What is Phenoxine?
Phenoxine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. Constriction of blood vessels in your sinuses, nose, and chest allows drainage of those areas, which decreases congestion.
Phenoxine is used to treat the congestion associated with allergies, hay fever, sinus irritation, and the common cold. Phenoxine also causes a decrease in appetite and is used in some over-the-counter diet aids.
Phenoxine has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain Phenoxine.
Phenoxine may also be used for purposes other than those listed in this medication guide.
Phenoxine indications
Oral
Nasal congestion
Adult: Per cap contains a combination w/ Phenoxine HCl 18 mg: ≥13 yr 2 cap 4 hrly. Max: 8 cap/day. Per tab contains a combination w/ Phenoxine HCl 25 mg: ≥13 yr 1 tab 4 hrly. Max: 4 tab/day.
Child: Per cap contains a combination w/ Phenoxine HCl 18 mg: 6-12 yr 1 cap 4 hrly. Max: 4 cap/day. As oral liquid containing Phenoxine 2.5 mg/5 mL: 6 mth-2 yr 2.5 mL tid, 3-5 yr 5 mL 3-4 times daily, 6-12 yr 5-10 mL 3-4 times daily.
Uses of Phenoxine in details
Phenoxine is used to relieve blocked nose or sinuses caused by common cold and seasonal nasal allergies (hay fever). It is also used to decrease appetite for weight Phenoxine.
Phenoxine description
Phenoxine has been withdrawn in Canada and the United States. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug.
Phenoxine dosage
Phenoxine Dosage
Applies to the following strengths: 75 mg; 25 mg; 37.5 mg; 50 mg; 180 mg-75 mg
Usual Adult Dose for:
- Nasal Congestion
- Weight Loss
Usual Pediatric Dose for:
- Nasal Congestion
Additional dosage information:
- Renal Dose Adjustments
- Other Comments
Usual Adult Dose for Nasal Congestion
25 mg orally every 4 hours.
-or-
75 mg orally extended release every 12 hours.
Not to exceed 150 mg/day.
Usual Adult Dose for Weight Loss
25 mg orally 3 times a day, one-half hour before meals.
-or-
75 mg orally extended release once a day in the morning.
The use of Phenoxine for weight loss should be limited to 12 weeks.
Usual Pediatric Dose for Nasal Congestion
2 to 6 years:
6.25 mg orally every 4 hours. Maximum daily dose is 37.5 mg.
6 to 12 years:
12.5 mg orally every 4 hours. Maximum daily dose is 75 mg.
> 12 years:
25 mg orally every 4 hours.
-or-
75 mg orally extended release every 12 hours.
Not to exceed 150 mg/day.
Renal Dose Adjustments
Because Phenoxine is eliminated primarily by the kidneys, one-half of the normally recommended dosage should be given. Patients with renal dysfunction should be monitored for signs and symptoms of toxicity when using Phenoxine.
Other Comments
In November 2000, the Food and Drug Administration (FDA), in response to reports of increased risk of hemorrhagic stroke, requested that all drug companies discontinue marketing products containing Phenoxine.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Phenoxine
- Phenoxine Side Effects
- During Pregnancy
- Drug Interactions
- Support Group
- 2 Reviews
- Drug class: decongestants
Related treatment guides
- Weight Loss
- Cold Symptoms
- Nasal Congestion
Phenoxine interactions
See also:
What other drugs will affect Phenoxine?
The benzodiazepines, including Ativan (lorazepam), produce increased CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics.
Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.
Concurrent administration of lorazepam with valproate results in increased plasma concentrations and reduced clearance of lorazepam. Lorazepam dosage should be reduced to approximately 50% when coadministered with valproate.
Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half-life and decreased total clearance. Lorazepam dosage needs to be reduced by approximately 50% when coadministered with probenecid.
The effects of probenecid and valproate on lorazepam may be due to inhibition of glucuronidation.
Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.
Phenoxine side effects
See also:
What are the possible side effects of Phenoxine?
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Constipation.
Skin rash.
Codeine can cause drowsiness, although at the dose contained in this medicine this is very unlikely. However, if you do find this medicine makes you feel sleepy or dizzy you should not drive or operate machinery and avoid alcoholic drink.
The side effects listed above may not include all of the side effects reported by the medicines’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Phenoxine contraindications
See also:
What is the most important information I should know about Phenoxine?
Do not use lorazepam if you have narrow-angle glaucoma, or if you are allergic to lorazepam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax).
Before taking lorazepam, tell your doctor if you are allergic to any drugs, or if you have:
glaucoma;
asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
kidney or liver disease;
a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.
Active ingredient matches for Phenoxine:
Phenylpropanolamine in United States.
Phenylpropanolamine hydrochloride in United States.
List of Phenoxine substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Partuss | |
| Phenyldrine | |
| Phenylpropanolamine (Australia, Austria, Finland, France, Germany, Israel, Italy, Luxembourg, Netherlands, Poland, Switzerland, United Kingdom) | |
| Naldecon Senior EX 200 mg/5ml Syrup 118ml Bottle | $ 15.99 |
| Entex ER 10-300 mg 12 Hour Capsule | $ 1.14 |
| Codimal la capsule | $ 0.70 |
| Despec-dm tablet | $ 0.61 |
| Despec-tab tablet | $ 0.47 |
| Triaminic allergy thin strip | $ 0.35 |
| Triaminic cold-stuff nose strip | $ 0.35 |
| Conex tablet | $ 0.33 |
| Triaminic cgh-runny nose strip | $ 0.30 |
| Triaminic cough strips | $ 0.30 |
| Triaminic cough-cold chew | $ 0.27 |
| Triaminic softchew tablet | $ 0.27 |
| Triaminic softchews tablet | $ 0.25 |
| Childrens triaminic decon spray | $ 0.24 |
| Triaminicin tablet | $ 0.23 |
| Dexatrim natural caplet | $ 0.19 |
| Codimal DH 5-8.33-1.66 mg/5ml Syrup | $ 0.18 |
| Despec-exp syrup | $ 0.18 |
| Codimal dm syrup | $ 0.16 |
| Naldecon-dx senior | $ 0.06 |
| Apap allergy sinus caplet | $ 0.05 |
| Triaminic chest-nasal cong liq | $ 0.04 |
| Triaminic cold & cough liquid | $ 0.04 |
| Triaminic cold-allergy pe liq | $ 0.04 |
| Triaminic cough-nasal cong liquid | $ 0.04 |
| Triaminic cough-sore throat liquid | $ 0.04 |
| Triaminic flu cough-fever suspension | $ 0.04 |
| Triaminic flu-cough-fever liquid | $ 0.04 |
| Triaminic-d syrup | $ 0.04 |
| Triaminic cold & cough liquid | $ 0.04 |
| Phénylpropanolamine | |
| Naldecon Senior EX 200 mg/5ml Syrup 118ml Bottle | $ 15.99 |
| Entex ER 10-300 mg 12 Hour Capsule | $ 1.14 |
| Codimal la capsule | $ 0.70 |
| Despec-dm tablet | $ 0.61 |
| Despec-tab tablet | $ 0.47 |
| Triaminic allergy thin strip | $ 0.35 |
| Triaminic cold-stuff nose strip | $ 0.35 |
| Conex tablet | $ 0.33 |
| Triaminic cgh-runny nose strip | $ 0.30 |
| Triaminic cough strips | $ 0.30 |
| Triaminic cough-cold chew | $ 0.27 |
| Triaminic softchew tablet | $ 0.27 |
| Triaminic softchews tablet | $ 0.25 |
| Childrens triaminic decon spray | $ 0.24 |
| Triaminicin tablet | $ 0.23 |
| Dexatrim natural caplet | $ 0.19 |
| Codimal DH 5-8.33-1.66 mg/5ml Syrup | $ 0.18 |
| Despec-exp syrup | $ 0.18 |
| Codimal dm syrup | $ 0.16 |
| Naldecon-dx senior | $ 0.06 |
| Apap allergy sinus caplet | $ 0.05 |
| Triaminic chest-nasal cong liq | $ 0.04 |
| Triaminic cold & cough liquid | $ 0.04 |
| Triaminic cold-allergy pe liq | $ 0.04 |
| Triaminic cough-nasal cong liquid | $ 0.04 |
| Triaminic cough-sore throat liquid | $ 0.04 |
| Triaminic flu cough-fever suspension | $ 0.04 |
| Triaminic flu-cough-fever liquid | $ 0.04 |
| Triaminic-d syrup | $ 0.04 |
| Triaminic cold & cough liquid | $ 0.04 |
| Naldecon Senior EX 200 mg/5ml Syrup 118ml Bottle | $ 15.99 |
| Entex ER 10-300 mg 12 Hour Capsule | $ 1.14 |
| Codimal la capsule | $ 0.70 |
| Despec-dm tablet | $ 0.61 |
| Despec-tab tablet | $ 0.47 |
| Triaminic allergy thin strip | $ 0.35 |
| Triaminic cold-stuff nose strip | $ 0.35 |
| Conex tablet | $ 0.33 |
| Triaminic cgh-runny nose strip | $ 0.30 |
| Triaminic cough strips | $ 0.30 |
| Triaminic cough-cold chew | $ 0.27 |
| Triaminic softchew tablet | $ 0.27 |
| Triaminic softchews tablet | $ 0.25 |
| Childrens triaminic decon spray | $ 0.24 |
| Triaminicin tablet | $ 0.23 |
| Dexatrim natural caplet | $ 0.19 |
| Codimal DH 5-8.33-1.66 mg/5ml Syrup | $ 0.18 |
| Despec-exp syrup | $ 0.18 |
| Codimal dm syrup | $ 0.16 |
| Naldecon-dx senior | $ 0.06 |
| Apap allergy sinus caplet | $ 0.05 |
| Triaminic chest-nasal cong liq | $ 0.04 |
| Triaminic cold & cough liquid | $ 0.04 |
| Triaminic cold-allergy pe liq | $ 0.04 |
| Triaminic cough-nasal cong liquid | $ 0.04 |
| Triaminic cough-sore throat liquid | $ 0.04 |
| Triaminic flu cough-fever suspension | $ 0.04 |
| Triaminic flu-cough-fever liquid | $ 0.04 |
| Triaminic-d syrup | $ 0.04 |
| Triaminic cold & cough liquid | $ 0.04 |
| Phenylpropanolamine Hydrochloride | |
| Phenylpropanolamine Pharmasant (Thailand) | |
| Proin (United States) | |
| Propadrine | |
| Propagest | |
| Propalin (Australia, Austria, Finland, France, Germany, Israel, Italy, Luxembourg, Netherlands, Poland, Switzerland, United Kingdom) | |
| Syrup; Oral; Phenylpropanolamine Hydrochloride 50 mg / ml | |
See 297 substitutes for Phenoxine | |
Reviews
The results of a survey conducted on ndrugs.com for Phenoxine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Phenoxine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
