes only be observed after a couple of weeks of treatment. The best results are sometimes obtained after a few months. There are indications that treatment from the onset of the disease prevents the progression of the disease and/or the loss of hearing in later phases of the disease.
Pediatric: Meni is not recommended for use in children below18 years due to insufficient data on safety and efficacy.
Geriatric: Although there are limited data from clinical studies in this patient group, extensive post-marketing experience suggests that no dose adjustment is necessary in this patient population.
Renal and/or Hepatic Impairment: There are no specific clinical trials available in this patient groups, but according to the post-marketing experience, no dose adjustment appears to be necessary.
Administration: Should be swallowed with water.
Meni interactions
No in vivo interaction studies have been performed. Based on in vitro data, no in vivo inhibition on cytochrome P-450 enzymes is expected.
In vitro data indicate an inhibition of Meni metabolism by drugs that inhibit monoamine oxidase (MAO), including MAO subtype B (eg, selegiline). Caution is recommended when using Meni and MAO inhibitors (including MAO-B selective) concomitantly.
As Meni is an analogue of histamine, interaction of Meni with antihistamines may in theory affect the efficacy of one of these drugs.
Incompatibilities: Not applicable.
Meni side effects
The following undesirable effects have been experienced with the below indicated frequencies in Meni-treated patients in placebocontrolled clinical trials [very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000)].
Gastrointestinal Disorders: Common: Nausea and dyspepsia.
Nervous System Disorders: Common: Headache.
In addition to those events reported during clinical trials, the following undesirable effects have been reported spontaneously during post-marketing use and in scientific literature. A frequency cannot be estimated from the available data and is therefore classified as "not known".
Immune System Disorders: Hypersensitivity reactions, e.g. anaphylaxis.
Gastrointestinal Disorders: Mild gastric complaints (e.g. vomiting, gastrointestinal pain, abdominal distension and bloating). These can normally be dealt with by taking the dose during meals or by lowering the dose.
Skin and Subcutaneous Tissue Disorders: Cutaneous and subcutaneous hypersensitivity reactions, in particular angioneurotic oedema, urticaria, rash, and pruritus.
Meni contraindications
Hypersensitivity to Meni diHCl or to any of the excipients of Meni.
Phaeochromocytoma.
Active ingredient matches for Meni:
Betahistine in India.
Betahistine hydrochloride in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Meni 8mg TAB / 10 | $ 0.28 |
| Meni 16mg TAB / 10 | $ 0.52 |
| 8 mg x 10's | $ 0.28 |
| 16 mg x 10's | $ 0.52 |
| MENI 16 MG TABLET 1 strip / 10 tablets each (FDC Ltd) | $ 0.62 |
| MENI 4 MG TABLET 1 strip / 10 tablets each (FDC Ltd) | $ 0.28 |
| MENI 8 MG TABLET 1 strip / 10 tablets each (FDC Ltd) | $ 0.34 |
| MENI tab 8 mg x 10's (FDC (Spectra)) | $ 0.28 |
| MENI tab 16 mg x 10's (FDC (Spectra)) | $ 0.52 |
| Meni 16mg Tablet (FDC Ltd) | $ 0.06 |
| Meni 4mg Tablet (FDC Ltd) | $ 0.03 |
| Meni 8mg Tablet (FDC Ltd) | $ 0.03 |
List of Meni substitutes (brand and generic names): | |
| MENEAS | |
| Meneas 8mg Tablet (Shreeyam Healthcare) | $ 0.04 |
| Meniace (South Korea) | |
| Meniero (Hong Kong) | |
| Menietol (Japan) | |
| Meniex (Argentina) | |
| Meniserc (Poland) | |
| Menistin (Peru) | |
| Menitazine (Japan, Taiwan) | |
| Menitazine 12 mg | |
| Mepahist (Egypt) | |
| MERIS (Taiwan) | |
| 0.3 % w/v x 5ml (Mepfarma) | $ 0.29 |
| Meris 6 mg (Mepfarma) | |
| Meris 0.3% w/v EYE DPS / 5ml (Mepfarma) | $ 0.29 |
| MERIS eye drops 0.3 % w/v x 5ml (Mepfarma) | $ 0.29 |
| Meris 0.3% w/v EYE DPS / 5ml (Mepfarma) | $ 0.29 |
| Merislon (China, Costa Rica, Dominican Republic, El Salvador, Guatemala, Hong Kong, Japan, Malaysia, Myanmar, Philippines, Singapore, Taiwan, Thailand, Vietnam) | |
| Merislon 6 mg x 100's (Eisai) | $ 45.05 |
| Merislon 12 mg x 100's (Eisai) | $ 65.69 |
| Merislon 6 mg x 3 x 10's (Eisai) | |
| Merislon 12 mg x 100 x 10's (Eisai) | |
| Merislon 6 mg x 1000's (Eisai) | $ 64.00 |
| Merislon 6 mg x 1, 000's (Eisai) | |
| Merislon 6 mg x 50 Blister x 10 Tablet (Eisai) | |
| Merislon 6 mg x 100 x 10's (Eisai) | |
| Merislon 12 mg x 1000's (Eisai) | |
| Merislon 12mg TAB / 10 (Eisai) | $ 1.37 |
| Merislon 6mg TAB / 10 (Eisai) | $ 0.71 |
| MERISLON 12 MG TABLET 1 strip / 10 tablets each (Eisai) | $ 1.49 |
| MERISLON 6 MG TABLET 1 strip / 10 tablets each (Eisai) | $ 0.77 |
| Merislon tab 6 mg 1000's (Eisai) | $ 64.00 |
| Merislon tab 12 mg 100 x 10's (Eisai) | |
| Merislon tab 6 mg 3 x 10's (Eisai) | |
| Merislon tab 12 mg 100's (Eisai) | $ 68.97 |
| Merislon tab 6 mg 100's (Eisai) | $ 0.58 |
| MERISLON tab 6 mg x 10's (Eisai) | $ 0.71 |
| MERISLON tab 12 mg x 10's (Eisai) | $ 1.37 |
| Merislon tab 6 mg 50 x 10's (Eisai) | |
| Merislon 12mg Tablet (Eisai) | $ 0.16 |
| Merislon 6mg Tablet (Eisai) | $ 0.08 |
| Merison (Bangladesh) | |
| Meristin (Indonesia) | |
| Merlin (Thailand) | |
| Merlin 6 mg x 50 x 10's (T. O. Chemicals) | |
| Merlin tab 6 mg 50 x 10's (T. O. Chemicals) | |
| Mertigo (Indonesia, Thailand) | |
| Mertigo 6 mg x 50 x 10's (Dexa Medica) | |
See 1281 substitutes for Meni | |
References
- PubChem. "betahistine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "betahistine". http://www.drugbank.ca/drugs/DB06698 (accessed September 17, 2018).
- DTP/NCI. "betahistine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Meni are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Meni. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology
