What is Penicigran?
Penicillins are used to treat infections caused by bacteria. They work by killing the bacteria or preventing their growth.
There are several different kinds of penicillins. Each is used to treat different kinds of infections. One kind of Penicigran usually may not be used in place of another. In addition, penicillins are used to treat bacterial infections in many different parts of the body. They are sometimes given with other antibacterial medicines (antibiotics). Some of the penicillins may also be used for other problems as determined by your doctor. However, none of the penicillins will work for colds, flu, or other virus infections.
Penicillins are available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, penicillins are used in certain patients with the following medical conditions:
- Chlamydia infections in pregnant women—Amoxicillin and ampicillin
- Gas gangrene—Penicigran G
- Helicobacter pylori-associated gastritis or peptic ulcer disease—Amoxicillin
- Leptospirosis—Ampicillin and Penicigran G
- Lyme disease—Amoxicillin and Penicigran
- Typhoid fever—Amoxicillin and ampicillin
Penicigran indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Penicigran Potassium and other antibacterial drugs, Penicigran Potassium should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Penicigran Potassium tablets are indicated in the treatment of mild to moderately severe infections due to Penicigran G-sensitive microorganisms. Therapy should be guided by bacteriologic studies (including sensitivity tests) and by clinical response.
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with Penicigran during the acute stage. Indicated surgical procedures should be performed.
The following infections will usually respond to adequate dosage of Penicigran.
Streptococcal Infections (without bacteremia)
Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas.
NOTE: Streptococci in groups A, C, G, H, L, and M are very sensitive to Penicigran. Other groups, including group D (enterococcus), are resistant.
Pneumococcal Infections
Mild to moderately severe infections of the respiratory tract.
Staphylococcal infections – Penicigran G-sensitive
Mild infections of the skin and soft tissues.
NOTE: Reports indicate an increasing number of strains of staphylococci resistant to Penicigran G, emphasizing the need for culture and sensitivity studies in treating suspected staphylococcal infections.
Fusospirochetosis (Vincent’s gingivitis and pharyngitis)
Mild to moderately severe infections of the oropharynx usually respond to therapy with oral Penicigran.
NOTE: Necessary dental care should be accomplished in infections involving the gum tissue.
Medical conditions in which oral Penicigran therapy is indicated as prophylaxis: For the prevention of recurrence following rheumatic fever and/or chorea: Prophylaxis with oral Penicigran on a continuing basis has proven effective in preventing recurrence of these conditions.
Although no controlled clinical efficacy studies have been conducted, Penicigran has been suggested by the American Heart Association and the American Dental Association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients who have congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract1.
Oral Penicigran should not be used in those patients at particularly high risk for endocarditis (e.g., those with prosthetic heart valves or surgically constructed systemic pulmonary shunts). Penicigran should not be used as adjunctive prophylaxis for genitourinary instrumentation or surgery, lower-intestinal tract surgery, sigmoidoscopy, and childbirth. Since it may happen that alpha hemolytic streptococci relatively resistant to Penicigran may be found when patients are receiving continuous oral Penicigran for secondary prevention of rheumatic fever, prophylactic agents other than Penicigran may be chosen for these patients and prescribed in addition to their continuous rheumatic fever prophylactic regimen.
NOTE: When selecting antibiotics for the prevention of bacterial endocarditis, the physician or dentist should read the full joint statement of the American Heart Association and the American Dental Association1.
How should I use Penicigran?
Use Penicigran as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Penicigran is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Penicigran at home, a health care provider will teach you how to use it. Be sure you understand how to use Penicigran. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Penicigran if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Penicigran works best if it is given at the same time each day.
- Penicigran is injected into a muscle. Penicigran should not be injected into or near an artery or vein.
- To clear up your infection completely, use Penicigran for the full course of treatment. Keep using it even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Penicigran and you are using it regularly, use it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Penicigran.
Uses of Penicigran in details
Use: Labeled Indications
Fusospirochetosis (Vincent gingivitis and pharyngitis): Treatment of fusospirochetosis (Vincent gingivitis and pharyngitis), in conjunction with dental care for infections involving gum tissue.
Pneumococcal infections: Treatment of mild to moderately severe pneumococcal respiratory tract infections, including otitis media.
Rheumatic fever and/or chorea prophylaxis: Prophylaxis (chronic, secondary) of rheumatic fever and/or chorea.
Staphylococcal infections (Penicigran G-sensitive): Treatment of mild infections of the skin and soft tissues.
Streptococcal infections (without bacteremia): Treatment of mild to moderate streptococcal infections of the upper respiratory tract, scarlet fever, and mild erysipelas.
Off Label Uses
Actinomycosis
Data from a limited number of clinical studies suggest that Penicigran potassium may be beneficial for the treatment of actinomycosis after initial surgical intervention and IV therapy with Penicigran G (if clinically indicated).
Streptococcus (group A) chronic carrier
Based on the Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis, Penicigran potassium given to chronic carriers of group A streptococcal is effective and recommended in the management of this condition.
Penicigran description
A broad-spectrum Penicigran antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Penicigran dosage
The dosage of Penicigran should be determined according to the sensitivity of the causative microorganism and the severity of infection, and adjusted to the clinical response of the patient.
The usual dosage recommendations for adults and children 12 years and over are as follows:
Streptococcal Infections
Mild to moderately severe - of the upper respiratory tract and including scarlet fever and erysipelas: 125 to 250 mg (200,000 to 400,000 units) every 6 to 8 hours for 10 days.
Pneumococcal Infections
Mild to moderately severe - of the respiratory tract, including otitis media: 250 to 500 mg (400,000 to 800,000 units) every 6 hours until the patient has been afebrile for at least 2 days.
Staphylococcal Infections
Mild infections of skin and soft tissue (culture and sensitive tests should be performed): 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.
Fusospirochetosis (Vincent’s infection) of the oropharynx. Mild to moderately severe infections: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.
For the prevention of recurrence following rheumatic fever and/or chorea: 125 mg to 250 mg (200,000 to 400,000 units) twice daily on a continuing basis.
For prophylaxis against bacterial endocarditis1 in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when undergoing dental procedures or surgical procedures of the upper respiratory tract: 2 gram of Penicigran (1 gram for children under 60 lbs.) 1 hour before the procedure, and then, 1 gram (500 mg for children under 60 lbs.) 6 hours later.
Penicigran interactions
See also:
What other drugs will affect Penicigran?
Amoxicillin may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of Penicigran Vista Health Care with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Amoxicillin increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Amoxicillin reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.
With the combined use of amoxicillin and clavulanic acid pharmacokinetics of both components unchanged.
Penicigran side effects
See also:
What are the possible side effects of Penicigran?
Applies to Penicigran potassium: capsule, powder for solution, powder for suspension, solution, suspension, syrup, tablet, tablet for suspension, tablet chewable, tablet extended release
As well as its needed effects, Penicigran potassium may cause unwanted side effects that require medical attention.
Stop taking Penicigran potassium and get emergency help immediately if any of the following effects occur:
Less common:
- Fast or irregular breathing
- fever
- joint pain
- lightheadedness or fainting (sudden)
- puffiness or swelling around the face
- red, scaly skin
- shortness of breath
- skin rash, hives, itching
Major Side Effects
If any of the following side effects occur while taking Penicigran potassium, check with your doctor immediately:
Rare
- Abdominal or stomach cramps and pain (severe)
- abdominal tenderness
- convulsions (seizures)
- decreased amount of urine
- diarrhea (watery and severe), which may also be bloody
- mental depression
- nausea and vomiting
- pain at place of injection
- sore throat and fever
- unusual bleeding or bruising
- yellow eyes or skin
- Agitation or combativeness
- anxiety
- confusion
- fear of impending death
- feeling, hearing, or seeing things that are not real
Minor Side Effects
Some Penicigran potassium side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
- Diarrhea (mild)
- headache
- sore mouth or tongue
- vaginal itching and discharge
- white patches in the mouth and/or on the tongue
Penicigran contraindications
See also:
What is the most important information I should know about Penicigran?
A history of a previous hypersensitivity reaction to any of the penicillins is a contraindication. Penicigran is also contraindicated in infections caused by penicillinase-producing organisms.
Active ingredient matches for Penicigran:
Penicillin V in Brazil.
Phenoxymethylpenicillin potassium in Brazil.
List of Penicigran substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Peni-V (Tunisia) | |
| Penicilina Fenoximetil Mintlab (Chile) | |
| Penicilina Lepetit (Argentina) | |
| Penicilina Oral Lepetit (Argentina) | |
| Penicilina Oral Richet (Argentina) | |
| Penicilina Richet (Argentina) | |
| Penicilinã V (Romania) | |
| Tablet; Oral; Penicillin V Potassium 1, 000, 000 IU | |
| Penicilina V | |
| Tablet; Oral; Penicillin V Potassium 1, 000, 000 IU | |
| Penicilina V Potasica Farmatech (Colombia) | |
| Penicilina V Sandoz (Argentina) | |
| Penicillat (Germany) | |
| Penicillin (Hungary, Malta, Poland, United States) | |
| Syrup; Oral; Benzathine Phenoxymethylpenicillin 250, 000 IU / 5 ml | |
| Syrup; Oral; Benzathine Phenoxymethylpenicillin 500, 000 IU / 5 ml | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1 MIU | |
| Suspension; Oral; Penicillin G Potassium 125 mg / 5 ml | |
| Suspension; Oral; Penicillin G Potassium 250 mg / 5 ml | |
| Tablet; Oral; Penicillin G Potassium 250 mg | |
| Penicillin 1 Mega | |
| Tablet; Oral; Penicillin V | |
| Injectable; Injection; Penicillin G Sodium 1 MIU | |
| Penicillin Sandoz (Germany) | |
| Penicillin Spirig (Switzerland) | |
| Penicillin Spirig HC (Switzerland) | |
| Penicillin V AbZ (Germany) | |
| Penicillin V acis (Germany) | |
| Penicillin V AL (Germany) | |
| Penicillin V Asian Union (Thailand) | |
| Penicillin V Asian Union 250 mg x 500's | |
| Penicillin V Asian Union 250 mg x 1, 000's | |
| Penicillin V Athlone (Hong Kong) | |
| Penicillin V Athlone 125 mg/5 mL x 100 mL (Athlone) | |
| Penicillin V Athlone elixir 125 mg/5 mL 100 mL x 1's (Athlone) | |
| Penicillin V Athlone tab 250 mg 1000's (Athlone) | |
| Penicillin V Billix (Germany) | |
| Penicillin V CCPC (Taiwan) | |
| Penicillin V dura (Germany) | |
| Penicillin V Heumann (Germany) | |
| Penicillin V Osoth (Thailand) | |
| Penicillin V Osoth 400000 IU x 1, 000's | |
| Penicillin V Osoth 200000 IU x 500's | |
| Penicillin V Osoth 400000 IU x 500's | |
| Penicillin V Osoth 200000 IU/5 mL x 60 mL | |
| Penicillin V Potassium - Sandoz (China) | |
| Penicillin V Stada (Germany) | |
| Penicillin V-CT (Germany) | |
| Penicillin V-ratiopharm (Germany, Luxembourg) | |
See 512 substitutes for Penicigran | |
References
- DailyMed. "PENICILLIN V POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "penicillin v". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "penicillin v". http://www.drugbank.ca/drugs/DB00417 (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
