What is Nubeta?
Nubeta is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Nubeta is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.
Nubeta is available only with your doctor's prescription.
Nubeta indications
Nubeta is indicated for the treatment of hypertension. Nubeta may be used alone or in combination with other antihypertensive agents.
How should I use Nubeta?
Use Nubeta as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Nubeta by mouth with or without food.
- Take Nubeta on a regular schedule to get the most benefit from it. Taking Nubeta at the same time each day will help you remember to take it.
- Continue to take Nubeta even if you fell well. Do not miss any doses.
- Do not suddenly stop taking Nubeta without first talking with your doctor. You may have an increased risk of side effects (eg, chest pain, irregular heartbeat). If you need to stop Nubeta or add a new medicine, your doctor may need to gradually lower your dose.
- If you miss a dose of Nubeta, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Nubeta.
Uses of Nubeta in details
Nubeta is used to treat high blood pressure and chronic heart failure.
Nubeta description
Each tablet contains Nebivolol HCl 5.45 mg equivalent to Nubeta 5 mg: 2.5 mg of d-Nubeta and 2.5 mg l-Nubeta. It also contains the following excipients: Lactose monohydrate, polysorbate 80 (E433), hypromellose (E464), maize starch, croscarmellose sodium (E468), microcrystalline cellulose (E460), anhydrous colloidal silica (E551), magnesium stearate (E572).
The tablets can be divided in equal quarters.
Nubeta dosage
Nubeta Dosage
Generic name: Nubeta
Dosage form: tablets
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
The dose of Nubeta should be individualized to the needs of the patient. For most patients, the recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents. For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg. A more frequent dosing regimen is unlikely to be beneficial.
Renal Impairment
In patients with severe renal impairment (ClCr less than 30 mL/min) the recommended initial dose is 2.5 mg once daily; upward titration should be performed cautiously if needed. Nubeta has not been studied in patients receiving dialysis.
Hepatic Impairment
In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily; upward titration should be performed cautiously if needed. Nubeta has not been studied in patients with severe hepatic impairment and therefore it is not recommended in that population.
Geriatric Patients
It is not necessary to adjust the dose in the elderly.
CYP2D6 Polymorphism
No dose adjustments are necessary for patients who are CYP2D6 poor metabolizers. The clinical effect and safety profile observed in poor metabolizers were similar to those of extensive metabolizers.
More about Nubeta (Nubeta)
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Consumer resources
- Nubeta
- Nubeta (Advanced Reading)
Professional resources
- Nubeta (AHFS Monograph)
- Nubeta (FDA)
Related treatment guides
- High Blood Pressure
- Mitral Valve Prolapse
Nubeta interactions
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What other drugs will affect Nubeta?
The following interactions apply to β-adrenergic antagonists in general: Calcium Antagonists: Care should be exercised when administering β-adrenergic antagonists with calcium antagonists of the verapamil or diltiazem type, because of their negative effect on contractility and AV conduction. IV verapamil is contraindicated in patients on Nubeta.
Antiarrhythmics: Caution should be exercised when administering β-adrenergic antagonists in association with Class I antiarrhythmic drugs and amiodarone, as their effect on atrial conduction time and their negative inotropic effect may be potentiated.
Clonidine: β-adrenergic antagonists increase the risk of rebound hypertension after sudden withdrawal of chronic clonidine treatment.
Digitalis: Digitalis glycosides associated with β-adrenergic antagonists may increase AV conduction time. Clinical trials with Nubeta have not shown any clinical evidence of an interaction. Nubeta does not influence the kinetics of digoxin.
Insulin andOral Antidiabetic Drugs:
Although Nubeta does not affect glucose levels, certain symptoms of hypoglycaemia (palpitations, tachycardia) may be masked.
Anaesthetics: Concomitant use of β-adrenergic antagonists and anaesthetics may attenuate reflex tachycardia and increase the risk of hypotension. The anaesthesiologist should be informed when the patient is receiving Nubeta.
Others: Concomitant use of NSAIDs had no effect on the blood pressure-lowering effect of Nubeta. Co-administration of cimetidine increased the plasma levels of Nubeta, without changing the clinical effect. Co-administration of ranitidine did not affect the pharmacokinetics of Nubeta. Provided Nubeta is taken with the meal, and an antacid between meals, the 2 treatments can be co-prescribed. Combining Nubeta with nicardipine slightly increased the plasma levels of both drugs, without changing the clinical effect. Co-administration of alcohol, furosemide or hydrochlorothiazide did not affect the pharmacokinetics of Nubeta. Nubeta does not affect the pharmacokinetics and pharmacodynamics of warfarin. Sympathicomimetic agents may counteract the effect of β-adrenergic antagonists. β-adrenergic agents may lead to unopposed α-adrenergic activity of sympathicomimetic agents with both α- and β-adrenergic effects (risk of hypertension, severe bradycardia and heart block). Concomitant administration of tricyclic antidepressants, barbiturates and phenothiazines may increase the blood-pressure lowering effect. As Nubeta metabolism involves the CYP2D6 isoenzyme, concomitant administration of serotonin reuptake inhibitors, dextrometorphan or other compounds predominantly metabolised via this pathway, may make extensive metabolisers resemble poor metabolisers.
Nubeta side effects
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What are the possible side effects of Nubeta?
Adverse events are listed separately for hypertension and chronic heart failure because of differences in the background diseases.
Hypertension: The adverse reactions reported, which are in most of the cases of mild to moderate intensity, are tabulated, classified by system organ class and ordered by frequency. The following adverse reactions have also been reported with some β-adrenergic antagonists: Hallucinations, psychoses, confusion, cold/cyanotic extremities, Raynaud's phenomenon, dry eyes and oculo-mucocutaneous toxicity of the practolol type.
Chronic Heart Failure: Data on adverse reactions in chronic heart failure patients are available from 1 placebo-controlled clinical trial involving 1067 patients taking Nubeta and 1061 patients taking placebo. In this study, a total of 449 Nubeta patients (42.1%) reported at least possibly casually related adverse reactions compared to 334 placebo patients (31.5%). The most commonly reported adverse reactions in Nubeta patients were bradycardia and dizziness, both occurring in approximately 11% of patients. The corresponding frequencies among placebo patients were approximately 2% and 7%, respectively.
The following incidences were reported for adverse reactions (at least possibly drug-related) which are considered specifically relevant in the treatment of chronic heart failure: Aggravation of cardiac failure occurred in 5.8% of Nubeta patients compared to 5.2% of placebo patients; postural hypotension was reported in 2.1% of Nubeta patients compared to 1% of placebo patients; drug intolerance occurred in 1.6% of Nubeta patients compared to 0.8% of placebo patients; 1st-degree atrioventricular block occurred in 1.4% of Nubeta patients compared to 0.9% of placebo patients; edema of the lower limb were reported by 1% of Nubeta patients compared to 0.2% of placebo patients.
Nubeta contraindications
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What is the most important information I should know about Nubeta?
Hypersensitivity to Nubeta or to any of the excipients of Nubeta.
Liver insufficiency or liver function impairment.
β-adrenergic antagonists are contraindicated in the following conditions: Cardiogenic shock; uncontrolled heart failure; sick sinus syndrome, including sino-atrial block; 2nd and 3rd degree heart block; history of bronchospasm and bronchial asthma; untreated phaeochromocytoma; metabolic acidosis; bradycardia (heart rate <50 bpm); hypotension; severe peripheral circulatory disturbances.
Use in pregnancy: Insufficient data exist on the use of Nubeta in human pregnancy to determine its potential harmfulness. Animal studies have not shown any indication of harmful effects, other than on the basis of its pharmacological properties. β-blockers reduce placental perfusion, which may result in intrauterine fetal death and in immature and premature delivery. In addition, adverse effects (hypoglycaemia and bradycardia) may occur in the fetus and the neonate. There is an increased risk of cardiac and pulmonary complications in the neonate in the postnatal period. Therefore, Nubeta should not be used during pregnancy.
Use in lactation: Most β-blockers, particularly lipophilic compounds eg, Nubeta and its active metabolites, pass into breast milk although to a variable extent. Since it is not known whether Nubeta is excreted into human milk, the use of Nubeta when breastfeeding is contraindicated. Animal studies have shown that Nubeta is excreted in breast milk.
Active ingredient matches for Nubeta:
Nebivolol in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| NUBETA Capsule/ Tablet / 5mg / 10 units (Nicholas Piramal) | $ 0.74 |
| NUBETA Capsule/ Tablet / 2.5mg / 10 units (Nicholas Piramal) | $ 0.44 |
| Nubeta 2.5mg TAB / 10 | $ 0.53 |
| Nubeta 5mg TAB / 10 | $ 0.81 |
| 2.5 mg x 10's | $ 0.48 |
| 5 mg x 10's | $ 0.74 |
| Nubeta 2.5 mg Tablet | $ 0.05 |
| Nubeta 5 mg Tablet | $ 0.08 |
| NUBETA 2.5 MG TABLET 1 strip / 10 tablets each (Abbott India Ltd) | $ 0.70 |
| NUBETA 5 MG TABLET 1 strip / 10 tablets each (Abbott India Ltd) | $ 1.06 |
| NUBETA tab 2.5 mg x 10's (AHPL) | $ 0.53 |
| NUBETA tab 5 mg x 10's (AHPL) | $ 0.81 |
| Nubeta 2.5mg TAB / 10 | $ 0.53 |
| Nubeta 5mg TAB / 10 | $ 0.81 |
| Nubeta 2.5mg Tablet (Abbott India Ltd) | $ 0.08 |
| Nubeta 5mg Tablet (Abbott India Ltd) | $ 0.12 |
List of Nubeta substitutes (brand and generic names): | |
| Nozac (Greece) | |
| NYFE (India) | |
| 2.5 mg x 10's (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.36 |
| 5 mg x 10's (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.60 |
| Nyfe 2.5mg TAB / 10 (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.36 |
| Nyfe 5mg TAB / 10 (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.60 |
| Nyfe 5 mg Tablet (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.06 |
| Nyfe 2.5 mg Tablet (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.04 |
| NYFE tab 2.5 mg x 10's (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.36 |
| NYFE tab 5 mg x 10's (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.60 |
| Nyfe 2.5mg TAB / 10 (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.36 |
| Nyfe 5mg TAB / 10 (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.60 |
| OD-Neb (Russian Federation) | |
| Pertium (Chile) | |
| Silostar (Spain) | |
| SONICARD | |
| SONICARD 2.5MG TABLET 1 strip / 10 tablets each (Blue Cross Laboratories Ltd) | $ 0.32 |
| SONICARD 5MG TABLET 1 strip / 10 tablets each (Blue Cross Laboratories Ltd) | $ 0.56 |
| Sonicard 5mg Tablet (Blue Cross Laboratories Ltd) | $ 0.06 |
| Symbian (Egypt) | |
| Syncrocor (Argentina) | |
| Taneleb (Georgia) | |
| Temerit (France) | |
| Tablet; Oral; Nebivolol Hydrochloride 5 mg (Menarini) | |
| Tevaneb (Slovakia) | |
| Toricard (Philippines) | |
| Toricard-5 (Philippines) | |
| Toricard-5 tab 5 mg 100's (Torrent) | $ 40.00 |
| Tyskiten (Belgium) | |
| Valende (Turkey) | |
| Vascura (Turkey) | |
| Vasilol (Turkey) | |
| Vasoxen (Turkey) | |
| Vibolol (Croatia (Hrvatska)) | |
| Volone (Croatia (Hrvatska)) | |
| WONVOLOL (India) | |
| WONVOLOL tab 2.5 mg x 10's (Wonder (Xtra)) | |
| WONVOLOL tab 5 mg x 10's (Wonder (Xtra)) | |
| X-Pressol (Romania) | |
| Zenebi (India) | |
| Zenebi 2.5mg TAB / 10 (FDC Limited) | $ 0.39 |
| Zenebi 5mg TAB / 10 (FDC Limited) | $ 0.63 |
| 2.5 mg x 10's (FDC Limited) | $ 0.39 |
| 5 mg x 10's (FDC Limited) | $ 0.63 |
| Zenebi 2.5 mg Tablet (FDC Limited) | $ 0.04 |
| Zenebi 5 mg Tablet (FDC Limited) | $ 0.06 |
| ZENEBI tab 2.5 mg x 10's (FDC Limited) | $ 0.39 |
| ZENEBI tab 5 mg x 10's (FDC Limited) | $ 0.63 |
See 609 substitutes for Nubeta | |
References
- PubChem. "Nebivolol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Nebivolol". http://www.drugbank.ca/drugs/DB04861 (accessed September 17, 2018).
- MeSH. "Adrenergic beta-1 Receptor Agonists". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
