What is Plosat?
Plosat lotion is a prescription corticosteroid medicine used on the skin (topical) for the relief of swelling (inflammation) and itching caused by certain skin conditions in people 18 years of age and older.
Plosat lotion should not be used for the treatment of acne vulgaris, rosacea or red, dry itchy skin (dermatitis) around the mouth.
Plosat lotion is not recommended in children under 18 years of age.
Important: Plosat lotion is for use on the skin only. Do not get the lotion near or in your eyes, mouth or vagina.
Plosat indications
Indication
Plosat® Spray, 0.05% is a super-high potent topical corticosteroid formulation indicated for the treatment of moderate to severe plaque psoriasis affecting up to 20% body surface area (BSA) in patients 18 years of age or older. The total dosage should not exceed 50 g (59 mL or 2 fl. oz.) per week. Do not use more than 26 sprays per application or 52 sprays per day. Treatment should be limited to 4 consecutive weeks.
Patients should be instructed to use Plosat® Spray, 0.05% for the minimum amount of time necessary to achieve the desired results see [Dosage and Administration (2)].
Use in patients under 18 years of age is not recommended because safety has not been established and because numerically high rates of HPA axis suppression were seen with other clobetasol propionate topical formulations.
Limitations of Use
Plosat® Spray, 0.05% should not be used on the face, axillae, or groin. Plosat® Spray, 0.05% should not be used if there is atrophy at the treatment site. Plosat® Spray, 0.05% should not be used in the treatment of rosacea or perioral dermatitis.
How should I use Plosat?
Use Plosat as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before using Plosat. If your fingers are warm, rinse them in cold water and dry before you apply Plosat.
- Use the smallest amount of medicine necessary to cover the affected area.
- Turn the can upside down and squirt a small amount of foam (up to the size of a golf ball or about 1½ capfuls) into the cap of the can, onto a clean saucer, or onto another cool, clean surface. You may also squirt it directly onto the affected area. Do not squirt the medicine directly into the hand because it will start to melt immediately upon touching warm skin.
- If you are applying Plosat to the scalp, move the hair away from the affected area and gently rub the medicine into the affected area until the foam disappears. Repeat until the entire affected area of the scalp is treated.
- If you are applying Plosat to other areas, gently rub the medicine into the skin until it disappears.
- Throw away any unused medicine that has been squirted out of the can.
- Wash your hands immediately after using Plosat, unless your hands are a part of the treated area.
- Do not use Plosat on your face, groin, or underarms unless your doctor tells you otherwise.
- Do not use Plosat over large areas of the body without first checking with your doctor.
- Do not bandage or wrap the affected area unless directed to do so by your doctor.
- If the can seems warm or the foam seems runny, rinse the can with cool water.
- If you miss a dose of Plosat, apply it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Plosat.
Uses of Plosat in details
Plosat is used to treat itching, redness, dryness, inflammation, and discomfort of various scalp and skin conditions, including immune-mediated skin disease with red scaly patches (psoriasis).
Plosat description
Plosat scalp application also contains the following excipients: Carbomer, isopropyl alcohol, sodium hydroxide and purified water.
Plosat cream also contains the following excipients: Glyceryl monostearate, cetostearyl alcohol, chlorocresol, sodium citrate, monohydrated citric acid, purified water, Arlacel 165, beeswax substitute 6621 and propylene glycol.
Plosat ointment also contains the following excipients: Propylene glycol, white soft paraffin and sorbitan sesquioleate.
Plosat dosage
Plosat Dosage
Generic name: clobetasol propionate 0.5mg in 1g
Dosage form: cream, ointment
See also:
- Plosat Cream cream
- Plosat E Cream cream
- Plosat Gel topical gel
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Apply a thin layer of Plosat® Cream or Ointment to the affected skin areas twice daily and rub in gently and completely.
Plosat® Cream and Ointment are super-high potency topical corti-costeroids; therefore, treatment should be limited to 2 consecutive weeks and amounts greater than 50 g/week should not be used.
As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.
Plosat® Cream and Ointment should not be used with occlusive dressings.
Geriatric Use: In studies where geriatric patients (65 years of age or older, see PRECAUTIONS) have been treated with Plosat® Cream or Ointment, safety did not differ from that in younger patients; therefore, no dosage adjustment is recommended.
More about Plosat (Plosat)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
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- En Espanol
- 3 Reviews - Add your own review/rating
Consumer resources
- Plosat cream
- Plosat gel
- Plosat solution
- Plosat
- Plosat (Advanced Reading)
- Other brands: Plosat, Olux, Plosat, Plosat, More (7) »
Professional resources
- Plosat (FDA)
- More (3) »
Other formulations
- Plosat E
Related treatment guides
- Dermatological Disorders
- Lichen Planus
- Atopic Dermatitis
- Dermatitis
- Eczema
- More (2) »
Plosat interactions
See also:
What other drugs will affect Plosat?
Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Avoid combination
Corticorelin: Corticosteroids may diminish the therapeutic effect of Corticorelin. Specifically, the plasma ACTH response to corticorelin may be blunted by recent or current corticosteroid therapy. Monitor therapy
Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased. Monitor therapy
Hyaluronidase: Corticosteroids may diminish the therapeutic effect of Hyaluronidase. Management: Patients receiving corticosteroids (particularly at larger doses) may not experience the desired clinical response to standard doses of hyaluronidase. Larger doses of hyaluronidase may be required. Consider therapy modification
Ritodrine: Corticosteroids may enhance the adverse/toxic effect of Ritodrine. Monitor therapy
Plosat side effects
See also:
What are the possible side effects of Plosat?
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.
Plosat Cream was evaluated in two randomized, multicenter, prospective, vehicle-controlled clinical trials in subjects with moderate to severe plaque psoriasis. Subjects applied Plosat Cream or vehicle cream twice daily for 14 days. A total of 354 subjects applied Plosat Cream and 178 subjects applied vehicle.
The adverse reaction that occurred in at least 1% of subjects treated with Plosat Cream and at a higher incidence than in subjects treated with vehicle cream was application site discoloration (2% versus 1%).
Less common local adverse events occurring in < 1% of subjects treated with Plosat Cream were application site atrophy, telangiectasia and rash.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of clobetasol propionate: striae, irritation, dryness, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, and miliaria. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Plosat contraindications
See also:
What is the most important information I should know about Plosat?
Hypersensitivity to clobetasol propionate or to any of the excipients of Plosat.
Scalp Application: Infections of the scalp.
Cream/Ointment: Primary skin lesions caused by infection with fungi or bacteria; primary cutaneous viral infections (eg, herpes simplex, chickenpox); rosacea; acne vulgaris; pruritus without inflammation; perianal and genital pruritus; perioral dermatitis.
Use in children: Plosat is contraindicated in children <1 year.
Children are more likely to develop local and systemic side effects of topical corticosteroids and in general, require shorter courses and less potent agents than adults.
Care should be taken when using Plosat to ensure the amount applied is the minimum that provides therapeutic benefit.
Active ingredient matches for Plosat:
| Unit description / dosage (Manufacturer) | Price, USD |
| PLOSAT 0.05% CREAM 1 tube / 15 GM cream each (Winsome Laboratories Pvt Ltd) | $ 0.39 |
List of Plosat substitutes (brand and generic names): | |
| NIOSOL | |
| NIOSOL 0.05% CREAM 1 tube / 30 GM cream each (KLM Laboratories Pvt Ltd) | $ 1.47 |
| Niosol 0.05% Ointment (KLM Laboratories Pvt Ltd) | $ 0.05 |
| OCOVATE | |
| OCOVATE 0.05% CREAM 1 tube / 30 GM cream each (Ochoa Laboratories Ltd) | $ 0.61 |
| Olux / Olux-E Kit | |
| Olux Foam | |
| Olux-E | |
| 100 gram in 1 can | |
| 50 gram in 1 can | |
| Olux-E aerosol, foam .5 mg/g (Prestium Pharma, Inc. (US)) | |
| Olux-E aerosol, foam 0.05 % (Glaxosmithkline Inc (Canada)) | |
| Olux-E Emollient Foam | |
| Olux/ Olux-E Complete Pack foam | |
| Olux/ Olux-E Complete Pack foam | |
| Olux/Olux-E Complete Pack | |
| PSORICORT C | |
| PSORICORT C 0.05% W/W GEL 1 tube / 20 GM gel each (Curatio Healthcare India Pvt Ltd) | $ 1.19 |
| SACLO | |
| SACLO TOPICAL 0.05% W/V SOLUTION 1 bottle / 30 ML solution each (Mohrish Pharmaceuticals) | $ 0.96 |
| SOLTOP | |
| SOLTOP 0.05% CREAM 1 tube / 30 GM cream each (Ipca Laboratories Ltd) | $ 1.51 |
| SUPRAVATE | |
| SUPRAVATE 0.05% CREAM 1 tube / 10 GM cream each (Parker Robinson Pvt Ltd) | $ 0.20 |
| Temovate | |
| Cream; Topical; Clobetasol Propionate 0.05% (Pharmaderm) | |
| Gel; Topical; Clobetasol Propionate 0.05% (Pharmaderm) | |
| Ointment; Topical; Clobetasol Propionate 0.05% (Pharmaderm) | |
| Solution; Topical; Clobetasol Propionate 0.05% (Pharmaderm) | |
| Temovate cream .5 mg/g (Pharmaderm) | |
| Temovate gel .5 mg/g (Pharmaderm) | |
| Temovate ointment .5 mg/g (Pharmaderm) | |
| Temovate Cream | |
| Temovate E | |
| Cream; Topical; Clobetasol Propionate 0.05% | |
| Temovate E cream .5 mg/g (Pharma Derm A Division Of Fougera Pharmaceuticals Inc. (US)) | |
| Temovate Emollient | |
| Temovate Gel | |
| Temovate Solution | |
| TEZCORT | |
| TEZCORT 0.05% CREAM 1 tube / 30 GM cream each (Glowderma Labs Pvt Ltd) | $ 0.95 |
| TEZCORT 0.05% CREAM 1 tube / 15 GM cream each (Glowderma Labs Pvt Ltd) | $ 0.75 |
| Tovet | |
| TRIFEC | |
| TRIFEC CREAM 1 tube / 10 GM cream each (Win-Medicare Pvt Ltd) | $ 0.43 |
| TUFDERM | |
| TUFDERM CREAM 1 tube / 30 GM cream each (Apex Laboratories Pvt Ltd) | $ 0.96 |
| TUFFCLO | |
| VICLOB | |
| VICLOB CREAM 1 tube / 30 GM cream each (Kivi Labs Ltd) | $ 1.18 |
| VICLOB CREAM 1 tube / 15 GM cream each (Kivi Labs Ltd) | $ 0.56 |
| VICLOB OINTMENT 1 tube / 20 GM ointment each (Kivi Labs Ltd) | $ 0.56 |
| Viclob NA Ointment (Kivi Labs Ltd) | $ 0.03 |
| ZINCORT | |
| ZINCORT 0.05% W/W CREAM 1 tube / 15 GM cream each (Megha Healthcare Pvt Ltd) | $ 0.48 |
See 172 substitutes for Plosat | |
References
- PubChem. "clobetasol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Clobetasol". http://www.drugbank.ca/drugs/DB11750 (accessed September 17, 2018).
- MeSH. "Glucocorticoids". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Plosat are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Plosat. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
