Oxatect Uses

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Oxatect indications

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Oral

Allergic conditions

Adult: As anhydrous substance: 30 mg bid.

Child: As anhydrous substance: Initially, 0.5 mg/kg bid. Optimal dose: 0.5-1 mg/kg bid.

Hepatic impairment: Initiate at 50% of the normal dose.

Oxatect description

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Oxatect dosage

Oral

Allergic conditions

Adult: As anhydrous substance: 30 mg bid.

Child: As anhydrous substance: Initially, 0.5 mg/kg bid. Optimal dose: 0.5-1 mg/kg bid.

Hepatic impairment: Initiate at 50% of the normal dose.

Oxatect interactions

May enhance effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and tranquillizers. Anticholinergic effects of atropine, TCAs, MAOIs may be enhanced. May mask signs of ototoxicity caused by aminoglycosides.

Oxatect side effects

Sedation, inability to concentrate, lassitude, dizziness, hypotension, muscular weakness, incoordination. Nausea, vomiting, diarrhoea or constipation, epigastric pain. Headache, blurred vision, tinnitus, elation or depression, irritability, nightmares, anorexia, urinary retention, dry mouth, chest tightness, dysuria and tingling. Rash, urticaria. Agranulocytosis, haemolytic anaemia. Increased appetite, wt gain. Convulsions, increased transaminase, hepatitis. Dyskinetic neurological reactions (infants and young children).

Potentially Fatal: Anaphylactoid reactions, angioedema.

Oxatect contraindications

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Oxatect should not be given to patients who are hypersensitive to erythromycin, sulfonamides, or any component of the formulation, who have hepatic dysfunction, and porphyria. It is containdicated in infants of less than 2 months of age.

Oxatect can not be used concurrently with pimozide or cisapride.

Active ingredient matches for Oxatect:

Oxatomide in Japan.


List of Oxatect substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Oxamide 30 mg x 500's
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Oxtin 30 mg x 5 x 10's (Guardian)$ 13.95
Gel; Topical; Oxatomide Hydrate 5% (Cilag)
Suspension; Oral; Oxatomide 2.5 mg / ml (Cilag)
Tablet; Oral; Oxatomide 30 mg (Cilag)
Tinset 30 mg x 250's (Cilag)
Tinset 30 mg x 25 x 10's (Cilag)
Tinset 30 mg x 50 x 10's (Cilag)
Tinset 30 mg x 50's (Cilag)$ 18.41
Ulymin 30 mg x 100 x 10's
Ulymin 30 mg x 1000's

References

  1. PubChem. "oxatomide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Oxatomide". http://www.drugbank.ca/drugs/DB12877 (accessed September 17, 2018).
  3. DTP/NCI. "oxatomide: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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