Picolax-Aversi indications
* this medicineis used to relieve constipation (difficulty with bowel movements).
* It is a stimulant laxative, which induces a laxative effect (stimulating stool production).
* It is used to relieve constipation and works by stimulating nerve endings in the walls of part of the gut called the large intestine (colon) and rectum. This causes the muscles in the intestine wall to contract more often and with increased force, emptying the bowel and relieving constipation. As this medicineis activated by natural bacteria found in the colon, it does not start working until it reaches this part of the gut.
* In general, this drug is used to relieve constipation and to empty the bowel before surgery, childbirth or certain medical procedures such as radiological examination of the bowel.
* Benefits of being on this drug can include regular bowel movements.
Listed below are the typical uses of Picolax-Aversi.
* Short-term relief of constipation
* Management of constipation (of any cause)
* Clearing the bowel before surgery, childbirth or radiological investigations.
Uses of Picolax-Aversi in details
Picolax-Aversi is used to provide relief from constipation (difficulty in passing stools). It also used (in combination with magnesium oxide and anhydrous citric acid) to empty the bowel before colonoscopy (internal examination of colon to check for cancers or other abnormalities).
Picolax-Aversi description
Each 5 mL syrup contains 5 mg 4,4'-(2-pyridyl-methylene)-diphenol-bis(hydrogen sulfate-ester) disodium salt (equivalent to Picolax-Aversi 5 mg). It also contains the following excipients: Sodium carboxymethylcellulose, methylparaben, propylparaben, glycerin, aroma tutti frutti, sodium saccharin, FD & C yellow #6, ethanol and purified water.
Picolax-Aversi dosage
A low residue diet is recommended on the day prior to the hospital procedure. To avoid dehydration, it is recommended to drink a sufficient amount of clear liquids whilst the effects of Picolax-Aversi persist. Clear liquids may include water, clear soup, fruit juice without pulp, softdrinks, tea and/or even coffee without milk.
Adults (including the Elderly): Split-Dose Regimen (evening-before and day of the procedure): The 1st Picolax-Aversi sachet is taken the night before the procedure and the 2nd is taken the next day, in the morning prior to the procedure. On the day before the procedure: 1 sachet. The 1st reconstituted sachet is taken in the evening (eg, 5-9 PM), followed by at least five 250 mL drinks of clear liquids, spread over several hrs.
On the day of the procedure: 1 sachet. The 2nd reconstituted sachet is taken in the morning (5-9 hrs before the procedure), followed by at least three 250 mL drinks of clear liquids, spread over several hours.
Day-Before Regimen (evening-before the procedure): The 1st Picolax-Aversi sachet is taken in the afternoon or early evening and the 2nd is taken approximately 6 hrs later, the night before the procedure.
On the day before the procedure: 2 sachets. The 1st reconstituted sachet is taken in the afternoon or early evening (eg, 4-6 PM), followed by at least five 250 mL drinks of clear liquids, spread over several hours. The 2nd reconstituted sachet is taken in the late evening (eg, 10-12 AM), followed by at least three 250 mL drinks of clear liquids, spread over several hours.
Clear liquids may be consumed until 2 hrs before the time of the procedure.
Administration: Directions for Reconstitution: Reconstitute the Picolax-Aversi powder right before each administration. Do not prepare the solution in advance. Reconstitute the contents of 1 sachet in a cup of water (approximately 150 mL). Stir for 2-3 minutes, the solution should now become an off-white, cloudy liquid with a faint odour of orange.
Picolax-Aversi interactions
As a purgative, Picolax-Aversi increases the gastrointestinal transit rate. The absorption of other orally administered medicines (eg, antiepileptics, contraceptives, antidiabetics, antibiotics) may therefore be modified during the treatment period.
Oral medication administered within 1 hr of the start of administration of Picolax-Aversi solution may be flushed from the gastrointestinal tract and the medication may not be absorbed. Tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, should be taken at least 2 hrs before and ≥6 hrs after administration of Picolax-Aversi to avoid chelation with magnesium.
The efficacy of Picolax-Aversi is lowered by bulk-forming laxatives.
Prior or concomitant use of antibiotics with Picolax-Aversi may reduce efficacy of Picolax-Aversi as conversion of Picolax-Aversi to its active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) is mediated by colonic bacteria.
Use caution when prescribing Picolax-Aversi for patients with conditions or who are using medications that increase the risk for fluid and electrolyte disturbances or may increase the risk of seizure, arrhythmias and prolonged QT in the setting of fluid and electrolyte abnormalities. This include patients receiving drugs which may be associated with hypokalemia (eg, diuretics or corticosteroids, or drugs where hypokalaemia is a particular risk ie, cardiac glycosides). Caution is also advised when Picolax-Aversi is used in patients on angiotensin converting enzyme inhibitors, NSAIDs or drugs known to induce syndrome of inappropriate antidiuretic hormone secretion (SIADH) eg, tricyclic antidepressants, selective serotonin re-uptake inhibitors, antipsychotic drugs and carbamazepine as these drugs may increase the risk of water retention and/or electrolyte imbalance.
Picolax-Aversi side effects
MedDRA Organ Class: Common (≥1/100 to ≤1/10); uncommon (≥1/1000 to ≤1/100); not known (cannot be estimated from the available data).
Immune System Disorder: Uncommon: Anaphylactic reaction, hypersensitivity.
Metabolism and Nutrition Disorders: Uncommon: Hyponatremia and hypokalaemia.
Nervous System Disorders: Common: Headache. Uncommon: Epilepsy, grand mal convulsion, convulsions, confusional state.
Gastrointestinal Disorders: Common: Nausea and proctalgia. Uncommon: Vomiting, abdominal pain, aphthoid ileal ulcers*. Not Known: Diarrhea, faecal incontinence.
Skin and Subcutaneous Tissue Disorders: Uncommon: Rash (including erythematous and maculopapular rash, urticaria, purpura).
*Isolated cases of mild reversible aphthoid ileal ulcers have been reported.
The frequencies of the side effects are based on post-marketing experience.
Diarrhea and faecal incontinence are the primary clinical effect of Picolax-Aversi. Isolated cases of severe diarrhea have been reported post-marketing.
Hyponatremia has been reported with or without associated convulsions. In epileptic patients, there have been isolated reports of seizure/grand mal convulsion without associated hyponatraemia. There have been isolated reports of anaphylactoid reaction.
Picolax-Aversi contraindications
Hypersensitivity to Picolax-Aversi or any of the component of Dulcolax. In case of rare hereditary conditions that may be incompatible with the excipients, the use of Picolax-Aversi is contraindicated. Patients with ileus, intestinal obstruction, acute abdominal conditions including appendicitis, acute inflammatory bowel diseases and severe abdominal pain associated with nausea and vomiting which may be indicative of the aforementioned severe conditions. It is also contraindicated in severe dehydration.
Active ingredient matches for Picolax-Aversi:
Sodium Picosulfate in Georgia.
List of Picolax-Aversi substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| PICOLAX(SP PHARMA) | |
| PICOLAX TABLET 1 strip / 10 tablets each (S P Pharma) | $ 0.36 |
| Picolaxine (Belgium) | |
| Picolaxine 7.5 | |
| Picolon (Denmark) | |
| PICOPIL | |
| PICOPIL 5MG SYRUP 1 bottle / 100 ML syrup each (Psychotropics India Ltd) | $ 0.78 |
| Picoprep (Austria, Estonia, Norway) | |
| PICORAG (India) | |
| 5 mg x 100ml (Auriga) | $ 0.66 |
| PICORAG syr 5 mg x 100ml (Auriga) | $ 0.66 |
| Picorion (Finland) | |
| Picorula (Japan) | |
| Picosalax (Bulgaria, Malta) | |
| Picoslon (Japan) | |
| Picosulfat (Japan) | |
| Picosulfat Toyo Capsule (Japan) | |
| Picosulfate | |
| Drops; Oral; Sodium Picosulfate 7.5 mg / ml | |
| Picosulfate Na (Japan) | |
| Picosulfate Na 0.75% (Japan) | |
| Picosulfate Na 0.75% Towa (Japan) | |
| Picosulfate Na Sawai (Japan) | |
| Picosulfol | |
| PICOSYM (India) | |
| 5 mg x 100ml (Symbiosis) | $ 0.54 |
| PICOSYM syr 5 mg x 100ml (Symbiosis) | $ 0.54 |
| PICOTEL (India) | |
| 5 mg x 100ml (Intel Pharma) | $ 0.54 |
| PICOTEL syr 5 mg x 100ml (Intel Pharma) | $ 0.54 |
| PICOWIN | |
| PICOWIN 5MG SYRUP 1 bottle / 100 ML syrup each (Keen Healthcare Pvt Ltd) | $ 0.72 |
| Picoz (Peru) | |
| PICOZAN | |
| PICOZAN SYRUP 1 bottle / 100 ML syrup each (Zaneka Healthcare Pvt Ltd) | $ 0.58 |
| PICOZAN TABLET 1 strip / 10 tablets each (Zaneka Healthcare Pvt Ltd) | $ 0.43 |
| Picozan NA Tablet (Zaneka Healthcare Pvt Ltd) | $ 0.04 |
| PICSUL | |
| PICSUL 10 MG TABLET 1 strip / 10 tablets each (MRL) | $ 0.46 |
| PICSUL 5 MG/5 ML SYRUP 1 bottle / 100 ML syrup each (MRL) | $ 0.87 |
| PICSUL syr 5 mg x 5 mL x 100ml (MRL) | |
| PICSUL tab 10 mg x 10's (MRL) | |
| Picsul 10mg Tablet (MRL) | $ 0.05 |
| Picsul 5mg/ml Syrup (MRL) | $ 0.87 |
| Pikopil (Netherlands) | |
| Pilules de Vichy (Belgium, Luxembourg) | |
| Pisucon (Indonesia) | |
| PIXIT (India) | |
| PIXIT 5MG/5ML SYRUP 1 bottle / 100 ML syrup each (Endocard) | $ 0.90 |
| PIXIT syr 5 mg x 5 mL x 100ml (Endocard) | $ 0.72 |
| Pixit 5mg/ml Syrup (Endocard) | $ 0.95 |
| Progut (Czech Republic, Japan) | |
See 326 substitutes for Picolax-Aversi | |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
