What is Murozo?
Murozo is used to help prevent the symptoms of asthma and improve breathing in patients 4 years of age and older. When used regularly every day, inhaled Murozo decreases the number and severity of asthma attacks. However, it will not relieve an asthma attack that has already started.
Murozo HFA is used as a maintenance treatment for the prevention and control of asthma symptoms in patients 12 years of age and older.
Inhaled Murozo belongs to the family of medicines known as corticosteroids (cortisone-like medicines). It works by preventing certain cells in the lungs and breathing passages from releasing substances that cause asthma symptoms.
Murozo is available only with your doctor's prescription.
Murozo indications
Murozo is a cortisone-like steroid available in cream, ointment, and lotion form. It is used to treat certain itchy rashes and other inflammatory skin conditions.
How should I use Murozo?
Use Murozo spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Murozo spray. Talk to your pharmacist if you have questions about this information.
- Murozo spray is used in the nose.
- Before using Murozo spray the first time, pump it up to 10 times or until a fine mist appears. If Murozo spray has not been used for more than 1 week, prime it by pumping it 2 times or until a fine mist appears before using it.
- Shake well before each use.
- Use Murozo spray at regular intervals exactly as prescribed by your health care provider.
- Blow your nose gently to clear passages before using Murozo spray. Spray into each nostril as directed.
- Avoid spraying into the eyes, mouth, or directly onto the nasal septum (the wall between your nostrils).
- After using Murozo spray, wipe the applicator with a clean tissue and replace the lid.
- The maximum benefit of Murozo spray is usually achieved within 1 to 2 weeks. Contact your doctor if symptoms worsen or do not improve.
- If Murozo spray is being used to prevent seasonal allergy symptoms, begin treatment 2 to 4 weeks before the expected start of the pollen season.
- Use Murozo spray on a regular schedule to get the most benefit from it.
- Continue to use Murozo spray even if you feel well. Do not miss any doses.
- If you miss a dose of Murozo spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Murozo spray.
Uses of Murozo in details
Murozo is used to treat used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. It is also used to relieve symptoms of hay fever, allergies of nose and nasal polyps (fleshy swelling inside the nose).
Murozo description
Murozo is a medium-potency synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that Murozo provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of Murozo furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Murozo dosage
Murozo Dosage
Applies to the following strength(s): 220 mcg/inh; 110 mcg/inh; 100 mcg/inh; 200 mcg/inh
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Asthma - Maintenance
Usual Pediatric Dose for:
- Asthma - Maintenance
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dose Adjustments
- Precautions
- Dialysis
- Other Comments
Usual Adult Dose for Asthma - Maintenance
Inhalation Aerosol Powder:
Previous therapy with bronchodilators alone, or inhaled corticosteroids:
-Initial dose: 220 mcg inhaled orally in the evening
-Maximum dose: 440 mcg in divided doses of 220 mcg twice a day, or as 440 mcg once daily.
Previous therapy with oral corticosteroids:
-Initial dose: 440 mcg inhaled orally twice a day
-Maximum dose: 880 mcg
Inhalation Aerosol:
Previous therapy with inhaled medium-dose corticosteroids:
-2 inhalations of 100 mcg orally twice a day
Previous therapy with inhaled high-dose or oral corticosteroids:
-2 inhalations of 200 mcg orally twice a day
-Maximum dose: 800 mcg per day
For Patients Currently Receiving Chronic
Oral Corticosteroid Therapy
:-Prednisone should be weaned slowly, beginning after at least 1 week of therapy with this drug.
-Monitor for signs of asthma instability, including serial objective measures of airflow, and for signs of adrenal insufficiency during steroid taper and following discontinuation of oral corticosteroid therapy.
Comments:
-The time to onset and degree of symptom relief varies based on individual patient.
-Maximum benefit may not be achieved for 1 week or longer.
-After asthma stability has been achieved, titrate to the lowest effective dosage to reduce side effects.
-If there is no response to the starting dose after 2 weeks of therapy, higher doses may provide additional asthma control.
-Re-evaluate therapy and consider additional therapeutic options (e.g., initiating an inhaled corticosteroid and long-acting beta2-agonist combination product, or initiating oral corticosteroids) if asthma control is not achieved.
-Doses above the recommended should not be used.
Use: Maintenance treatment of asthma as prophylactic therapy
Usual Pediatric Dose for Asthma - Maintenance
Inhalation Aerosol Powder:
Less than 4 years: Not approved for this age.
4 to 11 years:
-110 mcg orally once a day, in the evening
12 years and older:
Previous therapy with bronchodilators alone or inhaled corticosteroids:
-Initial dose: 220 mcg inhaled orally in the evening
-Maximum dose: 440 mcg in divided doses of 220 mcg twice a day, or as 440 mcg once daily.
Previous therapy with oral corticosteroids:
-Initial dose: 440 mcg inhaled orally twice a day
-Maximum dose: 880 mcg
Inhalation Aerosol:
Less than 12 years: Not approved for this age.
12 years or older:
Previous therapy with inhaled medium-dose corticosteroids:
-2 inhalations of 100 mcg orally twice a day
Previous therapy with inhaled high-dose or oral corticosteroids:
-2 inhalations of 200 mcg orally twice a day
-Maximum dose: 800 mcg per day
For Patients Currently Receiving Chronic
Oral Corticosteroid Therapy
:-Prednisone should be weaned slowly, beginning after at least 1 week of therapy with this drug.
-Monitor for signs of asthma instability, including serial objective measures of airflow, and for signs of adrenal insufficiency during steroid taper and following discontinuation of oral corticosteroid therapy
Comments:
-The time to onset and degree of symptom relief varies based on individual patient.
-Maximum benefit may not be achieved for 1 week or longer.
-After asthma stability has been achieved, titrate to the lowest effective dosage to reduce side effects.
-For patients older than 12 years, if there is no response to the starting dose after 2 weeks of therapy, higher doses may provide additional asthma control.
-Re-evaluate therapy and consider additional therapeutic options (e.g., initiating an inhaled corticosteroid and long-acting beta2-agonist combination product, or initiating oral corticosteroids) if asthma control is not achieved.
-Doses above the recommended should not be used.
Use: Maintenance treatment of asthma as prophylactic therapy
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
No adjustment recommended.
Dose Adjustments
The dose of Murozo should be individualized and titrated to the lowest effective dose for the control of asthma.
Precautions
Inhalation aerosol powder: Safety and efficacy have not been established in patients younger than 4 years.
Inhalation aerosol: Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-For oral inhalation only.
-Inhale rapidly and deeply.
-After each inhalation, rinse mouth with water without swallowing.
-Once a day dose should be taken only in the evening.
-If a dose is missed, take the next dose at the regular time.
Reconstitution/preparation techniques:
-The pressurized metered dose aerosol inhaler should be primed before using for the first time and if not used for more than 5 days.
-To prime the pressurized aerosol, release 4 test sprays into the air, away from the face, shaking well before each spray.
-The manufacturer product information should be consulted.
General:
-Limitations of Use: This drug is not indicated for the relief of acute bronchospasm.
-This drug is not a bronchodilator and should not be used to treat status asthmaticus or to relieve acute asthma symptoms.
-Acute asthma symptoms should be treated with an inhaled, short-acting beta2-agonist.
Monitoring:
-Respiratory: Asthma signs, symptoms, instability
-Gastrointestinal: Signs of adverse effect on the oral cavity
-Musculoskeletal: Decrease in bone mineral density (BMD), growth in pediatric patients
-Ocular: Changes in vision, increase of intraocular pressure, glaucoma, cataracts
Patient advice:
-Use this drug at regular intervals, since its effectiveness depends on regular use.
-Contact physician if symptoms get worse, more inhalation of the rescue inhaler than usual is needed, significant decrease in lung function as outlined by the physician.
-Therapy with this drug should not be stopped without physician advice since symptoms may recur after discontinuation.
More about Murozo
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 15 Reviews - Add your own review/rating
Consumer resources
- Murozo inhalation solution
- Murozo powder
- Murozo inhalation
- Murozo Inhalation, oral/nebulization (Advanced Reading)
- Other brands: Asmanex Twisthaler, Asmanex HFA
Professional resources
- Murozo Furoate (AHFS Monograph)
- Murozo (Oral Inhalation) (Wolters Kluwer)
Related treatment guides
- Asthma, Maintenance
Murozo interactions
Possible food and drug interactions when taking Murozo furoate:
No interactions have been noted.
Murozo side effects
See also:
What are the possible side effects of Murozo?
Applies to Murozo nasal: nasal spray
In addition to its needed effects, some unwanted effects may be caused by Murozo nasal. In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Murozo nasal:
More common:
- Bloody mucus or unexplained nosebleeds
- chills
- cold or flu-like symptoms
- cough or hoarseness
- fever
- headache
- increased abdominal or stomach pain and cramping during menstrual periods
- muscle or bone pain
- stuffy or runny nose
- Chest pain
- discharge or redness in the eye, eyelid, or inner lining of the eyelid
- earache
- shortness of breath
- tightness in the chest
- troubled breathing
- wheezing
- Sores inside the nose
- white patches inside the nose or mouth
- Difficulty with swallowing
- dizziness
- fast heartbeat
- hives
- itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- skin rash
- unusual tiredness or weakness
Minor Side Effects
Some of the side effects that can occur with Murozo nasal may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Sore throat
- Diarrhea
- joint or muscle ache or pain
- nasal burning or irritation
- nausea
- sneezing
- stomach upset or discomfort following meals
- Bad, unusual, or unpleasant (after) taste or smell
- change in taste or smell
Murozo contraindications
See also:
What is the most important information I should know about Murozo?
Hypersensitivity to Murozo furoate or to other corticosteroids. Rosacea, acne vulgaris, skin atrophy, inflammation around the mouth, TB, ulcerated skin or wounds, genital itching, diaper rash, viral infection (cold sores, chickenpox, shingles), fungal skin infection (thrush, tinea/ringworm), other skin infections. Childn <2 yr.
Active ingredient matches for Murozo:
Mometasone in Taiwan.
| Unit description / dosage (Manufacturer) | Price, USD |
| Murozo 0.1 % x 10 mL | |
| Murozo 0.1 % x 30 mL | |
List of Murozo substitutes (brand and generic names): | |
| Mundoson (Italy) | |
| Myrey (Turkey) | |
| Myrey-Sanovel (Georgia) | |
| Mysera (Japan) | |
| Mysera 0.1% (Japan) | |
| Narinex (South Korea) | |
| Nasamet (Greece) | |
| Nasative (South Korea) | |
| Nasehaler (Poland) | |
| Nasoaldo (Spain) | |
| Nasocobi (South Korea) | |
| Nasocure (South Korea) | |
| Nasomet Singad Pharma (Denmark) | |
| Nasometin (Estonia, Poland) | |
| Nasonex (Merck Sharp & Dohme (China) | |
| Nasonex 0.05% (Hungary) | |
| Nasonex 50mcg (Luxembourg, Switzerland) | |
| Nasonex Allergy (Australia) | |
| Nasonex Allergy 0.05% (United Kingdom) | |
| Nasonex Aquous (Turkey) | |
| Nasonex Bb Farma (Italy) | |
| Nasonex Pediátrico (Peru) | |
| Nasonex Programmi Saniari (Italy) | |
| Nasostad (Bulgaria) | |
| Nassomet (Georgia) | |
| Nazofix (Turkey) | |
| Nazomac-M (India) | |
| Nazomac-M 50mcg N-SPY / 120md (Macleods (Oxalis)) | $ 1.93 |
| NAZOMAC-M NASAL SPRAY 1 packet / 12 ML nasal spray each (Macleods (Oxalis)) | $ 2.98 |
| NAZOMAC-M nasal spray 50 mcg x 120md (Macleods (Oxalis)) | $ 2.71 |
| Nazomed (Georgia) | |
| Nazoster (Georgia, Turkey) | |
| Netonox (Netherlands) | |
| Nexomist (South Africa) | |
| NIDSONE (India) | |
| 0.1 % w/w x 10g (Nidus Pharma Pvt Ltd) | $ 0.96 |
| Nidsone Skin 10 gm Cream (Nidus Pharma Pvt Ltd) | $ 0.96 |
| Nidsone 0.1% w/w CRM / 10g (Nidus Pharma Pvt Ltd) | $ 0.96 |
| NIDSONE cream 0.1 % w/w x 10g (Nidus Pharma Pvt Ltd) | $ 0.96 |
| NIDSONE cream 0.1 % w/w x 15g (Nidus Pharma Pvt Ltd) | $ 1.08 |
| NIDSONE lotion 0.1 % w/w x 25ml (Nidus Pharma Pvt Ltd) | $ 1.52 |
| Nidsone 0.1% w/w CRM / 10g (Nidus Pharma Pvt Ltd) | $ 0.96 |
| Nites (Brazil) | |
| Novase SP (Peru) | |
See 1005 substitutes for Murozo | |
References
- PubChem. "Mometasone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Mometasone". http://www.drugbank.ca/drugs/DB00764 (accessed September 17, 2018).
- MeSH. "Anti-Allergic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Murozo are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Murozo. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
