Olux/ Olux-E Complete Pack foam Uses

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What is Olux/ Olux-E Complete Pack foam?

Olux/ Olux-E Complete Pack foam lotion is a prescription corticosteroid medicine used on the skin (topical) for the relief of swelling (inflammation) and itching caused by certain skin conditions in people 18 years of age and older.

Olux/ Olux-E Complete Pack foam lotion should not be used for the treatment of acne vulgaris, rosacea or red, dry itchy skin (dermatitis) around the mouth.

Olux/ Olux-E Complete Pack foam lotion is not recommended in children under 18 years of age.

Important: Olux/ Olux-E Complete Pack foam lotion is for use on the skin only. Do not get the lotion near or in your eyes, mouth or vagina.

Olux/ Olux-E Complete Pack foam indications

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Indication

Olux/ Olux-E Complete Pack foam® Spray, 0.05% is a super-high potent topical corticosteroid formulation indicated for the treatment of moderate to severe plaque psoriasis affecting up to 20% body surface area (BSA) in patients 18 years of age or older. The total dosage should not exceed 50 g (59 mL or 2 fl. oz.) per week. Do not use more than 26 sprays per application or 52 sprays per day. Treatment should be limited to 4 consecutive weeks.

Patients should be instructed to use Olux/ Olux-E Complete Pack foam® Spray, 0.05% for the minimum amount of time necessary to achieve the desired results see [Dosage and Administration (2)].

Use in patients under 18 years of age is not recommended because safety has not been established and because numerically high rates of HPA axis suppression were seen with other clobetasol propionate topical formulations.

Limitations of Use

Olux/ Olux-E Complete Pack foam® Spray, 0.05% should not be used on the face, axillae, or groin. Olux/ Olux-E Complete Pack foam® Spray, 0.05% should not be used if there is atrophy at the treatment site. Olux/ Olux-E Complete Pack foam® Spray, 0.05% should not be used in the treatment of rosacea or perioral dermatitis.

How should I use Olux/ Olux-E Complete Pack foam?

Use Olux/ Olux-E Complete Pack foam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Olux/ Olux-E Complete Pack foam.

Uses of Olux/ Olux-E Complete Pack foam in details

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Olux/ Olux-E Complete Pack foam is used to treat itching, redness, dryness, inflammation, and discomfort of various scalp and skin conditions, including immune-mediated skin disease with red scaly patches (psoriasis).

Olux/ Olux-E Complete Pack foam description

Olux/ Olux-E Complete Pack foam scalp application also contains the following excipients: Carbomer, isopropyl alcohol, sodium hydroxide and purified water.

Olux/ Olux-E Complete Pack foam cream also contains the following excipients: Glyceryl monostearate, cetostearyl alcohol, chlorocresol, sodium citrate, monohydrated citric acid, purified water, Arlacel 165, beeswax substitute 6621 and propylene glycol.

Olux/ Olux-E Complete Pack foam ointment also contains the following excipients: Propylene glycol, white soft paraffin and sorbitan sesquioleate.

Olux/ Olux-E Complete Pack foam dosage

Olux/ Olux-E Complete Pack foam Dosage

Generic name: clobetasol propionate 0.5mg in 1g

Dosage form: cream, ointment

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The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Apply a thin layer of Olux/ Olux-E Complete Pack foam® Cream or Ointment to the affected skin areas twice daily and rub in gently and completely.

Olux/ Olux-E Complete Pack foam® Cream and Ointment are super-high potency topical corti-costeroids; therefore, treatment should be limited to 2 consecutive weeks and amounts greater than 50 g/week should not be used.

As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.

Olux/ Olux-E Complete Pack foam® Cream and Ointment should not be used with occlusive dressings.

Geriatric Use: In studies where geriatric patients (65 years of age or older, see PRECAUTIONS) have been treated with Olux/ Olux-E Complete Pack foam® Cream or Ointment, safety did not differ from that in younger patients; therefore, no dosage adjustment is recommended.

More about Olux/ Olux-E Complete Pack foam (Olux/ Olux-E Complete Pack foam)

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Olux/ Olux-E Complete Pack foam interactions

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What other drugs will affect Olux/ Olux-E Complete Pack foam?

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Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Avoid combination

Corticorelin: Corticosteroids may diminish the therapeutic effect of Corticorelin. Specifically, the plasma ACTH response to corticorelin may be blunted by recent or current corticosteroid therapy. Monitor therapy

Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased. Monitor therapy

Hyaluronidase: Corticosteroids may diminish the therapeutic effect of Hyaluronidase. Management: Patients receiving corticosteroids (particularly at larger doses) may not experience the desired clinical response to standard doses of hyaluronidase. Larger doses of hyaluronidase may be required. Consider therapy modification

Ritodrine: Corticosteroids may enhance the adverse/toxic effect of Ritodrine. Monitor therapy

Olux/ Olux-E Complete Pack foam side effects

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What are the possible side effects of Olux/ Olux-E Complete Pack foam?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.

Olux/ Olux-E Complete Pack foam Cream was evaluated in two randomized, multicenter, prospective, vehicle-controlled clinical trials in subjects with moderate to severe plaque psoriasis. Subjects applied Olux/ Olux-E Complete Pack foam Cream or vehicle cream twice daily for 14 days. A total of 354 subjects applied Olux/ Olux-E Complete Pack foam Cream and 178 subjects applied vehicle.

The adverse reaction that occurred in at least 1% of subjects treated with Olux/ Olux-E Complete Pack foam Cream and at a higher incidence than in subjects treated with vehicle cream was application site discoloration (2% versus 1%).

Less common local adverse events occurring in < 1% of subjects treated with Olux/ Olux-E Complete Pack foam Cream were application site atrophy, telangiectasia and rash.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of clobetasol propionate: striae, irritation, dryness, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, and miliaria. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Olux/ Olux-E Complete Pack foam contraindications

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What is the most important information I should know about Olux/ Olux-E Complete Pack foam?

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Hypersensitivity to clobetasol propionate or to any of the excipients of Olux/ Olux-E Complete Pack foam.

Scalp Application: Infections of the scalp.

Cream/Ointment: Primary skin lesions caused by infection with fungi or bacteria; primary cutaneous viral infections (eg, herpes simplex, chickenpox); rosacea; acne vulgaris; pruritus without inflammation; perianal and genital pruritus; perioral dermatitis.

Use in children: Olux/ Olux-E Complete Pack foam is contraindicated in children <1 year.

Children are more likely to develop local and systemic side effects of topical corticosteroids and in general, require shorter courses and less potent agents than adults.

Care should be taken when using Olux/ Olux-E Complete Pack foam to ensure the amount applied is the minimum that provides therapeutic benefit.

Active ingredient matches for Olux/ Olux-E Complete Pack foam:

Clobetasol topical


List of Olux/ Olux-E Complete Pack foam substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
NIOSOL 0.05% CREAM 1 tube / 30 GM cream each (KLM Laboratories Pvt Ltd)$ 1.47
Niosol 0.05% Ointment (KLM Laboratories Pvt Ltd)$ 0.05
OCOVATE 0.05% CREAM 1 tube / 30 GM cream each (Ochoa Laboratories Ltd)$ 0.61
100 gram in 1 can
50 gram in 1 can
Olux-E aerosol, foam .5 mg/g (Prestium Pharma, Inc. (US))
Olux-E aerosol, foam 0.05 % (Glaxosmithkline Inc (Canada))
PLOSAT 0.05% CREAM 1 tube / 15 GM cream each (Winsome Laboratories Pvt Ltd)$ 0.39
PSORICORT C 0.05% W/W GEL 1 tube / 20 GM gel each (Curatio Healthcare India Pvt Ltd)$ 1.19
SACLO TOPICAL 0.05% W/V SOLUTION 1 bottle / 30 ML solution each (Mohrish Pharmaceuticals)$ 0.96
SOLTOP 0.05% CREAM 1 tube / 30 GM cream each (Ipca Laboratories Ltd)$ 1.51
SUPRAVATE 0.05% CREAM 1 tube / 10 GM cream each (Parker Robinson Pvt Ltd)$ 0.20
Cream; Topical; Clobetasol Propionate 0.05% (Pharmaderm)
Gel; Topical; Clobetasol Propionate 0.05% (Pharmaderm)
Ointment; Topical; Clobetasol Propionate 0.05% (Pharmaderm)
Solution; Topical; Clobetasol Propionate 0.05% (Pharmaderm)
Temovate cream .5 mg/g (Pharmaderm)
Temovate gel .5 mg/g (Pharmaderm)
Temovate ointment .5 mg/g (Pharmaderm)
Cream; Topical; Clobetasol Propionate 0.05%
Temovate E cream .5 mg/g (Pharma Derm A Division Of Fougera Pharmaceuticals Inc. (US))
TEZCORT 0.05% CREAM 1 tube / 30 GM cream each (Glowderma Labs Pvt Ltd)$ 0.95
TEZCORT 0.05% CREAM 1 tube / 15 GM cream each (Glowderma Labs Pvt Ltd)$ 0.75
TRIFEC CREAM 1 tube / 10 GM cream each (Win-Medicare Pvt Ltd)$ 0.43
TUFDERM CREAM 1 tube / 30 GM cream each (Apex Laboratories Pvt Ltd)$ 0.96
VICLOB CREAM 1 tube / 30 GM cream each (Kivi Labs Ltd)$ 1.18
VICLOB CREAM 1 tube / 15 GM cream each (Kivi Labs Ltd)$ 0.56
VICLOB OINTMENT 1 tube / 20 GM ointment each (Kivi Labs Ltd)$ 0.56
Viclob NA Ointment (Kivi Labs Ltd)$ 0.03
ZINCORT 0.05% W/W CREAM 1 tube / 15 GM cream each (Megha Healthcare Pvt Ltd)$ 0.48

References

  1. PubChem. "clobetasol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Clobetasol". http://www.drugbank.ca/drugs/DB11750 (accessed September 17, 2018).
  3. MeSH. "Glucocorticoids". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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