What is Neocenta?
Neocenta is an antibiotic that fights bacteria in the body.
Neocenta is used to reduce the risk of infection during surgery of your intestines. Neocenta is also used to reduce the symptoms of hepatic coma.
Neocenta may also be used for purposes not listed in this medication guide.
Neocenta indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Neocenta tablets and other antibacterial drugs, Neocenta tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Suppression of Intestinal Bacteria
Neocenta tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base.
Hepatic Coma (Portal-Systemic Encephalopathy)
Neocenta has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.
How should I use Neocenta?
Use Neocenta as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Neocenta by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Neocenta with plenty of water to avoid dehydration.
- Do not take Neocenta for more than 2 weeks unless advised to do so by your health care provider.
- Take Neocenta on a regular schedule to get the most benefit from it.
- To clear up your infection completely, use Neocenta for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Neocenta, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.
Ask your health care provider any questions you may have about how to use Neocenta.
Uses of Neocenta in details
Oral Neocenta is used before the operation of the gut to kill the bacteria which normally live in the gut that may cause a serious infection and in treatment of patients with coma due to liver disease (hepatic coma).
Neocenta description
Each mL of sterile ophthalmic suspension contains prednisolone acetate (microfine) 0.5 mg, Neocenta (equivalent to Neocenta base 0.35%) 0.5 mg, polymyxin B sulfate 10,000 units and Liquifilm (polyvinyl alcohol) 1.4%. It also contains thimerosal (1:100,000), polysorbate 80, propylene glycol, sodium acetate and purified water.
Neocenta dosage
Administer to turkeys at a dose of 10 mg Neocenta per pound of body weight per day for 5 days. Administer to cattle (excluding veal calves), swine, sheep and goats at a dose of 10 mg Neocenta per pound of body weight per day in divided doses for a maximum of 14 days.
Herd/Flock Treatment
Each packet will treat 143,000 pounds body weight.
Therefore, estimate the total number of pounds of body weight of the animals to be treated and administer one (1) packet (or portion thereof) for each 143,000 pounds. The product should be added to the amount of drinking water estimated to be consumed in 12-24 hours. Provide medicated water as the sole source of water each day until consumed, followed by non-medicated water as required.
Fresh medicated water should be prepared each day.
Individual Animal Treatment
To provide 10 mg Neocenta per pound of body weight, mix one (1) level teaspoon in water or milk for each 160 pounds body weight. Administer daily either as a drench in divided doses or in the drinking water to be consumed in 12 - 24 hours.
For Use in Animals Only.
Not for Human Use.
Keep Out of Reach of Children.
Net wt
70.5 oz (2000 gm)
Trademarks registered by Alpharma Inc.
ANADA #200-130, Approved by FDA
23369 0905
Alpharma Inc.
Bridgewater, New Jersey 08807
Neocenta interactions
See also:
What other drugs will affect Neocenta?
Caution should be taken in concurrent or serial use of other neurotoxic and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of Neocenta.
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance Neocenta's nephrotoxicity and/or ototoxicity and potentiate Neocenta's neuromuscular blocking effects.
Oral Neocenta inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.
Oral Neocenta may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.
Neocenta side effects
See also:
What are the possible side effects of Neocenta?
The most common adverse reactions to oral Neocenta are nausea, vomiting and diarrhea. The "Malabsorption Syndrome" characterized by increased fecal fat, decreased serum carotene and fall in xylose absorption has been reported with prolonged therapy. Nephrotoxicity, ototoxicity and neuromuscular blockage have been reported.
Neocenta contraindications
See also:
What is the most important information I should know about Neocenta?
Neocenta oral preparations are contraindicated in the presence of intestinal obstruction and in individuals with a history of hypersensitivity to the drug.
Patients with a history of hypersensitivity or serious toxic reaction to other aminoglycosides may have a cross-sensitivity to Neocenta.
Neocenta oral preparations are contraindicated in patients with inflammatory or ulcerative gastrointestinal disease because of the potential for enhanced gastrointestinal absorption of Neocenta.
Active ingredient matches for Neocenta:
Neomycin sulfate in Indonesia.
Neomycin sulfate 05%/placenta extr 10% in Indonesia.
| Unit description / dosage (Manufacturer) | Price, USD |
| Neocenta 15 g x 1's | $ 2.47 |
List of Neocenta substitutes (brand and generic names): | |
| DEXONA DPS (India) | |
| 3ml (Zydus Cadila) | $ 0.10 |
| Dexona DPS Neomycin sulfate 0.5 %, dexamethasone sodium phosphate0.1 %. EYE/EAR DPS / 3ml (Zydus Cadila) | $ 0.10 |
| DEXONA DPS eye/ear drops 3ml (Zydus Cadila) | $ 0.10 |
| Dexona DPS Neomycin sulfate 0.5 %, Dexamethasone sodium phosphate0.1 %. EYE/EAR DPS / 3ml (Zydus Cadila) | $ 0.10 |
| Durvet | |
| Gyno-V (Vietnam) | |
| Gyno-V 2 Blister x 6 Tablet | |
| Gywell (Vietnam) | |
| Gywell 2 Blister x 6 Tablet | |
| Kimianeo - 20 | |
| Neo Sol 50 | |
| Neomed 325 | |
| Neomycin 500 | |
| Neomycin sulfate (Vietnam) | |
| Neomycin Sulfate 250 mg x 1000's | |
| Neomycin Sulfate tablet 500 mg/1 (ECI Pharmaceuticals, LLC (US)) | |
| Neomycin sulfate 05%/placenta extr 10% (Indonesia) | |
| Neomycin Sulfate 325 | |
| Neomycin Xepa-Soul (Singapore) | |
| Neomycin Xepa-Soul 0.5 % w/w x 1's | |
| Neovet 325 | |
| Oziadecordex-N (Vietnam) | |
| Oziadecordex-N 1 Bottle 5 mL | |
| Predmycin-P (Philippines) | |
| Predmycin-P 5 mL (Allergan) | $ 6.62 |
| Predmycin-P ophth susp 5 mL x 1's (Allergan) | |
| Terinale Vaginal Soft Capsule (Vietnam) | |
| Terinale Vaginal Soft Capsule 2 Blister x 12 Tablet | |
| Tyrocim (Taiwan) | |
| Tyrocim 15 g | |
| Vaginapoly (Vietnam) | |
| Vaginapoly 2 Blister x 6 Tablet | |
| Woundhealed (Taiwan) | |
| Woundhealed 5 g | |
| Woundhealed 15 g | |
| Ya Fu (Taiwan) | |
| Ya Fu 5 g | |
| Ya Fu 10 g | |
| Ya Fu 15 g | |
References
- DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "neomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "neomycin". http://www.drugbank.ca/drugs/DB00452 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Neocenta are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Neocenta. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
